LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Torgerson, David J"
  2. AU="Sui-Chu Ho, Esther"
  3. AU="González-Hermosillo, Jesús A"
  4. AU="Holt, Katlyn"
  5. AU="Badulescu, Daniel"
  6. AU="Granata, Mariagrazia"
  7. AU="Atek, Hakim"
  8. AU="Liu, Tingwen"
  9. AU="Cable, Jo"
  10. AU="Orsetta Zuffardi"
  11. AU="Brunner, David"
  12. AU="Monserrat, Nuria"
  13. AU="Dufresne, Philippe J"
  14. AU="Dickey, Erin M"
  15. AU="Alessia Nava"
  16. AU="Yamoah, Peter"
  17. AU="Solit, David"
  18. AU="Raymond, Benjamin"
  19. AU="Maddi, Abhiram"
  20. AU="Rodríguez, Johanna G"
  21. AU="Frans, J"
  22. AU="Elisa Palazzari"

Suchergebnis

Treffer 1 - 10 von insgesamt 151

Suchoptionen

  1. Artikel ; Online: Revised Meta-analysis of Vitamin K and Fractures-Reply.

    Torgerson, David J

    JAMA internal medicine

    2018  Band 178, Heft 8, Seite(n) 1135

    Mesh-Begriff(e) Female ; Fractures, Bone ; Humans ; Osteoporosis, Postmenopausal ; Vitamin K
    Chemische Substanzen Vitamin K (12001-79-5)
    Sprache Englisch
    Erscheinungsdatum 2018-09-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2018.2865
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Ua VI Zs.119: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel ; Online: Caution to Readers About Systematic Review on Vitamin K and Prevention of Fractures That Included Problematic Trials.

    Torgerson, David J

    JAMA internal medicine

    2018  Band 178, Heft 6, Seite(n) 863–864

    Mesh-Begriff(e) Fractures, Bone ; Humans ; Randomized Controlled Trials as Topic ; Vitamin K ; Vitamins
    Chemische Substanzen Vitamins ; Vitamin K (12001-79-5)
    Sprache Englisch
    Erscheinungsdatum 2018-03-23
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2018.1127
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Ua VI Zs.119: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel ; Online: Effects of rapid recruitment and dissemination on Covid-19 mortality: the RECOVERY trial.

    Knowlson, Catherine / Torgerson, David J

    F1000Research

    2020  Band 9, Seite(n) 1017

    Abstract: The RECOVERY trial is a large multi-armed, adaptive randomised controlled trial of treatments for Covid-19.  It has rapidly recruited and demonstrated that hydroxychloroquine is ineffective in reducing mortality for hospitalised patients, whilst ... ...

    Abstract The RECOVERY trial is a large multi-armed, adaptive randomised controlled trial of treatments for Covid-19.  It has rapidly recruited and demonstrated that hydroxychloroquine is ineffective in reducing mortality for hospitalised patients, whilst dexamethasone significantly reduces mortality among those patients using supplemental oxygen or on a ventilator.  We estimate that the speed of recruitment and dissemination has probably decreased mortality in the UK by at least 200 hospitalised patients in the first month since the British Prime Minister announced the results.  Despite its impressive speed, the trial only recruited about 10-15% of eligible patients, with recruitment rates ranging between 3% to 80% at participating hospitals.  Had the trial recruited 50% of the eligible patients then our analysis suggests that more than 2,000 additional lives could have been saved.  In a pandemic, rapid recruitment with high centre recruitment is absolutely essential to reduce deaths.  Methods of improving site specific recruitment rates need investigating urgently.
    Mesh-Begriff(e) COVID-19/mortality ; COVID-19/therapy ; Dexamethasone/therapeutic use ; Humans ; Hydroxychloroquine ; Multicenter Studies as Topic ; Pandemics ; Patient Selection ; Randomized Controlled Trials as Topic ; Treatment Outcome ; United Kingdom/epidemiology
    Chemische Substanzen Hydroxychloroquine (4QWG6N8QKH) ; Dexamethasone (7S5I7G3JQL)
    Sprache Englisch
    Erscheinungsdatum 2020-08-21
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.25842.2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  4. Buch: Designing randomised trials in health, education and the social sciences

