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  1. Article ; Online: Osteomyelitis of the Calcaneus with Pathologic Fracture.

    Torre, Alessandro / De Monti, Marco

    The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

    2020  Volume 59, Issue 3, Page(s) 641

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Calcaneus/surgery ; Combined Modality Therapy ; Diabetic Foot/complications ; Diabetic Foot/therapy ; Fractures, Spontaneous/etiology ; Fractures, Spontaneous/therapy ; Humans ; Osteomyelitis/etiology ; Osteomyelitis/therapy ; Wounds and Injuries/etiology ; Wounds and Injuries/therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-04-29
    Publishing country United States
    Document type Letter
    ZDB-ID 1146972-9
    ISSN 1542-2224 ; 1067-2516
    ISSN (online) 1542-2224
    ISSN 1067-2516
    DOI 10.1053/j.jfas.2019.09.022
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    Zs.A 1468: Show issues Location:
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  2. Article ; Online: Management of Polypharmacy and Potential Drug-Drug Interactions in Patients with Pulmonary Aspergillosis: A 2-Year Study of a Multidisciplinary Outpatient Clinic.

    Cattaneo, Dario / Torre, Alessandro / Schiuma, Marco / Civati, Aurora / Casalini, Giacomo / Gori, Andrea / Antinori, Spinello / Gervasoni, Cristina

    Journal of fungi (Basel, Switzerland)

    2024  Volume 10, Issue 2

    Abstract: Pulmonary aspergillosis mainly affects elderly patients, patients with pulmonary complications, patients with hematological malignancies, organ transplant recipients, or critically ill patients. Co-morbidities may result in a high rate of polypharmacy ... ...

    Abstract Pulmonary aspergillosis mainly affects elderly patients, patients with pulmonary complications, patients with hematological malignancies, organ transplant recipients, or critically ill patients. Co-morbidities may result in a high rate of polypharmacy and a high risk of potential drug-drug interaction (pDDI)-related antifungal azoles, which are perpetrators of several pharmacokinetic- and pharmacodynamic-driven pDDIs. Here, we report the results of the first 2-year study of an outpatient clinic focusing on the management of therapies in patients with pulmonary aspergillosis. All patients who underwent an outpatient visit from May 2021 to May 2023 were included in this retrospective analysis. A total of 34 patients who were given an azole as an antifungal treatment (53% voriconazole, 41% isavuconazole, and 6% itraconazole) were included. Overall, 172 pDDIs were identified and classified as red- (8%), orange- (74%), or yellow-flag (18%) combinations. We suggested handling polypharmacy in those patients using specific diagnostic and pharmacologic interventions. As expected, red-flag pDDIs involved mainly voriconazole as a perpetrator (71%). However, nearly 30% of red-flag pDDIs were not related to antifungal therapy. These findings highlight the importance of conducting an overall assessment of the pharmacologic burden and the key role played by a multidisciplinary team for the optimization of therapies in patients with pulmonary aspergillosis.
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof10020107
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  3. Article ; Online: A Hard Mass of the Right Submandibular Gland in an 83-Yr-Old Lady.

    Migliora, Paola / Barizzi, Jessica / Torre, Alessandro / Ermanni, Stefano / Fulciniti, Franco

    Acta cytologica

    2021  Volume 65, Issue 2, Page(s) 194–196

    MeSH term(s) Aged, 80 and over ; Cytodiagnosis/methods ; Female ; Humans ; Prognosis ; Retroperitoneal Fibrosis/diagnosis ; Retroperitoneal Fibrosis/surgery ; Submandibular Gland/pathology ; Submandibular Gland/surgery
    Language English
    Publishing date 2021-01-05
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 80003-x
    ISSN 1938-2650 ; 0001-5547
    ISSN (online) 1938-2650
    ISSN 0001-5547
    DOI 10.1159/000512414
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    Zs.A 358: Show issues Location:
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  4. Article ; Online: Photodynamic Therapy for the Treatment of Vascularized Intraretinal Tuberculoma.

    Parrulli, Salvatore / Zicarelli, Federico / Torre, Alessandro / Pellegrini, Marco / Invernizzi, Alessandro

    Ocular immunology and inflammation

    2021  Volume 30, Issue 5, Page(s) 1203–1206

    Abstract: Purpose: To report a case of intraretinal tubercular granuloma successfully treated with photodynamic therapy (PDT).: Methods: Retrospective case report. Multimodal imaging was performed at each follow-up visit.: Results: The tuberculoma did not ... ...

