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Article ; Online: An Artificial Intelligence Prediction Model of Insulin Sensitivity, Insulin Resistance, and Diabetes Using Genes Obtained through Differential Expression.

González-Martín, Jesús María / Torres-Mata, Laura B / Cazorla-Rivero, Sara / Fernández-Santana, Cristina / Gómez-Bentolila, Estrella / Clavo, Bernardino / Rodríguez-Esparragón, Francisco

Genes

2023 Volume 14, Issue 12

Abstract: Insulin is a powerful pleiotropic hormone that affects processes such as cell growth, energy expenditure, and carbohydrate, lipid, and protein metabolism. The molecular mechanisms by which insulin regulates muscle metabolism and the underlying defects ... ...

Abstract	Insulin is a powerful pleiotropic hormone that affects processes such as cell growth, energy expenditure, and carbohydrate, lipid, and protein metabolism. The molecular mechanisms by which insulin regulates muscle metabolism and the underlying defects that cause insulin resistance have not been fully elucidated. This study aimed to perform a microarray data analysis to find differentially expressed genes. The analysis has been based on the data of a study deposited in Gene Expression Omnibus (GEO) with the identifier "GSE22309". The selected data contain samples from three types of patients after taking insulin treatment: patients with diabetes (DB), patients with insulin sensitivity (IS), and patients with insulin resistance (IR). Through an analysis of omics data, 20 genes were found to be differentially expressed (DEG) between the three possible comparisons obtained (DB vs. IS, DB vs. IR, and IS vs. IR); these data sets have been used to develop predictive models through machine learning (ML) techniques to classify patients with respect to the three categories mentioned previously. All the ML techniques present an accuracy superior to 80%, reaching almost 90% when unifying IR and DB categories.
MeSH term(s)	Humans ; Insulin Resistance/genetics ; Artificial Intelligence ; Diabetes Mellitus/genetics ; Insulin/genetics ; Microarray Analysis
Chemical Substances	Insulin
Language	English
Publishing date	2023-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14122119
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Article ; Online: In vitro antimicrobial activity of ozonated sunflower oil in milk against Escherichia coli: comparative study in cow, goat and sheep

Guadalupe Armas, Gloria del Carmen / Martel-Benítez, Carlos José / Alayón-Afonso, Rafael / Clavo, Bernardino / Bordes Benítez, Ana / González-Martín, Jesús María / Torres-Mata, Laura B / Martín-Barrasa, José Luis

Journal of Applied Animal Research. 2022 Dec. 31, v. 50, no. 1 p.715-724

2022

Abstract: Mastitis is one of the most impacting diseases in dairy farming. Conventional treatment of mastitis using antibiotics is costly and has led to the emergence of antimicrobial resistance against most of the commonly used antibacterial agents. Research has ... ...

Abstract	Mastitis is one of the most impacting diseases in dairy farming. Conventional treatment of mastitis using antibiotics is costly and has led to the emergence of antimicrobial resistance against most of the commonly used antibacterial agents. Research has begun to focus on molecules with antimicrobial potentials structurally different from conventional antibiotics We compared the antibacterial activity in vitro of ozonized sunflower oil (OSO) with different peroxide concentrations (150, 300, and 600 PI) against E. coli in goat, cow and sheep milk. It was found that the antibacterial effect, after 72 h, was more important for the goat's milk with OSO 150 (p < 0.001) and OSO 300 (p < 0.001). However, the effect was greater for cow's milk, when OSO 600 was used (p < 0.001). In the case of sheep's milk, it was observed that the antimicrobial effect was only significant with the use of OSO 600, however, this decrease in the concentration of E. coli (p < 0.001) remained practically unchanged from 24 h to 72 h of incubation. In conclusion, ozonated sunflower oil offers many therapeutic possibilities that would reduce the use of antibiotics for the prevention or treatments of mastitis, and its antimicrobial effect is greater with cow's milk and less with sheep's milk.
Keywords	Escherichia coli ; animal research ; antibacterial properties ; antibiotic resistance ; comparative study ; cows ; ewe milk ; goat milk ; goats ; mastitis ; milk ; ozonation ; sheep ; sunflower oil ; therapeutics ; cow ; goat ; ozone
Language	English
Dates of publication	2022-1231
Size	p. 715-724.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1353626-6
ISSN	0974-1844 ; 0971-2119
ISSN (online)	0974-1844
ISSN	0971-2119
DOI	10.1080/09712119.2022.2147186
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Analysis of ANRIL Isoforms and Key Genes in Patients with Severe Coronary Artery Disease.

