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  1. Article ; Online: FoxO3 and oxidative stress: a multifaceted role in cellular adaptation.

    Bernardo, Victoria Simões / Torres, Flaviene Felix / da Silva, Danilo Grünig Humberto

    Journal of molecular medicine (Berlin, Germany)

    2023  Volume 101, Issue 1-2, Page(s) 83–99

    Abstract: Oxidative stress is a major cause of morbidity and mortality in human health and disease. In this review, we focus on the Forkhead Box (Fox) subclass O3 (FoxO3), an extensively studied transcription factor that plays a pleiotropic role in a wide range of ...

    Abstract Oxidative stress is a major cause of morbidity and mortality in human health and disease. In this review, we focus on the Forkhead Box (Fox) subclass O3 (FoxO3), an extensively studied transcription factor that plays a pleiotropic role in a wide range of physiological and pathological processes by regulating multiple gene regulatory networks involved in the modulation of numerous aspects of cellular metabolism, including fuel metabolism, cell death, and stress resistance. This review will also focus on regulatory mechanisms of FoxO3 expression and activity, such as crucial post-translational modifications and non-coding RNAs. Moreover, this work discusses and evidences some pathways to how this transcription factor and reactive oxygen species regulate each other, which may lead to the pathogenesis of various types of diseases. Therefore, in addition to being a promising therapeutic target, the FoxO3-regulated signaling pathways can also be used as reliable diagnostic and prognostic biomarkers and indicators for drug responsiveness.
    MeSH term(s) Humans ; Forkhead Box Protein O3/metabolism ; Forkhead Transcription Factors/metabolism ; Gene Expression Regulation ; Oxidative Stress/genetics ; Signal Transduction
    Chemical Substances Forkhead Box Protein O3 ; Forkhead Transcription Factors ; FOXO3 protein, human
    Language English
    Publishing date 2023-01-04
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1223802-8
    ISSN 1432-1440 ; 0946-2716
    ISSN (online) 1432-1440
    ISSN 0946-2716
    DOI 10.1007/s00109-022-02281-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Arsenic bioaccumulation and biotransformation in different tissues of Nile tilapia (Oreochromis niloticus): A comparative study between As(III) and As(V) exposure and evaluation of antagonistic effects of selenium.

    Ferreira, Nathalia Dos Santos / Costa, Pedro Henrique da / de Sá, Ívero Pita / Bernardo, Victoria Simões / Torres, Flaviene Felix / Figueiredo, Jozi Godoy / do Amaral, Clarice Dias Britto / Nogueira, Ana Rita Araujo / Humberto da Silva, Danilo Grünig / Gonzalez, Mario Henrique

    Chemosphere

    2024  Volume 359, Page(s) 142289

    Abstract: The speciation of arsenic in fish has been widely investigated, but bioaccumulation and biotransformation of inorganic As in different tissues of Nile tilapia (Oreochromis niloticus) are not fully understood. The present study aimed to investigate the ... ...

    Abstract The speciation of arsenic in fish has been widely investigated, but bioaccumulation and biotransformation of inorganic As in different tissues of Nile tilapia (Oreochromis niloticus) are not fully understood. The present study aimed to investigate the bioaccumulation of As in Nile tilapia, as well as to evaluate the distribution of the main arsenic species (As(III), As(V), MMA, DMA, and AsB) in liver, stomach, gill, and muscle, after controlled exposures to As(III) and As(V) at concentrations of 5.0 and 10.0 mg L
    Language English
    Publishing date 2024-05-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2024.142289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Peroxiredoxins in erythrocytes: far beyond the antioxidant role.

    de Paula, Carla Peres / de Oliveira da Silva, João Pedro Maia / Romanello, Karen Simone / Bernardo, Victoria Simões / Torres, Flaviene Felix / da Silva, Danilo Grünig Humberto / da Cunha, Anderson Ferreira

    Journal of molecular medicine (Berlin, Germany)

    2023  Volume 101, Issue 11, Page(s) 1335–1353

    Abstract: The red blood cells (RBCs) are essential to transport oxygen ( ... ...

