LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 158

Search options

  1. Article ; Online: Lipid mediators in the regulation of innate and adaptive immunity.

    Torres, Raul M / Cyster, Jason

    Immunological reviews

    2023  Volume 317, Issue 1, Page(s) 4–7

    MeSH term(s) Humans ; Adaptive Immunity ; Immunity, Innate ; Lipids
    Chemical Substances Lipids
    Language English
    Publishing date 2023-05-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13228
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Se 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book: CRISPR in animals and animal models

    Torres-Ruiz, Raúl

    (Progress in molecular biology and translational science ; volume 152)

    2017  

    Author's details edited by Raúl Torres-Ruiz, Sandra Rodriguez-Perales
    Series title Progress in molecular biology and translational science ; volume 152
    Collection
    Language English
    Size x, 138 Seiten, Illustrationen
    Edition First edition
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT019530089
    ISBN 978-0-12-812506-9 ; 0-12-812506-3
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uc I Zs 357 -152- verfügbar in Königswinter Königswinter

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Lysophosphatidic Acid Is an Inflammatory Lipid Exploited by Cancers for Immune Evasion

    Mathew, Divij / Torres, Raul M

    Frontiers in immunology

    2021  Volume 11, Page(s) 531910

    Abstract: Immunological tolerance has evolved to curtail immune responses against self-antigens and prevent autoimmunity. One mechanism that contributes to immunological tolerance is the expression of inhibitory receptors by lymphocytes that signal to dampen ... ...

    Abstract Immunological tolerance has evolved to curtail immune responses against self-antigens and prevent autoimmunity. One mechanism that contributes to immunological tolerance is the expression of inhibitory receptors by lymphocytes that signal to dampen immune responses during the course of an infection and to prevent immune-mediated collateral damage to the host. The understanding that tumors exploit these physiological mechanisms to avoid elimination has led to remarkable, but limited, success in the treatment of cancer through the use of biologics that interfere with the ability of cancers to suppress immune function. This therapy, based on the understanding of how T lymphocytes are normally activated and suppressed, has led to the development of therapeutic blocking antibodies, referred to as immune checkpoint blockade, which either directly or indirectly promote the activation of CD8 T cells to eradicate cancer. Here, we highlight the distinct signaling mechanisms, timing and location of inhibition used by the CTLA-4 and PD-1 inhibitory receptors compared to a novel inhibitory signaling axis comprised of the bioactive lipid, lysophosphatidic acid (LPA), signaling via the LPA5 receptor expressed by CD8 T cells. Importantly, abundant evidence indicates that an LPA-LPA5 signaling axis is also exploited by diverse cancers to suppress T cell activation and function. Clearly, a thorough molecular and biochemical understanding of how diverse T cell inhibitory receptors signal to suppress T cell antigen receptor signaling and function will be important to inform the choice of which complimentary checkpoint blockade modalities might be used for a given cancer.
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/pathology ; CTLA-4 Antigen/immunology ; Humans ; Inflammation/immunology ; Inflammation/pathology ; Lysophospholipids/immunology ; Neoplasm Proteins/immunology ; Neoplasms/immunology ; Neoplasms/pathology ; Programmed Cell Death 1 Receptor/immunology ; Receptors, Lysophosphatidic Acid/immunology ; Signal Transduction/immunology ; Tumor Escape
    Chemical Substances CTLA-4 Antigen ; CTLA4 protein, human ; LPAR5 protein, human ; Lysophospholipids ; Neoplasm Proteins ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor ; Receptors, Lysophosphatidic Acid ; lysophosphatidic acid (PG6M3969SG)
    Language English
    Publishing date 2021-01-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.531910
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Autologous platelet-rich plasma (APRP) in diabetes foot disease: a meta-analysis.

    Ruiz-Muñoz, Maria / Martinez-Barrios, Francisco-Javier / Fernandez-Torres, Raul / Lopezosa-Reca, Eva / Marchena-Rodriguez, Ana

    Journal of diabetes and its complications

    2024  Volume 38, Issue 2, Page(s) 108690

    Abstract: Introduction: This study will explore the effectiveness of autologous platelet-rich plasma in the treatment of diabetic foot disease compared to conventional treatments, based on the ulcer healing rate.: Methods: The electronic databases of PubMed, ... ...

