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  1. Article ; Online: Using Bioluminescence to Image Candida glabrata Urinary Tract Infections in Mice.

    Schrevens, Sanne / Torelli, Riccardo / Sanguinetti, Maurizio / Sanglard, Dominque

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2658, Page(s) 239–247

    Abstract: The human fungal pathogen Candida glabrata is less virulent compared to the most isolated Candida species including Candida albicans. Its reduced metabolic flexibility, haploidy, and auxotrophies contribute to a "stealth and evasion" infection strategy, ... ...

    Abstract The human fungal pathogen Candida glabrata is less virulent compared to the most isolated Candida species including Candida albicans. Its reduced metabolic flexibility, haploidy, and auxotrophies contribute to a "stealth and evasion" infection strategy, resulting in minimal tissue damage in the host. C. glabrata seems to be optimally adapted to infection of the urinary tract (UTI), especially in catheterized patients. UTIs are not well studied and often difficult to treat, given that not all antifungals penetrate in the bladder and that treatments through the catheter are not always possible since maintained catheterization increases the infection risk.In the recent effort to reduce the amount of animals used during scientific experiments, bioluminescence imaging is a useful tool. In this protocol, C. glabrata urinary tract infections were imaged in mice, thus facilitating the testing of possible new antifungals and novel treatment strategies.
    MeSH term(s) Mice ; Humans ; Animals ; Candida glabrata ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Candida ; Candida albicans ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/microbiology
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3155-3_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Credibility of environmental issues in non-financial mandatory disclosure: Measurement and determinants

    Balluchi, Federica / Lazzini, Arianna / Torelli, Riccardo

    Journal of cleaner production. 2021 Mar. 15, v. 288

    2021  

    Abstract: Through the lens of legitimacy theory and starting from Habermas’s communication theory the paper aims to extend and contribute to the research fields related to the quality of social and environmental disclosure and corporate legitimacy by focusing on ... ...

    Abstract Through the lens of legitimacy theory and starting from Habermas’s communication theory the paper aims to extend and contribute to the research fields related to the quality of social and environmental disclosure and corporate legitimacy by focusing on firms’ environmental reporting credibility. The study proposes an operationalization of the corporate environmental reporting credibility concept identifying possible determinants, related measurements and indicators. Through a content analysis we have measured the credibility of non-financial reports of 152 business entities that, in accordance with the Italian law, published for the first time in 2018, at a mandatory level, social and environmental reports. The results show a good level of credibility in Italian reporting context and in particular a high level of understandability, but a low level of exhaustivity. Findings highlight also the important role of experience in voluntary non-financial reporting, the use of stand-alone document and the belonging to an ESI in influencing the credibility of the communication. The results offer implications and scientific contributions related to the proposal of a detailed model for the measurement of social and environmental reporting applicable to any type of document, in any geographical contest, and any time frame.
    Keywords Lens ; fields ; measurement ; models ; paper ; research
    Language English
    Dates of publication 2021-0315
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-light
    ISSN 0959-6526
    DOI 10.1016/j.jclepro.2020.125744
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Non-Pathogenic

    Mosca, Luigi / Guccione, Laura / Toro, Maria Emanuela / Scartozzi, Luca / Fasciani, Romina / Torelli, Riccardo / Sanguinetti, Maurizio / Rizzo, Stanislao

    Case reports in ophthalmology

    2023  Volume 14, Issue 1, Page(s) 654–659

    Abstract: The authors report a singular case of post-operative exogenous fungal endophthalmitis caused by a non-pathogenic fungal agent: ...

    Abstract The authors report a singular case of post-operative exogenous fungal endophthalmitis caused by a non-pathogenic fungal agent:
    Language English
    Publishing date 2023-11-27
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2577666-6
    ISSN 1663-2699
    ISSN 1663-2699
    DOI 10.1159/000531801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Colonic histoplasmosis.

    Sangiorgi, Flavio / Torelli, Riccardo / Castri, Federica / Siciliano, Valentina / Cauda, Roberto / Fantoni, Massimo / Sanguinetti, Maurizio / Taccari, Francesco

    Journal of travel medicine

    2023  Volume 30, Issue 6

    MeSH term(s) Humans ; Histoplasmosis
    Language English
    Publishing date 2023-01-13
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taad007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pilot study on cultural and metagenomic analysis of bile and biliary stentslead to unveiling the key players in stent occlusion.

