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  1. Article: Metastatic thyroid carcinoma in the appendicular skeleton and tibial plateau leveling osteotomy site of a dog.

    Fontes, Gabrielle S / Topulos, Sophia P / Jennings, Samuel H

    The Canadian veterinary journal = La revue veterinaire canadienne

    2023  Volume 64, Issue 2, Page(s) 132–136

    Abstract: A 13-year-old spayed female Labrador retriever cross dog was referred to the Foster Hospital for Small Animals at Tufts University for evaluation of a metastatic carcinoma discovered at the site of a previous tibial plateau leveling osteotomy (TPLO). The ...

    Abstract A 13-year-old spayed female Labrador retriever cross dog was referred to the Foster Hospital for Small Animals at Tufts University for evaluation of a metastatic carcinoma discovered at the site of a previous tibial plateau leveling osteotomy (TPLO). The dog was previously evaluated at the primary care veterinarian for a complaint of lameness, and radiographs of the previous TPLO site revealed bony lysis associated with the TPLO plate. Surgical exploration of the site by the primary veterinarian provided evidence of osteolysis. The lytic area of the proximal tibia was biopsied, and a metastatic carcinoma was confirmed. The patient was referred for further evaluation. Following consultation and examination, a full body computed tomography (CT) scan was performed to determine the source of the carcinoma. A well-defined soft tissue attenuating mass effacing the right thyroid gland was located, along with 3, well-defined soft tissue attenuating nodules within the pulmonary parenchyma, consistent with metastatic disease. The previously diagnosed osteolytic, aggressive bone lesion of the proximal left tibia was visualized. Following the CT scan, palliative left hind-limb amputation
    MeSH term(s) Animals ; Dogs ; Female ; Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/pathology ; Bone Neoplasms/secondary ; Bone Neoplasms/surgery ; Bone Neoplasms/veterinary ; Dog Diseases/diagnostic imaging ; Dog Diseases/pathology ; Dog Diseases/surgery ; Osteotomy/veterinary ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/surgery ; Thyroid Neoplasms/veterinary ; Tibia/surgery ; Amputation, Surgical/veterinary
    Language English
    Publishing date 2023-02-02
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 41603-4
    ISSN 0008-5286
    ISSN 0008-5286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 572: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Predicting the effect of fresh gas flow on tidal volume in volume-controlled mechanically ventilated dogs

    Topulos, Sophia P. / Topulos, George P. / Abelson, Amanda L. / Lindsey, Jane C. / Wetmore, Lois A.

    Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Veterinary Anaesthesia and Analgesia. 2023 Jan., v. 50, no. 1 p.57-62

    2023  

    Abstract: To determine if the tidal volume (VT) delivered (VTDEL) to canine patients being mechanically ventilated by a volume-controlled ventilator differed from the volume set on the ventilator (VTSET) at three fresh gas flow (FGF) rates. To determine if VTDEL ... ...