    Abstract Introduction: This study will explore the effectiveness of autologous platelet-rich plasma in the treatment of diabetic foot disease compared to conventional treatments, based on the ulcer healing rate.
    Methods: The electronic databases of PubMed, EMBASE, and WOS internet were searched. Evaluated outcome rate of complete ulcer healing. Statistical analysis was performed with RevMan 5.0 software and SPSS 25.0.
    Results: Eleven RCTs with 828 patients were included in this study. The meta-analysis showed a higher complete ulcer healing rate (OR = 3.69, 95 % CI 2.62 to 5.20, P < 0.01, I
    Conclusion: Autologous platelet-rich plasma can improve the complete healing rate of the ulcer compared to current conventional treatments in diabetic foot ulcer patients.
    MeSH term(s) Humans ; Diabetic Foot/therapy ; Platelet-Rich Plasma ; Research Design ; Wound Healing ; Outcome Assessment, Health Care ; Diabetes Mellitus
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Meta-Analysis ; Journal Article ; Review
    ZDB-ID 1105840-7
    ISSN 1873-460X ; 1056-8727
    ISSN (online) 1873-460X
    ISSN 1056-8727
    DOI 10.1016/j.jdiacomp.2024.108690
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2225: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Validity and reliability of the English version of the Diabetic Foot Self-Care Questionnaire: a cross-cultural adaptation.

    Ruiz-Muñoz, María / Fernández-Torres, Raúl / Formosa, Cynthia / Gatt, Alfred / Gijón-Noguerón, Gabriel / Navarro-Flores, Emmanuel / González-Sánchez, Manuel

    Frontiers in public health

    2024  Volume 11, Page(s) 1326439

    Abstract: Introduction: The objective of this study was to carry out the cross-cultural adaptation and validation of the Diabetic Foot Self-Care Questionnaire into the English language, broadening the applicability of this patient-reported outcome measure and ... ...

    Abstract Introduction: The objective of this study was to carry out the cross-cultural adaptation and validation of the Diabetic Foot Self-Care Questionnaire into the English language, broadening the applicability of this patient-reported outcome measure and improving the monitoring of patients with diabetic foot disease.
    Methods: The validation study into English was conducted in two phases: cross-cultural adaptation and psychometric validation study. Short Form-12 Version 2, EuroQoL-5D and Foot Function Index were used to analyze the criterion validity. Item response, internal consistency, standard error of measurement, minimal detectable change and construct validity were calculated in the validation phase.
    Results: An English version of the questionnaire (DFSQ-UMA-En) was successfully obtained. A total of
    Conclusion: DFSQ-UMA-En is a valid and reliable tool with good readability and comprehension features. This questionnaire addresses foot self-care behaviors in patients with diabetic foot disease, standing out as essential for early diagnosis and prevention strategies in clinical and research settings.
    MeSH term(s) Humans ; Diabetic Foot/diagnosis ; Cross-Cultural Comparison ; Reproducibility of Results ; Self Care ; Surveys and Questionnaires ; Language ; Diabetes Mellitus
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1326439
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Ushering along B cells to neutralize HIV.

    Agazio, Amanda / Torres, Raul M

    Science (New York, N.Y.)

    2019  Volume 366, Issue 6470, Page(s) 1197–1198

    MeSH term(s) AIDS Vaccines ; Antibodies, Neutralizing ; B-Lymphocytes/immunology ; HIV Antibodies ; HIV Infections ; Humans
    Chemical Substances AIDS Vaccines ; Antibodies, Neutralizing ; HIV Antibodies
    Language English
    Publishing date 2019-10-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aaz8647
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 77: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Autoreactive Antibodies Associated with Castleman Disease Triad.

    Turner, Jacqueline A / Hakimi, Ali / Lee, Hannah / Schowinsky, Jeffrey T / Sippel, Jeffrey M / Siegele, Bradford J / Torres, Raul M / Robinson, William A

    Case reports in immunology

    2024  Volume 2024, Page(s) 9382107

    Abstract: The Castleman triad has been described in a select few patients presenting with a retroperitoneal mass, mucocutaneous pemphigus vulgaris, and bronchiolitis obliterans. Here, we describe the Castleman triad in a 19-year-old male with unicentric hyaline ... ...