    Torgerson, David John / Torgerson, Carole J.

    an introduction

    2008  

    Verfasserangabe David J. Torgerson and Carole J. Torgerson
    Schlagwörter Randomized Controlled Trials as Topic / methods ; Health Services Research ; Education ; Social Sciences ; Research Design ; Clinical trials ; Social sciences / Research
    Sprache Englisch
    Umfang XV, 210 S. : graph. Darst., 22cm
    Verlag Palgrave Macmillan
    Erscheinungsort Basingstoke u.a.
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    Anmerkung Includes bibliographical references and index
    HBZ-ID HT015485308
    ISBN 0-230-53735-9 ; 978-0-230-53735-4 ; 978-0-230-53736-1 ; 0-230-53736-7
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    2008 A 4254 bestellbar zur Ausleihe Magazin

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Artikel ; Online: Can routine assessment of older people's mental health lead to improved outcomes: A regression discontinuity analysis.

    Baird, Kalpita / Byrne, Ailish / Cockayne, Sarah / Cunningham-Burley, Rachel / Fairhurst, Caroline / Adamson, Joy / Vernon, Wesley / Torgerson, David J

    PloS one

    2024  Band 19, Heft 3, Seite(n) e0300651

    Abstract: Objective: To assess whether case finding for depression among people aged 65 and above improves mental health.: Design: Opportunistic evaluation using a regression discontinuity analysis with data from a randomised controlled trial.: Setting: The ...

    Abstract Objective: To assess whether case finding for depression among people aged 65 and above improves mental health.
    Design: Opportunistic evaluation using a regression discontinuity analysis with data from a randomised controlled trial.
    Setting: The REFORM trial, a falls prevention study that recruited patients from NHS podiatry clinics.
    Participants: 1010 community-dwelling adults over the age of 65 with at least one risk factor for falling (recent previous fall or fear of falling).
    Intervention: Letter sent to patient's General Practitioner if they scored 10 points or above on the 15-item Geriatric Depression Scale (GDS-15) informing them of the patient's risk of depression.
    Main outcome measure: GDS-15 score six months after initial completion of GDS-15.
    Results: 895 (88.6%) of the 1010 participants randomised into REFORM had a valid baseline and six-month GDS-15 score and were included in this study. The mean GDS-15 baseline score was 3.5 (SD 3.0, median 3.0, range 0-15); 639 (71.4%) scored 0-4, 204 (22.8%) scored 5-9 indicating mild depression, and 52 (5.8%) scored 10 or higher indicating severe depression. At six months follow-up, those scoring 10 points or higher at baseline had, on average, a reduction of 1.08 points on the GDS-15 scale (95% confidence interval -1.83 to -0.33, p = 0.005) compared to those scoring less than 10, using the simplest linear regression model.
    Conclusion: Case finding of depression in podiatry patients based on a GDS-15 score of 10 or more followed by a letter to their General Practitioner significantly reduced depression severity. Whether this applies to all older patients in primary care is unknown. Further research is required to confirm these findings. Regression discontinuity analyses could be prespecified and embedded within other existing research studies.
    Mesh-Begriff(e) Aged ; Humans ; Depression/diagnosis ; Depressive Disorder ; Fear/psychology ; Mental Health ; Regression Analysis ; Randomized Controlled Trials as Topic
    Sprache Englisch
    Erscheinungsdatum 2024-03-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0300651
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  6. Artikel ; Online: Efficacy of a Sexual Assault Resistance Program for University Women.

    Torgerson, David J

    The New England journal of medicine

    2015  Band 373, Heft 14, Seite(n) 1375–1376

    Mesh-Begriff(e) Female ; Health Education/methods ; Humans ; Male ; Rape/prevention & control ; Student Health Services ; Universities
    Sprache Englisch
    Erscheinungsdatum 2015-10
    Erscheinungsland United States
    Dokumenttyp Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1509345#SA1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Ua VI Zs.34: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  7. Artikel ; Online: Relationship between age, workplace slips and the effectiveness of slip-resistant footwear among healthcare workers.

