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  1. Article ; Online: Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer.

    Zagorulya, Maria / Yim, Leon / Morgan, Duncan M / Edwards, Austin / Torres-Mejia, Elen / Momin, Noor / McCreery, Chloe V / Zamora, Izabella L / Horton, Brendan L / Fox, James G / Wittrup, K Dane / Love, J Christopher / Spranger, Stefani

    Immunity

    2023  Volume 56, Issue 2, Page(s) 386–405.e10

    Abstract: Local environmental factors influence ... ...

    Abstract Local environmental factors influence CD8
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes ; Interferon-gamma ; Lung Neoplasms ; T-Lymphocytes, Cytotoxic ; T-Lymphocytes, Regulatory
    Chemical Substances Interferon-gamma (82115-62-6) ; IFNG protein, human
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2023.01.010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4227: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Lack of CD8

    Horton, Brendan L / Morgan, Duncan M / Momin, Noor / Zagorulya, Maria / Torres-Mejia, Elen / Bhandarkar, Vidit / Wittrup, K Dane / Love, J Christopher / Spranger, Stefani

    Science immunology

    2021  Volume 6, Issue 64, Page(s) eabi8800

    Abstract: In non–small cell lung cancer (NSCLC), response to immune checkpoint blockade (ICB) is associated with programmed cell death ligand 1 expression that is induced by interferon-γ–producing, tumor-infiltrating ... ...

    Abstract In non–small cell lung cancer (NSCLC), response to immune checkpoint blockade (ICB) is associated with programmed cell death ligand 1 expression that is induced by interferon-γ–producing, tumor-infiltrating CD8
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/immunology ; Carcinoma, Non-Small-Cell Lung/immunology ; Cell Differentiation/immunology ; Cell Line, Tumor ; Humans ; Immune Checkpoint Inhibitors/immunology ; Lung Neoplasms/immunology ; Mice
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2021-10-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abi8800
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  3. Book ; Online ; Thesis: Identification of Sox2 as a key regulator of cell-matrix adhesion in Schwann cells

    Torres Mejía, Elen Raquel Sarabasti [Verfasser] / Wurst, Wolfgang [Akademischer Betreuer] / Wurst, Wolfgang [Gutachter] / Götz, Magdalena [Gutachter]

    2018  

    Author's details Elen Raquel Sarabasti Torres Mejía ; Gutachter: Wolfgang Wurst, Magdalena Götz ; Betreuer: Wolfgang Wurst
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
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  4. Article ; Online: Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis.

    Torres-Mejía, Elen / Trümbach, Dietrich / Kleeberger, Charlotte / Dornseifer, Ulf / Orschmann, Tanja / Bäcker, Theresa / Brenke, Jara Kerstin / Hadian, Kamyar / Wurst, Wolfgang / López-Schier, Hernán / Desbordes, Sabrina C

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 1984

    Abstract: The extracellular matrix is known to modulate cell adhesion and migration during tissue regeneration. However, the molecular mechanisms that fine-tune cells to extra-cellular matrix dynamics during regeneration of the peripheral nervous system remain ... ...

    Abstract The extracellular matrix is known to modulate cell adhesion and migration during tissue regeneration. However, the molecular mechanisms that fine-tune cells to extra-cellular matrix dynamics during regeneration of the peripheral nervous system remain poorly understood. Using the RSC96 Schwann cell line, we show that Sox2 directly controls fibronectin fibrillogenesis in Schwann cells in culture, to provide a highly oriented fibronectin matrix, which supports their organization and directional migration. We demonstrate that Sox2 regulates Schwann cell behaviour through the upregulation of multiple extracellular matrix and migration genes as well as the formation of focal adhesions during cell movement. We find that mouse primary sensory neurons and human induced pluripotent stem cell-derived motoneurons require the Sox2-dependent fibronectin matrix in order to migrate along the oriented Schwann cells. Direct loss of fibronectin in Schwann cells impairs their directional migration affecting the alignment of the axons in vitro. Furthermore, we show that Sox2 and fibronectin are co-expressed in proregenerative Schwann cells in vivo in a time-dependent manner during sciatic nerve regeneration. Taken together, our results provide new insights into the mechanisms by which Schwann cells regulate their own extracellular microenvironment in a Sox2-dependent manner to ensure the proper migration of neurons.
    MeSH term(s) Animals ; Cell Adhesion/physiology ; Cell Communication/physiology ; Cell Line ; Cell Movement/physiology ; Cells, Cultured ; Cellular Microenvironment/physiology ; Disease Models, Animal ; Extracellular Matrix/metabolism ; Female ; Fibronectins/metabolism ; Focal Adhesions/metabolism ; Humans ; Induced Pluripotent Stem Cells ; Intravital Microscopy ; Nerve Regeneration ; Neurons/physiology ; Peripheral Nerve Injuries/pathology ; Primary Cell Culture ; Rats ; SOXB1 Transcription Factors/metabolism ; Schwann Cells/cytology ; Schwann Cells/physiology ; Sciatic Nerve/injuries
    Chemical Substances Fibronectins ; SOX2 protein, human ; SOXB1 Transcription Factors ; Sox2 protein, mouse
    Language English
    Publishing date 2020-02-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-56877-y
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  5. Article ; Online: Inexhaustible hair-cell regeneration in young and aged zebrafish.

