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  1. Article ; Online: Design and Development of Transient Sensing Devices for Healthcare Applications.

    Janićijević, Željko / Huang, Tao / Bojórquez, Diana Isabel Sandoval / Tonmoy, Taufhik Hossain / Pané, Salvador / Makarov, Denys / Baraban, Larysa

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2024  , Page(s) e2307232

    Abstract: With the ever-growing requirements in the healthcare sector aimed at personalized diagnostics and treatment, continuous and real-time monitoring of relevant parameters is gaining significant traction. In many applications, health status monitoring may be ...

    Abstract With the ever-growing requirements in the healthcare sector aimed at personalized diagnostics and treatment, continuous and real-time monitoring of relevant parameters is gaining significant traction. In many applications, health status monitoring may be carried out by dedicated wearable or implantable sensing devices only within a defined period and followed by sensor removal without additional risks for the patient. At the same time, disposal of the increasing number of conventional portable electronic devices with short life cycles raises serious environmental concerns due to the dangerous accumulation of electronic and chemical waste. An attractive solution to address these complex and contradictory demands is offered by biodegradable sensing devices. Such devices may be able to perform required tests within a programmed period and then disappear by safe resorption in the body or harmless degradation in the environment. This work critically assesses the design and development concepts related to biodegradable and bioresorbable sensors for healthcare applications. Different aspects are comprehensively addressed, from fundamental material properties and sensing principles to application-tailored designs, fabrication techniques, and device implementations. The emerging approaches spanning the last 5 years are emphasized and a broad insight into the most important challenges and future perspectives of biodegradable sensors in healthcare are provided.
    Language English
    Publishing date 2024-03-14
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202307232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Corrigendum to "Multiplexed extended gate field-effect transistor biosensor with gold nanoantennae as signal amplifiers" [Biosens. Bioelectron. 241 (2023) 115701].

    Janićijević, Željko / Nguyen-Le, Trang-Anh / Alsadig, Ahmed / Cela, Isli / Žilėnaite, Rugilė / Tonmoy, Taufhik Hossain / Kubeil, Manja / Bachmann, Michael / Baraban, Larysa

    Biosensors & bioelectronics

    2023  Volume 243, Page(s) 115715

    Language English
    Publishing date 2023-10-13
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2023.115715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Methods gold standard in clinic millifluidics multiplexed extended gate field-effect transistor biosensor with gold nanoantennae as signal amplifiers.

    Janićijević, Željko / Nguyen-Le, Trang-Anh / Alsadig, Ahmed / Cela, Isli / Žilėnaite, Rugilė / Tonmoy, Taufhik Hossain / Kubeil, Manja / Bachmann, Michael / Baraban, Larysa

    Biosensors & bioelectronics

    2023  Volume 241, Page(s) 115701

    Abstract: We present a portable multiplexed biosensor platform based on the extended gate field-effect transistor and demonstrate its amplified response thanks to gold nanoparticle-based bioconjugates introduced as a part of the immunoassay. The platform comprises ...

    Abstract We present a portable multiplexed biosensor platform based on the extended gate field-effect transistor and demonstrate its amplified response thanks to gold nanoparticle-based bioconjugates introduced as a part of the immunoassay. The platform comprises a disposable chip hosting an array of 32 extended gate electrodes, a readout module based on a single transistor operating in constant charge mode, and a multiplexer to scan sensing electrodes one-by-one. Although employing only off-the-shelf electronic components, our platform achieves sensitivities comparable to fully customized nanofabricated potentiometric sensors. In particular, it reaches a detection limit of 0.2 fM for the pure molecular assay when sensing horseradish peroxidase-linked secondary antibody (∼0.4 nM reached by standard microplate methods). Furthermore, with the gold nanoparticle bioconjugation format, we demonstrate ca. 5-fold amplification of the potentiometric response compared to a pure molecular assay, at the detection limit of 13.3 fM. Finally, we elaborate on the mechanism of this amplification and propose that nanoparticle-mediated disruption of the diffusion barrier layer is the main contributor to the potentiometric signal enhancement. These results show the great potential of our portable, sensitive, and cost-efficient biosensor for multidimensional diagnostics in the clinical and laboratory settings, including e.g., serological tests or pathogen screening.
    MeSH term(s) Gold ; Metal Nanoparticles ; Biosensing Techniques/methods ; Potentiometry ; Immunoassay ; Electrodes
    Chemical Substances Gold (7440-57-5)
    Language English
    Publishing date 2023-09-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2023.115701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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