    Frost, Gillian / Liddle, Mark / Cockayne, Sarah / Cunningham-Burley, Rachel / Fairhurst, Caroline / Torgerson, David J

    Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention

    2022  Band 28, Heft 3, Seite(n) 256–258

    Abstract: Objectives: To explore any age-related trend in workplace slip rate and assess the effectiveness of appropriate slip-resistant footwear in preventing workplace slips by age.: Methods: Secondary data analysis of the Stopping Slips among Healthcare ... ...

    Abstract Objectives: To explore any age-related trend in workplace slip rate and assess the effectiveness of appropriate slip-resistant footwear in preventing workplace slips by age.
    Methods: Secondary data analysis of the Stopping Slips among Healthcare Workers trial, a two-arm randomised controlled trial conducted between March 2017 and May 2019. 4553 National Health Service (NHS) staff across seven sites in England were randomised 1:1 to the intervention group (provision of 5* GRIP-rated slip-resistant footwear) or the control group (usual work footwear). The primary outcome was self-reported workplace slips, ascertained primarily through weekly text messages throughout the 14-week trial follow-up and analysed using mixed-effects negative binomial regression. This paper reports a control group-only analysis of the association between age and slip rate, and a full intention-to-treat analysis of the effectiveness of slip-resistant footwear by age.
    Results: The mean age of participants was 43 years (range 18-74). In the control group-only analysis, slip rate differed by age (p<0.001) with those aged 60+ having double the slip rate of those aged <30 years (95% CI 1.40 to 2.87). In the intention-to-treat analysis, the interaction between allocation and age was statistically significant (p=0.002). In addition, for all age groups except those aged <30 years, the slip rate in the intervention group was statistically significantly lower than the control group; the smallest incidence rate ratio (ie, the biggest effect) was 0.39 (95% CI 0.24 to 0.64) in the 60+ age group.
    Conclusion: The provision of appropriate slip-resistant footwear was more effective at reducing workplace slips for older NHS staff.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Health Personnel ; Humans ; Infant ; Middle Aged ; Shoes ; State Medicine ; Workplace ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2022-04-12
    Erscheinungsland England
    Dokumenttyp Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1433667-4
    ISSN 1475-5785 ; 1353-8047
    ISSN (online) 1475-5785
    ISSN 1353-8047
    DOI 10.1136/injuryprev-2022-044533
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4910: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  8. Artikel ; Online: Communication interventions for medically unexplained symptom conditions in general practice: A systematic review and meta-analysis of randomised controlled trials.

    Byrne, Ailish Katherine / Scantlebury, Arabella / Jones, Katherine / Doherty, Laura / Torgerson, David J

    PloS one

    2022  Band 17, Heft 11, Seite(n) e0277538

    Abstract: Background: Medically unexplained symptoms (MUS) account for 3-50% of all General Practitioner (GP) consultations and are difficult to diagnose due to their unknown aetiology, symptom overlap between conditions, and lack of effective treatment options. ... ...

    Abstract Background: Medically unexplained symptoms (MUS) account for 3-50% of all General Practitioner (GP) consultations and are difficult to diagnose due to their unknown aetiology, symptom overlap between conditions, and lack of effective treatment options. MUS patients' and primary care clinicians frequently face challenges during consultations, with GPs reporting difficulty identifying and classifying MUS, whilst patients report stigma and feeling illegitimised by clinicians. Communication interventions have been proposed as a method to facilitate the doctor-patient relationship and aid the management of MUS.
    Aim: This systematic review aims to evaluate the effectiveness of primary care based communication interventions at improving MUS patients' and/or clinician outcomes.
    Method: Four electronic databases were searched from inception to November 2021. Two researchers independently undertook screening, data extraction and quality appraisal. Given the heterogeneous nature of the studies identified, narrative syntheses were conducted, along with meta-analyses where possible to pool data.
    Results: 9 papers from 10 Randomised Controlled Trials were included. The included studies displayed considerable risk of bias and poor reporting. Some limited evidence suggests that communication interventions tailored to MUS and not following a pre-specified model (such as reattribution) could improve pain, mental and physical functioning whilst reattribution training may improve clinician confidence treating MUS. However, methodological limitations mean that these findings should be interpreted with caution.
    Conclusion: A range of interventions for improving communication with MUS patients in primary care have been evaluated. However, the heterogeneous nature of existing evidence and poor study quality mean we cannot conclude whether these interventions are effective. Before considering further randomised controlled trials researchers should focus on developing a new or modified communication intervention for MUS patients and their clinicians.
    Trail registration: The systematic review was prospectively registered with PROSPERO (registration record CRD42020206437).
    Mesh-Begriff(e) Humans ; Physician-Patient Relations ; Medically Unexplained Symptoms ; General Practitioners ; Communication ; General Practice ; Randomized Controlled Trials as Topic
    Sprache Englisch
    Erscheinungsdatum 2022-11-14
    Erscheinungsland United States
    Dokumenttyp Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0277538
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  9. Artikel ; Online: Baseline testing in cluster randomised controlled trials: should this be done?