    Abstract Purpose: To report a case of intraretinal tubercular granuloma successfully treated with photodynamic therapy (PDT).
    Methods: Retrospective case report. Multimodal imaging was performed at each follow-up visit.
    Results: The tuberculoma did not regress and did not significantly reduce its exudation after anti-tubercular therapy (ATT), systemic steroid therapy and intravitreal anti-VEGF. Second line treatment with PDT was attempted. The lesion showed a regression with reduced sub-retinal fluid and intra-retinal exudates. A second PDT was performed for reactivation of the lesion 5 months after the first treatment. Further regression of the lesion was observed.
    Conclusion: PDT may be a valuable second-line therapeutic approach for vascularized intraretinal granulomas.
    MeSH term(s) Angiogenesis Inhibitors ; Fluorescein Angiography ; Humans ; Intravitreal Injections ; Photochemotherapy/methods ; Photosensitizing Agents/therapeutic use ; Retrospective Studies ; Steroids/therapeutic use ; Tomography, Optical Coherence ; Tuberculoma/diagnosis ; Tuberculoma/drug therapy
    Chemical Substances Angiogenesis Inhibitors ; Photosensitizing Agents ; Steroids
    Language English
    Publishing date 2021-01-21
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2020.1869788
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    Zs.A 4004: Show issues Location:
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  5. Article ; Online: Optical Coherence Tomography Angiography Findings of Iris Ischemia and Reperfusion in Cytomegalovirus Panuveitis.

    Zicarelli, Federico / Parrulli, Salvatore / Torre, Alessandro / Oldani, Marta / Invernizzi, Alessandro

    Ocular immunology and inflammation

    2021  Volume 30, Issue 7-8, Page(s) 1595–1598

    Abstract: Purpose: To report a case of iris ischemia in an eye affected by Cytomegalovirus (CMV)-related Chronic Retinal Necrosis (CRN) with partial reperfusion after antiviral therapy demonstrated by optical coherence tomography angiography (OCTA).: Methods: ... ...

    Abstract Purpose: To report a case of iris ischemia in an eye affected by Cytomegalovirus (CMV)-related Chronic Retinal Necrosis (CRN) with partial reperfusion after antiviral therapy demonstrated by optical coherence tomography angiography (OCTA).
    Methods: Retrospective case report. Multimodal imaging was performed at each follow-up visits.
    Results: At baseline, the clinical findings and PCR on aqueous confirmed the diagnosis of CMV-induced CRN, while OCTA and Fluorescein Angiography showed multi-sectoral retinal and iris non-perfusion. After three weekly intravitreal injections of Foscarnet and retinal photocoagulation, the clinical and angiographic picture improved, with partial reperfusion of both retinal and iris vasculature.
    Conclusion: Retinal and iris non-perfusion in CRN can be partially reversible, if prompt treatment is administered. OCTA of the anterior segment allowed an accurate follow-up of the iris vasculature and its perfusion.
    MeSH term(s) Humans ; Tomography, Optical Coherence ; Cytomegalovirus/genetics ; Retrospective Studies ; Iris/diagnostic imaging ; Ischemia/diagnosis
    Language English
    Publishing date 2021-06-11
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2021.1916041
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    Zs.A 4004: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Management of Polypharmacy and Potential Drug-Drug Interactions in Patients with Mycobacterial Infection: A 1-Year Experience of a Multidisciplinary Outpatient Clinic.

    Cattaneo, Dario / Torre, Alessandro / Schiuma, Marco / Civati, Aurora / Lazzarin, Samuel / Rizzardini, Giuliano / Gori, Andrea / Antinori, Spinello / Gervasoni, Cristina

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 7

    Abstract: In 2022, we opened an outpatient clinic for the management of polypharmacy and potential drug-drug interactions (pDDIs) in patients with mycobacterial infection (called GAP-MyTB). All patients who underwent a GAP-MyTB visit from March 2022 to March 2023 ... ...

    Abstract In 2022, we opened an outpatient clinic for the management of polypharmacy and potential drug-drug interactions (pDDIs) in patients with mycobacterial infection (called GAP-MyTB). All patients who underwent a GAP-MyTB visit from March 2022 to March 2023 were included in this retrospective analysis. Fifty-two patients were included in the GAP-MyTB database. They were given 10.4 ± 3.7 drugs (2.8 ± 1.0 and 7.8 ± 3.9 were, respectively, antimycobacterial agents and co-medications). Overall, 262 pDDIs were identified and classified as red-flag (2%), orange-flag (72%), or yellow-flag (26%) types. The most frequent actions suggested after the GAP-MyTB assessment were to perform ECG (52%), therapeutic drug monitoring (TDM, 40%), and electrolyte monitoring (33%) among the diagnostic interventions and to reduce/stop proton pump inhibitors (37%), reduce/change statins (14%), and reduce anticholinergic burden (8%) among the pharmacologic interventions. The TDM of rifampicin revealed suboptimal exposure in 39% of patients that resulted in a TDM-guided dose increment (from 645 ± 101 to 793 ± 189 mg/day,
    Language English
    Publishing date 2023-07-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12071171
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  7. Article ; Online: Incidence and outcome of delirium during helmet CPAP treatment in COVID-19 patients.

    Samartin, Federica / Salvi, Emanuele / Brambilla, Anna Maria / Torre, Alessandro / Ingrassia, Stella / Gidaro, Antonio

    Internal and emergency medicine

    2021  Volume 17, Issue 1, Page(s) 307–309

    MeSH term(s) COVID-19 ; Continuous Positive Airway Pressure ; Delirium/epidemiology ; Delirium/etiology ; Delirium/prevention & control ; Humans ; Incidence ; Respiratory Insufficiency ; SARS-CoV-2
    Language English
    Publishing date 2021-08-14
    Publishing country Italy
    Document type Letter
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-021-02810-z
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    Zs.A 6673: Show issues Location:
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  8. Article ; Online: Opioid-Free Anesthesia in Bariatric Surgery: a Propensity Score-Matched Analysis.

    Torre, Alessandro / Marengo, Michele / Ledingham, Nicola S / Ajani, Costanza / Volontè, Francesco / Garofalo, Fabio / Mongelli, Francesco

    Obesity surgery

    2022  Volume 32, Issue 5, Page(s) 1673–1680

    Abstract: Purpose: Patients undergoing bariatric surgery are at particular high risk of postoperative nausea and vomiting (PONV). Few studies have shown the superiority of opioid-free anesthesia (OFA) over general anesthesia with opioids in bariatric surgery. The ...

    Abstract Purpose: Patients undergoing bariatric surgery are at particular high risk of postoperative nausea and vomiting (PONV). Few studies have shown the superiority of opioid-free anesthesia (OFA) over general anesthesia with opioids in bariatric surgery. The aim was to investigate the potential advantages of the OFA in bariatric surgery.
    Materials and methods: This is a retrospective study on a prospectively collected database that included bariatric patients over a 3-year period. All patients who underwent bariatric surgery at our institution were included and divided into opioid-free or standard anesthesia. The primary endpoint was the length of hospital stay. Data was collected and analyzed using a propensity score.
    Results: We included 344 patients, of these 209 (60.8%) received opioid-free and 135 (39.2%) received a standard anesthesia. Mean age was 46.2 ± 11.2 years, 265 (77.0%) patients were female, and 238 (69.2%) had at least one associated medical problem. The two groups were similar in terms of age, gender, BMI, associated medical problems, and type of operations. Postoperatively, we observed no significant difference in opioid requirement, while significantly less doses of antiemetics were administered in the OFA group at postoperative day 1 (0.4 ± 0.7 vs. 0.7 ± 1.0 doses, p = 0.006) and 2 (0.1 ± 0.4 vs. 0.2 ± 0.6 doses, p = 0.022). Length of stay was significantly shorter in the OFA group (2.8 ± 0.9 vs. 3.5 ± 2.0 days, p < 0.001) both in the overall and in the propensity score-matched analyses.
    Conclusion: OFA is effective for patients undergoing bariatric surgery. Perioperative outcomes are similar, while OFA patients required less antiemetics and were discharged earlier from hospital.
    MeSH term(s) Adult ; Analgesics, Opioid/therapeutic use ; Anesthesia, General ; Antiemetics/therapeutic use ; Bariatric Surgery/adverse effects ; Female ; Humans ; Middle Aged ; Obesity, Morbid/surgery ; Pain, Postoperative/drug therapy ; Propensity Score ; Retrospective Studies
    Chemical Substances Analgesics, Opioid ; Antiemetics
    Language English
    Publishing date 2022-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-022-06012-0
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    Zs.A 3381: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: The performance of levothyroxine tablet is impaired by bariatric surgery.

