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  1. Article ; Online: Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy.

    Ghasemi, Ali / Martinez-Usatorre, Amaia / Li, Luqing / Hicham, Mehdi / Guichard, Alan / Marcone, Rachel / Fournier, Nadine / Torchia, Bruno / Martinez Bedoya, Darel / Davanture, Suzel / Fernández-Vaquero, Mirian / Fan, Chaofan / Janzen, Jakob / Mohammadzadeh, Yahya / Genolet, Raphael / Mansouri, Nahal / Wenes, Mathias / Migliorini, Denis / Heikenwalder, Mathias /
    De Palma, Michele

    Nature cancer

    2023  Volume 5, Issue 2, Page(s) 240–261

    Abstract: Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation, trafficking and function. Monocyte-derived DCs pulsed with tumor antigens have been tested extensively for therapeutic vaccination in cancer, with mixed clinical ... ...

    Abstract Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation, trafficking and function. Monocyte-derived DCs pulsed with tumor antigens have been tested extensively for therapeutic vaccination in cancer, with mixed clinical results. Here, we present a cell-therapy platform based on mouse or human DC progenitors (DCPs) engineered to produce two immunostimulatory cytokines, IL-12 and FLT3L. Cytokine-armed DCPs differentiated into conventional type-I DCs (cDC1) and suppressed tumor growth, including melanoma and autochthonous liver models, without the need for antigen loading or myeloablative host conditioning. Tumor response involved synergy between IL-12 and FLT3L and was associated with natural killer and T cell infiltration and activation, M1-like macrophage programming and ischemic tumor necrosis. Antitumor immunity was dependent on endogenous cDC1 expansion and interferon-γ signaling but did not require CD8
    MeSH term(s) Humans ; Mice ; Animals ; Cytokines ; Immunotherapy ; Dendritic Cells ; Neoplasms/therapy ; Interleukin-12
    Chemical Substances Cytokines ; Interleukin-12 (187348-17-0)
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article
    ISSN 2662-1347
    ISSN (online) 2662-1347
    DOI 10.1038/s43018-023-00668-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models.

    Martinez-Usatorre, Amaia / Kadioglu, Ece / Boivin, Gael / Cianciaruso, Chiara / Guichard, Alan / Torchia, Bruno / Zangger, Nadine / Nassiri, Sina / Keklikoglou, Ioanna / Schmittnaegel, Martina / Ries, Carola H / Meylan, Etienne / De Palma, Michele

    Science translational medicine

    2021  Volume 13, Issue 606

    Abstract: Immune checkpoint blockade (ICB) with PD-1 or PD-L1 antibodies has been approved for the treatment of non-small cell lung cancer (NSCLC). However, only a minority of patients respond, and sustained remissions are rare. Both chemotherapy and ... ...

    Abstract Immune checkpoint blockade (ICB) with PD-1 or PD-L1 antibodies has been approved for the treatment of non-small cell lung cancer (NSCLC). However, only a minority of patients respond, and sustained remissions are rare. Both chemotherapy and antiangiogenic drugs may improve the efficacy of ICB in mouse tumor models and patients with cancer. Here, we used genetically engineered mouse models of
    MeSH term(s) Animals ; B7-H1 Antigen ; CD8-Positive T-Lymphocytes ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Mice ; Programmed Cell Death 1 Receptor ; Tumor Microenvironment ; Vascular Endothelial Growth Factor A
    Chemical Substances B7-H1 Antigen ; Programmed Cell Death 1 Receptor ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2021-08-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.abd1616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles.

    Cianciaruso, Chiara / Beltraminelli, Tim / Duval, Florent / Nassiri, Sina / Hamelin, Romain / Mozes, André / Gallart-Ayala, Hector / Ceada Torres, Gerardo / Torchia, Bruno / Ries, Carola H / Ivanisevic, Julijana / De Palma, Michele

    Cell reports

    2019  Volume 27, Issue 10, Page(s) 3062–3080.e11

    Abstract: Extracellular vesicles (EVs), including exosomes, modulate multiple aspects of cancer biology. Tumor-associated macrophages (TAMs) secrete EVs, but their molecular features and functions are poorly characterized. Here, we report methodology for the ... ...

    Abstract Extracellular vesicles (EVs), including exosomes, modulate multiple aspects of cancer biology. Tumor-associated macrophages (TAMs) secrete EVs, but their molecular features and functions are poorly characterized. Here, we report methodology for the enrichment, quantification, and proteomic and lipidomic analysis of EVs released from mouse TAMs (TAM-EVs). Compared to source TAMs, TAM-EVs present molecular profiles associated with a Th1/M1 polarization signature, enhanced inflammation and immune response, and a more favorable patient prognosis. Accordingly, enriched TAM-EV preparations promote T cell proliferation and activation ex vivo. TAM-EVs also contain bioactive lipids and biosynthetic enzymes, which may alter pro-inflammatory signaling in the cancer cells. Thus, whereas TAMs are largely immunosuppressive, their EVs may have the potential to stimulate, rather than limit, anti-tumor immunity.
    MeSH term(s) Animals ; Antibodies/therapeutic use ; Bone Marrow Cells/cytology ; Cell Line, Tumor ; Cell Proliferation ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Extracellular Vesicles/metabolism ; Female ; Interleukin-4/pharmacology ; Lipopolysaccharides/pharmacology ; Macrophages/cytology ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Protein Interaction Maps ; Proteome/analysis ; Proteomics ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/immunology ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Th1 Cells/cytology ; Th1 Cells/immunology ; Th1 Cells/metabolism ; Transplantation, Homologous
    Chemical Substances Antibodies ; Csf1r protein, mouse ; Lipopolysaccharides ; Proteome ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor ; Interleukin-4 (207137-56-2)
    Language English
    Publishing date 2019-06-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2019.05.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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