    Bolzern, Jaime E / Mitchell, Alex / Torgerson, David J

    BMC medical research methodology

    2019  Band 19, Heft 1, Seite(n) 106

    Abstract: Background: Comparisons of baseline covariates in randomised controlled trials whilst often undertaken is regarded by many as an exercise in futility. Because of randomisation the null hypothesis is true for baseline comparisons and therefore any ... ...

    Abstract Background: Comparisons of baseline covariates in randomised controlled trials whilst often undertaken is regarded by many as an exercise in futility. Because of randomisation the null hypothesis is true for baseline comparisons and therefore any differences will occur by chance. However, this is only the case if allocations are not known in advance of recruitment. If this occurs then selection bias at randomisation may be present and it is possible that the statistical testing of covariates may unveil selection bias. In this paper we show that this is particularly the case for cluster randomised trials when post-randomised recruitment often occurs and can lead to selection bias.
    Main text: We take a recently published cluster randomised trial that has suffered from selection bias due to differential recruitment and calculate baseline p values. We show that statistically significant imbalances of p < 0.0001 occurred in 5 of the 10 covariates. In comparison for an individually randomised trial that had no evidence of selection bias only 1 p value of p < 0.05 out of 20 tests was observed. Had baseline p values for the cluster trial been presented to journal editors, reviewers and readers then the results of the trial might have been treated with more caution.
    Conclusion: We argue that the blanket ban of baseline testing as advocated by some may reduce the chance of identifying deficient cluster randomised trials and this opposition should be reconsidered for cluster trials.
    Mesh-Begriff(e) Acupuncture Therapy ; Adolescent ; Australia ; Female ; Humans ; Patient Selection ; Pregnancy ; Pregnancy Outcome ; Pregnancy in Adolescence/prevention & control ; Random Allocation ; Randomized Controlled Trials as Topic/methods ; Selection Bias ; Urinary Incontinence, Stress/prevention & control ; Urinary Incontinence, Stress/therapy
    Sprache Englisch
    Erscheinungsdatum 2019-05-17
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1471-2288
    ISSN (online) 1471-2288
    DOI 10.1186/s12874-019-0750-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  10. Artikel ; Online: Effectiveness of pre-operative anaemia screening and increased Tranexamic acid dose policies on outcomes following unilateral primary, elective total hip or knee replacement: a statistical analysis plan for an interrupted time series and regression discontinuity study.

    Scrimshire, Ashley B / Fairhurst, Caroline / McDaid, Catriona / Torgerson, David J

    F1000Research

    2020  Band 9, Seite(n) 224

    Abstract: Perioperative blood transfusion is associated with poorer postoperative outcomes following hip and knee replacement surgery. Evidence for the effectiveness of some measures aimed at reducing blood transfusions in this setting are limited and often rely ... ...

    Abstract Perioperative blood transfusion is associated with poorer postoperative outcomes following hip and knee replacement surgery. Evidence for the effectiveness of some measures aimed at reducing blood transfusions in this setting are limited and often rely on weak pre-post study designs. Quasi-experimental study designs such as interrupted time series (ITS) and regression discontinuity design (RDD) address many of the weaknesses of the pre-post study design. In addition,
    Sprache Englisch
    Erscheinungsdatum 2020-04-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.22962.2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang