Article: Blood system ABO antigens as risk factor for severity of SARS-CoV-2 infection.
2021 Volume 157, Issue 2, Page(s) 174–180
Abstract: Introduction: Whether there is an influence of the ABO blood system on SARS-CoV-2 infection is unknown.: Objective: To analyze if there is an association between the ABO system antigens and susceptibility to and severity of SARS-CoV-2 infection.: ... ...
Title translation | Antígenos del sistema sanguíneo ABO como factor de riesgo para la gravedad de la infección por SARS-CoV-2. |
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Abstract | Introduction: Whether there is an influence of the ABO blood system on SARS-CoV-2 infection is unknown. Objective: To analyze if there is an association between the ABO system antigens and susceptibility to and severity of SARS-CoV-2 infection. Material and methods: The frequency of ABO system antigens was compared in 73 confirmed cases of SARS-CoV-2 infection and 52 clinically healthy donors. Infection severity was assessed by comparing the frequency of antigens by disease severity and mortality. Results: The risk of suffering from SARS-CoV-2 infection increases in subjects with A vs. non-A antigen (OR = 1.45; 95 % CI: 1.061-1.921). Blood phenotype O reduces the risk of SARS-CoV-2 infection (OR = 0.686; 95 % CI: 0.522-0.903). No differences were found regarding disease severity. In critically ill patients, the risk of mortality increased in subjects with A vs. non-A antigen (OR = 3.34; 95 % CI: 1.417-8.159). Conclusion: Blood group A is a risk factor for SARS-CoV-2 infection, but not for disease severity, although in critically ill patients it is a risk factor for mortality. |
MeSH term(s) | ABO Blood-Group System/adverse effects ; ABO Blood-Group System/immunology ; Adult ; Aged ; COVID-19/blood ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/mortality ; Case-Control Studies ; Confidence Intervals ; Critical Illness ; Disease Susceptibility/blood ; Disease Susceptibility/immunology ; Female ; Humans ; Male ; Middle Aged ; Odds Ratio ; Risk Factors ; Severity of Illness Index ; Young Adult |
Chemical Substances | ABO Blood-Group System |
Language | English |
Publishing date | 2021-07-16 |
Publishing country | Mexico |
Document type | Journal Article |
ZDB-ID | 425456-9 |
ISSN | 0016-3813 |
ISSN | 0016-3813 |
DOI | 10.24875/GMM.20000498 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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