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  1. Article ; Online: Why is early detection of colon cancer still not possible in 2023?

    Tonini, Valeria / Zanni, Manuel

    World journal of gastroenterology

    2024  Volume 30, Issue 3, Page(s) 211–224

    Abstract: Colorectal cancer (CRC) screening is a fundamental tool in the prevention and early detection of one of the most prevalent and lethal cancers. Over the years, screening, particularly in those settings where it is well organized, has succeeded in reducing ...

    Abstract Colorectal cancer (CRC) screening is a fundamental tool in the prevention and early detection of one of the most prevalent and lethal cancers. Over the years, screening, particularly in those settings where it is well organized, has succeeded in reducing the incidence of colon and rectal cancer and improving the prognosis related to them. Despite considerable advancements in screening technologies and strategies, the effectiveness of CRC screening programs remains less than optimal. This paper examined the multifaceted reasons behind the persistent lack of effectiveness in CRC screening initiatives. Through a critical analysis of current methodologies, technological limitations, patient-related factors, and systemic challenges, we elucidated the complex interplay that hampers the successful reduction of CRC morbidity and mortality rates. While acknowledging the advancements that have improved aspects of screening, we emphasized the necessity of addressing the identified barriers comprehensively. This study aimed to raise awareness of how important CRC screening is in reducing costs for this disease. Screening and early diagnosis are not only important in improving the prognosis of patients with CRC but can lead to an important reduction in the cost of treating a disease that is often diagnosed at an advanced stage. Spending more sooner can mean saving money later.
    MeSH term(s) Humans ; Colonic Neoplasms ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Early Detection of Cancer/methods ; Prognosis ; Rectal Neoplasms ; Mass Screening/methods ; Colonoscopy
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v30.i3.211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6039: Show issues Location:
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  2. Article: Impact of anastomotic leakage on long-term prognosis after colorectal cancer surgery.

    Tonini, Valeria / Zanni, Manuel

    World journal of gastrointestinal surgery

    2023  Volume 15, Issue 5, Page(s) 745–756

    Abstract: Colorectal cancer (CRC) is one of the most common malignancies in the world. Despite significant improvements in surgical technique, postoperative complications still occur in a fair percentage of patients undergoing colorectal surgery. The most feared ... ...

    Abstract Colorectal cancer (CRC) is one of the most common malignancies in the world. Despite significant improvements in surgical technique, postoperative complications still occur in a fair percentage of patients undergoing colorectal surgery. The most feared complication is anastomotic leakage. It negatively affects short-term prognosis, with increased post-operative morbidity and mortality, higher hospitalization time and costs. Moreover, it may require further surgery with the creation of a permanent or temporary stoma. While there is no doubt about the negative impact of anastomotic dehiscence on the short-term prognosis of patients operated on for CRC, still under discussion is its impact on the long-term prognosis. Some authors have described an association between leakage and reduced overall survival, disease-free survival, and increased recurrence, while other Authors have found no real impact of dehiscence on long term prognosis. The purpose of this paper is to review all the literature about the impact of anastomotic dehiscence on long-term prognosis after CRC surgery. The main risk factors of leakage and early detection markers are also summarized.
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573700-4
    ISSN 1948-9366
    ISSN 1948-9366
    DOI 10.4240/wjgs.v15.i5.745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Early diagnosis of pancreatic cancer: What strategies to avoid a foretold catastrophe.

    Tonini, Valeria / Zanni, Manuel

    World journal of gastroenterology

    2022  Volume 28, Issue 31, Page(s) 4235–4248

    Abstract: While great strides in improving survival rates have been made for most cancers in recent years, pancreatic ductal adenocarcinoma (PDAC) remains one of the solid tumors with the worst prognosis. PDAC mortality often overlaps with incidence. Surgical ... ...

    Abstract While great strides in improving survival rates have been made for most cancers in recent years, pancreatic ductal adenocarcinoma (PDAC) remains one of the solid tumors with the worst prognosis. PDAC mortality often overlaps with incidence. Surgical resection is the only potentially curative treatment, but it can be performed in a very limited number of cases. In order to improve the prognosis of PDAC, there are ideally two possible ways: the discovery of new strategies or drugs that will make it possible to treat the tumor more successfully or an earlier diagnosis that will allow patients to be operated on at a less advanced stage. The aim of this review was to summarize all the possible strategies available today for the early diagnosis of PDAC and the paths that research needs to take to make this goal ever closer. All the most recent studies on risk factors and screening modalities, new laboratory tests including liquid biopsy, new imaging methods and possible applications of artificial intelligence and machine learning were reviewed and commented on. Unfortunately, in 2022 the results for this type of cancer still remain discouraging, while a catastrophic increase in cases is expected in the coming years. The article was also written with the aim of highlighting the urgency of devoting more attention and resources to this pathology in order to reach a solution that seems more and more unreachable every day.
    MeSH term(s) Artificial Intelligence ; Biomarkers, Tumor ; Carcinoma, Pancreatic Ductal/diagnosis ; Carcinoma, Pancreatic Ductal/therapy ; Early Detection of Cancer ; Humans ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/therapy ; Pancreatic Neoplasms
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2022-09-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v28.i31.4235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: En bloc resection of giant retroperitoneal liposarcoma involving the right colon - a video vignette.

    Tonini, V / Ussia, A / Cervellera, M

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2020  Volume 22, Issue 11, Page(s) 1772–1773

    MeSH term(s) Colon ; Humans ; Liposarcoma/diagnostic imaging ; Liposarcoma/surgery ; Retroperitoneal Neoplasms/diagnostic imaging ; Retroperitoneal Neoplasms/surgery
    Language English
    Publishing date 2020-06-14
    Publishing country England
    Document type Letter ; Video-Audio Media
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.15163
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5799: Show issues Location:
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  5. Article ; Online: Pancreatic cancer in 2021: What you need to know to win.