Rodríguez-Esparragón, Francisco / Torres-Mata, Laura B / Cazorla-Rivero, Sara E / Serna Gómez, Jaime A / González Martín, Jesús M / Cánovas-Molina, Ángeles / Medina-Suárez, José A / González-Hernández, Ayose N / Estupiñán-Quintana, Lidia / Bartolomé-Durán, María C / Rodríguez-Pérez, José C / Varas, Bernardino Clavo

International journal of molecular sciences

2023 Volume 24, Issue 22

Abstract: ANRIL (Antisense Noncoding RNA in the INK4 Locus), also named CDKN2B-AS1, is a long non-coding RNA with outstanding functions that regulates genes involved in atherosclerosis development. ANRIL genotypes and the expression of linear and circular isoforms ...

Abstract	ANRIL (Antisense Noncoding RNA in the INK4 Locus), also named CDKN2B-AS1, is a long non-coding RNA with outstanding functions that regulates genes involved in atherosclerosis development. ANRIL genotypes and the expression of linear and circular isoforms have been associated with coronary artery disease (CAD). The CDKN2A and the CDKN2B genes at the CDKN2A/B locus encode the Cyclin-Dependent Kinase inhibitor protein (CDKI) p16INK4a and the p53 regulatory protein p14ARF, which are involved in cell cycle regulation, aging, senescence, and apoptosis. Abnormal ANRIL expression regulates vascular endothelial growth factor (VEGF) gene expression, and upregulated Vascular Endothelial Growth Factor (VEGF) promotes angiogenesis by activating the NF-κB signaling pathway. Here, we explored associations between determinations of the linear, circular, and linear-to-circular ANRIL gene expression ratio, CDKN2A, VEGF and its receptor kinase insert domain-containing receptor (KDR) and cardiovascular risk factors and all-cause mortality in high-risk coronary patients before they undergo coronary artery bypass grafting surgery (CABG). We found that the expression of ANRIL isoforms may help in the prediction of CAD outcomes. Linear isoforms were correlated with a worse cardiovascular risk profile while the expression of circular isoforms of ANRIL correlated with a decrease in oxidative stress. However, the determination of the linear versus circular ratio of ANRIL did not report additional information to that determined by the evaluation of individual isoforms. Although the expressions of the VEFG and KDR genes correlated with a decrease in oxidative stress, in binary logistic regression analysis it was observed that only the expression of linear isoforms of ANRIL and VEGF significantly contributed to the prediction of the number of surgical revascularizations.
MeSH term(s)	Humans ; Coronary Artery Disease/genetics ; Vascular Endothelial Growth Factor A ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; NF-kappa B/genetics ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Protein Isoforms/genetics
Chemical Substances	Vascular Endothelial Growth Factor A ; RNA, Long Noncoding ; NF-kappa B ; Cyclin-Dependent Kinase Inhibitor p16 ; Protein Isoforms
Language	English
Publishing date	2023-11-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242216127
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Review of Genetic Polymorphisms and Susceptibilities to Complications after Aneurysmal Subarachnoid Hemorrhage.

Medina-Suárez, Jose / Rodríguez-Esparragón, Francisco / Sosa-Pérez, Coralia / Cazorla-Rivero, Sara / Torres-Mata, Laura B / Jiménez-O'Shanahan, Aruma / Clavo, Bernardino / Morera-Molina, Jesús

International journal of molecular sciences

2022 Volume 23, Issue 23

Abstract: Delayed cerebral ischemia (DCI) and vasospasm are two complications of subarachnoid hemorrhages (SAHs) which entail high risks of morbidity and mortality. However, it is unknown why only some patients who suffer SAHs will experience DCI and vasospasm. ... ...