    Abstract The Castleman triad has been described in a select few patients presenting with a retroperitoneal mass, mucocutaneous pemphigus vulgaris, and bronchiolitis obliterans. Here, we describe the Castleman triad in a 19-year-old male with unicentric hyaline vascular type Castleman disease (HV-CD). This patient presented with an array of positive antibodies, including anti-cyclic citrullinated peptide, anti-double-stranded DNA, and Sjogren's IgG. Interestingly, the patient's rheumatologic symptoms resolved after tumor resection, while his antibody profile remained relatively unchanged. HV-CD, with a triad presentation, was thought to be from a paraneoplastic syndrome secondary to an underlying lymphoproliferative disorder. The findings presented here identify multiple autoantibodies potentially contributing to this patient's presentation with HV-CD.
    Language English
    Publishing date 2024-03-06
    Publishing country Egypt
    Document type Case Reports
    ZDB-ID 2695564-7
    ISSN 2090-6617 ; 2090-6609
    ISSN (online) 2090-6617
    ISSN 2090-6609
    DOI 10.1155/2024/9382107
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Bidirectional photoswitchability in an iron(iii) spin crossover complex: symmetry-breaking and solvent effects.

    Díaz-Torres, Raúl / Chastanet, Guillaume / Collet, Eric / Trzop, Elzbieta / Harding, Phimphaka / Harding, David J

    Chemical science

    2023  Volume 14, Issue 26, Page(s) 7185–7191

    Abstract: The impact of solvent on spin crossover (SCO) behaviour is reported in two solvates [Fe(qsal-I) ...

    Abstract The impact of solvent on spin crossover (SCO) behaviour is reported in two solvates [Fe(qsal-I)
    Language English
    Publishing date 2023-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc01495a
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: CD19 Is Internalized Together with IgM in Proportion to B Cell Receptor Stimulation and Is Modulated by Phosphatidylinositol 3-Kinase in Bone Marrow Immature B Cells.

    McCaleb, Megan R / Miranda, Anjelica M / Ratliff, Kaysie C / Torres, Raul M / Pelanda, Roberta

    ImmunoHorizons

    2023  Volume 7, Issue 1, Page(s) 49–63

    Abstract: Newly generated immature B cells that bind self-antigen with high avidity arrest in differentiation and undergo central tolerance via receptor editing and clonal deletion. These autoreactive immature B cells also express low surface levels of the ... ...

    Abstract Newly generated immature B cells that bind self-antigen with high avidity arrest in differentiation and undergo central tolerance via receptor editing and clonal deletion. These autoreactive immature B cells also express low surface levels of the coreceptor CD19, a key activator of the PI3K pathway. Signals emanating from both CD19 and PI3K are known to be critical for attenuating receptor editing and selecting immature B cells into the periphery. However, the mechanisms that modulate CD19 expression at this stage of B cell development have not yet been resolved. Using in vivo and in vitro models, we demonstrate that Cd19 de novo gene transcription and translation do not significantly contribute to the differences in CD19 surface expression in mouse autoreactive and nonautoreactive immature B cells. Instead, CD19 downregulation is induced by BCR stimulation in proportion to BCR engagement, and the remaining surface IgM and CD19 molecules promote intracellular PI3K-AKT activity in proportion to their level of expression. The internalized CD19 is degraded with IgM by the lysosome, but inhibiting lysosome-mediated protein degradation only slightly improves surface CD19. In fact, CD19 is restored only upon Ag removal. Our data also reveal that the PI3K-AKT pathway positively modulates CD19 surface expression in immature B cells via a mechanism that is independent of inhibition of FOXO1 and its role on Cd19 gene transcription while is dependent on mTORC1.
    MeSH term(s) Mice ; Animals ; Precursor Cells, B-Lymphoid/metabolism ; B-Lymphocytes ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Bone Marrow/metabolism ; Receptors, Antigen, B-Cell/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Immunoglobulin M
    Chemical Substances Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Receptors, Antigen, B-Cell ; Adaptor Proteins, Signal Transducing ; Immunoglobulin M
    Language English
    Publishing date 2023-01-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2573-7732
    ISSN (online) 2573-7732
    DOI 10.4049/immunohorizons.2200092
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Improving spin crossover characteristics in heteroleptic [Fe

    Díaz-Torres, Raúl / Gómez-Coca, Silvia / Ruiz, Eliseo / Harding, Phimphaka / Harding, David J

    Dalton transactions (Cambridge, England : 2003)

    2023  Volume 52, Issue 48, Page(s) 18148–18157

    Abstract: A family of heteroleptic spin crossover (SCO) [ ... ...

    Abstract A family of heteroleptic spin crossover (SCO) [Fe
    Language English
    Publishing date 2023-12-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt02503a
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top