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Article: LOIS DE BIOÉTHIQUE ET RÉALITE DU TERRAIN LORS D'ÉTUDES ÉPIDÉMIOLOGIQUES EN GUYANE ET AU CAMEROUN.

Tortevoye, Patricia / Gessain, Antoine

Journal international de bioethique = International journal of bioethics

2015 Volume 26, Issue 2, Page(s) 135–62, 170–1

Abstract: The objective of this article is to describe the difficulties encountered, during the twenty last years, to obey the laws of bioethics in force during epidemiological investigations, carried out in French Guiana and in Cameroon. These research tasks aim ... ...

Title translation	BIOETHICS LAWS AND REALITY ON THE GROUND DURING EPIDEMIOLOGICAL STUDIES IN FRENCH GUINEA AND CAMEROON.
Abstract	The objective of this article is to describe the difficulties encountered, during the twenty last years, to obey the laws of bioethics in force during epidemiological investigations, carried out in French Guiana and in Cameroon. These research tasks aim to better understanding the transmission of two viruses: the human T lymphotropic retrovirus type 1 and the human herpes virus 8. These investigations, carried out in highly endemic villages, for one or two of these viruses, also aim at searching susceptibility genetic factors for infection in children by these viruses. They are scientific researches carried out in populations on low level of education and strong socio-economic constraints. These studies performed in general population are without benefit for the people. They require a collection of the family data, to build genealogic pedigrees, and a blood sampling. Using concrete examples, collected during field-investigations, we illustrate the problems encountered to apply, practically, the laws of bioethics. We will introduce and discuss thus the legislative framework in force, the studied populations, the concepts of preliminary information and informed consent, the adaptation necessary to take into account the local social organization and the importance of the family hierarchy. Lastly, the question of returned results of this kind of investigation will be discussed like that of the possible compensatory measures. This inventory reveals the limits of the current regulation, which is often poorly adapted to research in epidemiology in this kind of population and the ethical choices that has thus to be decided by the investigator.
MeSH term(s)	Biomedical Research/legislation & jurisprudence ; Cameroon ; Educational Status ; Epidemiologic Studies ; Ethics, Research ; Guinea ; Herpesvirus 8, Human ; Human T-lymphotropic virus 1 ; Humans ; Social Class
Language	French
Publishing date	2015-10
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	1085532-4
ISSN	2102-5169 ; 1145-0762 ; 1287-7352
ISSN (online)	2102-5169
ISSN	1145-0762 ; 1287-7352
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Zs.A 3526: Show issues

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Article ; Online: Adult T-cell leukemia/lymphoma incidence rate in French Guiana: a prospective cohort of women infected with HTLV-1.

Ramassamy, Jill-Léa / Tortevoye, Patricia / Ntab, Balthazar / Seve, Béatrice / Carles, Gabriel / Gaquière, Dominique / Madec, Yoann / Fontanet, Arnaud / Gessain, Antoine

Blood advances

2020 Volume 4, Issue 9, Page(s) 2044–2048

Abstract: Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy caused by the human T-cell leukemia virus type 1 (HTLV-1). The incidence of ATL among HTLV-1 carriers remains largely unknown in endemic countries other than Japan as very few prospective ... ...

Abstract	Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy caused by the human T-cell leukemia virus type 1 (HTLV-1). The incidence of ATL among HTLV-1 carriers remains largely unknown in endemic countries other than Japan as very few prospective studies have been performed. We assessed the ATL incidence rate among HTLV-1 infected women in a prospective cohort in French Guiana. This is the first prospective study to assess the ATL incidence rate in an area of South America where HTLV-1 prevalence is high. Patients were enrolled between 1991 and 2005, and follow-up continued until April 2018. In the general hospital in Saint-Laurent-du-Maroni, 307 pregnant women were diagnosed with HTLV-1 infection, and 268 of them were observed for a median of 16.7 years. During follow-up, 9 ATL incident cases occurred resulting in an ATL incidence rate of 2.03 per 1000 HTLV-1 carrier-years (95% confidence interval, 0.93-3.85 per 1000 HTLV-1 carrier-years). The median age at diagnosis was 47.4 years, and median survival from diagnosis was low at 3.5 months. The ATL incidence rate was elevated for a study population consisting mostly of young people, which could either be a general feature in South America or could be specific to the Noir Marron population that constituted most of the cohort.
MeSH term(s)	Adolescent ; Adult ; Female ; French Guiana/epidemiology ; Human T-lymphotropic virus 1 ; Humans ; Incidence ; Japan ; Leukemia-Lymphoma, Adult T-Cell/diagnosis ; Leukemia-Lymphoma, Adult T-Cell/epidemiology ; Pregnancy ; Prospective Studies
Language	English
Publishing date	2020-05-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2020001628
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Article ; Online: Trichodysplasia Spinulosa Polyomavirus Infection Occurs during Early Childhood with Intrafamilial Transmission, Especially from Mother to Child.

