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  1. Article ; Online: Flourishing Antibacterial Strategies for Osteomyelitis Therapy

    Xukai Wang / Mingran Zhang / Tongtong Zhu / Qiuhua Wei / Guangyao Liu / Jianxun Ding

    Advanced Science, Vol 10, Iss 11, Pp n/a-n/a (2023)

    2023  

    Abstract: Abstract Osteomyelitis is a destructive disease of bone tissue caused by infection with pathogenic microorganisms. Because of the complex and long‐term abnormal conditions, osteomyelitis is one of the refractory diseases in orthopedics. Currently, anti‐ ... ...

    Abstract Abstract Osteomyelitis is a destructive disease of bone tissue caused by infection with pathogenic microorganisms. Because of the complex and long‐term abnormal conditions, osteomyelitis is one of the refractory diseases in orthopedics. Currently, anti‐infective therapy is the primary modality for osteomyelitis therapy in addition to thorough surgical debridement. However, bacterial resistance has gradually reduced the benefits of traditional antibiotics, and the development of advanced antibacterial agents has received growing attention. This review introduces the main targets of antibacterial agents for treating osteomyelitis, including bacterial cell wall, cell membrane, intracellular macromolecules, and bacterial energy metabolism, focuses on their mechanisms, and predicts prospects for clinical applications.
    Keywords antibacterial agent ; antibacterial mechanism ; biomaterial ; osteomyelitis therapy ; targeted antibacterial strategy ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Clinical application of the modified posterolateral approach for treating posterior tibial plateau fractures.

    Shuaishuai, Wang / Minglei, Zhang / Yue, Yu / Dapeng, Wang / Tongtong, Zhu / Huimin, Liu

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1150541

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2023-02-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1150541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Host-mediated RNA editing in viruses

    Tongtong Zhu / Guangyi Niu / Yuansheng Zhang / Ming Chen / Chuan-Yun Li / Lili Hao / Zhang Zhang

    Biology Direct, Vol 18, Iss 1, Pp 1-

    2023  Volume 12

    Abstract: Abstract Viruses rely on hosts for life and reproduction, cause a variety of symptoms from common cold to AIDS to COVID-19 and provoke public health threats claiming millions of lives around the globe. RNA editing, as a crucial co-/post-transcriptional ... ...

    Abstract Abstract Viruses rely on hosts for life and reproduction, cause a variety of symptoms from common cold to AIDS to COVID-19 and provoke public health threats claiming millions of lives around the globe. RNA editing, as a crucial co-/post-transcriptional modification inducing nucleotide alterations on both endogenous and exogenous RNA sequences, exerts significant influences on virus replication, protein synthesis, infectivity and toxicity. Hitherto, a number of host-mediated RNA editing sites have been identified in diverse viruses, yet lacking a full picture of RNA editing-associated mechanisms and effects in different classes of viruses. Here we synthesize the current knowledge of host-mediated RNA editing in a variety of viruses by considering two enzyme families, viz., ADARs and APOBECs, thereby presenting a landscape of diverse editing mechanisms and effects between viruses and hosts. In the ongoing pandemic, our study promises to provide potentially valuable insights for better understanding host-mediated RNA editing on ever-reported and newly-emerging viruses.
    Keywords Virus ; RNA editing ; Deamination ; Proviral ; Antiviral ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Implantable biomedical materials for treatment of bone infection.

    Shuaishuai, Wang / Tongtong, Zhu / Dapeng, Wang / Mingran, Zhang / Xukai, Wang / Yue, Yu / Hengliang, Dong / Guangzhi, Wu / Minglei, Zhang

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1081446

    Abstract: The treatment of bone infections has always been difficult. The emergence of drug-resistant bacteria has led to a steady decline in the effectiveness of antibiotics. It is also especially important to fight bacterial infections while repairing bone ... ...

