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  1. Article ; Online: Prenatal Exposure to Potentially Toxic Metals and Their Effects on Genetic Material in Offspring: a Systematic Review

    Paz-Sabillón, Marvin / Torres-Sánchez, Luisa / Piña-Pozas, Maricela / Del Razo, Luz M. / Quintanilla-Vega, Betzabet

    Biol Trace Elem Res. 2023 May, v. 201, no. 5 p.2125-2150

    2023  

    Abstract: In recent years, the background level of environmental pollutants, including metals, has increased. Pollutant exposure during the earliest stages of life may determine chronic disease susceptibility in adulthood because of genetic or epigenetic changes. ... ...

    Abstract In recent years, the background level of environmental pollutants, including metals, has increased. Pollutant exposure during the earliest stages of life may determine chronic disease susceptibility in adulthood because of genetic or epigenetic changes. The objective of this review was to identify the association between prenatal and early postnatal exposure to potentially toxic metals (PTMs) and their adverse effects on the genetic material of offspring. A systematic review was carried out following the Cochrane methodology in four databases: PubMed, Scopus, Web of Science, and the Cochrane Library. Eligible papers were those conducted in humans and published in English between 2010/01/01 and 2021/04/30. A total of 57 articles were included, most of which evaluated prenatal exposure. Most commonly evaluated PTMs were As, Cd, and Pb. Main adverse effects on the genetic material of newborns associated with PTM prenatal exposure were alterations in telomere length, gene or protein expression, mitochondrial DNA content, metabolomics, DNA damage, and epigenetic modifications. Many of these effects were sex-specific, being predominant in boys. One article reported a synergistic interaction between As and Hg, and two articles observed antagonistic interactions between PTMs and essential metals, such as Cu, Se, and Zn. The findings in this review highlight that the problem of PTM exposure persists, affecting the most susceptible populations, such as newborns. Some of these associations were observed at low concentrations of PTMs. Most of the studies have focused on single exposures; however, three interactions between essential and nonessential metals were observed, highlighting that metal mixtures need more attention.
    Keywords DNA damage ; adulthood ; chronic diseases ; disease susceptibility ; epigenetics ; genes ; maternal exposure ; metabolomics ; mitochondrial DNA ; pollutants ; progeny ; protein synthesis ; synergism ; systematic review ; telomeres ; toxicity
    Language English
    Dates of publication 2023-05
    Size p. 2125-2150.
    Publishing place Springer US
    Document type Article ; Online
    Note Review
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-022-03323-2
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  2. Article ; Online: Language development in children of adolescent mothers by residence area, Ensanut 100k

    Torres-Sánchez, Luisa / Romero, Martín / Vázquez-Salas, Ruth Argelia

    Salud publica de Mexico

    2021  Volume 63, Issue 4, Page(s) 521–529

    Abstract: Objective: To evaluate the association between adolescent pregnancy and language development in children living in socioeconomically vulnerable areas of Mexico.: Materials and methods: We estimated the standardized language score of children aged 12- ... ...

    Title translation Desarrollo del lenguaje en hijos e hijas de madres adolescentes por área de residencia, Ensanut 100k.
    Abstract Objective: To evaluate the association between adolescent pregnancy and language development in children living in socioeconomically vulnerable areas of Mexico.
    Materials and methods: We estimated the standardized language score of children aged 12-59 months who participated in the Ensanut 100k. Teenage mothers (TM) were those who at delivery was between 12-19 years old. The association was estimated using multivariate linear regression; moreover, we evaluated an interaction between type of mother and place of residence.
    Results: Children of TM who lived in urban areas had lower standardized language scores than those of adult mothers (ß= -0.33 95%CI: -0.65 a -0.01; p for interaction<0.01). However, book availability and/or mother’s support for learning significantly reduce this difference.
    Conclusions: Sociocultural pressures towards TM in urban areas could explain the results; nevertheless, this population could be susceptible to strategies aimed to improve the mother-child relationship and support for learning.
    MeSH term(s) Adolescent ; Adolescent Mothers ; Adult ; Child ; Female ; Humans ; Language Development ; Mexico ; Mothers ; Pregnancy ; Pregnancy in Adolescence ; Young Adult
    Language Spanish
    Publishing date 2021-06-18
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 954220-6
    ISSN 1606-7916 ; 0036-3634
    ISSN (online) 1606-7916
    ISSN 0036-3634
    DOI 10.21149/12200
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  3. Article ; Online: Decreased DNA repair capacity caused by exposure to metal mixtures is modulated by the PARP1 rs1136410 variant in newborns from a polluted metropolitan area.