    Abstract To determine if the tidal volume (VT) delivered (VTDEL) to canine patients being mechanically ventilated by a volume-controlled ventilator differed from the volume set on the ventilator (VTSET) at three fresh gas flow (FGF) rates. To determine if VTDEL could be accurately predicted by an FGF-based mathematical model. Prospective proof-of-concept study. A total of 23 adult client-owned dogs undergoing elective orthopedic surgery. Dogs were anesthetized and ventilated with a volume-controlled mechanical ventilator with constant respiratory rate (fR) of 10 breaths minute–¹, inspiratory-to-expiratory ratio of 1:2 [fraction of inspiratory time (TI) in one respiratory cycle (Tₜₒₜ) 1:3], and VTSET as body weight (kg) × 15 (mL kg–¹). VTDEL was measured in 20 dogs at three FGF (500, 1000 and 4000 mL minute–¹). A mathematical model was used to calculate predicted volume (VTPRED) for each animal at each FGF: VTSET + {FGF × [(TI/Tₜₒₜ)/fR]}. Linear repeated measures models were fit comparing VTDEL to VTSET and to VTPRED by FGF. VTDEL was significantly higher than VTSET at every FGF (p < 0.05), and differences were larger at higher FGF (p < 0.001). There were no statistically significant differences between VTDEL and VTPRED at FGF rates of 500 and 4000 mL minute–¹ and, although the mean VTDEL was statistically significantly higher than VTPRED at FGF 1000 mL minute–¹ (p = 0.017), the mean difference of 9 mL was not clinically significant. Dogs on volume-controlled ventilators may be ventilated at a higher VTDEL than intended depending on the FGF settings. Ventilation of small animals at high FGF could inadvertently induce pulmonary damage. A mathematical equation can be used to achieve a desired VTDEL by adjusting VTSET values based on FGF, fR and TI/Tₜₒₜ.
    Keywords adults ; analgesia ; anesthesia ; body weight ; dogs ; equations ; mathematical models ; orthopedics ; respiratory rate ; surgery ; tidal volume ; fresh gas flow ; mechanical ventilation ; safety ; volume-controlled ventilation
    Language English
    Dates of publication 2023-01
    Size p. 57-62.
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 2020582-X
    ISSN 1467-2995 ; 1467-2987
    ISSN (online) 1467-2995
    ISSN 1467-2987
    DOI 10.1016/j.vaa.2022.10.003
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  3. Article ; Online: Predicting the effect of fresh gas flow on tidal volume in volume-controlled mechanically ventilated dogs.

    Topulos, Sophia P / Topulos, George P / Abelson, Amanda L / Lindsey, Jane C / Wetmore, Lois A

    Veterinary anaesthesia and analgesia

    2022  Volume 50, Issue 1, Page(s) 57–62

    Abstract: Objectives: To determine if the tidal volume (V: Study design: Prospective proof-of-concept study.: Animals: A total of 23 adult client-owned dogs undergoing elective orthopedic surgery.: Methods: Dogs were anesthetized and ventilated with a ... ...

    Abstract Objectives: To determine if the tidal volume (V
    Study design: Prospective proof-of-concept study.
    Animals: A total of 23 adult client-owned dogs undergoing elective orthopedic surgery.
    Methods: Dogs were anesthetized and ventilated with a volume-controlled mechanical ventilator with constant respiratory rate (f
    Results: V
    Conclusions and clinical relevance: Dogs on volume-controlled ventilators may be ventilated at a higher V
    MeSH term(s) Dogs ; Animals ; Tidal Volume ; Respiration, Artificial/veterinary ; Prospective Studies ; Ventilators, Mechanical ; Respiration
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2020582-X
    ISSN 1467-2995 ; 1467-2987
    ISSN (online) 1467-2995
    ISSN 1467-2987
    DOI 10.1016/j.vaa.2022.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pathology in Practice.

    Topulos, Sophia P / Alloway, Elizabeth C / Tokarz, Debra A / Guevar, Julien

    Journal of the American Veterinary Medical Association

    2020  Volume 257, Issue 10, Page(s) 1017–1020

    MeSH term(s) Animals
    Language English
    Publishing date 2020-11-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390811-2
    ISSN 1943-569X ; 0003-1488
    ISSN (online) 1943-569X
    ISSN 0003-1488
    DOI 10.2460/javma.2020.257.10.1017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 423: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Presumed pituitary apoplexy in 26 dogs: Clinical findings, treatments, and outcomes

    Woelfel, Christian W. / Mariani, Christopher L. / Nolan, Michael W. / Keenihan, Erin K. / Topulos, Sophia P. / Early, Peter J. / Muñana, Karen R. / Musulin, Sarah E. / Olby, Natasha J.

    Journal of Veterinary Internal Medicine. 2023 , v. 37, no. 3 p.1119-1128

    2023  

    Abstract: BACKGROUND: Pituitary apoplexy refers to hemorrhage or infarction within the pituitary gland resulting in acute neurological abnormalities. This condition is poorly described in dogs. OBJECTIVES: To document presenting complaints, examination findings, ... ...