Pedergnana, Vincent / Martel-Jantin, Claire / Nicol, Jérôme T J / Leblond, Valérie / Tortevoye, Patricia / Coursaget, Pierre / Touzé, Antoine / Abel, Laurent / Gessain, Antoine

The Journal of investigative dermatology

2017 Volume 137, Issue 5, Page(s) 1181–1183

MeSH term(s)	Adolescent ; Adult ; Age Factors ; Antibodies/blood ; Cameroon ; Child ; Child, Preschool ; Female ; Hair Diseases ; Humans ; Infant ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Male ; Mothers ; Odds Ratio ; Polyomavirus ; Polyomavirus Infections/epidemiology ; Polyomavirus Infections/immunology ; Polyomavirus Infections/transmission ; Seroepidemiologic Studies ; Skin Diseases/epidemiology ; Skin Diseases/immunology ; Skin Diseases/virology ; Young Adult
Chemical Substances	Antibodies
Language	English
Publishing date	2017-01-17
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	80136-7
ISSN	1523-1747 ; 0022-202X
ISSN (online)	1523-1747
ISSN	0022-202X
DOI	10.1016/j.jid.2016.12.017
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Article ; Online: Frequent and recent human acquisition of simian foamy viruses through apes' bites in central Africa.

Betsem, Edouard / Rua, Réjane / Tortevoye, Patricia / Froment, Alain / Gessain, Antoine

PLoS pathogens

2011 Volume 7, Issue 10, Page(s) e1002306

Abstract: Human infection by simian foamy viruses (SFV) can be acquired by persons occupationally exposed to non-human primates (NHP) or in natural settings. This study aimed at getting better knowledge on SFV transmission dynamics, risk factors for such a ... ...

Abstract	Human infection by simian foamy viruses (SFV) can be acquired by persons occupationally exposed to non-human primates (NHP) or in natural settings. This study aimed at getting better knowledge on SFV transmission dynamics, risk factors for such a zoonotic infection and, searching for intra-familial dissemination and the level of peripheral blood (pro)viral loads in infected individuals. We studied 1,321 people from the general adult population (mean age 49 yrs, 640 women and 681 men) and 198 individuals, mostly men, all of whom had encountered a NHP with a resulting bite or scratch. All of these, either Pygmies (436) or Bantus (1085) live in villages in South Cameroon. A specific SFV Western blot was used and two nested PCRs (polymerase, and LTR) were done on all the positive/borderline samples by serology. In the general population, 2/1,321 (0.2%) persons were found to be infected. In the second group, 37/198 (18.6%) persons were SFV positive. They were mostly infected by apes (37/39) FV (mainly gorilla). Infection by monkey FV was less frequent (2/39). The viral origin of the amplified sequences matched with the history reported by the hunters, most of which (83%) are aged 20 to 40 years and acquired the infection during the last twenty years. The (pro)viral load in 33 individuals infected by a gorilla FV was quite low (<1 to 145 copies per 10(5) cells) in the peripheral blood leucocytes. Of the 30 wives and 12 children from families of FV infected persons, only one woman was seropositive in WB without subsequent viral DNA amplification. We demonstrate a high level of recent transmission of SFVs to humans in natural settings specifically following severe gorilla bites during hunting activities. The virus was found to persist over several years, with low SFV loads in infected persons. Secondary transmission remains an open question.
MeSH term(s)	Adolescent ; Adult ; Africa, Central/epidemiology ; African Continental Ancestry Group/ethnology ; Aged ; Aged, 80 and over ; Animals ; Antibodies, Viral ; Ape Diseases/transmission ; Ape Diseases/virology ; Bites and Stings ; Child ; Child, Preschool ; DNA, Viral/analysis ; Female ; Hominidae/virology ; Humans ; Male ; Middle Aged ; Retroviridae Infections/ethnology ; Retroviridae Infections/transmission ; Retroviridae Infections/virology ; Sequence Analysis, DNA ; Seroepidemiologic Studies ; Simian foamy virus/genetics ; Simian foamy virus/immunology ; Simian foamy virus/isolation & purification ; Young Adult ; Zoonoses/epidemiology ; Zoonoses/virology
Chemical Substances	Antibodies, Viral ; DNA, Viral
Language	English
Publishing date	2011-10-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7366
ISSN (online)	1553-7374
ISSN	1553-7366
DOI	10.1371/journal.ppat.1002306
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Article ; Online: A Severe Bite From a Nonhuman Primate Is a Major Risk Factor for HTLV-1 Infection in Hunters From Central Africa.

