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  1. Article ; Online: Theranostics for COVID-19 Antiviral Drugs: Prospects and Challenges for Worldwide Precision/Personalized Medicine.

    Manóchio, Caíque / Torres-Loureiro, Sabrina / Scudeler, Mariana M / Miwa, Bruno / Souza-Santos, Fernanda C / Rodrigues-Soares, Fernanda

    Omics : a journal of integrative biology

    2023  Volume 27, Issue 1, Page(s) 6–14

    Abstract: Coronavirus disease 2019 (COVID-19) is a systemic disease that impacts multiple organ systems with a complex clinical presentation and outcomes that can vary from person to person and between populations. To optimize COVID-19 treatment outcomes, and in ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is a systemic disease that impacts multiple organ systems with a complex clinical presentation and outcomes that can vary from person to person and between populations. To optimize COVID-19 treatment outcomes, and in light of the availability of antiviral drugs, there is a need for greater attention to the field of theranostics, the fusion of therapeutics and diagnostics. Theranostics tests would be invaluable, we suggest in this expert review, so as to optimize the efficacy and safety of current and future antiviral drugs against COVID-19. Theranostics would also assist in the design and implementation of clinical trials with antiviral drug candidates. We discuss here theranostics considering drugs such as remdesivir, Paxlovid™, and molnupiravir. All in all, we underscore that theranostics as a concept and practice is essential for efficient and safe health interventions against COVID-19 and other ecological crises in the 21st century.
    MeSH term(s) Humans ; COVID-19 ; Antiviral Agents/therapeutic use ; Precision Medicine ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-01-04
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2030312-9
    ISSN 1557-8100 ; 1536-2310
    ISSN (online) 1557-8100
    ISSN 1536-2310
    DOI 10.1089/omi.2022.0151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: GSTM1

    Nakanishi, Giovana / Bertagnolli, Laísa S / Pita-Oliveira, Murilo / Scudeler, Mariana M / Torres-Loureiro, Sabrina / Almeida-Dantas, Thaís / Alves, Maria Laura C / Cirino, Heithor S / Rodrigues-Soares, Fernanda

    Drug metabolism reviews

    2022  Volume 54, Issue 1, Page(s) 37–45

    Abstract: ... ...

    Abstract The
    MeSH term(s) Genetic Predisposition to Disease ; Genotype ; Glutathione Transferase/genetics ; Healthy Volunteers ; Humans ; Polymorphism, Genetic
    Chemical Substances glutathione S-transferase T1 (EC 2.5.1.-) ; Glutathione Transferase (EC 2.5.1.18) ; glutathione S-transferase M1 (EC 2.5.1.18)
    Language English
    Publishing date 2022-02-15
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 184967-0
    ISSN 1097-9883 ; 0360-2532 ; 0012-6594
    ISSN (online) 1097-9883
    ISSN 0360-2532 ; 0012-6594
    DOI 10.1080/03602532.2022.2036996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1030: Show issues Location:
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  3. Article ; Online: Worldwide Systematic Review of

    Nakanishi, Giovana / Pita-Oliveira, Murilo / Bertagnolli, Laísa S / Torres-Loureiro, Sabrina / Scudeler, Mariana M / Cirino, Heithor S / Chaves, Maria Laura / Miwa, Bruno / Rodrigues-Soares, Fernanda

    Omics : a journal of integrative biology

    2022  Volume 26, Issue 10, Page(s) 528–541

    Abstract: Glutathione S-transferase Mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1) enzymes are glutathione-S-transferases with broad significance for susceptibility or resistance to multifactorial human diseases, as well as detoxification of ... ...

    Abstract Glutathione S-transferase Mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1) enzymes are glutathione-S-transferases with broad significance for susceptibility or resistance to multifactorial human diseases, as well as detoxification of environmental chemicals and drugs. Moreover, some individuals may have a complete deletion of
    MeSH term(s) Humans ; Ethnicity/genetics ; Polymorphism, Genetic ; Glutathione Transferase/genetics ; Genotype ; Glutathione/genetics ; Genetic Predisposition to Disease ; Risk Factors ; Case-Control Studies
    Chemical Substances Glutathione Transferase (EC 2.5.1.18) ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2022-09-16
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2030312-9
    ISSN 1557-8100 ; 1536-2310
    ISSN (online) 1557-8100
    ISSN 1536-2310
    DOI 10.1089/omi.2022.0090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pharmacogenetics research in Brazil: a systematic review.

    Torres-Loureiro, Sabrina / Scudeler, Mariana M / Andrade, Poliana Xc / Sampaio-Coelho, Julia / Nobre, Igor H / Céspedes-Garro, Carolina / Tarazona-Santos, Eduardo / Llerena, Adrián / Rodrigues-Soares, Fernanda

    Pharmacogenomics

    2022  Volume 23, Issue 4, Page(s) 263–275

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Brazil ; Ethnicity ; HLA-B Antigens ; Humans ; Medical Oncology ; Pharmacogenetics
    Chemical Substances HLA-B Antigens
    Language English
    Publishing date 2022-02-21
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs-2021-0128
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5247: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article: Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans.

    Kehdy, Fernanda S G / Pita-Oliveira, Murilo / Scudeler, Mariana M / Torres-Loureiro, Sabrina / Zolini, Camila / Moreira, Rennan / Michelin, Lucas A / Alvim, Isabela / Silva-Carvalho, Carolina / Furlan, Vinicius C / Aquino, Marla M / Santolalla, Meddly L / Borda, Victor / Soares-Souza, Giordano B / Jaramillo-Valverde, Luis / Vasquez-Dominguez, Andres / Neira, Cesar Sanchez / Aguiar, Renato S / Verdugo, Ricardo A /
    O Connor, Timothy D / Guio, Heinner / Tarazona-Santos, Eduardo / Leal, Thiago P / Rodrigues-Soares, Fernanda

    Genetics and molecular biology

    2021  Volume 44, Issue 1 Suppl 1, Page(s) e20200484

    Abstract: For human/SARS-CoV-2 interactome genes ACE2, TMPRSS2 and BSG, there is a convincing evidence of association in Asians with influenza-induced SARS for TMPRSS2-rs2070788, tag-SNP of the eQTL rs383510. This case illustrates the importance of population ... ...

    Abstract For human/SARS-CoV-2 interactome genes ACE2, TMPRSS2 and BSG, there is a convincing evidence of association in Asians with influenza-induced SARS for TMPRSS2-rs2070788, tag-SNP of the eQTL rs383510. This case illustrates the importance of population genetics and of sequencing data in the design of genetic association studies in different human populations: the high linkage disequilibrium (LD) between rs2070788 and rs383510 is Asian-specific. Leveraging on a combination of genotyping and sequencing data for Native Americans (neglected in genetic studies), we show that while their frequencies of the Asian tag-SNP rs2070788 is, surprisingly, the highest worldwide, it is not in LD with the eQTL rs383510, that therefore, should be directly genotyped in genetic association studies of SARS in populations with Native American ancestry.
    Language English
    Publishing date 2021-08-25
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 1445712-x
    ISSN 1678-4685 ; 1415-4757
    ISSN (online) 1678-4685
    ISSN 1415-4757
    DOI 10.1590/1678-4685-GMB-2020-0484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3079: Show issues Location:
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