    Paz-Sabillón, Marvin / Montes-Castro, Nereida / Torres-Sánchez, Luisa / Del Razo, Luz M / Córdova, Emilio J / Quintanilla-Vega, Betzabet

    Environmental research

    2023  Volume 241, Page(s) 117631

    Abstract: Background: DNA damage caused by exposure to metal mixtures and the potential modulating role of genes involved in DNA repair and the antioxidant response have not been evaluated in newborns.: Aim: The aim was to evaluate the association between ... ...

    Abstract Background: DNA damage caused by exposure to metal mixtures and the potential modulating role of genes involved in DNA repair and the antioxidant response have not been evaluated in newborns.
    Aim: The aim was to evaluate the association between prenatal exposure to metal mixtures and DNA repair capacity (DRC) in newborns from the Metropolitan Area of Mexico City (MAMC), a heavily polluted area, and the impact of variants in genes involved in DNA repair and the antioxidant response on this association.
    Methods: We analyzed cord blood samples obtained at delivery from 125 healthy newborns from the MAMC. Twenty-four elements were determined by inductively coupled plasma mass spectrometry (ICP‒MS), but only 12 (Cu, I, Se, Zn, As, Ba, Cs, Mn, Sb, Sr, Pb, and Ti) were quantified in most samples. DRC was assessed by the challenge-comet assay, and OGG1, PARP1, and NFE2L2 genotyping was performed with TaqMan probes. Metal mixtures were identified and analyzed using principal component analysis (PCA) and weighted quantile sum (WQS) regression. Independent adjusted linear regression models were used to evaluate the associations.
    Results: A null DRC was observed in 46% of newborns. The metals with the highest concentrations were Mn, Sr, Ti, and Pb. Essential elements showed normal levels. Only the mixture characterized by increased As, Cs, Cu, Se, and Zn levels was inversely associated with DRC. As was the principal contributor (37.8%) in the negative direction in the DRC followed by Ba and Sb, according to the WQS regression. Newborns carrying of the derived (G) allele of the PARP1 rs1136410 variant showed decreased DRC by exposure to some potentially toxic metals (PTMs) (As, Cs, and Ba).
    Conclusion: Prenatal exposure to metal mixtures negatively affected DRC in newborns, and the PARP1 rs1136410 variant had a modulating role in this association.
    MeSH term(s) Pregnancy ; Female ; Infant, Newborn ; Humans ; Antioxidants ; Prenatal Exposure Delayed Effects ; Lead ; DNA Damage ; DNA Repair ; Poly (ADP-Ribose) Polymerase-1/genetics
    Chemical Substances Antioxidants ; Lead (2P299V784P) ; PARP1 protein, human (EC 2.4.2.30) ; Poly (ADP-Ribose) Polymerase-1 (EC 2.4.2.30)
    Language English
    Publishing date 2023-11-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2023.117631
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  4. Article ; Online: Use of weight loss medications in relation with prostate, colorectal and male breast cancers among older men: SEER-Medicare 2007-2015.

    Lopez, David S / Kim, Hyunkyoung / Polychronopoulou, Efstathia / Torres-Sanchez, Luisa E / Villasante-Tezanos, Alejandro / Baillargeon, Jacques / Canfield, Steven / Kuo, Yong-Fang

    Journal of cancer research and clinical oncology

    2023  Volume 149, Issue 11, Page(s) 8255–8265

    Abstract: Background: The association of weight loss medications with prostate (PCa), colorectal (CRC) or male breast cancers, including assessment of these cancers combined (HRCs, hormone-associated cancers) remain poorly understood. Testosterone replacement ... ...

    Abstract Background: The association of weight loss medications with prostate (PCa), colorectal (CRC) or male breast cancers, including assessment of these cancers combined (HRCs, hormone-associated cancers) remain poorly understood. Testosterone replacement therapy (TTh) is reported to be inversely associated with obesity, PCa and CRC, but it is unclear whether TTh modifies the association of weight loss medications with HRCs.
    Methods: In 49,038 men (≥ 65 years) of SEER-Medicare, we identified 15,471 men diagnosed with PCa, 4836 with CRC, and 141 with male breast cancers. Pre-diagnostic prescription of weight loss medications and TTh was ascertained for this analysis. Weighted multivariable-adjusted conditional logistic and Cox proportional hazards (mortality) models were conducted.
    Results: We found an inverse association between use of weight loss medications and incident PCa (OR 0.59, 95% CI 0.57-0.62), CRC (OR 0.86, 95% CI 0.80-0.92), and HRCs (OR 0.65, 95% CI 0.62-0.68). Similar associations were observed for advanced stage at diagnosis of PCa and CRC. Effects of weight loss medications on PCa and HRC remained significant irrespective of the use of TTh but were only suggestive with CRC with positive TTh use. No associations were observed with male breast cancer and HRCs mortality.
    Conclusion: Pre-diagnostic use of weight loss medications reduced the incidence of PCa, CRC, and HRCs. These associations persisted in the same direction irrespective of the history of TTh use. Future studies are needed to confirm these findings and to identify underlying biological mechanisms of weight loss medications and TTh on the risk of cancer.
    MeSH term(s) Humans ; Male ; Aged ; United States/epidemiology ; Medicare ; Prostate ; Breast Neoplasms, Male ; Colorectal Neoplasms ; Weight Loss ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/epidemiology
    Language English
    Publishing date 2023-04-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-023-04778-z
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  5. Article ; Online: Late puberty onset and lack of acne during adolescence reduce high-grade prostate cancer at adulthood.

