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  1. Article ; Online: Reply to the Commentary on "An appraisal of neostigmine versus sugammadex for neuromuscular blockade reversal in patients with a prior heart transplant".

    Paredes, Stephania / Torres, Vivian Hernandez / Chaves-Cardona, Harold / Porter, Steven / Renew, Johnathan Ross

    Anaesthesiology intensive therapy

    2023  Volume 55, Issue 3, Page(s) 241–242

    MeSH term(s) Humans ; Neuromuscular Blockade ; Neostigmine/therapeutic use ; Sugammadex ; Anesthetics ; Neuromuscular Diseases
    Chemical Substances Neostigmine (3982TWQ96G) ; Sugammadex (361LPM2T56) ; Anesthetics
    Language English
    Publishing date 2023-09-20
    Publishing country Poland
    Document type Letter ; Comment
    ISSN 1731-2531
    ISSN (online) 1731-2531
    DOI 10.5114/ait.2023.130640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An appraisal of neostigmine versus sugammadex for neuromuscular blockade reversal in patients with a prior heart transplant.

    Paredes, Stephania / Torres, Vivian Hernandez / Chaves-Cardona, Harold / Matus, Mark / Porter, Steven / Renew, Johnathan Ross

    Anaesthesiology intensive therapy

    2023  Volume 55, Issue 1, Page(s) 46–51

    Abstract: Introduction: Heart transplant recipients present unique perioperative challenges for surgery. Specifically, autonomic system denervation has significant implications for commonly used perioperative drugs. This study investigates neuromuscular blocking ... ...

    Abstract Introduction: Heart transplant recipients present unique perioperative challenges for surgery. Specifically, autonomic system denervation has significant implications for commonly used perioperative drugs. This study investigates neuromuscular blocking antagonists in this population when undergoing subsequent non-cardiac surgery.
    Material and methods: A retrospective review was performed for the period 2015-2019 across our health care enterprise. Patients with previous orthotopic heart transplant and subsequent non-cardiac surgery were identified. A total of 185 patients were found, 67 receiving neostigmine (NEO) and 118 receiving sugammadex (SGX). Information of patient characteristics, prior heart transplant, and subsequent non-cardiac surgery was collected. Our primary outcome was the incidence of bradycardia (heart rate < 60 bpm) and/or hypotension (mean blood pressure (MAP) < 65 mmHg) following neuromuscular blockade reversal. Secondary outcomes included need of intra-operative inotropic agents, arrhythmia, cardiac arrest, hospital length of stay (hLOS), ICU admission, and death within 30 postoperative days.
    Results: In unadjusted analysis, no significant differences were found between the two groups in change in heart rate [0 (-26, 14) vs. 1 (-19, 10), P = 0.59], change in MAP [0 (-22, 28) vs. 0 (-40, 47), P = 0.96], hLOS [2 days (1, 72) vs. 2 (0, 161), P = 0.92], or intraoperative hypotension [4 (6.0%) vs. 5 (4.2%), OR = 0.70, P = 0.60] for NEO and SGX respectively. After multivariable analysis, the results were similar for change in heart rate ( P = 0.59) and MAP ( P = 0.90).
    Conclusions: No significant differences in the incidence of bradycardia and hypotension were found in the NEO versus SGX groups. NEO and SGX may have similar safety profiles in patients with prior heart transplant undergoing non-cardiac surgery.
    MeSH term(s) Humans ; Neuromuscular Blockade ; Neostigmine ; Sugammadex ; Bradycardia/chemically induced ; Bradycardia/epidemiology ; Anesthetics ; Neuromuscular Diseases ; Heart Transplantation ; Hypotension/chemically induced ; Hypotension/epidemiology
    Chemical Substances Neostigmine (3982TWQ96G) ; Sugammadex (361LPM2T56) ; Anesthetics
    Language English
    Publishing date 2023-05-22
    Publishing country Poland
    Document type Journal Article
    ISSN 1731-2531
    ISSN (online) 1731-2531
    DOI 10.5114/ait.2023.125337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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