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  1. Article: Reversible Acute Lung Injury due to Bleomycin.

    Ghalamkari, Marziyeh / Khatuni, Mahdi / Toogeh, Gholamreza / Haghighi, Sepehr / Taherkhani, Maryam

    Tanaffos

    2023  Volume 21, Issue 2, Page(s) 253–256

    Abstract: Bleomycin is a unique antibiotic agent with cytotoxic activity and is used successfully in various malignant diseases, such as Hodgkin lymphoma and germ cell tumors. Drug-induced lung injury (DILI) is one of the major limitations of bleomycin ... ...

    Abstract Bleomycin is a unique antibiotic agent with cytotoxic activity and is used successfully in various malignant diseases, such as Hodgkin lymphoma and germ cell tumors. Drug-induced lung injury (DILI) is one of the major limitations of bleomycin administration in particular clinical settings. The incidence varies among patients and depends on a variety of risk factors, such as cumulative drug dose, underlying malignant disease, and concurrent radiation. The clinical presentations are non-specific for bleomycin-induced lung injury (BILI), depending on the onset and severity of symptoms. There is no established guideline for the best treatment of DILI and the treatment is based on the time and severity of pulmonary symptoms. It is important to consider BILI in any patient with pulmonary clinical manifestations who has been treated with bleomycin. Here, we report a 19-year-old woman who is a known case of Hodgkin lymphoma. She was treated with a bleomycin-containing chemotherapy regimen. On the 5th month of therapy, she was admitted to hospital with severe acute pulmonary symptoms and decreased oxygen saturation. She was treated successfully with high-dose corticosteroid without any significant sequelae.
    Language English
    Publishing date 2023-01-18
    Publishing country Iran
    Document type Case Reports
    ZDB-ID 2233372-1
    ISSN 1735-0344
    ISSN 1735-0344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Comparison of Long-Acting G-CSF (PD-Lasta) with Short-Acting G-CSF (PD-Grastim) in Neutrophil Recovery Following Consolidation Chemotherapy with High-Dose Cytarabine in Acute Myeloid Leukemia: A Randomized Clinical Trial.

    Esfandbod, Mohsen / Agha Bararzadeh, Fatemeh / Faraz, Mona / Zarrabi, Fariba / Toogeh, Gholamreza

    International journal of hematology-oncology and stem cell research

    2021  Volume 15, Issue 2, Page(s) 96–102

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-08-27
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2652853-8
    ISSN 2008-2207 ; 2008-3009
    ISSN (online) 2008-2207
    ISSN 2008-3009
    DOI 10.18502/ijhoscr.v15i2.6040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Fertility Preservation in Iranian Cancer Patients: A Continuing Neglect.

    Toogeh, Gholamreza / Razzaghof, Mohammadreza / Zarrabi, Fariba

    International journal of fertility & sterility

    2017  Volume 11, Issue 3, Page(s) 234–237

    Language English
    Publishing date 2017-08-27
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2570865-X
    ISSN 2008-0778 ; 2008-076X
    ISSN (online) 2008-0778
    ISSN 2008-076X
    DOI 10.22074/ijfs.2017.4960
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  4. Article: Genetic analysis of non-severe hemophilia A phenotype with A discrepancy between one-stage and chromogenic factor VIII activity assays.

    Valikhani, Amir / Mirakhorly, Mojgan / Namvar, Ali / Rastegarlari, Ghasem / Toogeh, Gholamreza / Shirayeh, Fatemeh Vossough / Ahmadinejad, Minoo

    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

    2021  Volume 60, Issue 5, Page(s) 103194

    Abstract: Introduction: The diagnosis of hemophilia A (HA) is based on the measurement of factor VIII activity (VIII:C). About one-third of non-severe HA patients show a discrepancy of VIII:C measured by one-stage (VIII:C 1st) and chromogenic (VIII:C chr) assays. ...