    Hernández-Pérez, Jesús Gibran / López, David S / Rodríguez-Valentín, Rocío / Vázquez-Salas, Ruth Argelia / Sierra-Santoyo, Adolfo / Torres-Sánchez, Luisa

    The Prostate

    2023  Volume 83, Issue 14, Page(s) 1342–1350

    Abstract: Background: The interplay between pubertal events patterns (PEP) and prostate cancer (PCa) remains poorly understood. Therefore, we investigated the association of PEP with the odds of PCa, and PCa histological differentiation in men residents of Mexico ...

    Abstract Background: The interplay between pubertal events patterns (PEP) and prostate cancer (PCa) remains poorly understood. Therefore, we investigated the association of PEP with the odds of PCa, and PCa histological differentiation in men residents of Mexico city.
    Methods: In this case-control study, we analyzed the information of 371 incident prostate cancer cases and 775 controls matched on age (±5 years). High-grade prostate cancer was classified with Gleason score at diagnosis as ≥8. With information related to beard growth, age at maximum height attainment, and acne severity, the k-medoids algorithm was used to identify three mutually exclusive PEP (early, intermediate, and late). This association was evaluated using multivariable nonconditional logistic regression models.
    Results: Men with late PEP, characterized by age at maximum height attainment at around 23 years and no history of acne, was inversely associated with incident (odds ratio [OR]: 0.27; 95% confidence interval [CI]: 0.15-0.48, p trend <0.01) and high-grade prostate cancer (OR: 0.24; 95% CI: 0.09-0.59, p trend <0.01). Similar associations were observed even after adjusting by IGF-1 (OR: 0.19; 95% CI: 0.06-0.58) and androgens excretion (OR: 0.21; 95% CI: 0.06-0.66). Only the association between the absence of acne and prostate cancer remained significant after adjustment by these biomarkers.
    Conclusions: This study suggests that pubertal characteristics might be helpful in identifying risk groups, among which, secondary prevention strategies could be applied. Also, the results agree with previous work suggesting other potential biological mechanisms involved in the etiology of prostate cancer such as the infectious and inflammatory pathways.
    MeSH term(s) Male ; Humans ; Adolescent ; Adult ; Case-Control Studies ; Prostatic Neoplasms/etiology ; Prostate-Specific Antigen ; Risk Factors ; Puberty
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604707-5
    ISSN 1097-0045 ; 0270-4137
    ISSN (online) 1097-0045
    ISSN 0270-4137
    DOI 10.1002/pros.24596
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  6. Article ; Online: Estableciendo asociaciones.

    Torres-Sánchez, Luisa

    Salud publica de Mexico

    2014  Volume 56, Issue 1, Page(s) 2

    Title translation Establishing associations.
    MeSH term(s) Data Interpretation, Statistical ; Humans ; Mexico ; Vaccination/statistics & numerical data
    Language Spanish
    Publishing date 2014-01
    Publishing country Mexico
    Document type Letter
    ZDB-ID 954220-6
    ISSN 1606-7916 ; 0036-3634
    ISSN (online) 1606-7916
    ISSN 0036-3634
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  7. Article ; Online: Differential association between dairy intake patterns and incident prostate cancer: a potential dairy matrix effect.

    Armenta-González, Leticia Lizbeth / Hernández-Pérez, Jesús Gibran / Feeney, Emma L / Vázquez-Salas, Argelia / Galván-Portillo, Marcia / López, David S / Torres-Sánchez, Luisa

    European journal of nutrition

    2024  Volume 63, Issue 3, Page(s) 847–857

    Abstract: Objective: To evaluate the association between dairy intake patterns and the risk of prostate cancer (PC), and its histological differentiation, among men from Mexico City.: Methods: We analyzed the information from 394 incident PC cases paired by ... ...