    Abstract The treatment of bone infections has always been difficult. The emergence of drug-resistant bacteria has led to a steady decline in the effectiveness of antibiotics. It is also especially important to fight bacterial infections while repairing bone defects and cleaning up dead bacteria to prevent biofilm formation. The development of biomedical materials has provided us with a research direction to address this issue. We aimed to review the current literature, and have summarized multifunctional antimicrobial materials that have long-lasting antimicrobial capabilities that promote angiogenesis, bone production, or "killing and releasing." This review provides a comprehensive summary of the use of biomedical materials in the treatment of bone infections and a reference thereof, as well as encouragement to perform further research in this field.
    Language English
    Publishing date 2023-01-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1081446
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Poly(lactic-co-glycolic acid)-based composite bone-substitute materials

    Duoyi Zhao / Tongtong Zhu / Jie Li / Liguo Cui / Zhiyu Zhang / Xiuli Zhuang / Jianxun Ding

    Bioactive Materials, Vol 6, Iss 2, Pp 346-

    2021  Volume 360

    Abstract: Research and development of the ideal artificial bone-substitute materials to replace autologous and allogeneic bones for repairing bone defects is still a challenge in clinical orthopedics. Recently, poly(lactic-co-glycolic acid) (PLGA)-based artificial ...

    Abstract Research and development of the ideal artificial bone-substitute materials to replace autologous and allogeneic bones for repairing bone defects is still a challenge in clinical orthopedics. Recently, poly(lactic-co-glycolic acid) (PLGA)-based artificial bone-substitute materials are attracting increasing attention as the benefit of their suitable biocompatibility, degradability, mechanical properties, and capabilities to promote bone regeneration. In this article, we comprehensively review the artificial bone-substitute materials made from PLGA or the composites of PLGA and other organic and inorganic substances, elaborate on their applications for bone regeneration with or without bioactive factors, and prospect the challenges and opportunities in clinical bone regeneration.
    Keywords Poly(lactic-co-glycolic acid) ; Composite organic−inorganic biomaterial ; Bone-substitute material ; Bone tissue engineering ; Bone regeneration ; Materials of engineering and construction. Mechanics of materials ; TA401-492 ; Biology (General) ; QH301-705.5
    Subject code 616
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Construction and validation of steroid-induced rabbit osteonecrosis model

    Tongtong Zhu / Mengyang Jiang / Mingran Zhang / Liguo Cui / Xiaoyu Yang / Xukai Wang / Guangyao Liu / Jianxun Ding / Xuesi Chen

    MethodsX, Vol 9, Iss , Pp 101713- (2022)

    2022  

    Abstract: Osteonecrosis is a common orthopedic disease in clinic, resulting in joint collapse if appropriate treatment is not given in time. The clinical usage of high-dose steroid is one of the common causes of osteonecrosis. In several studies, the intravenous ... ...

    Abstract Osteonecrosis is a common orthopedic disease in clinic, resulting in joint collapse if appropriate treatment is not given in time. The clinical usage of high-dose steroid is one of the common causes of osteonecrosis. In several studies, the intravenous injection of steroid with or without lipopolysaccharide is the most commonly used strategy to construct osteonecrosis animal model. However, the injection dose, frequency, and interval of steroid and validation of successful model construction lack generally accepted protocol, and the survival and model formation rates are unsatisfactory. We have optimized the construction protocol of osteonecrosis animal model based on the previously reported ones and established a mature animal model of osteonecrosis for future studies. • A rabbit model of osteonecrosis was constructed by multiple injections of high-dose methylprednisolone. • The multidisciplinary biomedical examinations demonstrated the successful construction of osteonecrosis model in the rabbit.
    Keywords Steroid-induced rabbit osteonecrosis model ; Science ; Q
    Subject code 690
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Design, Synthesis and Biological Evaluation of N -phenylindole Derivatives as Pks13 Inhibitors against Mycobacterium tuberculosis

    Yanpeng Cai / Wei Zhang / Shichun Lun / Tongtong Zhu / Weijun Xu / Fan Yang / Jie Tang / William R. Bishai / Lifang Yu

    Molecules, Vol 27, Iss 2844, p

    2022  Volume 2844

    Abstract: Polyketide synthase 13 (Pks13), an essential enzyme for the survival of Mycobacterium tuberculosis ( Mtb ), is an attractive target for new anti-TB agents. In our previous work, we have identified 2-phenylindole derivatives against Mtb . The ... ...