    Abstract Introduction: The diagnosis of hemophilia A (HA) is based on the measurement of factor VIII activity (VIII:C). About one-third of non-severe HA patients show a discrepancy of VIII:C measured by one-stage (VIII:C 1st) and chromogenic (VIII:C chr) assays. Different mutations in the F8 gene may cause the discrepancy in results of the FVIII activity assay. The aim of this study was to investigate F8 gene mutations in patients with assay discrepancies and to evaluate their impact on the results of VIII:C assays.
    Methods: Mutation analysis was performed on 41 individuals with a discrepancy in VIII:C 1st and FVIII: C chr assays by direct sequencing. In addition, the effect of the variants on FVIII macromolecule structure was investigated by in silico and bioinformatics tools.
    Results: Genetic analysis disclosed 22 different variants, of which 19 were identified for the first time to be involved in the phenotype of VIII:C discrepancy. Most of the variants related to the higher VIII:C 1st were found in A1, A2, A3 domains. The variant related to VIII:C chr > VIII:C 1st was located in the thrombin cleavage site. In silico analysis showed the effect of variants on FVIII macromolecule stability, which may be the possible mechanism causing the discrepancy.
    Conclusion: Our data shed light on the impact of genetic defects on VIII:C assay and provided evidence that the consideration of these mutations may open a new window to the proper diagnosis and treatment monitoring of non-severe HA patients.
    MeSH term(s) Adult ; Binding Sites ; Blood Coagulation ; Blood Coagulation Tests/methods ; Computational Biology ; Computer Simulation ; DNA Mutational Analysis ; Factor VIII/biosynthesis ; Genetic Testing ; Genetic Variation ; Hemophilia A/blood ; Hemophilia A/genetics ; Humans ; Male ; Mutation ; Mutation, Missense ; Phenotype ; Thrombin
    Chemical Substances Factor VIII (9001-27-8) ; Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2021-07-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2046795-3
    ISSN 1878-1683 ; 1473-0502
    ISSN (online) 1878-1683
    ISSN 1473-0502
    DOI 10.1016/j.transci.2021.103194
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1739: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Acute Compartment Syndrome After Knee Synovectomy in a Patient with Hemophilia A: A Case Report.

    Baghdadi, Soroush / Baghdadi, Taghi / Ayati Firoozabadi, Mohammad / Toogeh, Gholamreza / Mortazavi, S M Javad

    JBJS case connector

    2019  Volume 9, Issue 3, Page(s) e0402

    Abstract: Case: A 19-year-old man with severe hemophilia A underwent open surgical synovectomy to treat recurrent hemarthrosis of the knee. He developed symptoms and signs of acute compartment syndrome (ACS) despite receiving full-dose factor replacement. ... ...

    Abstract Case: A 19-year-old man with severe hemophilia A underwent open surgical synovectomy to treat recurrent hemarthrosis of the knee. He developed symptoms and signs of acute compartment syndrome (ACS) despite receiving full-dose factor replacement. Arthrotomy was performed twice, and massive hemarthrosis was evacuated. The symptoms subsided after supplementing clotting factor with prednisone.
    Conclusions: ACS may complicate hemophilia. Diagnosis is mainly based on clinical judgment. Proper factor replacement is the mainstay of treatment. Surgery is reserved for patients with no improvement following factor administration.
    MeSH term(s) Compartment Syndromes/etiology ; Hemarthrosis/etiology ; Hemarthrosis/surgery ; Hemophilia A/complications ; Humans ; Knee Joint/surgery ; Male ; Postoperative Complications/etiology ; Synovectomy ; Young Adult
    Language English
    Publishing date 2019-09-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2160-3251
    ISSN (online) 2160-3251
    DOI 10.2106/JBJS.CC.18.00402
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  6. Article ; Online: Discrepancy between the results of one-stage and chromogenic factor VIII: C assays in patients with mild/moderate hemophilia A.

    Vosough, Fatemeh / Ahmadinejad, Minoo / Toogeh, Gholamreza / Karimi, Katayoun / Homayoun, Sanaz / Managhchi, Mohammad Reza / Arabkhazaeli, Ali

    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis

    2020  Volume 31, Issue 8, Page(s) 530–535

    Abstract: Diagnosis of hemophilia A is generally based on the measurement of plasma factor VIII activity (FVIII:C) using the one-stage assay (OSA) or the two-stage chromogenic substrate assay (CSA). The results of these methods show considerable discrepancy in ... ...