    Cacaci, Margherita / De Maio, Flavio / Matteo, Maria Valeria / Posteraro, Brunella / Di Vito, Maura / Menchinelli, Giulia / Tringali, Andrea / Monzo, Francesca Romana / Torelli, Riccardo / Costamagna, Guido / Spada, Cristiano / Bugli, Francesca / Sanguinetti, Maurizio / Boskoski, Ivo

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 3344

    Abstract: Endoscopic Retrograde Cholangio-Pancreatography (ERCP) with biliary stenting is a minimally invasive medical procedure employed to address both malignant and benign obstructions within the biliary tract. Benign biliary strictures (BBSs), typically ... ...

    Abstract Endoscopic Retrograde Cholangio-Pancreatography (ERCP) with biliary stenting is a minimally invasive medical procedure employed to address both malignant and benign obstructions within the biliary tract. Benign biliary strictures (BBSs), typically arising from surgical interventions such as liver transplants and cholecystectomy, as well as chronic inflammatory conditions, present a common clinical challenge. The current gold standard for treating BBSs involves the periodic insertion of plastic stents at intervals of 3-4 months, spanning a course of approximately one year. Unfortunately, stent occlusion emerges as a prevalent issue within this treatment paradigm, leading to the recurrence of symptoms and necessitating repeated ERCPs. In response to this clinical concern, we initiated a pilot study, delving into the microbial composition present in bile and on the inner surfaces of plastic stents. This investigation encompassed 22 patients afflicted by BBSs who had previously undergone ERCP with plastic stent placement. Our preliminary findings offered promising insights into the microbial culprits behind stent occlusion, with Enterobacter and Lactobacillus spp. standing out as prominent bacterial species known for their biofilm-forming tendencies on stent surfaces. These revelations hold promise for potential interventions, including targeted antimicrobial therapies aimed at curtailing bacterial growth on stents and the development of advanced stent materials boasting anti-biofilm properties.
    MeSH term(s) Humans ; Bile ; Pilot Projects ; Treatment Outcome ; Cholestasis/surgery ; Cholangiopancreatography, Endoscopic Retrograde/methods ; Biliary Tract ; Stents ; Retrospective Studies
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-51480-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Green natural nail polish modified with essential oils to treat onychomycosis.

    Di Vito, Maura / Scafuro, Claudia / Mariotti, Melinda / Garzoli, Stefania / Torelli, Riccardo / Zhiri, Abdesselam / Sanguinetti, Maurizio / Bugli, Francesca

    Mycoses

    2022  Volume 65, Issue 12, Page(s) 1127–1136

    Abstract: Background: Onychomycosis (OM) accounts for about 50% of nail disorders in industrialised countries. Essential oils (EOs), aromatic natural compounds, are known for their antimicrobial activity.: Objective: The aim of this work was to evaluate the ... ...

    Abstract Background: Onychomycosis (OM) accounts for about 50% of nail disorders in industrialised countries. Essential oils (EOs), aromatic natural compounds, are known for their antimicrobial activity.
    Objective: The aim of this work was to evaluate the antifungal efficacy of seven EOs and a commercial MIX against 10 dermatophytes responsible for OM to select the most effective ones to be included in a preventive or curative formulation based on a green natural nail polish (GNNP).
    Methods: Micro-broth dilution tests in line with EUCAST guidelines and olfactory satisfaction test were performed to select the best natural compounds previously analysed by SPME coupled with GC-MS. The same method was used to evaluate the release over time of the active compounds present in the two modified-GNNPs made by adding the best natural compound selected (the C. citratus EO) and the MIX. Furthermore, to evaluate the preventive and curative activity of modified-GNNPs, ex vivo experiments on healthy or colonised nails were performed.
    Results and conclusions: Data showed that MIX-modified-GNNP had preventive activity as it inhibits the fungal growth by releasing its active ingredients for 7 days, while the OE-modified GNNP acts as a natural drug showing cytocidal activity on nails colonised by dermatophytes, but it requires two weekly applications.
    MeSH term(s) Humans ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Nails ; Oils, Volatile/pharmacology ; Oils, Volatile/therapeutic use ; Onychomycosis/drug therapy
    Chemical Substances Antifungal Agents ; Oils, Volatile
    Language English
    Publishing date 2022-07-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 392487-7
    ISSN 1439-0507 ; 0933-7407
    ISSN (online) 1439-0507
    ISSN 0933-7407
    DOI 10.1111/myc.13499
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.176: Show issues Location:
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  7. Article ; Online: Slow and steady wins the race: Fractionated near-infrared treatment empowered by graphene-enhanced 3D scaffolds for precision oncology.