Filippone, Claudia / Betsem, Edouard / Tortevoye, Patricia / Cassar, Olivier / Bassot, Sylviane / Froment, Alain / Fontanet, Arnaud / Gessain, Antoine

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2015 Volume 60, Issue 11, Page(s) 1667–1676

Abstract: Background: HTLV-1 infection is endemic to Central African populations. The risk factors for HTLV-1 acquisition in humans via the interspecies transmission of STLV-1 (its simian counterpart) remain largely unknown.: Methods: We studied 269 ... ...

Abstract	Background: HTLV-1 infection is endemic to Central African populations. The risk factors for HTLV-1 acquisition in humans via the interspecies transmission of STLV-1 (its simian counterpart) remain largely unknown. Methods: We studied 269 individuals (254 men, 15 women) bitten by a nonhuman primate (NHP), mostly during hunting activities. These, Pygmies and Bantus, living in the southern Cameroonian rainforest, were matched for sex, age, and ethnicity with individuals from the same settlements reporting no NHP bites. HTLV-1 serology was performed by Western blot on plasma samples. PCR was carried out for HTLV-1 provirus on buffy-coat DNAs. The amplified products were sequenced and analyzed by phylogenetic analyses. Results: HTLV-1 prevalence was 8.6% (23/269) in individuals with bites, vs 1.5% (4/269) in matched controls (P < .001). Moreover, HTLV-1 infection was linked to bite severity. The 23 HTLV-1-positive bitten individuals reported being bitten by a gorilla (17), chimpanzee (3), or small monkey (3). Thirteen (56%) were coinfected with a simian foamy virus known to be acquired through severe bites. Mother-to-child infection was excluded in 6 HTLV-1-infected bitten individuals. All the HTLV-1-positive hunters bitten by a gorilla or chimpanzee were infected with a subtype B strain similar to that present in apes from the same area. Two hunters bitten by small monkeys (C. agilis in one case) were infected with a HTLV-1 subtype F strain very similar to the STLV-1 strains present in such monkeys. Conclusions: These results strongly suggest ongoing direct zoonotic acquisition of STLV-1 in humans through severe NHP bites during hunting activities.
MeSH term(s)	Adult ; Animals ; Antibodies, Viral/blood ; Bites and Stings/complications ; Blotting, Western ; Cameroon/epidemiology ; Cross-Sectional Studies ; Female ; HTLV-I Infections/epidemiology ; Humans ; Male ; Middle Aged ; Occupational Diseases/epidemiology ; Primates ; Risk Factors ; Seroepidemiologic Studies
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2015-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/civ145
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: A new and frequent human T-cell leukemia virus indeterminate Western blot pattern: epidemiological determinants and PCR results in central African inhabitants.

Filippone, Claudia / Bassot, Sylviane / Betsem, Edouard / Tortevoye, Patricia / Guillotte, Micheline / Mercereau-Puijalon, Odile / Plancoulaine, Sabine / Calattini, Sara / Gessain, Antoine

Journal of clinical microbiology

2012 Volume 50, Issue 5, Page(s) 1663–1672

Abstract: Human T-cell leukemia virus (HTLV) indeterminate Western blot (WB) serological patterns are frequently observed in plasma/serum from persons living in intertropical areas. In the framework of ongoing projects on HTLV-1/2 and related viruses in Central ... ...