    Trimboli, Pierpaolo / Ossola, Nicola / Torre, Alessandro / Mongelli, Francesco / Quarenghi, Massimo / Camponovo, Chiara / Lucchini, Barbara / Rotondi, Mario / Ruinelli, Lorenzo / Garofalo, Fabio

    Endocrine

    2022  Volume 80, Issue 3, Page(s) 563–569

    Abstract: Objective: The aim was to evaluate if bariatric surgery can affect the LT4 performance. The endpoints were the following: 1) difference between LT4 daily dose before and 1 year after surgery, 2) difference between LT4 dose per weight before and 1 year ... ...

    Abstract Objective: The aim was to evaluate if bariatric surgery can affect the LT4 performance. The endpoints were the following: 1) difference between LT4 daily dose before and 1 year after surgery, 2) difference between LT4 dose per weight before and 1 year after surgery, 3) difference among LT4 preparations.
    Methods: The study period was between January 2018 and May 2022. Inclusion criteria were a) adults undergone bariatric surgery, b) with proven autoimmune hypothyroidism, c) on LT4 therapy before bariatric surgery, d) using any commercialized LT4 preparation. Excluded were patients a) proven to have or suspected for pre-surgical intestinal malabsorption, b) with other potential interfering factors on LT4 absorption; c) with heart, renal, and/or hepatic failure, d) with recent/current infection/inflammation, e) in pregnancy, f) with incomplete data about LT4 therapy.
    Results: According to the selection criteria, 40 patients were included. Both TSH and LT4 daily doses were not significantly different with respect to baseline values. On the contrary, the LT4 dose per weight was significantly increased, especially in RYGB patients. An increased LT4 dose per weight was observed with the reduction of weight.
    Conclusion: One year after bariatric surgery 1) the daily dose of LT4 remains unchanged, and 2) despite the significant weight reduction, LT4 dose per weight increases. Most data are referred to LT4 tablet and the performance of LT4 caps should be further investigated.
    MeSH term(s) Adult ; Female ; Pregnancy ; Humans ; Thyroxine/therapeutic use ; Hypothyroidism/drug therapy ; Bariatric Surgery/methods ; Weight Loss ; Tablets/therapeutic use ; Thyrotropin
    Chemical Substances Thyroxine (Q51BO43MG4) ; Tablets ; Thyrotropin (9002-71-5)
    Language English
    Publishing date 2022-12-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-022-03289-0
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    Zs.A 3884: Show issues Location:
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  10. Article ; Online: Incidence and outcome of delirium during Helmet CPAP treatment in COVID-19 patients

    Samartin, Federica / Salvi, Emanuele / Brambilla, Anna Maria / Ingrassia, Stella / Torre, Alessandro / Gidaro, Antonio

    medRxiv

    Abstract: It is estimated that almost one-third of patients with COVID-19 develop delirium in the course of disease, actually it may be the only presenting symptom, especially in dementia patients. In COVID-19 patients delirium is associated with higher mortality ... ...

    Abstract It is estimated that almost one-third of patients with COVID-19 develop delirium in the course of disease, actually it may be the only presenting symptom, especially in dementia patients. In COVID-19 patients delirium is associated with higher mortality rate, increased length of stay and a greater rate of admission in Intensive Care Unit and ventilator utilisation. We hypothesized a greater rate of delirium in Helmet CPAP COVID-19 ventilated patients because many known risk factors for delirium co-exist in these kind of patients (i.e. isolation, noise, dehydration). The first aim of our study is to investigate the incidence of delirium occurring during Helmet CPAP therapy in COVID-19 patients. Moreover, we wanted to verify if there are predictable risk factors for delirium and to determine if delirium increases the risk of adverse outcomes (need of endotracheal intubation and death). The cohort of CPAP ventilated COVID-19 patients were composed by 194 patients. Of them, 57 patients (29.3%) developed delirium during CPAP, more than two third in the first 48h. Age over 70 years, previous diagnosis of dementia or psychiatric condition, P/F < 150 after starting CPAP and Gr/Lys >8 resulted risk factors for delirium. Delirium group had a significantly higher mortality rate (47% vs 23%) and lower intubation rate (12% vs 26%) compared to non-delirious ones. Despite many potential predisposing factors are common in CPAP ventilated patients, delirium incidence in our population seems not to differ from what reported by other studies. Moreover, the occurrence of delirium seems not to be related to prolonged CPAP treatment, indeed no correlation between time spent in CPAP and delirium onset was found.
    Keywords covid19
    Language English
    Publishing date 2021-05-03
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.05.01.21256071
    Database COVID19

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