    Abstract Polyketide synthase 13 (Pks13), an essential enzyme for the survival of Mycobacterium tuberculosis ( Mtb ), is an attractive target for new anti-TB agents. In our previous work, we have identified 2-phenylindole derivatives against Mtb . The crystallography studies demonstrated that the two-position phenol was solvent-exposed in the Pks13-TE crystal structure and a crucial hydrogen bond was lost while introducing bulkier hydrophobic groups at indole N moieties. Thirty-six N -phenylindole derivatives were synthesized and evaluated for antitubercular activity using a structure-guided approach. The structure–activity relationship (SAR) studies resulted in the discovery of the potent Compounds 45 and 58 against Mtb H37Rv, with an MIC value of 0.0625 μg/mL and 0.125 μg/mL, respectively. The thermal stability analysis showed that they bind with high affinity to the Pks13-TE domain. Preliminary ADME evaluation showed that Compound 58 displayed modest human microsomal stability. This report further validates that targeting Pks13 is a valid strategy for the inhibition of Mtb and provides a novel scaffold for developing leading anti-TB compounds.
    Keywords tuberculosis ; polyketide synthase 13 ; N -phenylindole derivatives ; structure–activity relationship ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Biofunctionalized composite scaffold to potentiate osteoconduction, angiogenesis, and favorable metabolic microenvironment for osteonecrosis therapy

    Tongtong Zhu / Mengyang Jiang / Mingran Zhang / Liguo Cui / Xiaoyu Yang / Xukai Wang / Guangyao Liu / Jianxun Ding / Xuesi Chen

    Bioactive Materials, Vol 9, Iss , Pp 446-

    2022  Volume 460

    Abstract: Osteonecrosis is a common orthopedic disease in clinic, resulting in joint collapse if no appropriate treatment is performed in time. Core decompression is a general treatment modality for early osteonecrosis. However, effective bone regeneration in the ... ...

    Abstract Osteonecrosis is a common orthopedic disease in clinic, resulting in joint collapse if no appropriate treatment is performed in time. Core decompression is a general treatment modality for early osteonecrosis. However, effective bone regeneration in the necrotic area is still a significant challenge. This study developed a biofunctionalized composite scaffold (PLGA/nHA30VEGF) for osteonecrosis therapy through potentiation of osteoconduction, angiogenesis, and a favorable metabolic microenvironment. The composite scaffold had a porosity of 87.7% and compressive strength of 8.9 MPa. PLGA/nHA30VEGF had an average pore size of 227.6 μm and a water contact angle of 56.5° with a sustained release profile of vascular endothelial growth factor (VEGF). After the implantation of PLGA/nHA30VEGF, various osteogenic and angiogenic biomarkers were upregulated by 2–9 fold compared with no treatment. Additionally, the metabolomic and lipidomic profiling studies demonstrated that PLGA/nHA30VEGF effectively regulated the multiple metabolites and more than 20 inordinate metabolic pathways in osteonecrosis. The excellent performances reveal that the biofunctionalized composite scaffold provides an advanced adjuvant therapy modality for osteonecrosis.
    Keywords Biofunctionalized scaffold ; Osteoconduction ; Angiogenesis ; Favorable metabolic microenvironment ; Osteonecrosis therapy ; Materials of engineering and construction. Mechanics of materials ; TA401-492 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Evaluation of the impacts of ozone on the vegetation productivity of woodland and grassland ecosystems in China

    Qinyi, WANG / Mei, HUANG / Shaoqiang, Wang / Bin, CHEN / Liu, Zhenhai / Zhaosheng, WANG / Shiliang, CHEN / Hui, LI / Tongtong, ZHU / Donghui, LI / Yuelin, LI / Hu, Lin / Leigang, Sun

    Ecological Modelling. 2023 Sept., v. 483 p.110426-

    2023  

    Abstract: In the context of global warming, with the increasing tropospheric ozone concentration and the obvious trend of aridity, terrestrial ecosystems are experiencing multiple pressures. However, there are still many uncertainties in modeling the effects of ... ...

