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Article ; Online: Central hypersomnia and chronic insomnia: expanding the spectrum of sleep disorders in long COVID syndrome - a prospective cohort study.

Moura, Alissa Elen Formiga / Oliveira, Danilo Nunes / Torres, Danielle Mesquista / Tavares-Júnior, José Wagner Leonel / Nóbrega, Paulo Ribeiro / Braga-Neto, Pedro / Sobreira-Neto, Manoel Alves

BMC neurology

2022  Volume 22, Issue 1, Page(s) 417

Abstract: Introduction: Long-onset COVID syndrome has been described in patients with COVID-19 infection with persistence of symptoms or development of sequelae beyond 4 weeks after the onset of acute symptoms, a medium- and long-term consequence of COVID-19. ... ...

Abstract Introduction: Long-onset COVID syndrome has been described in patients with COVID-19 infection with persistence of symptoms or development of sequelae beyond 4 weeks after the onset of acute symptoms, a medium- and long-term consequence of COVID-19. This syndrome can affect up to 32% of affected individuals, with symptoms of fatigue, dyspnea, chest pain, cognitive disorders, insomnia, and psychiatric disorders. The present study aimed to characterize and evaluate the prevalence of sleep symptoms in patients with long COVID syndrome.
Methodology: A total of 207 patients with post-COVID symptoms were evaluated through clinical evaluation with a neurologist and specific exams in the subgroup complaining of excessive sleepiness.
Results: Among 189 patients included in the long COVID sample, 48 (25.3%) had sleep-related symptoms. Insomnia was reported by 42 patients (22.2%), and excessive sleepiness (ES) was reported by 6 patients (3.17%). Four patients with ES were evaluated with polysomnography and test, multiple sleep latencies test, and actigraphic data. Two patients had a diagnosis of central hypersomnia, and one had narcolepsy. A history of steroid use was related to sleep complaints (insomnia and excessive sleepiness), whereas depression was related to excessive sleepiness. We observed a high prevalence of cognitive complaints in these patients.
Conclusion: Complaints related to sleep, such as insomnia and excessive sleepiness, seem to be part of the clinical post-acute syndrome (long COVID syndrome), composing part of its clinical spectrum, relating to some clinical data.
MeSH term(s) Humans ; Sleep Initiation and Maintenance Disorders/epidemiology ; COVID-19/complications ; COVID-19/epidemiology ; Prospective Studies ; Sleepiness ; Disorders of Excessive Somnolence/diagnosis ; Disorders of Excessive Somnolence/epidemiology ; Sleep Wake Disorders/epidemiology ; Syndrome
Language English
Publishing date 2022-11-09
Publishing country England
Document type Journal Article
ZDB-ID 2041347-6
ISSN 1471-2377 ; 1471-2377
ISSN (online) 1471-2377
ISSN 1471-2377
DOI 10.1186/s12883-022-02940-7
Database MEDical Literature Analysis and Retrieval System OnLINE

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