    Abstract Objective: To evaluate the association between dairy intake patterns and the risk of prostate cancer (PC), and its histological differentiation, among men from Mexico City.
    Methods: We analyzed the information from 394 incident PC cases paired by age (± 5 years) with 794 population controls. According to the Gleason score at diagnosis, cases were classified as well- (≤ 6), moderately- (= 7), and poorly differentiated PC (≥ 8). Based on a semiquantitative-food frequency questionnaire and using energy-density approach, we estimated the energy-adjusted daily intake of whole milk, cheese (fresh, Oaxaca, and Manchego), cream, and yogurt. Through a principal component analysis, we identified three dairy intake patterns: whole milk, cheese, and yogurt. The association between each dairy intake pattern and PC was evaluated from independent nonconditional logistic regression models. We also evaluated the mediator role of calcium and saturated fat intake.
    Results: After adjustment, a high intake of whole milk pattern was associated with a 63% increased risk of PC (OR
    Conclusions: A differential association of dairy intake patterns with risk of PC, and the poorly differentiated PC, was identified. This association seems to be determined by different dairy matrices and it is mediated by calcium content. Longitudinal studies are needed to confirm these findings and be able to identify other potential mediators in the etiology of PC.
    MeSH term(s) Male ; Humans ; Animals ; Dairy Products ; Calcium ; Milk ; Cheese ; Prostatic Neoplasms/epidemiology ; Longitudinal Studies ; Risk Factors ; Diet
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2024-01-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-023-03315-5
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  8. Article ; Online: Prenatal Exposure to Potentially Toxic Metals and Their Effects on Genetic Material in Offspring: a Systematic Review.

    Paz-Sabillón, Marvin / Torres-Sánchez, Luisa / Piña-Pozas, Maricela / Del Razo, Luz M / Quintanilla-Vega, Betzabet

    Biological trace element research

    2022  Volume 201, Issue 5, Page(s) 2125–2150

    Abstract: In recent years, the background level of environmental pollutants, including metals, has increased. Pollutant exposure during the earliest stages of life may determine chronic disease susceptibility in adulthood because of genetic or epigenetic changes. ... ...

    Abstract In recent years, the background level of environmental pollutants, including metals, has increased. Pollutant exposure during the earliest stages of life may determine chronic disease susceptibility in adulthood because of genetic or epigenetic changes. The objective of this review was to identify the association between prenatal and early postnatal exposure to potentially toxic metals (PTMs) and their adverse effects on the genetic material of offspring. A systematic review was carried out following the Cochrane methodology in four databases: PubMed, Scopus, Web of Science, and the Cochrane Library. Eligible papers were those conducted in humans and published in English between 2010/01/01 and 2021/04/30. A total of 57 articles were included, most of which evaluated prenatal exposure. Most commonly evaluated PTMs were As, Cd, and Pb. Main adverse effects on the genetic material of newborns associated with PTM prenatal exposure were alterations in telomere length, gene or protein expression, mitochondrial DNA content, metabolomics, DNA damage, and epigenetic modifications. Many of these effects were sex-specific, being predominant in boys. One article reported a synergistic interaction between As and Hg, and two articles observed antagonistic interactions between PTMs and essential metals, such as Cu, Se, and Zn. The findings in this review highlight that the problem of PTM exposure persists, affecting the most susceptible populations, such as newborns. Some of these associations were observed at low concentrations of PTMs. Most of the studies have focused on single exposures; however, three interactions between essential and nonessential metals were observed, highlighting that metal mixtures need more attention.
    MeSH term(s) Male ; Pregnancy ; Female ; Infant, Newborn ; Humans ; Prenatal Exposure Delayed Effects/genetics ; Metals/toxicity ; Heavy Metal Poisoning ; Environmental Pollutants/toxicity ; Mercury ; Metals, Heavy/toxicity ; Metals, Heavy/metabolism
    Chemical Substances Metals ; Environmental Pollutants ; Mercury (FXS1BY2PGL) ; Metals, Heavy
    Language English
    Publishing date 2022-06-17
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-022-03323-2
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  9. Article: Dietary flavonoid patterns and prostate cancer: evidence from a Mexican population-based case–control study

    Galván-Portillo, Marcia / Vázquez-Salas, Ruth Argelia / Hernández-Pérez, Jesús Gibran / Blanco-Muñoz, Julia / López-Carrillo, Lizbeth / Torres-Sánchez, Luisa

    British journal of nutrition. 20222021 June 14 14, July 14 14, v. 127, no. 11

    2022  

    Abstract: Flavonoids are a broad group of bioactive compounds with anticarcinogenic effects on the prostate that have been scarcely evaluated in Latin American populations. Our objective was to evaluate the association between dietary patterns of flavonoid intake ... ...