Abstract	Human T-cell leukemia virus (HTLV) indeterminate Western blot (WB) serological patterns are frequently observed in plasma/serum from persons living in intertropical areas. In the framework of ongoing projects on HTLV-1/2 and related viruses in Central Africa, we systematically analyzed plasma from villagers living in South Cameroon by WB. The group included 1,968 individuals (mean age, 44 years; age range, 5 to 90 years; 978 women/990 men), both Bantus (1,165) and Pygmies (803). Plasma samples were tested by WB analysis (MPD HTLV Blot 2.4) and interpreted according to the manufacturer's instructions. Only clear bands were considered in the analysis. Among the 1,968 plasma samples, 38 (1.93%) were HTLV-1, 13 (0.66%) were HTLV-2, and 6 (0.3%) were HTLV WB seropositive. Furthermore, 1,292 (65.65%) samples were WB sero-indeterminate, including 104 (5.28%) with an HTLV-1 Gag-indeterminate pattern (HGIP) and 68 (3.45%) with a peculiar yet unreported pattern exhibiting mostly a strong shifted GD21 and a p28. The other 619 (31.45%) samples were either WB negative or exhibited other patterns, mostly with unique p19 or p24 bands. DNA, extracted from peripheral blood buffy coat, was subjected to PCR using several primer pairs known to detect HTLV-1/2/3/4. Most DNAs from HTLV-1- and HTLV-seropositive individuals were PCR positive. In contrast, all the others, from persons with HTLV-2, HGIP, new WB, and other indeterminate patterns, were PCR negative. Epidemiological determinant analysis of the persons with this new peculiar WB pattern revealed that seroprevalence was independent from age, sex, or ethnicity, thus resembling the indeterminate profile HGIP rather than HTLV-1. Moreover, this new pattern persists over time.
MeSH term(s)	Adolescent ; Adult ; Africa, Central/epidemiology ; Aged ; Aged, 80 and over ; Antibodies, Viral/blood ; Blotting, Western/methods ; Child ; Child, Preschool ; Ethnic Groups ; Female ; Human T-lymphotropic virus 1/immunology ; Human T-lymphotropic virus 2/immunology ; Humans ; Leukemia, T-Cell/epidemiology ; Leukemia, T-Cell/virology ; Male ; Middle Aged ; Polymerase Chain Reaction/methods ; Seroepidemiologic Studies ; Young Adult
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2012-03-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/JCM.06540-11
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Article ; Online: A major locus on chromosome 3p22 conferring predisposition to human herpesvirus 8 infection.

Pedergnana, Vincent / Gessain, Antoine / Tortevoye, Patricia / Byun, Minji / Bacq-Daian, Delphine / Boland, Anne / Casanova, Jean-Laurent / Abel, Laurent / Plancoulaine, Sabine

European journal of human genetics : EJHG

2012 Volume 20, Issue 6, Page(s) 690–695

Abstract: Infection with human herpesvirus 8 (HHV-8), the etiological agent of Kaposi's sarcoma, has been shown to display strong familial aggregation, in countries in which HHV-8 infection is endemic. We investigated 40 large families (608 subjects aged one to 88 ...

Abstract	Infection with human herpesvirus 8 (HHV-8), the etiological agent of Kaposi's sarcoma, has been shown to display strong familial aggregation, in countries in which HHV-8 infection is endemic. We investigated 40 large families (608 subjects aged one to 88 years) living in an isolated area of Cameroon in which HHV-8 is highly endemic. We performed a two-step genetic analysis for HHV-8 infection status (HHV-8+/HHV-8- determined by immunofluorescence) consisting of an initial segregation analysis followed by a model-based genome-wide linkage analysis. Overall HHV-8 seroprevalence was 60%, increasing with age. Segregation analysis provided strong evidence for a recessive major gene conferring predisposition to HHV-8 infection. This gene is predicted to have a major effect during childhood, with almost all homozygous predisposed subjects (∼7% of the population) becoming infected by the age of 10. Linkage analysis was carried out on the 15 most informative families, corresponding to 205 genotyped subjects. A single region on chromosome 3p22 was significantly linked to HHV-8 infection (LOD score=3.83, P=2.0 × 10(-5)). This study provides the first evidence that HHV-8 infection in children in endemic areas has a strong genetic basis involving at least one recessive major locus on chromosome 3p22.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Viral/immunology ; Cameroon ; Child ; Child, Preschool ; Chromosomes, Human, Pair 3/genetics ; Family ; Female ; Genes, Recessive ; Genetic Predisposition to Disease ; Herpesviridae Infections/genetics ; Herpesviridae Infections/transmission ; Herpesviridae Infections/virology ; Herpesvirus 8, Human/immunology ; Herpesvirus 8, Human/pathogenicity ; Humans ; Infant ; Male ; Middle Aged ; Seroepidemiologic Studies
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2012-01-18
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1141470-4
ISSN	1476-5438 ; 1018-4813
ISSN (online)	1476-5438
ISSN	1018-4813
DOI	10.1038/ejhg.2011.260
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Article: Comparative trends of seroprevalence and seroincidence rates of human T cell lymphotropic virus type I and human immunodeficiency virus 1 in pregnant women of various ethnic groups sharing the same environment in French Guiana.

Tortevoye, Patricia / Tuppin, Philippe / Carles, Gabriel / Peneau, Christian / Gessain, Antoine

The American journal of tropical medicine and hygiene

2005 Volume 73, Issue 3, Page(s) 560–565

Abstract: The objectives of this study were to compare the seroprevalence and seroincidence rates of human T cell lymphotropic virus type I (HTLV-I) and human immunodeficiency virus 1 (HIV-1) in pregnant women in several ethnic groups in French Guiana between July ...