    Abstract : Diagnosis of hemophilia A is generally based on the measurement of plasma factor VIII activity (FVIII:C) using the one-stage assay (OSA) or the two-stage chromogenic substrate assay (CSA). The results of these methods show considerable discrepancy in about one-third of non-severe hemophilia A patients. The aim of this study was to assess the prevalence of FVIII:C assay discrepancy in non-severe hemophilia A patients in Iran and the relationship between the bleeding tendency with the level of FVIII:C by each method. Patients registered as mild or moderate hemophilia A in hemophilia clinic of Imam Khomeini Hospital were included. In each patient, FVIII:C level was assessed using one-stage (FVIII:C1) and chromogenic (FVIII:CR) methods. Assay discrepancy was defined as a two-fold or greater difference between the results of two assays. Bleeding tendency of the patients was recorded based on 'ISTH-BAT'. Sixty male patients were eligible for the study. The levels of FVIII:C1 was higher than FVIII:CR in 90% of patients. Assay discrepancy was seen in 41 (68%) patients. The classification of hemophilia A in 23 (38%) patients was modified by chromogenic method. No significant correlation was noted between the results of ISTH BAT with FVIII:C levels of each method. Regarding the prevalence of FVIII:C assay discrepancy in 2/3 of our non-severe hemophilia A patients, high rate of disease severity modification by chromogenic method and no significant relation between the clinical bleeding phenotype with any method, the authors highly recommend to perform both FVIII:C assays for the diagnosis and classification of non-severe hemophilia A.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Blood Coagulation ; Blood Coagulation Tests ; Child ; Child, Preschool ; Factor VIII/analysis ; Hemophilia A/blood ; Hemophilia A/diagnosis ; Hemophilia A/epidemiology ; Humans ; Iran/epidemiology ; Male ; Middle Aged ; Young Adult
    Chemical Substances F8 protein, human (839MOZ74GK) ; Factor VIII (9001-27-8)
    Language English
    Publishing date 2020-11-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1033551-1
    ISSN 1473-5733 ; 0957-5235
    ISSN (online) 1473-5733
    ISSN 0957-5235
    DOI 10.1097/MBC.0000000000000959
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2920: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Association between Perceived Stress and Neutropenia in Patients with Leukemia under Chemotherapy.

    Esfandbod, Mohsen / Abazaria Tehrani, Maryam / Haghshomar, Maryam / Arya, Pantea / Shateri Amiri, Bahareh / Toogeh, Gholamreza / Keyhani, Manouchehr

    International journal of hematology-oncology and stem cell research

    2020  Volume 16, Issue 2, Page(s) 103–109

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2020-07-07
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2652853-8
    ISSN 2008-2207 ; 2008-3009
    ISSN (online) 2008-2207
    ISSN 2008-3009
    DOI 10.18502/ijhoscr.v16i2.9203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: In silico

    Sajjadi, Seyed Mehdi / Rahimi, Hamzeh / Mohammadi, Saeed / Faranoush, Mohammad / Mirzahoseini, Hasan / Toogeh, Gholamreza

    Research in pharmaceutical sciences

    2017  Volume 12, Issue 1, Page(s) 60–66

    Abstract: Hirudin is an anticoagulant agent of the salivary glands of the medicinal leech. Recombinant hirudin (r-Hir) displays certain drawbacks including bleeding and immunogenicity. To solve these problems, cysteine-specific PEGylation has been proposed as a ... ...

    Abstract Hirudin is an anticoagulant agent of the salivary glands of the medicinal leech. Recombinant hirudin (r-Hir) displays certain drawbacks including bleeding and immunogenicity. To solve these problems, cysteine-specific PEGylation has been proposed as a successful technique. However, proper selection of the appropriate cysteine residue for substitution is a critical step. This study has, for the first time, used a computational approach aimed at identifying a single potential PEGylation site for replacement by cysteine residue in the hirudin variant 3 (HV3). Homology modeling (HM) was performed using MODELLER. All non-cysteine residues of the HV3 were replaced with the cysteine. The best model was selected based on the results of discrete optimized protein energy score, PROCHECK software, and Verify3D. The receptor binding was investigated using protein-protein docking by ClusPro web tool which was then visualized using LigPlot+ software and PyMOL. Finally, multiple sequence alignment (MSA) using ClustalW software and disulfide bond prediction were performed. According to the results of HM and docking, Q33C, which was located on the surface of the protein, was the best site for PEGylation. Furthermore, MSA showed that Q33 was not a conserved residue and LigPlot+ software showed that it is not involved in the hirudin-thrombin binding pocket. Moreover, prediction softwares established that it is not involved in disulfide bond formation. In this study, for the first time, the utility of the
    Language English
    Publishing date 2017-02-01
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2400156-9
    ISSN 1735-9414 ; 1735-5362
    ISSN (online) 1735-9414
    ISSN 1735-5362
    DOI 10.4103/1735-5362.199048
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  9. Article: Myelodysplastic Syndrome with 6q Deletion as the Sole Chromosome Abnormality in an Iranian Patient: A Case Report with Review of Literature.