    Pinto-Teixeira, Filipe / Viader-Llargués, Oriol / Torres-Mejía, Elen / Turan, Melissa / González-Gualda, Estela / Pola-Morell, Laura / López-Schier, Hernán

    Biology open

    2015  Volume 4, Issue 7, Page(s) 903–909

    Abstract: Animals have evolved two general strategies to counter injury and maintain physiological function. The most prevalent is protection by isolating vital organs into body cavities. However, protection is not optimal for sensory systems because their ... ...

    Abstract Animals have evolved two general strategies to counter injury and maintain physiological function. The most prevalent is protection by isolating vital organs into body cavities. However, protection is not optimal for sensory systems because their external components need to be exposed to the environment to fulfill their receptive function. Thus, a common strategy to maintain sensory abilities against persistent environmental insult involves repair and regeneration. However, whether age or frequent injuries affect the regenerative capacity of sensory organs remains unknown. We have found that neuromasts of the zebrafish lateral line regenerate mechanosensory hair cells after recurrent severe injuries and in adulthood. Moreover, neuromasts can reverse transient imbalances of Notch signaling that result in defective organ proportions during repair. Our results reveal inextinguishable hair-cell regeneration in the lateral line, and suggest that the neuromast epithelium is formed by plastic territories that are maintained by continuous intercellular communication.
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article
    ISSN 2046-6390
    ISSN (online) 2046-6390
    DOI 10.1242/bio.012112
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  6. Article ; Online: Daily exposure to summer circadian cycles affects spermatogenesis, but not fertility in an in vivo rabbit model.

    Sabés-Alsina, Maria / Planell, Núria / Torres-Mejia, Elen / Taberner, Ester / Maya-Soriano, Maria José / Tusell, Llibertat / Ramon, Josep / Dalmau, Antoni / Piles, Miriam / Lopez-Bejar, Manel

    Theriogenology

    2015  Volume 83, Issue 2, Page(s) 246–252

    Abstract: Heat stress (HS) in mammals is a determining factor in the deterioration of spermatogenesis and can cause infertility. The aim of this study was to evaluate the effect of continuous summer circadian cycles on semen production, sperm cell features, ... ...

    Abstract Heat stress (HS) in mammals is a determining factor in the deterioration of spermatogenesis and can cause infertility. The aim of this study was to evaluate the effect of continuous summer circadian cycles on semen production, sperm cell features, fertility, prolificacy, and fecal cortisol metabolites from rabbits kept under an in vivo HS model. We split randomly 60 New Zealand White rabbits into two temperature-controlled rooms: The control group was maintained at comfort temperature (18 °C-22 °C) and an HS group, where the environmental temperature was programmed to increase from 22 °C to 31 °C and be maintained for 3 hours to this temperature at the central part of the day. Fecal cortisol metabolites were assessed to evaluate the stress conditions. Seminal parameters were analyzed. Although animals exposed to HS showed higher values of fecal cortisol metabolites (P = 0.0003), no differences were detected in fertility or prolificacy. Semen samples from HS males showed a significant decrease (P < 0.05) with respect to the controls in the percentage of viable spermatozoa (80.71% vs. 74.21%), and a significant (P ≤ 0.01) increase in the percentage of acrosomic abnormalities (22.57% vs. 36.96%) and tailless spermatozoa (7.91% vs. 12.83). Among motility parameters, no differences were found. This study describes a model of HS simulating a continuous summer daily cycle that allows periods of time to recover as it occurs under natural conditions. Although negative effects have been detected in several sperm parameters, fertility and prolificacy were not affected, suggesting a recovery of the reproductive function when normal conditions are reestablished.
    MeSH term(s) Acrosome/ultrastructure ; Animals ; Cell Survival ; Circadian Rhythm/physiology ; Feces/chemistry ; Fertility/physiology ; Hot Temperature ; Hydrocortisone/analysis ; Male ; Models, Animal ; Rabbits ; Seasons ; Sperm Motility ; Spermatogenesis/physiology ; Spermatozoa/abnormalities ; Spermatozoa/physiology
    Chemical Substances Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2015-01-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 189232-0
    ISSN 1879-3231 ; 0093-691X
    ISSN (online) 1879-3231
    ISSN 0093-691X
    DOI 10.1016/j.theriogenology.2014.09.013
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    Zs.A 3929: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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