Abstract	Delayed cerebral ischemia (DCI) and vasospasm are two complications of subarachnoid hemorrhages (SAHs) which entail high risks of morbidity and mortality. However, it is unknown why only some patients who suffer SAHs will experience DCI and vasospasm. The purpose of this review is to describe the main genetic single nucleotide polymorphisms (SNPs) that have demonstrated a relationship with these complications. The SNP of the nitric oxide endothelial synthase (eNOS) has been related to the size and rupture of an aneurysm, as well as to DCI, vasospasm, and poor neurological outcome. The SNPs responsible for the asymmetric dimetilarginine and the high-mobility group box 1 have also been associated with DCI. An association between vasospasm and the SNPs of the eNOS, the haptoglobin, and the endothelin-1 receptor has been found. The SNPs of the angiotensin-converting enzyme have been related to DCI and poor neurological outcome. Studies on the SNPs of the Ryanodine Receptor yielded varying results regarding their association with vasospasm.
Language	English
Publishing date	2022-12-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232315427
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Article ; Online: Clinical relevance of circulating angiogenic cells in patients with ischemic stroke.

Rodríguez-Esparragón, Francisco / Torres-Mata, Laura B / López-Fernández, Juan Carlos / Cappiello, Laura / González-Martín, Jesús M / Clavo, Bernardino / Serna-Gómez, Jaime A / Estupiñán-Quintana, Lidia / Torres-Ascensión, Cristina / Villar, Jesús

BMC cardiovascular disorders

2022 Volume 22, Issue 1, Page(s) 118

Abstract: Background: Endothelial progenitor cells (EPCs) are circulating angiogenic cells with endothelial features associated with risk for stroke. We aimed to delve into their functional characteristics. EPCs were isolated and cultured from Ischemic Stroke (IS) ...

Abstract	Background: Endothelial progenitor cells (EPCs) are circulating angiogenic cells with endothelial features associated with risk for stroke. We aimed to delve into their functional characteristics. EPCs were isolated and cultured from Ischemic Stroke (IS) patients and predictors of their variance evaluated. Methods: This is a single-center observational study evaluating 187 consecutively hospitalized patients with IS. EPCs were isolated from blood samples. The number of circulating angiogenic cells (CACs), colony-forming units (CFU-ECs) and the emergence of late outgrowths endothelial cells (LOECs) were counted. We collected clinical variables and measured the stromal cell-derived factor 1 alpha (SDF1α) serum levels. We also examined the relative telomere length and the expression of osteogenic gene markers in CACs. Results: CACs counts and CFU-ECs colony numbers were positively correlated (rho = 0.41, p < 0.001, n = 187). We found significant differences according to whether thrombolytic treatment was performed in the distribution of CFU-ECs (odds ratio (OR) = 2.5; 95% confidence interval (CI) 1.01-6.35; p = 0.042) and CACs (OR = 4.45; 95% IC 1.2-15.5; p = 0.012). The main determinants of CACs variation were the number of risks factors, thrombolysis treatment, arterial hypertension, LOECs occurrence, and the vascular endothelial growth factor expression, whereas CFU-ECs variations depended on hemoglobin content and the relative reduction in the National Institutes of Health Stroke Scale (NIHSS) criteria. The main predictors of LOECs appearance were thrombolysis and length of hospital stay. Conclusions: Our study supports the relevance of patient risk factors and treatments in the analysis of the functional properties of EPCs.
MeSH term(s)	Endothelial Progenitor Cells ; Humans ; Ischemic Stroke ; Stem Cells/metabolism ; Stroke/diagnosis ; Stroke/therapy ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Vascular Endothelial Growth Factor A
Language	English
Publishing date	2022-03-21
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2059859-2
ISSN	1471-2261 ; 1471-2261
ISSN (online)	1471-2261
ISSN	1471-2261
DOI	10.1186/s12872-021-02421-8
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Article ; Online: Ozone treatment effectively eliminates SARS-CoV-2 from infected face masks.