    Perini, Giordano / Palmieri, Valentina / Papait, Andrea / Augello, Alberto / Fioretti, Daniela / Iurescia, Sandra / Rinaldi, Monica / Vertua, Elsa / Silini, Antonietta / Torelli, Riccardo / Carlino, Angela / Musarra, Teresa / Sanguinetti, Maurizio / Parolini, Ornella / De Spirito, Marco / Papi, Massimiliano

    Materials today. Bio

    2024  Volume 25, Page(s) 100986

    Abstract: Surgically addressing tumors poses a challenge, requiring a tailored, multidisciplinary approach for each patient based on the unique aspects of their case. Innovative therapeutic regimens combined to reliable reconstructive methods can contribute to an ... ...

    Abstract Surgically addressing tumors poses a challenge, requiring a tailored, multidisciplinary approach for each patient based on the unique aspects of their case. Innovative therapeutic regimens combined to reliable reconstructive methods can contribute to an extended patient's life expectancy. This study presents a detailed comparative investigation of near-infrared therapy protocols, examining the impact of non-fractionated and fractionated irradiation regimens on cancer treatment. The therapy is based on the implantation of graphene oxide/poly(lactic-co-glycolic acid) three-dimensional printed scaffolds, exploring their versatile applications in oncology by the examination of pro-inflammatory cytokine secretion, immune response, and in vitro and in vivo tumor therapy. The investigation into cell death patterns (apoptosis vs necrosis) underlines the pivotal role of protocol selection underscores the critical influence of treatment duration on cell fate, establishing a crucial parameter in therapeutic decision-making. In vivo experiments corroborated the profound impact of protocol selection on tumor response. The fractionated regimen emerged as the standout performer, achieving a substantial reduction in tumor size over time, surpassing the efficacy of the non-fractionated approach. Additionally, the fractionated regimen exhibited efficacy also in targeting tumors in proximity but not in direct contact to the scaffolds. Our results address a critical gap in current research, highlighting the absence of a standardized protocol for optimizing the outcome of photodynamic therapy. The findings underscore the importance of personalized treatment strategies in achieving optimal therapeutic efficacy for precision cancer therapy.
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ISSN 2590-0064
    ISSN (online) 2590-0064
    DOI 10.1016/j.mtbio.2024.100986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: New Data on the

    Cacaci, Margherita / Menchinelli, Giulia / Torelli, Riccardo / Sanglard, Dominique / Sanguinetti, Maurizio / Posteraro, Brunella

    Antimicrobial agents and chemotherapy

    2020  Volume 64, Issue 12

    MeSH term(s) Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Candida ; Drug Resistance, Fungal/genetics ; Fluconazole/pharmacology ; Imidazoles/pharmacology ; Microbial Sensitivity Tests
    Chemical Substances Antifungal Agents ; Imidazoles ; Fluconazole (8VZV102JFY) ; fenticonazole (QG05NRB077)
    Language English
    Publishing date 2020-11-17
    Publishing country United States
    Document type Letter
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01459-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Einzelsignatur: Show issues

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  9. Article: Curcumin-Functionalized Graphene Oxide Strongly Prevents

    Cacaci, Margherita / Squitieri, Damiano / Palmieri, Valentina / Torelli, Riccardo / Perini, Giordano / Campolo, Michela / Di Vito, Maura / Papi, Massimiliano / Posteraro, Brunella / Sanguinetti, Maurizio / Bugli, Francesca

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 2

    Abstract: ... Candida ... ...

    Abstract Candida parapsilosis
    Language English
    Publishing date 2023-02-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16020275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Chip-Based Molecular Evaluation of a DNA Extraction Protocol for

    Ivagnes, Vittorio / Menchinelli, Giulia / Liotti, Flora Marzia / De Carolis, Elena / Torelli, Riccardo / De Lorenzis, Desy / Recine, Cinzia / Sanguinetti, Maurizio / D'Inzeo, Tiziana / Posteraro, Brunella

    Microorganisms

    2023  Volume 12, Issue 1

    Abstract: The diagnosis ... ...

    Abstract The diagnosis of
    Language English
    Publishing date 2023-12-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12010081
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