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  1. Article ; Online: Use of selective phenotyping and genotyping to identify rare blood donors in Canada.

    Tordon, Bryan / Montemayor, Celina / Clarke, Gwen / O'Brien, Sheila F / Goldman, Mindy

    Vox sanguinis

    2023  Volume 118, Issue 5, Page(s) 398–401

    Abstract: Background and objectives: The distribution of rare and specific red cell phenotypes varies between races and ethnicities. Therefore, the most compatible red cell units for patients with haemoglobinopathies and other rare blood requirements are most ... ...

    Abstract Background and objectives: The distribution of rare and specific red cell phenotypes varies between races and ethnicities. Therefore, the most compatible red cell units for patients with haemoglobinopathies and other rare blood requirements are most likely to be found in donors from similar genetic backgrounds. Our blood service introduced a voluntary question asking donors to provide their racial background/ethnicity. Results triggered additional phenotyping and/or genotyping.
    Materials and methods: We analysed the results of additional testing performed between January 2021 and June 2022, and rare donors were added to the Rare Blood Donor database. We determined the incidence of various rare phenotypes and blood group alleles based on donor race/ethnicity.
    Results: Over 95% of donors answered the voluntary question; 715 samples were tested, and 25 donors were added to the Rare Blood Donor database, including five k-, four U-, two Jk(a-b-) and two D- - phenotypes.
    Conclusion: Asking donors about their race/ethnicity was well received by donors, and the resulting selective testing enabled us to identify individuals with a higher likelihood of being rare blood donors, support patients with rare blood requirements and better understand the incidence of common and rare alleles and red blood cell phenotypes in the Canadian donor population.
    MeSH term(s) Humans ; Blood Donors ; Genotype ; Canada/epidemiology ; Blood Group Antigens/genetics ; Erythrocytes
    Chemical Substances Blood Group Antigens
    Language English
    Publishing date 2023-03-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.13419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 74: Show issues Location:
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  2. Article ; Online: Post-cardiac surgery thrombotic thrombocytopenic purpura: presence of anti-ADAMTS13 autoantibodies at preoperative baseline.

    Tordon, Bryan / Warkentin, Theodore E / Moore, Jane C / Arnold, Donald M

    Platelets

    2021  Volume 33, Issue 3, Page(s) 479–483

    Abstract: Thrombotic thrombocytopenic purpura (TTP) rarely complicates acute inflammatory conditions such as surgery, including post-cardiac surgery. Review of 32 previously-reported cases of post-cardiac surgery TTP indicates that this disorder often occurs as ... ...

    Abstract Thrombotic thrombocytopenic purpura (TTP) rarely complicates acute inflammatory conditions such as surgery, including post-cardiac surgery. Review of 32 previously-reported cases of post-cardiac surgery TTP indicates that this disorder often occurs as early as 2-3 days following surgery, which seems too soon to implicate new formation of anti-ADAMTS13 autoantibodies as a consequence of surgery itself. We diagnosed post-cardiac surgery TTP in a 60-year-old female that began approximately 3 days post-coronary artery bypass surgery in which anti-ADAMTS13 autoantibodies were implicated. We therefore investigated whether anti-ADAMTS13 autoantibodies were also present in a
    MeSH term(s) ADAMTS13 Protein/metabolism ; Autoantibodies/metabolism ; Cardiac Surgical Procedures/adverse effects ; Female ; Humans ; Middle Aged ; Postoperative Period ; Preoperative Period ; Purpura, Thrombotic Thrombocytopenic/etiology ; Purpura, Thrombotic Thrombocytopenic/physiopathology
    Chemical Substances Autoantibodies ; ADAMTS13 Protein (EC 3.4.24.87) ; ADAMTS13 protein, human (EC 3.4.24.87)
    Language English
    Publishing date 2021-04-14
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2021.1912314
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2888: Show issues Location:
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  3. Article ; Online: Canadian Blood Services traceback investigation of a suspected case of transfusion-transmitted malaria.

    Tordon, Bryan / Drews, Steven J / Flahr, Francine / Bennett, Kathleen / Gaziano, Teresa / Anderson, Danielle / Nahirniak, Susan / Gerges, Hanan / Tyrrell, Gregory J / Mah, Jordan / Ndao, Momar / Bigham, Mark / Seftel, Matthew

    Transfusion

    2023  Volume 63, Issue 10, Page(s) 2001–2006

    Abstract: Background: A 4-month-old infant hospitalized since birth received multiple blood transfusions. In March 2022, Plasmodium falciparum was confirmed with nucleic acid testing. As the mother was assessed as unlikely to be the source of infection, the blood ...