Córdoba-Lanús, Elizabeth / García-Pérez, Omar / Rodríguez-Esparragón, Francisco / Bethencourt-Estrella, Carlos J / Torres-Mata, Laura B / Blanco, Angeles / Villar, Jesús / Sanz, Oscar / Díaz, Juan J / Martín-Barrasa, José L / Serrano-Aguilar, Pedro / Piñero, José-Enrique / Clavo, Bernardino / Lorenzo-Morales, Jacob

PloS one

2022 Volume 17, Issue 7, Page(s) e0271826

Abstract: The current COVID-19 pandemic is causing profound health, economic, and social problems worldwide. The global shortage of medical and personal protective equipment (PPE) in specialized centers during the outbreak demonstrated the need for efficient ... ...

Abstract	The current COVID-19 pandemic is causing profound health, economic, and social problems worldwide. The global shortage of medical and personal protective equipment (PPE) in specialized centers during the outbreak demonstrated the need for efficient methods to disinfect and recycle them in times of emergency. We have previously described that high ozone concentrations destroyed viral RNA in an inactivated SARS-CoV-2 strain within a few minutes. However, the efficient ozone dosages for active SARS-CoV-2 are still unknown. The present study aimed to evaluate the systematic effects of ozone exposure on face masks from hospitalized patients infected with SARS-CoV-2. Face masks from COVID-19 patients were collected and treated with a clinical ozone generator at high ozone concentrations in small volumes for short periods. The study focused on SARS-CoV-2 gene detection (assessed by real-time quantitative polymerase chain reaction (RT-qPCR)) and on the virus inactivation by in vitro studies. We assessed the effects of different high ozone concentrations and exposure times on decontamination efficiency. We showed that high ozone concentrations (10,000, 2,000, and 4,000 ppm) and short exposure times (10, 10, and 2 minutes, respectively), inactivated both the original strain and the B.1.1.7 strain of SARS-CoV-2 from 24 contaminated face masks from COVID-19 patients. The validation results showed that the best condition for SARS-CoV-2 inactivation was a treatment of 4,000 ppm of ozone for 2 minutes. Further studies are in progress to advance the potential applications of these findings.
MeSH term(s)	COVID-19/prevention & control ; Humans ; Masks ; Ozone/pharmacology ; Ozone/therapeutic use ; Pandemics/prevention & control ; SARS-CoV-2
Chemical Substances	Ozone (66H7ZZK23N)
Language	English
Publishing date	2022-07-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0271826
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ozone Eliminates SARS-CoV-2 from Difficult-to-Clean Office Supplies and Clinical Equipment.

Torres-Mata, Laura B / García-Pérez, Omar / Rodríguez-Esparragón, Francisco / Blanco, Angeles / Villar, Jesús / Ruiz-Apodaca, Fernando / Martín-Barrasa, José L / González-Martín, Jesús M / Serrano-Aguilar, Pedro / Piñero, José E / Córdoba-Lanús, Elizabeth / Lorenzo-Morales, Jacob / Clavo, Bernardino

International journal of environmental research and public health

2022 Volume 19, Issue 14

Abstract: 1) Background: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) continues to cause profound health, economic, and social problems worldwide. The management and disinfection of materials used daily in health centers and common working ... ...

Abstract	(1) Background: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) continues to cause profound health, economic, and social problems worldwide. The management and disinfection of materials used daily in health centers and common working environments have prompted concerns about the control of coronavirus disease 2019 (COVID-19) infection risk. Ozone is a powerful oxidizing agent that has been widely used in disinfection processes for decades. The aim of this study was to assess the optimal conditions of ozone treatment for the elimination of heat-inactivated SARS-CoV-2 from office supplies (personal computer monitors, keyboards, and computer mice) and clinical equipment (continuous positive airway pressure tubes and personal protective equipment) that are difficult to clean. (2) Methods: The office supplies and clinical equipment were contaminated in an area of 1 cm
MeSH term(s)	COVID-19/prevention & control ; Humans ; Ozone ; Pandemics/prevention & control ; RNA, Viral ; SARS-CoV-2
Chemical Substances	RNA, Viral ; Ozone (66H7ZZK23N)
Language	English
Publishing date	2022-07-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19148672
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Article ; Online: Modulation by Ozone Therapy of Oxidative Stress in Chemotherapy-Induced Peripheral Neuropathy: The Background for a Randomized Clinical Trial.

