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  1. AU="Tong, Sun-Wing"
  2. AU="Yoxall, Charles William"
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  1. Article: Kikuchi-Fujimoto disease complicated by aseptic meningitis and hemophagocytosis successfully treated with intrathecal dexamethasone

    Huang, Xiaoyan / Chen, Xixi / Tong, Sun-Wing / Wang, Yan / Cai, Jifu / Deng, Chaowen / Zhang, Lijun

    Heliyon. 2020 June, v. 6, no. 6

    2020  

    Abstract: Kikuchi-Fujimoto disease (KFD) is thought to be a self-limited disease featuring fever and cervical lymphadenopathy; most cases having a favorable outcome. Severe disease and death are occasionally reported. Here we report a case of KFD complicated by ... ...

    Abstract Kikuchi-Fujimoto disease (KFD) is thought to be a self-limited disease featuring fever and cervical lymphadenopathy; most cases having a favorable outcome. Severe disease and death are occasionally reported. Here we report a case of KFD complicated by hemophagocytosis and aseptic meningitis. The symptoms and laboratory parameters improved after systemic glucocorticoids, intravenous immunoglobulin and one dose of intrathecal dexamethasone. Clinicians should aware of this disease and make early diagnosis by lymph node biopsy to avoid over-treatment.
    Keywords biopsy ; death ; dexamethasone ; disease severity ; early diagnosis ; fever ; glucocorticoids ; immunoglobulins ; intravenous injection ; lymph nodes ; lymphatic diseases ; meningitis
    Language English
    Dates of publication 2020-06
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2020.e04193
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Kikuchi-Fujimoto disease complicated by aseptic meningitis and hemophagocytosis successfully treated with intrathecal dexamethasone.

    Huang, Xiaoyan / Chen, Xixi / Tong, Sun-Wing / Wang, Yan / Cai, Jifu / Deng, Chaowen / Zhang, Lijun

    Heliyon

    2020  Volume 6, Issue 6, Page(s) e04193

    Abstract: Kikuchi-Fujimoto disease (KFD) is thought to be a self-limited disease featuring fever and cervical lymphadenopathy; most cases having a favorable outcome. Severe disease and death are occasionally reported. Here we report a case of KFD complicated by ... ...

    Abstract Kikuchi-Fujimoto disease (KFD) is thought to be a self-limited disease featuring fever and cervical lymphadenopathy; most cases having a favorable outcome. Severe disease and death are occasionally reported. Here we report a case of KFD complicated by hemophagocytosis and aseptic meningitis. The symptoms and laboratory parameters improved after systemic glucocorticoids, intravenous immunoglobulin and one dose of intrathecal dexamethasone. Clinicians should aware of this disease and make early diagnosis by lymph node biopsy to avoid over-treatment.
    Language English
    Publishing date 2020-06-18
    Publishing country England
    Document type Case Reports
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2020.e04193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The triptolide derivative MRx102 inhibits Wnt pathway activation and has potent anti-tumor effects in lung cancer.

    Reno, Theresa A / Tong, Sun-Wing / Wu, Jun / Fidler, John M / Nelson, Rebecca / Kim, Jae Y / Raz, Dan J

    BMC cancer

    2016  Volume 16, Page(s) 439

    Abstract: Background: The natural compound triptolide has been shown to decrease cell proliferation and induce apoptosis and cellular senescence. We previously demonstrated that triptolide decreases tumor formation and metastasis of human non-small cell lung ... ...

