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  1. Book: Apoptosis in the retina 2006

    Torriglia, Alicia

    2006  

    Author's details ed. Alicia Torriglia
    Language English
    Size 187 S. : Ill., graph. Darst.
    Publisher Transworld Researach Network
    Publishing place Trivandrum
    Publishing country India
    Document type Book
    HBZ-ID HT015236672
    ISBN 81-7895-217-3 ; 978-81-7895-217-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 4234 order for loan Magazin

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  2. Article: Les lampes LED sont-elles dangereuses pour la vision ?

    Torriglia, Alicia

    La Revue du praticien

    2019  Volume 68, Issue 10, Page(s) 1064–1066

    Title translation Are LED lights dangerous for vision?
    MeSH term(s) Humans ; Lighting/adverse effects ; Vision Disorders/etiology
    Language French
    Publishing date 2019-04-03
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The blue light hazard and its use on the evaluation of photochemical risk for domestic lighting. An in vivo study.

    Françon, Anaïs / Behar-Cohen, Francine / Torriglia, Alicia

    Environment international

    2024  Volume 184, Page(s) 108471

    Abstract: Background: Nowadays artificial light highly increases human exposure to light leading to circadian rhythm and sleep perturbations. Moreover, excessive exposure of ocular structures to photons can induce irreversible retinal damage. Meta-analyses showed ...

    Abstract Background: Nowadays artificial light highly increases human exposure to light leading to circadian rhythm and sleep perturbations. Moreover, excessive exposure of ocular structures to photons can induce irreversible retinal damage. Meta-analyses showed that sunlight exposure influences the age of onset and the progression of Age-related macular degeneration (AMD), the leading cause of blindness in people over fifty-year old. Currently, the blue-light hazard (BLH) curve is used in the evaluation of the phototoxicity of a light source for domestic lighting regulations.
    Objectives: Here, we analyze the phototoxicity threshold in rats and investigate the role played by the light spectrum, assessing the relevance of the use of the BLH-weighting to define phototoxicity.
    Methods: We exposed albino rats to increasing doses of blue and white light, or to lights of different colors to evaluate the impact of each component of the white light spectrum on phototoxicity. Cellular mechanisms of cell death and cellular stress induced by light were analyzed.
    Results: Our results show that the phototoxicity threshold currently accepted for rats is overestimated by a factor of 50 when considering blue light and by a factor of 550 concerning white light. This is the result of the toxicity induced by green light that increases white light toxicity by promoting an inflammatory response. The content of green in white light induces 8 fold more invasion of macrophages in the retina than the content of blue light. Moreover, the use of BLH-weighting does not evaluate the amount of red radiations contained in white light that mitigates damage by inhibiting the nuclear translocation of L-DNase II and reducing by 33% the number of TUNEL-positive cells.
    Discussion: These findings question the current methods to determine the phototoxicity of a light source and show the necessity to take into account the entire emission spectrum. As current human phototoxicity thresholds were estimated with the same methods used for rats, our results suggest that they might need to be reconsidered.
    MeSH term(s) Animals ; Rats ; Blue Light/adverse effects ; Lighting/adverse effects ; Retina
    Language English
    Publishing date 2024-02-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2024.108471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A mathematical model of wound healing in bovine corneal endothelium.

    Hernández, Julio A / Chifflet, Silvia / Justet, Cristian / Torriglia, Alicia

    Journal of theoretical biology

    2022  Volume 559, Page(s) 111374

    Abstract: We developed a mathematical model to describe healing processes in bovine corneal endothelial (BCE) cells in culture, triggered by mechanical wounds with parallel edges. Previous findings from our laboratory show that, in these cases, BCE monolayers ... ...

    Abstract We developed a mathematical model to describe healing processes in bovine corneal endothelial (BCE) cells in culture, triggered by mechanical wounds with parallel edges. Previous findings from our laboratory show that, in these cases, BCE monolayers exhibit an approximately constant healing velocity. Also, that caspase-dependent apoptosis occurs, with the fraction of apoptotic cells increasing with the distance traveled by the healing edge. In addition, in this study we report the novel findings that, for wound scratch assays performed preserving the basal extracellular matrix: i) the healing cells increase their en face surface area in a characteristic fashion, and ii) the average length of the segments of the cell columns actively participating in the healing process increases linearly with time. These latter observations preclude the utilization of standard traveling wave formalisms to model wound healing in BCE cells. Instead, we developed and studied a simple phenomenological model based on a plausible formula for the spreading dynamics of the individual healing cells, that incorporates original evidence about the process in BCE cells. The model can be simulated to: i) obtain an approximately constant healing velocity; ii) reproduce the profile of the healing cell areas, and iii) obtain approximately linear time dependences of the mean cell area and average length of the front active segments per column. In view of its accuracy to account for the experimental observations, the model can also be acceptably employed to quantify the appearance of apoptotic cells during BCE wound healing. The strategy utilized here could offer a novel formal framework to represent modifications undergone by some epithelial cell lines during wound healing.
    MeSH term(s) Cattle ; Animals ; Endothelium, Corneal/metabolism ; Cells, Cultured ; Wound Healing ; Epithelial Cells/metabolism ; Models, Theoretical
    Language English
    Publishing date 2022-11-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2972-5
    ISSN 1095-8541 ; 0022-5193
    ISSN (online) 1095-8541
    ISSN 0022-5193
    DOI 10.1016/j.jtbi.2022.111374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 923: Show issues Location:
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  5. Article ; Online: Phototoxicity of low doses of light and influence of the spectral composition on human RPE cells.