    Ferdowsi, Shirin / Shirkoohi, Reza / Toogeh, Gholamreza

    Iranian journal of public health

    2013  Volume 42, Issue 10, Page(s) 1187–1191

    Abstract: Background: The myelodysplastic syndrome (MDS) is a highly heterogenous disorder and karyotype analysis is helpful for diagnostic and prognostic estimation. Deletion in long arm chromosome 6 (6q del) as a sole abnormality is a rare event in MDS. This is ...

    Abstract Background: The myelodysplastic syndrome (MDS) is a highly heterogenous disorder and karyotype analysis is helpful for diagnostic and prognostic estimation. Deletion in long arm chromosome 6 (6q del) as a sole abnormality is a rare event in MDS. This is the first case report of del (6q) as the only observed diagnostic change in Iran. We also reviewed the literature of this cytogenetic lesion.
    Language English
    Publishing date 2013-10
    Publishing country Iran
    Document type Journal Article
    ISSN 2251-6085
    ISSN 2251-6085
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  10. Article ; Online: Prevalence and Prognostic Impact of Wilms' Tumor 1 (WT1) Gene, Including SNP rs16754 in Cytogenetically Normal Acute Myeloblastic Leukemia (CN-AML): An Iranian Experience.

    Toogeh, Gholamreza / Ramzi, Mani / Faranoush, Mohammad / Amirizadeh, Naser / Haghpanah, Sezaneh / Moghadam, Mohammad / Cohan, Nader

    Clinical lymphoma, myeloma & leukemia

    2016  Volume 16, Issue 3, Page(s) e21–6

    Abstract: Background: The aim of this study was to evaluate the effect of Wilms' tumor 1 (WT1) gene mutations in adult cytogenetically normal acute myeloblastic leukemia (CN-AML) patients on survival and clinical outcome.: Patients and methods: A total of 88 ... ...

    Abstract Background: The aim of this study was to evaluate the effect of Wilms' tumor 1 (WT1) gene mutations in adult cytogenetically normal acute myeloblastic leukemia (CN-AML) patients on survival and clinical outcome.
    Patients and methods: A total of 88 untreated Iranian adult patients with CN-AML were selected as a study group. Exons 7 (including the SNP rs16754), 8, and 9 as a WT1 gene hotspot region were evaluated by polymerase chain reaction and direct sequencing for detection of mutations. Response to treatment and clinical outcome including overall survival (OS) and disease-free survival (DFS) were evaluated according to WT1 gene mutational status.
    Results: WT1 gene mutations were found in 12.5% of patients, most of which were found in exon 7. Complete remission was lower and relapse was higher in patients with WT1 gene mutation compared with WT1 gene wild type patients. OS and DFS was significantly lower in patients with WT1 gene mutation compared with patients with WT1 gene wild type (P < .001). Also, we did not find any significant effects of SNP rs16754 in exon 7 on clinical outcome and survival in patients with CN-AML.
    Conclusion: WT1 gene mutations are a predictor indicator of a poor prognosis factor in CN-AML patients. It is recommended that WT1 gene mutations be included in the molecular testing panel in order to better diagnose and confirm their prognostic significance for better management and treatment strategy.
    MeSH term(s) Adult ; Alleles ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor ; Female ; Genotype ; Humans ; Iran/epidemiology ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/epidemiology ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/mortality ; Male ; Middle Aged ; Mutation ; Polymorphism, Single Nucleotide ; Prevalence ; Prognosis ; Treatment Outcome ; WT1 Proteins/genetics
    Chemical Substances Biomarkers, Tumor ; WT1 Proteins
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2540992-X
    ISSN 2152-2669 ; 2152-2650
    ISSN (online) 2152-2669
    ISSN 2152-2650
    DOI 10.1016/j.clml.2015.11.017
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5903: Show issues Location:
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