    Abstract The red blood cells (RBCs) are essential to transport oxygen (O
    MeSH term(s) Humans ; Antioxidants/metabolism ; Peroxiredoxins/chemistry ; Peroxiredoxins/metabolism ; Oxidative Stress ; Erythrocytes/metabolism ; Oxidation-Reduction ; Hydrogen Peroxide ; Oxygen ; Hemolysis
    Chemical Substances Antioxidants ; Peroxiredoxins (EC 1.11.1.15) ; Hydrogen Peroxide (BBX060AN9V) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2023-09-20
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223802-8
    ISSN 1432-1440 ; 0946-2716
    ISSN (online) 1432-1440
    ISSN 0946-2716
    DOI 10.1007/s00109-023-02368-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.36: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Potential Cytoprotective and Regulatory Effects of Ergothioneine on Gene Expression of Proteins Involved in Erythroid Adaptation Mechanisms and Redox Pathways in K562 Cells

    Bernardo, Victoria Simões / Torres, Flaviene Felix / de Paula, Carla Peres / da Silva, João Pedro Maia de Oliveira / Almeida, Eduardo Alves de / da Cunha, Anderson Ferreira / da Silva, Danilo Grünig Humberto

    Genes (Basel). 2022 Dec. 15, v. 13, no. 12

    2022  

    Abstract: This study aimed to establish the importance of ergothioneine (ERT) in the erythroid adaptation mechanisms by appraising the expression levels of redox-related genes associated with the PI3K/AKT/FoxO3 and Nrf2-ARE pathways using K562 cells induced to ... ...

    Abstract This study aimed to establish the importance of ergothioneine (ERT) in the erythroid adaptation mechanisms by appraising the expression levels of redox-related genes associated with the PI3K/AKT/FoxO3 and Nrf2-ARE pathways using K562 cells induced to erythroid differentiation and H₂O₂-oxidative stress. Cell viability and gene expression were evaluated. Two concentrations of ERT were assessed, 1 nM (C1) and 100 µM (C2), with and without stress induction (100 µM H₂O₂). Assessments were made in three periods of the cellular differentiation process (D0, D2, and D4). The C1 treatment promoted the induction of FOXO3 (D0 and 2), PSMB5, and 6 expressions (D4); C1 + H₂O₂ treatment showed the highest levels of NRF2 transcripts, KEAP1 (D0), YWHAQ (D2 and 4), PSMB5 (D2) and PSMB6 (D4); and C2 + H₂O₂ (D2) an increase in FOXO3 and MST1 expression, with a decrease of YWHAQ and NRF2 was observed. in C2 + H₂O₂ (D2) an increase in FOXO3 and MST1, with a decrease in YWHAQ and NRF2 was observed All ERT treatments increased gamma-globin expression. Statistical multivariate analyzes highlighted that the Nrf2-ARE pathway presented a greater contribution in the production of PRDX1, SOD1, CAT, and PSBM5 mRNAs, whereas the PI3K/AKT/FoxO3 pathway was associated with the PRDX2 and TRX transcripts. In conclusion, ERT presented a cytoprotective action through Nrf2 and FoxO3, with the latter seeming to contribute to erythroid proliferation/differentiation.
    Keywords cell differentiation ; cell viability ; gene expression
    Language English
    Dates of publication 2022-1215
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13122368
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Influence of Melatonin Treatment on Cellular Mechanisms of Redox Adaptation in K562 Erythroleukemic Cells

    Torres, Flaviene Felix / Bernardo, Victoria Simões / de Paula, Carla Peres / da Silva, João Pedro Maia de Oliveira / Almeida, Eduardo Alves de / da Cunha, Anderson Ferreira / da Silva, Danilo Grünig Humberto

    Genes (Basel). 2022 Dec. 11, v. 13, no. 12

    2022  

    Abstract: Melatonin (MEL) presents well-documented pleiotropic actions against oxidative stress (OS), acting indirectly through activation of transcription factors, e.g., FoxO3 and Nrf2. Thus, this study aimed to investigate the possible modulating effects of MEL ... ...