    Françon, Anaïs / Delaunay, Kimberley / Jaworski, Thara / Lebon, Cécile / Picard, Emilie / Youale, Jenny / Behar-Cohen, Francine / Torriglia, Alicia

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 6839

    Abstract: Light is known to induce retinal damage affecting photoreceptors and retinal pigment epithelium. For polychromatic light, the blue part of the spectrum is thought to be the only responsible for photochemical damage, leading to the establishment of a ... ...

    Abstract Light is known to induce retinal damage affecting photoreceptors and retinal pigment epithelium. For polychromatic light, the blue part of the spectrum is thought to be the only responsible for photochemical damage, leading to the establishment of a phototoxicity threshold for blue light (445 nm). For humans it corresponds to a retinal dose of 22 J/cm
    MeSH term(s) Animals ; Humans ; Retinal Pigment Epithelium/metabolism ; Induced Pluripotent Stem Cells ; Retina ; Primates
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56980-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Les nouveaux éclairages et nos yeux.

    Torriglia, Alicia / Mascarelli, Frédéric / Behar-Cohen, Francine

    Medecine sciences : M/S

    2020  Volume 36, Issue 8-9, Page(s) 769–773

    Abstract: The retina is the neurosensitive layer of the eye. In this tissue, photoreceptors convert light into nerve signals to be relayed to the brain. Despite retinal specialization in the treatment of light, excessive exposure can cause retinal damage, called ... ...

    Title translation New lighting technology and our eyes.
    Abstract The retina is the neurosensitive layer of the eye. In this tissue, photoreceptors convert light into nerve signals to be relayed to the brain. Despite retinal specialization in the treatment of light, excessive exposure can cause retinal damage, called retinal phototoxicity. In recent years, lighting devices rich in wavelengths of high energy (blue light) appeared, raising new concerns about retinal protection against light damage. We focus here on light-induced ocular diseases and the possible influence on visual health of new lighting technologies.
    MeSH term(s) Adaptation, Ocular/physiology ; Adaptation, Ocular/radiation effects ; Eye/physiopathology ; Eye/radiation effects ; Humans ; Inventions ; Light/adverse effects ; Lighting/adverse effects ; Lighting/methods ; Lighting/trends ; Ocular Physiological Phenomena/radiation effects
    Language French
    Publishing date 2020-08-21
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2020133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2872: Show issues Location:
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  7. Article ; Online: Corrigendum to "Cell Death Mechanisms in a Mouse Model of Retinal Degeneration in Spinocerebellar Ataxia 7" [Neuroscience 400C (2019) 72-84].

    Lebon, Cecile / Behar-Cohen, Francine / Torriglia, Alicia

    Neuroscience

    2019  Volume 404, Page(s) 558–564

    Language English
    Publishing date 2019-02-27
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2019.01.058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1215: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Cell Death Mechanisms in a Mouse Model of Retinal Degeneration in Spinocerebellar Ataxia 7.

    Lebon, Cecile / Behar-Cohen, Francine / Torriglia, Alicia

    Neuroscience

    2019  Volume 400, Page(s) 72–84

    Abstract: Spino-cerebellar ataxia type 7 (SCA7) is a polyglutamine (polyQ) disorder characterized by neurodegeneration of the brain, cerebellum, and retina caused by a polyglutamine expansion in ataxin7. The presence of an expanded polyQ tract in a mutant protein ... ...