    Abstract Background: The natural compound triptolide has been shown to decrease cell proliferation and induce apoptosis and cellular senescence. We previously demonstrated that triptolide decreases tumor formation and metastasis of human non-small cell lung cancer cells (NSCLC). Due to the toxicity of triptolide, derivatives of the natural compound have been developed that show more favorable toxicity profiles and pharmacokinetics in animal models. The purpose of this study was to evaluate MRx102 as a novel therapeutic for lung cancer.
    Methods: Mice injected subcutaneously with H460 lung cancer cells were treated with MRx102 or carboplatin to determine the effect of MRx102 on tumor formation in comparison to standard treatment. Patient-derived xenografts (PDX) with different WIF1 expression levels were treated with MRx102 or cisplatin. We tested the effects of MRx102 treatment on migration and invasion of lung cancer cells using Transwell filters coated with fibronectin and Matrigel, respectively. Tail vein injections using H460 and A549 cells were performed.
    Results: Here we report that the triptolide derivative MRx102 significantly decreases NSCLC proliferation and stimulates apoptosis. Further, MRx102 potently inhibits NSCLC haptotactic migration and invasion through Matrigel. In vivo, NSCLC tumor formation and metastasis were greatly decreased by MRx102 treatment. The decrease in tumor formation by MRx102 in the patient-derived xenograft model was WIF1-dependent, demonstrating that MRx102 is a potent inhibitor of the Wnt pathway in low WIF1 expressing NSCLC patient tumors.
    Conclusions: These results indicate that MRx102 has potent antitumor effects both in vitro and in vivo, and is a potential novel therapy for the treatment of NSCLC.
    MeSH term(s) A549 Cells ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Carboplatin/administration & dosage ; Carboplatin/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Diterpenes/adverse effects ; Diterpenes/therapeutic use ; Drug Evaluation, Preclinical ; Drug Therapy, Combination ; Epoxy Compounds/adverse effects ; Epoxy Compounds/therapeutic use ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Mice ; Neoplasm Invasiveness ; Phenanthrenes/administration & dosage ; Phenanthrenes/adverse effects ; Phenanthrenes/therapeutic use ; Repressor Proteins/metabolism ; Wnt Signaling Pathway/drug effects ; Xenograft Model Antitumor Assays
    Chemical Substances Adaptor Proteins, Signal Transducing ; Antineoplastic Agents ; Diterpenes ; Epoxy Compounds ; MRx102 ; Phenanthrenes ; Repressor Proteins ; WIF1 protein, human ; triptolide (19ALD1S53J) ; Carboplatin (BG3F62OND5)
    Language English
    Publishing date 2016--11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 1471-2407
    ISSN (online) 1471-2407
    DOI 10.1186/s12885-016-2487-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Identification of Tissue-Specific DNA Methylation Signatures for Thyroid Nodule Diagnostics.

    Yim, John H / Choi, Audrey H / Li, Arthur X / Qin, Hanjun / Chang, Sue / Tong, Sun-Wing T / Chu, Peiguo / Kim, Byung-Wook / Schmolze, Daniel / Lew, Ryan / Ibrahim, Yasmine / Poroyko, Valeriy A / Salvatierra, Sylvana / Baker, Alysha / Wang, Jinhui / Wu, Xiwei / Pfeifer, Gerd P / Fong, Yuman / Hahn, Maria A

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2018  Volume 25, Issue 2, Page(s) 544–551

    Abstract: Purpose: Thyroid cancer is frequently difficult to diagnose due to an overlap of cytologic features between malignant and benign nodules. This overlap leads to unnecessary removal of the thyroid in patients without cancer. While providing some ... ...