    Abstract BACKGROUND: Pituitary apoplexy refers to hemorrhage or infarction within the pituitary gland resulting in acute neurological abnormalities. This condition is poorly described in dogs. OBJECTIVES: To document presenting complaints, examination findings, endocrinopathies, magnetic resonance imaging (MRI), treatments, and outcomes of dogs with pituitary apoplexy. ANIMALS: Twenty‐six client‐owned dogs with acute onset of neurological dysfunction. METHODS: Retrospective case series. Dogs were diagnosed with pituitary apoplexy if MRI or histopathology documented an intrasellar or suprasellar mass with evidence of hemorrhage or infarction in conjunction with acute neurological dysfunction. Clinical information was obtained from medical records and imaging reports. RESULTS: Common presenting complaints included altered mentation (16/26, 62%) and gastrointestinal dysfunction (14/26, 54%). Gait or posture changes (22/26, 85%), mentation changes (18/26, 69%), cranial neuropathies (17/26, 65%), cervical or head hyperpathia (12/26, 46%), and hyperthermia (8/26, 31%) were the most frequent exam findings. Ten dogs (38%) lacked evidence of an endocrinopathy before presentation. Common MRI findings included T1‐weighted hypo‐ to isointensity of the hemorrhagic lesion (21/25, 84%), peripheral enhancement of the pituitary mass lesion (15/25, 60%), brain herniation (14/25, 56%), and obstructive hydrocephalus (13/25, 52%). Fifteen dogs (58%) survived to hospital discharge. Seven of these dogs received medical management alone (median survival 143 days; range, 7‐641 days) and 8 received medications and radiation therapy (median survival 973 days; range, 41‐1719 days). CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with pituitary apoplexy present with a variety of acute signs of neurological disease and inconsistent endocrine dysfunction. Dogs that survive to discharge can have a favorable outcome.
    Keywords brain ; fever ; gait ; gastrointestinal system ; head ; hemorrhage ; histopathology ; hospitals ; hydrocephalus ; infarction ; magnetism ; peripheral nervous system diseases ; pituitary gland ; posture ; radiotherapy ; veterinary medicine
    Language English
    Dates of publication 2023-05
    Size p. 1119-1128.
    Publishing place John Wiley & Sons, Inc.
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 92798-3
    ISSN 1939-1676 ; 0891-6640
    ISSN (online) 1939-1676
    ISSN 0891-6640
    DOI 10.1111/jvim.16703
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4095: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Presumed pituitary apoplexy in 26 dogs: Clinical findings, treatments, and outcomes.

    Woelfel, Christian W / Mariani, Christopher L / Nolan, Michael W / Keenihan, Erin K / Topulos, Sophia P / Early, Peter J / Muñana, Karen R / Musulin, Sarah E / Olby, Natasha J

    Journal of veterinary internal medicine

    2023  Volume 37, Issue 3, Page(s) 1119–1128

    Abstract: Background: Pituitary apoplexy refers to hemorrhage or infarction within the pituitary gland resulting in acute neurological abnormalities. This condition is poorly described in dogs.: Objectives: To document presenting complaints, examination ... ...