    Abstract Melatonin (MEL) presents well-documented pleiotropic actions against oxidative stress (OS), acting indirectly through activation of transcription factors, e.g., FoxO3 and Nrf2. Thus, this study aimed to investigate the possible modulating effects of MEL on the redox signaling pathways PI3K/AKT/FoxO3 and Keap1/Nrf2/ARE in K562 erythroleukemic cells subjected to OS induction. For this, the viability, and transcript levels of genes involved in redox adaptation were evaluated in K562 cells in different periods of erythroid differentiation: under OS induction by hydrogen peroxide (100 µM H₂O₂); treated with 1 nM (C1) and 1 mM (C2) MEL; and associated or not with stress induction. We observed a restoration of physiological levels of Nrf2 in both MEL concentrations under OS. The C1 was related to enhanced expression of antioxidant and proteasome genes through the Nrf2-ARE pathway, while C2 to the induction of FOXO3 expression, suggesting an involvement with apoptotic pathway, according to BIM transcript levels. The effects of MEL administration in these cells showed a period and dose-dependent pattern against induced-OS, with direct and indirect actions through different pathways of cellular adaptation, reinforcing the importance of this indolamine in the regulation of cellular homeostasis, being a promising therapeutic alternative for diseases that present an exacerbated OS.
    Keywords apoptosis ; dose response ; homeostasis ; hydrogen peroxide ; melatonin ; oxidative stress ; proteasome endopeptidase complex ; therapeutics ; viability
    Language English
    Dates of publication 2022-1211
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13122337
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Influence of Melatonin Treatment on Cellular Mechanisms of Redox Adaptation in K562 Erythroleukemic Cells.

    Torres, Flaviene Felix / Bernardo, Victoria Simões / de Paula, Carla Peres / da Silva, João Pedro Maia de Oliveira / de Almeida, Eduardo Alves / da Cunha, Anderson Ferreira / da Silva, Danilo Grünig Humberto

    Genes

    2022  Volume 13, Issue 12

    Abstract: Melatonin (MEL) presents well-documented pleiotropic actions against oxidative stress (OS), acting indirectly through activation of transcription factors, e.g., FoxO3 and Nrf2. Thus, this study aimed to investigate the possible modulating effects of MEL ... ...

    Abstract Melatonin (MEL) presents well-documented pleiotropic actions against oxidative stress (OS), acting indirectly through activation of transcription factors, e.g., FoxO3 and Nrf2. Thus, this study aimed to investigate the possible modulating effects of MEL on the redox signaling pathways PI3K/AKT/FoxO3 and Keap1/Nrf2/ARE in K562 erythroleukemic cells subjected to OS induction. For this, the viability, and transcript levels of genes involved in redox adaptation were evaluated in K562 cells in different periods of erythroid differentiation: under OS induction by hydrogen peroxide (100 µM H
    Language English
    Publishing date 2022-12-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13122337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Potential Cytoprotective and Regulatory Effects of Ergothioneine on Gene Expression of Proteins Involved in Erythroid Adaptation Mechanisms and Redox Pathways in K562 Cells.

    Bernardo, Victoria Simões / Torres, Flaviene Felix / de Paula, Carla Peres / da Silva, João Pedro Maia de Oliveira / de Almeida, Eduardo Alves / da Cunha, Anderson Ferreira / da Silva, Danilo Grünig Humberto

    Genes

    2022  Volume 13, Issue 12

    Abstract: This study aimed to establish the importance of ergothioneine (ERT) in the erythroid adaptation mechanisms by appraising the expression levels of redox-related genes associated with the PI3K/AKT/FoxO3 and Nrf2-ARE pathways using K562 cells induced to ... ...

    Abstract This study aimed to establish the importance of ergothioneine (ERT) in the erythroid adaptation mechanisms by appraising the expression levels of redox-related genes associated with the PI3K/AKT/FoxO3 and Nrf2-ARE pathways using K562 cells induced to erythroid differentiation and H
    Language English
    Publishing date 2022-12-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13122368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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