    Tonini, Valeria / Zanni, Manuel

    World journal of gastroenterology

    2021  Volume 27, Issue 35, Page(s) 5851–5889

    Abstract: Pancreatic cancer is one of the solid tumors with the worst prognosis. Five-year survival rate is less than 10%. Surgical resection is the only potentially curative treatment, but the tumor is often diagnosed at an advanced stage of the disease and ... ...

    Abstract Pancreatic cancer is one of the solid tumors with the worst prognosis. Five-year survival rate is less than 10%. Surgical resection is the only potentially curative treatment, but the tumor is often diagnosed at an advanced stage of the disease and surgery could be performed in a very limited number of patients. Moreover, surgery is still associated with high post-operative morbidity, while other therapies still offer very disappointing results. This article reviews every aspect of pancreatic cancer, focusing on the elements that can improve prognosis. It was written with the aim of describing everything you need to know in 2021 in order to face this difficult challenge.
    MeSH term(s) Humans ; Pancreatic Neoplasms/therapy ; Prognosis
    Language English
    Publishing date 2021-09-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v27.i35.5851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Emergency Endoscopy During the SARS-CoV-2 Pandemic in the North of Italy: Experience from St. Orsola University Hospital-Bologna.

    Lauro, A / Pagano, N / Impellizzeri, G / Cervellera, M / Tonini, V

    Digestive diseases and sciences

    2020  Volume 65, Issue 6, Page(s) 1559–1561

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Emergency Treatment ; Endoscopy/statistics & numerical data ; Hospitals, University ; Humans ; Italy/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-020-06270-x
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  7. Article ; Online: Debris-Filled Duodenal Diverticulum and Lemmel's Syndrome.

    Zorzetti, Noemi / Lauro, A / Cervellera, M / Panarese, A / Khouzam, S / Marino, I R / Sorrenti, S / D'Andrea, V / Tonini, V

    Digestive diseases and sciences

    2022  Volume 67, Issue 7, Page(s) 2805–2808

    Abstract: We report a case of a 73-year-old woman affected by Lemmel's syndrome, a rare type of obstructive jaundice caused by a periampullary duodenal diverticulum. The patient was admitted to the Emergency Department for pneumonia associated with mild epigastric ...

    Abstract We report a case of a 73-year-old woman affected by Lemmel's syndrome, a rare type of obstructive jaundice caused by a periampullary duodenal diverticulum. The patient was admitted to the Emergency Department for pneumonia associated with mild epigastric pain and vomiting. While hospitalized for antibiotic treatment, the appearance of jaundice led us to discover a periampullary duodenal diverticulum by endoscopy and CT scan. The jaundice was successfully managed endoscopically with removal of food debris from the diverticulum.
    MeSH term(s) Abdominal Pain/etiology ; Aged ; Diverticulum/complications ; Diverticulum/diagnostic imaging ; Diverticulum/surgery ; Duodenal Diseases/complications ; Duodenal Diseases/diagnostic imaging ; Female ; Humans ; Jaundice ; Jaundice, Obstructive/etiology ; Syndrome
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-022-07571-z
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  8. Article: Emergency Endoscopy During the SARS-CoV-2 Pandemic in the North of Italy: Experience from St. Orsola University Hospital-Bologna

    Lauro, A / Pagano, N / Impellizzeri, G / Cervellera, M / Tonini, V

    Dig Dis Sci

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #102132
    Database COVID19

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  9. Article ; Online: Emergency Endoscopy During the SARS-CoV-2 Pandemic in the North of Italy

    Lauro, A. / Pagano, N. / Impellizzeri, G. / Cervellera, M. / Tonini, V.

    Digestive Diseases and Sciences

    Experience from St. Orsola University Hospital—Bologna

    2020  Volume 65, Issue 6, Page(s) 1559–1561

    Keywords Gastroenterology ; Physiology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-020-06270-x
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Bleeding Edge Therapy: Ileocolic Intussusception Due to Ileocecal Valve Adenocarcinoma and Its Management in an Adult Patient-Case Report and Literature Review.

    Zanni, M / Vaccari, S / Lauro, A / Marino, I R / Cervellera, M / D'Andrea, V / Tonini, V

    Digestive diseases and sciences

    2021  Volume 66, Issue 5, Page(s) 1436–1440

    Abstract: Adenocarcinoma as the primary cause of bowel intussusception is uncommon. We describe the case of a 86-year-old patient admitted for ileocecal intussusception due to the presence of adenocarcinoma, located in the ileocecal valve and right colon. The ... ...

    Abstract Adenocarcinoma as the primary cause of bowel intussusception is uncommon. We describe the case of a 86-year-old patient admitted for ileocecal intussusception due to the presence of adenocarcinoma, located in the ileocecal valve and right colon. The etiologies of intussusception, its diagnosis, and conservative or surgical treatments are discussed, with attention placed on the indications for reduction of the invagination prior to surgical resection.
    MeSH term(s) Adenocarcinoma/complications ; Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Aged, 80 and over ; Female ; Humans ; Ileal Diseases/diagnostic imaging ; Ileal Diseases/etiology ; Ileal Diseases/surgery ; Ileal Neoplasms/complications ; Ileal Neoplasms/diagnostic imaging ; Ileal Neoplasms/pathology ; Ileal Neoplasms/surgery ; Ileocecal Valve/diagnostic imaging ; Ileocecal Valve/pathology ; Ileocecal Valve/surgery ; Intussusception/diagnostic imaging ; Intussusception/etiology ; Intussusception/surgery ; Neoplasm Staging ; Treatment Outcome
    Language English
    Publishing date 2021-01-29
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-021-06849-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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