    Abstract Purpose: Thyroid cancer is frequently difficult to diagnose due to an overlap of cytologic features between malignant and benign nodules. This overlap leads to unnecessary removal of the thyroid in patients without cancer. While providing some improvement over cytopathologic diagnostics, molecular methods frequently fail to provide a correct diagnosis for thyroid nodules. These approaches are based on the difference between cancer and adjacent thyroid tissue and assume that adjacent tissues are the same as benign nodules. However, in contrast to adjacent tissues, benign thyroid nodules can contain genetic alterations that can be found in cancer.
    Results: By conducting reduced representation bisulfite sequencing in 109 thyroid specimens, we found significant differences between adjacent tissue, benign nodules, and cancer. These tissue-specific signatures are strongly linked to active enhancers and cancer-associated genes. Based on these signatures, we developed a new epigenetic approach for thyroid diagnostics. According to the validation cohort, our test has an estimated specificity of 97% [95% confidence interval (CI), 81-100], sensitivity of 100% (95% CI, 87-100), positive predictive value of 97% (95% CI, 83-100), and negative predictive value of 100% (95% CI, 86-100).
    Conclusions: These data show that epigenetic testing can provide outstanding diagnostic accuracy for thyroid nodules.
    MeSH term(s) Biomarkers, Tumor ; Biopsy, Fine-Needle ; DNA Methylation ; Diagnosis, Differential ; Epigenesis, Genetic ; Epigenomics/methods ; Humans ; Mutation ; Organ Specificity ; Polymerase Chain Reaction ; Protein Array Analysis ; Sensitivity and Specificity ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/genetics ; Thyroid Nodule/diagnosis ; Thyroid Nodule/genetics ; Transcriptome
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2018-08-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-18-0841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4223: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Transjugular liver biopsy with an automated trucut-type needle: comparative study with percutaneous liver biopsy.

    Chau, Tai-Nin / Tong, Sun-Wing / Li, Tat-Ming / To, Hing-Ting / Lee, Kam-Cheong / Lai, Jak-Yiu / Lai, Sik-To / Yuen, Hon

    European journal of gastroenterology & hepatology

    2001  Volume 14, Issue 1, Page(s) 19–24

    Abstract: Objective: Transjugular liver biopsy using the suction method usually produces small specimens with excessive fragmentation, hence the diagnosis adequacy of specimens and the clinical impact of performing the biopsy have been questioned. An alternative ... ...

    Abstract Objective: Transjugular liver biopsy using the suction method usually produces small specimens with excessive fragmentation, hence the diagnosis adequacy of specimens and the clinical impact of performing the biopsy have been questioned. An alternative biopsy needle, the Quick-Core needle system, which uses an automated trucut-type mechanism, has been shown to produce non-fragmented tissue specimens. The aim of the present study was to evaluate the safety, adequacy and clinical impact of the transjugular liver biopsy by comparing it with the standard percutaneous liver biopsy.
    Design: We recruited all patients who underwent liver biopsies by percutaneous or transjugular routes in the Department of Medicine, Princess Margaret Hospital, Hong Kong between January 1998 and December 1999.
    Method: We recorded demographics and clinical features of patients, indications and complications, and the clinical impact of the liver biopsy procedure. All liver biopsy specimens were reviewed by the histopathologist, who was blinded to the approach of taking the biopsy. All variables between patients undergoing transjugular and percutaneous liver biopsies were compared.
    Results: During the study period, 50 percutaneous and 18 transjugular liver biopsies were performed. All transjugular liver biopsies were performed successfully with adequate tissue for diagnosis. Although specimens obtained by the transjugular technique tended to be shorter (10 mm v. 18 mm by the percutaneous approach, P < 0.001), the presence of fragmentation was similar to that in biopsies obtained by the percutaneous approach. Respectively, 100% and 98% of specimens obtained by the transjugular and percutaneous approaches were considered to be adequate for histological assessment. The clinical impact of transjugular and percutaneous liver procedures was comparable (89% v. 76%, P = 0.25).
    Conclusion: Specimens obtained by a transjugular automated trucut needle are sufficient for histological assessment, and carry clinical impact in patient management.
    MeSH term(s) Adult ; Aged ; Biopsy, Needle/instrumentation ; Biopsy, Needle/methods ; Female ; Humans ; Liver/pathology ; Liver Diseases/pathology ; Male ; Middle Aged
    Language English
    Publishing date 2001-09-04
    Publishing country England
    Document type Comparative Study ; Journal Article ; Validation Studies
    ZDB-ID 1034239-4
    ISSN 1473-5687 ; 0954-691X
    ISSN (online) 1473-5687
    ISSN 0954-691X
    DOI 10.1097/00042737-200201000-00005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2932: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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