    Abstract Background: A 4-month-old infant hospitalized since birth received multiple blood transfusions. In March 2022, Plasmodium falciparum was confirmed with nucleic acid testing. As the mother was assessed as unlikely to be the source of infection, the blood operator initiated a traceback investigation for a potential blood donor source. The patient had received 13 red blood cell (RBC) transfusions (aliquoted from 11 donors), 4 apheresis platelet (PLT) transfusions and 16 buffy coat pooled PLT transfusions. The blood operator medical team developed a supplementary malaria infection risk questionnaire to identify donors at highest risk of life-time malaria infection, based on birthplace, residence, or travel in malaria-endemic regions.
    Results: With 79 donors initially implicated, initial focus was on donors of RBC components. The 11 RBC donors were contacted and assessed using the supplementary questionnaire. Three donors, all of whom met current malaria-related donor eligibility criteria, were deemed high risk of prior malaria infection. These donors consented to P. falciparum serology and nucleic acid testing (NAT). One donor who was born and had resided in an endemic West African country for 14 years, was positive for P. falciparum by serology (indirect fluorescent antibody test) and NAT-(Ct ≥32). Lookback of this donor's transfused fresh co-components and prior donation identified no other malaria cases.
    Conclusion: This was a probable transfusion-transmitted malaria (TTM) case from an eligible donor who in retrospect was found to have unrecognized, asymptomatic, semi-immune malaria infection, and who was potentially infectious. Blood donor lack of recall of prior malaria infection does not negate the risk of TTM from those who have lived in malaria-endemic countries.
    MeSH term(s) Humans ; Infant ; Canada ; Malaria ; Blood Transfusion ; Malaria, Falciparum/epidemiology ; Blood Donors ; Asymptomatic Infections ; Nucleic Acids
    Chemical Substances Nucleic Acids
    Language English
    Publishing date 2023-09-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17549
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 284: Show issues Location:
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  4. Article ; Online: Clinical Outcomes in a Large Canadian Centralized CLL Clinic Based on Treatment and Molecular Factors over a Decade.

    Yang, Jiayu / Yang, Lin / Tordon, Bryan / Bucher, Oliver / Nugent, Zoann / Landego, Ivan / Bourrier, Nicole / Uminski, Kelsey / Brown, Kevin / Squires, Mandy / Marshall, Aaron J / Katyal, Sachin / Mahmud, Salah / Decker, Kathleen / Geirnaert, Marc / Dawe, David E / Gibson, Spencer B / Johnston, James B / Banerji, Versha

    Current oncology (Toronto, Ont.)

    2023  Volume 30, Issue 7, Page(s) 6411–6431

    Abstract: FISH cytogenetics, TP53 sequencing, and IGHV mutational status are increasingly used as prognostic and predictive markers in chronic lymphocytic leukemia (CLL), particularly as components of the CLL International Prognostic Index (CLL-IPI) and in ... ...

    Abstract FISH cytogenetics, TP53 sequencing, and IGHV mutational status are increasingly used as prognostic and predictive markers in chronic lymphocytic leukemia (CLL), particularly as components of the CLL International Prognostic Index (CLL-IPI) and in directing therapy with novel agents. However, testing outside of clinical trials is not routinely available in Canada. As a centralized CLL clinic at CancerCare Manitoba, we are the first Canadian province to evaluate clinical outcomes and survivorship over a long period of time, incorporating the impact of molecular testing and the CLL-IPI score. We performed a retrospective analysis on 1315 patients diagnosed between 1960 and 2018, followed over a 12-year period, where 411 patients had molecular testing and 233 patients had a known CLL-IPI score at the time of treatment. Overall, 40.3% (
    MeSH term(s) Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Retrospective Studies ; Canada ; Prognosis ; Mutation
    Language English
    Publishing date 2023-07-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol30070472
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    Zs.A 4305: Show issues Location:
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  5. Article: Importance of Stereoscopy in Haptic Training of Novice Temporal Bone Surgery.

    Unger, Bertram / Tordon, Bryan / Pisa, Justyn / Hochman, Jordan B

    Studies in health technology and informatics

    2016  Volume 220, Page(s) 439–445

    Abstract: Unlabelled: We investigate the effects of stereoscopic simulation on novice trainee surgical performance.: Methods: 20 first year medical students were randomized into a stereo or non-stereo group. Each participant viewed a 13 minute instructional ... ...

    Abstract Unlabelled: We investigate the effects of stereoscopic simulation on novice trainee surgical performance.
    Methods: 20 first year medical students were randomized into a stereo or non-stereo group. Each participant viewed a 13 minute instructional video and then performed 3 mastoidectomy procedures with an in-house haptic temporal bone simulation, using a 3D-capable display with either active (stereo) or inactive (non-stero) shutter glasses. Following training, participants performed an actual mastoidectomy on a single 3D-printed bone model. The printed models were evaluated by 3 blinded neurotologic surgeons using a 7 point grading system.
    Results: Two-tailed t-tests showed no significant difference in overall performance (mean score across test categories over all subjects) between stereo (M=3.8, SD=1.1) and non-stereo (M=4.4, SD=1.5) conditions (p=0.163). No significant differences existed in any of the assessed sub-domains.
    Conclusions: The addition of stereo-vision to haptic training may not affect temporal bone surgical skill acquisition in novice users.
    MeSH term(s) Adult ; Clinical Competence ; Computer-Assisted Instruction/methods ; Educational Measurement ; Female ; High Fidelity Simulation Training/methods ; Humans ; Imaging, Three-Dimensional/methods ; Male ; Microsurgery/education ; Osteotomy/education ; Surgery, Computer-Assisted/methods ; Teaching ; Temporal Bone/cytology ; Temporal Bone/surgery ; Touch
    Language English
    Publishing date 2016
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article
    ISSN 0926-9630
    ISSN 0926-9630
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