    Abstract In the context of global warming, with the increasing tropospheric ozone concentration and the obvious trend of aridity, terrestrial ecosystems are experiencing multiple pressures. However, there are still many uncertainties in modeling the effects of ozone on ecosystem productivity. In this study, an ozone uptake module was coupled to the BEPS (Boreal Ecosystem Productivity Simulator) model, and the new version, the BEPS-O₃ model, was used to simulate the impacts of ozone on the gross primary productivity (GPP) of woodland and grassland ecosystems in China. Observational data from four sites were used to verify and improve the models, namely, DXG (grassland), HBG (shrub), DHS (evergreen broad-leaved) and CBS (coniferous forest). The regional results show that the total GPP of forest, grassland and shrub in China was 3.62 Pg C, 0.75 Pg C 0.33 Pg C in 2016, respectively. The GPP loss of forests, grasslands and shrubs caused by ozone was 2.8% and 1.1% and 1.5% of the GPP in woodland and grassland ecosystems, respectively (excluding farmland). Subtropical regions experienced the worst GPP losses, although ozone concentrations were not high. However, higher stomatal conductance leads to higher ozone absorption. By comparing the parameters of previous studies, we conclude that the ozone uptake function was better than the ozone exposure function in modeling. Furthermore, the selection of the ozone uptake function will have a significant impact on the final simulation results, especially for grassland.
    Keywords absorption ; agricultural land ; coniferous forests ; dry environmental conditions ; ecosystems ; grasslands ; gross primary productivity ; models ; observational studies ; ozone ; shrubs ; stomatal conductance ; troposphere ; woodlands ; China ; Grassland ; Shrub ; Forest ; POD
    Language English
    Dates of publication 2023-09
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 191971-4
    ISSN 0304-3800
    ISSN 0304-3800
    DOI 10.1016/j.ecolmodel.2023.110426
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Engineered three-dimensional scaffolds for enhanced bone regeneration in osteonecrosis

    Tongtong Zhu / Yutao Cui / Mingran Zhang / Duoyi Zhao / Guangyao Liu / Jianxun Ding

    Bioactive Materials, Vol 5, Iss 3, Pp 584-

    2020  Volume 601

    Abstract: Osteonecrosis, which is typically induced by trauma, glucocorticoid abuse, or alcoholism, is one of the most severe diseases in clinical orthopedics. Osteonecrosis often leads to joint destruction, and arthroplasty is eventually required. Enhancement of ... ...

    Abstract Osteonecrosis, which is typically induced by trauma, glucocorticoid abuse, or alcoholism, is one of the most severe diseases in clinical orthopedics. Osteonecrosis often leads to joint destruction, and arthroplasty is eventually required. Enhancement of bone regeneration is a critical management strategy employed in osteonecrosis therapy. Bone tissue engineering based on engineered three-dimensional (3D) scaffolds with appropriate architecture and osteoconductive activity, alone or functionalized with bioactive factors, have been developed to enhance bone regeneration in osteonecrosis. In this review, we elaborate on the ideal properties of 3D scaffolds for enhanced bone regeneration in osteonecrosis, including biocompatibility, degradability, porosity, and mechanical performance. In addition, we summarize the development of 3D scaffolds alone or functionalized with bioactive factors for accelerating bone regeneration in osteonecrosis and discuss their prospects for translation to clinical practice.
    Keywords Three-dimensional scaffold ; Functionalization ; Bone regeneration ; Bone tissue engineering ; Osteonecrosis therapy ; Materials of engineering and construction. Mechanics of materials ; TA401-492 ; Biology (General) ; QH301-705.5
    Subject code 616
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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