    Abstract Flavonoids are a broad group of bioactive compounds with anticarcinogenic effects on the prostate that have been scarcely evaluated in Latin American populations. Our objective was to evaluate the association between dietary patterns of flavonoid intake and prostate cancer (PC) in a population-based case–control study carried out in Mexico City. Based on a semi-quantitative FFQ with a frame reference of 3 years before diagnosis or interview, we used an updated database for estimating the daily intake (mg/d) of flavones, flavonols and flavanols for 395 confirmed incident PC cases and 797 population controls matched by age (± 5 years). Histological PC differentiation was evaluated using the Gleason score at diagnosis. Flavonoid dietary intake patterns (FDIP) were determined through principal component analysis, and their association with PC was estimated using logistic regression models. Three FDIP were identified: gallate pattern (GP) characterised by (–)-epicatechin-3-O-gallate, (–)-epigallocatechin-3-O-gallate and (+)-gallocatechin; luteolin pattern (LP) characterised by luteolin and (–)-epigallocatechin-3-O-gallate; and a mixed pattern (MP) that included (+)-catechin, (–)-epicatechin and quercetin. A higher GP (ORT₃ ᵥ.T₁ = 0·47; 95 % CI 0·33, 0·66) and LP intake (ORT₃ ᵥ. T₁ = 0·39; 95 % CI 0·27, 0·59) were associated with a decreased PC likelihood. In contrast, a higher MP intake (ORT₃ ᵥ. T₁ = 2·32; 95 % CI 1·67, 3·23) increased PC likelihood. The possible differential and synergistic anticarcinogenic role of flavonoid compounds in PC deserves further study.
    Keywords case-control studies ; databases ; flavanols ; food intake ; histology ; luteolin ; principal component analysis ; prostatic neoplasms ; quercetin ; regression analysis ; Mexico
    Language English
    Dates of publication 2022-0614
    Size p. 1695-1703.
    Publishing place Cambridge University Press
    Document type Article
    ZDB-ID 280396-3
    ISSN 1475-2662 ; 0007-1145
    ISSN (online) 1475-2662
    ISSN 0007-1145
    DOI 10.1017/S0007114521002646
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  10. Article ; Online: [No title information]

    Torres-Sánchez, Luisa Elvira / Hernández-Pérez, Jesús Gibran / Escamilla-Nuñez, Consuelo / Rodríguez-Covarrubias, Francisco / Manzanilla-García, Hugo / Mohar, Alejandro / Morales-Carmona, Evangelina / Espin-Arellano, Lucino Iván / Hernández-Ávila, Juan Eugenio / Lajous, Martin

    Salud publica de Mexico

    2023  Volume 65, Issue 3, may-jun, Page(s) 236–244

    Abstract: Objective: To estimate prostate cancer (PC) survival in Mexico and explore survival disparities according to the marginalization level of residence place.: Materials and methods: A nationwide administrative claims database (4 110 men) whose PC ... ...

    Title translation Disparities on prostate cancer survival in Mexico: a retrospective cohort study.
    Abstract Objective: To estimate prostate cancer (PC) survival in Mexico and explore survival disparities according to the marginalization level of residence place.
    Materials and methods: A nationwide administrative claims database (4 110 men) whose PC treatment was financed by Seguro Popular between 2012-2016, was cross-linked to the National Mortality Registry up to December 2019. Patients were classified according to their oncological risk at diagnosis and the marginalization level of the residence municipality. Cox proportional hazards regression was used to estimate multivariable survival functions.
    Results: Five-years PC survival (69%; 95%CI: 68,71%) ranged from 72% to 54% at very low and very high marginalization, respectively (p for trend<0.001). The lowest PC survival was observed in men with high-risk PC (47%; 95%CI: 33,66%) residents in very high marginalization municipalities.
    Conclusions: Overall, PC survival was lower than that reported in other Latin American countries. The distribution of oncologic risk and survival differences across marginalization levels suggests limited early detection and cancer health disparities.
    Language Spanish
    Publishing date 2023-04-21
    Publishing country Mexico
    Document type English Abstract ; Journal Article
    ZDB-ID 954220-6
    ISSN 1606-7916 ; 0036-3634
    ISSN (online) 1606-7916
    ISSN 0036-3634
    DOI 10.21149/14266
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