    Abstract Spino-cerebellar ataxia type 7 (SCA7) is a polyglutamine (polyQ) disorder characterized by neurodegeneration of the brain, cerebellum, and retina caused by a polyglutamine expansion in ataxin7. The presence of an expanded polyQ tract in a mutant protein is known to induce protein aggregation, cellular stress, toxicity, and finally cell death. However, the consequences of the presence of mutant ataxin7 in the retina and the mechanisms underlying photoreceptor degeneration remain poorly understood. In this study, we show that in a retinal SCA7 mouse model, polyQ ataxin7 induces stress within the retina and activates Muller cells. Moreover, unfolded protein response and autophagy are activated in SCA7 photoreceptors. We have also shown that the photoreceptor death does not involve a caspase-dependent apoptosis but instead involves apoptosis inducing factor (AIF) and Leukocyte Elastase Inhibitor (LEI/L-DNase II). When these two cell death effectors are downregulated by their siRNA, a significant reduction in photoreceptor death is observed. These results highlight the consequences of polyQ protein expression in the retina and the role of caspase-independent pathways involved in photoreceptor cell death.
    MeSH term(s) Animals ; Apoptosis Inducing Factor/metabolism ; Ataxin-7/genetics ; Ataxin-7/metabolism ; Calpain/metabolism ; Caspases/metabolism ; Cathepsins/metabolism ; Cell Death ; Disease Models, Animal ; Endodeoxyribonucleases/metabolism ; HEK293 Cells ; Humans ; Mice, Inbred C57BL ; Mice, Transgenic ; Peptides/metabolism ; Photoreceptor Cells/metabolism ; Retinal Degeneration/etiology ; Retinal Degeneration/metabolism ; Signal Transduction ; Spinocerebellar Ataxias/complications ; Spinocerebellar Ataxias/metabolism ; Stress, Physiological
    Chemical Substances Apoptosis Inducing Factor ; Ataxin-7 ; Atxn7 protein, mouse ; AIFM1 protein, mouse ; Peptides ; polyglutamine (26700-71-0) ; Endodeoxyribonucleases (EC 3.1.-) ; deoxyribonuclease II (EC 3.1.22.1) ; Cathepsins (EC 3.4.-) ; Calpain (EC 3.4.22.-) ; Caspases (EC 3.4.22.-)
    Language English
    Publishing date 2019-01-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2018.12.051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Retina: source of the earliest biomarkers for Alzheimer's disease?

    Krantic, Slavica / Torriglia, Alicia

    Journal of Alzheimer's disease : JAD

    2014  Volume 40, Issue 2, Page(s) 237–243

    Abstract: Alzheimer's disease (AD) develops undiagnosed for 10-15 years due to the lack of early diagnostic biomarkers. Visual deficits are common and crippling in AD patients and histopathological alterations found in the retina and brain are similar. We ... ...

    Abstract Alzheimer's disease (AD) develops undiagnosed for 10-15 years due to the lack of early diagnostic biomarkers. Visual deficits are common and crippling in AD patients and histopathological alterations found in the retina and brain are similar. We hypothesize that subtle morphological and functional changes in microglial and neuronal activities, such as those recently reported in the hippocampus, may also occur in retina during the preclinical stages of AD. These alterations are likely much more accessible to modern imaging and electrophysiological exploration than those occurring in the hippocampus and therefore, may serve as the earliest diagnostic biomarkers for AD.
    MeSH term(s) Alzheimer Disease/diagnosis ; Biomarkers ; Early Diagnosis ; Humans ; Neuroglia/metabolism ; Neuroglia/pathology ; Neurons/metabolism ; Neurons/pathology ; Retina/pathology ; Retina/physiopathology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2014
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-132105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6084: Show issues Location:
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  10. Article ; Online: The hidden side of SERPINB1/Leukocyte Elastase Inhibitor.

    Torriglia, Alicia / Martin, Elisabeth / Jaadane, Imene

    Seminars in cell & developmental biology

    2017  Volume 62, Page(s) 178–186

    Abstract: SERPINB1, also called Leukocyte Elastase Inhibitor (LEI) is a member of the clade B of SERPINS. It is an intracellular protein and acts primarily to protect the cell from proteases released into the cytoplasm during stress. Its role in inflammation is ... ...

    Abstract SERPINB1, also called Leukocyte Elastase Inhibitor (LEI) is a member of the clade B of SERPINS. It is an intracellular protein and acts primarily to protect the cell from proteases released into the cytoplasm during stress. Its role in inflammation is clear due to its involvement in the resolution of chronic inflammatory lung and bowel diseases. LEI/SERPINB1 intrinsically possesses two enzymatic activities: an antiprotease activity dependent on its reactive site loop, which is analogous to the other proteins of the family and an endonuclease activity which is unveiled by the cleavage of the reactive site loop. The conformational change induced by this cleavage also unveils a bipartite nuclear localization signal allowing the protein to translocate to the nucleus. Recent data indicate that it has also a role in cell migration suggesting that it could be involved in diverse processes like wound healing and malignant metastases.
    Language English
    Publishing date 2017-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2016.07.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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