    Abstract Background: Pituitary apoplexy refers to hemorrhage or infarction within the pituitary gland resulting in acute neurological abnormalities. This condition is poorly described in dogs.
    Objectives: To document presenting complaints, examination findings, endocrinopathies, magnetic resonance imaging (MRI), treatments, and outcomes of dogs with pituitary apoplexy.
    Animals: Twenty-six client-owned dogs with acute onset of neurological dysfunction.
    Methods: Retrospective case series. Dogs were diagnosed with pituitary apoplexy if MRI or histopathology documented an intrasellar or suprasellar mass with evidence of hemorrhage or infarction in conjunction with acute neurological dysfunction. Clinical information was obtained from medical records and imaging reports.
    Results: Common presenting complaints included altered mentation (16/26, 62%) and gastrointestinal dysfunction (14/26, 54%). Gait or posture changes (22/26, 85%), mentation changes (18/26, 69%), cranial neuropathies (17/26, 65%), cervical or head hyperpathia (12/26, 46%), and hyperthermia (8/26, 31%) were the most frequent exam findings. Ten dogs (38%) lacked evidence of an endocrinopathy before presentation. Common MRI findings included T1-weighted hypo- to isointensity of the hemorrhagic lesion (21/25, 84%), peripheral enhancement of the pituitary mass lesion (15/25, 60%), brain herniation (14/25, 56%), and obstructive hydrocephalus (13/25, 52%). Fifteen dogs (58%) survived to hospital discharge. Seven of these dogs received medical management alone (median survival 143 days; range, 7-641 days) and 8 received medications and radiation therapy (median survival 973 days; range, 41-1719 days).
    Conclusions and clinical importance: Dogs with pituitary apoplexy present with a variety of acute signs of neurological disease and inconsistent endocrine dysfunction. Dogs that survive to discharge can have a favorable outcome.
    MeSH term(s) Dogs ; Animals ; Pituitary Apoplexy/therapy ; Pituitary Apoplexy/veterinary ; Pituitary Apoplexy/diagnosis ; Pituitary Neoplasms/complications ; Pituitary Neoplasms/diagnostic imaging ; Pituitary Neoplasms/therapy ; Pituitary Neoplasms/veterinary ; Retrospective Studies ; Hydrocephalus/veterinary ; Infarction/veterinary ; Magnetic Resonance Imaging/veterinary ; Dog Diseases/diagnostic imaging ; Dog Diseases/therapy
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 92798-3
    ISSN 1939-1676 ; 0891-6640
    ISSN (online) 1939-1676
    ISSN 0891-6640
    DOI 10.1111/jvim.16703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4095: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Reliability in performance assessment creates a potential application of artificial intelligence in veterinary education: evaluation of suturing skills at a single institution.

    Kuzminsky, Jennifer / Phillips, Heidi / Sharif, Hajar / Moran, Clara / Gleason, Hadley E / Topulos, Sophia P / Pitt, Kathryn / McNeil, Leslie Klis / McCoy, Annette M / Kesavadas, Thenkurussi

    American journal of veterinary research

    2023  Volume 84, Issue 8

    Abstract: Objectives: To evaluate suturing skills of veterinary students using 3 common performance assessments (PAs) and to compare findings to data obtained by an electromyographic armband.: Sample: 16 second-year veterinary students.: Procedures: ... ...

    Abstract Objectives: To evaluate suturing skills of veterinary students using 3 common performance assessments (PAs) and to compare findings to data obtained by an electromyographic armband.
    Sample: 16 second-year veterinary students.
    Procedures: Students performed 4 suturing tasks on synthetic tissue models 1, 3, and 5 weeks after a surgical skills course. Digital videos were scored by 4 expert surgeons using 3 PAs (an Objective Structured Clinical Examination [OSCE]- style surgical binary checklist, an Objective Structured Assessment of Technical Skill [OSATS] checklist, and a surgical Global Rating Scale [GRS]). Surface electromyography (sEMG) data collected from the dominant forearm were input to machine learning algorithms. Performance assessment scores were compared between experts and correlated to task completion times and sEMG data. Inter-rater reliability was calculated using the intraclass correlation coefficient (ICC). Inter-rater agreement was calculated using percent agreement with varying levels of tolerance.
    Results: Reliability was moderate for the OSCE and OSATS checklists and poor for the GRS. Agreement was achieved for the checklists when moderate tolerance was applied but remained poor for the GRS. sEMG signals did not correlate well with checklist scores or task times, but features extracted from signals permitted task differentiation by routine statistical comparison and correct task classification using machine learning algorithms.
    Clinical relevance: Reliability and agreement of an OSCE-style checklist, OSATS checklist, and surgical GRS assessment were insufficient to characterize suturing skills of veterinary students. To avoid subjectivity associated with PA by raters, further study of kinematics and EMG data is warranted in the surgical skills evaluation of veterinary students.
    MeSH term(s) Animals ; Artificial Intelligence ; Education, Veterinary ; Reproducibility of Results
    Language English
    Publishing date 2023-06-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390796-x
    ISSN 1943-5681 ; 0002-9645
    ISSN (online) 1943-5681
    ISSN 0002-9645
    DOI 10.2460/ajvr.23.03.0058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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