Clavo, Bernardino / Martínez-Sánchez, Gregorio / Rodríguez-Esparragón, Francisco / Rodríguez-Abreu, Delvys / Galván, Saray / Aguiar-Bujanda, David / Díaz-Garrido, Juan A / Cañas, Silvia / Torres-Mata, Laura B / Fabelo, Himar / Téllez, Teresa / Santana-Rodríguez, Norberto / Fernández-Pérez, Leandro / Marrero-Callico, Gustavo

International journal of molecular sciences

2021 Volume 22, Issue 6

Abstract: 1) Background: Chemotherapy-induced peripheral neuropathy (CIPN) decreases the quality of life of patients and can lead to a dose reduction and/or the interruption of chemotherapy treatment, limiting its effectiveness. Potential pathophysiological ... ...

Abstract	(1) Background: Chemotherapy-induced peripheral neuropathy (CIPN) decreases the quality of life of patients and can lead to a dose reduction and/or the interruption of chemotherapy treatment, limiting its effectiveness. Potential pathophysiological mechanisms involved in the pathogenesis of CIPN include chronic oxidative stress and subsequent increase in free radicals and proinflammatory cytokines. Approaches for the treatment of CIPN are highly limited in their number and efficacy, although several antioxidant-based therapies have been tried. On the other hand, ozone therapy can induce an adaptive antioxidant and anti-inflammatory response, which could be potentially useful in the management of CIPN. (2) Methods: The aims of this works are: (a) to summarize the potential mechanisms that could induce CIPN by the most relevant drugs (platinum, taxanes, vinca alkaloids, and bortezomib), with particular focus on the role of oxidative stress; (b) to summarize the current situation of prophylactic and treatment approaches; (c) to describe the action mechanisms of ozone therapy to modify oxidative stress and inflammation with its potential repercussions for CIPN; (d) to describe related experimental and clinical reports with ozone therapy in chemo-induced neurologic symptoms and CIPN; and (e) to show the main details about an ongoing focused clinical trial. (3) Results: A wide background relating to the mechanisms of action and a small number of experimental and clinical reports suggest that ozone therapy could be useful to prevent or improve CIPN. (4) Conclusions: Currently, there are no clinically relevant approaches for the prevention and treatment of stablished CIPN. The potential role of ozone therapy in this syndrome merits further research. Randomized controlled trials are ongoing.
MeSH term(s)	Anti-Inflammatory Agents/therapeutic use ; Antineoplastic Agents/adverse effects ; Antioxidants/therapeutic use ; Humans ; Neoplasms/drug therapy ; Oxidative Stress/drug effects ; Ozone/therapeutic use ; Peripheral Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/prevention & control ; Quality of Life ; Randomized Controlled Trials as Topic
Chemical Substances	Anti-Inflammatory Agents ; Antineoplastic Agents ; Antioxidants ; Ozone (66H7ZZK23N)
Language	English
Publishing date	2021-03-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22062802
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Article ; Online: An Artificial Intelligence Prediction Model of Insulin Sensitivity, Insulin Resistance, and Diabetes Using Genes Obtained through Differential Expression.

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Article ; Online: In vitro antimicrobial activity of ozonated sunflower oil in milk against Escherichia coli: comparative study in cow, goat and sheep

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Article ; Online: Analysis of ANRIL Isoforms and Key Genes in Patients with Severe Coronary Artery Disease.

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Article ; Online: A Review of Genetic Polymorphisms and Susceptibilities to Complications after Aneurysmal Subarachnoid Hemorrhage.

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Article ; Online: Clinical relevance of circulating angiogenic cells in patients with ischemic stroke.

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Article ; Online: Ozone treatment effectively eliminates SARS-CoV-2 from infected face masks.

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Article ; Online: Ozone Eliminates SARS-CoV-2 from Difficult-to-Clean Office Supplies and Clinical Equipment.

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Article ; Online: Modulation by Ozone Therapy of Oxidative Stress in Chemotherapy-Induced Peripheral Neuropathy: The Background for a Randomized Clinical Trial.

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