Abstract	The objectives of this study were to compare the seroprevalence and seroincidence rates of human T cell lymphotropic virus type I (HTLV-I) and human immunodeficiency virus 1 (HIV-1) in pregnant women in several ethnic groups in French Guiana between July 1, 1991 and June 30, 2001. This study was conducted in the obstetrics unit of the hospital in Saint Laurent du Maroni in a dynamic cohort of 6,921 pregnant women with 11,679 deliveries, with new entrants each year. The overall seroprevalence of HTLV for all women differed between ethnic groups and was restricted mainly to the descendents of fugitive slaves of African origin known as Noir-Marron (181 of 4,266, 4.24%) and to Haitian women (12 of 287, 4.18%). A decrease in the biennial seroprevalence of HTLV-I was observed over time among deliveries of the Haitian women (P = 0.037), but it remained stable among Noir-Marron (P = 0.22). Fifteen of the 17 HTLV-I seroconversions occurred in the Noir-Marron, giving an incidence of 0.18 per 100 person-years. The overall seroprevalence of HIV-1 was higher in the Haitian women (10 of 293, 3.41%) than in the Noir-Marron (34 of 4,310, 0.79%) and Amerindians (4 of 552, 0.72%). A highly significant increase in the biennial seroprevalence of HIV-1 was observed among the deliveries of the Noir-Marron (P = 0.0003), but it remained stable among Haitian women (P = 0.44). Ten of the 13 HIV-1 seroconversions were observed in Noir-Marron, giving an incidence rate of 0.12 per 100 person-years. These data demonstrate the differential spreading of these two human retroviruses among pregnant women in different ethnic groups living in the same environment. While HTLV-I, which is highly endemic in groups of African origin, showed a slight decrease over time in a suspected cohort effect, HIV-1 spread rapidly in an epidemic mode, especially in the groups of the lowest socioeconomic levels.
MeSH term(s)	Adult ; Ethnic Groups ; Female ; French Guiana/epidemiology ; HIV Infections/blood ; HIV Infections/epidemiology ; HTLV-I Infections/blood ; HTLV-I Infections/epidemiology ; Humans ; Incidence ; Pregnancy ; Seroepidemiologic Studies
Language	English
Publishing date	2005-09
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
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Article ; Online: Multiple retroviral infection by HTLV type 1, 2, 3 and simian foamy virus in a family of Pygmies from Cameroon.

Calattini, Sara / Betsem, Edouard / Bassot, Sylviane / Chevalier, Sébastien Alain / Tortevoye, Patricia / Njouom, Richard / Mahieux, Renaud / Froment, Alain / Gessain, Antoine

Virology

2011 Volume 410, Issue 1, Page(s) 48–55

Abstract: To better understand the origins and modes of transmission of HTLV-3 and to search for other retroviral infections (HTLV-1, HTLV-2, foamy viruses), we studied the family of a HTLV-3-infected individual (Pyl43), from Cameroon. Thirty-five persons were ... ...

Abstract	To better understand the origins and modes of transmission of HTLV-3 and to search for other retroviral infections (HTLV-1, HTLV-2, foamy viruses), we studied the family of a HTLV-3-infected individual (Pyl43), from Cameroon. Thirty-five persons were included. All adult men were still actively hunting nonhuman primates (NHP). All women were also butchering and cutting-up animals. Five persons reported a bite by an NHP. While HTLV-3 infection was only found in Pyl43, HTLV-1 and HTLV-2 infections were found, respectively, in 5 and 9 persons with one being co-infected by both retroviruses. Phylogenetic analysis suggested intra-familial transmission of HTLV-1 subtypes B and D and HTLV-2. One man was infected by a chimpanzee foamy virus, acquired probably 45 years ago, through a bite. Acquisition of retroviral infections still occurs in central Africa involving to various extent not only intra-familial transmission for HTLV-1/HTLV-2 but also direct interspecies transmission from NHP for foamy virus and possibly for HTLV-1 and HTLV-3.
MeSH term(s)	Adolescent ; Adult ; Aged ; Cameroon/epidemiology ; Child ; Family ; Female ; Humans ; Male ; Middle Aged ; Molecular Sequence Data ; Pedigree ; Phylogeny ; Primate T-lymphotropic virus 1/classification ; Primate T-lymphotropic virus 1/genetics ; Primate T-lymphotropic virus 1/isolation & purification ; Primate T-lymphotropic virus 2/classification ; Primate T-lymphotropic virus 2/genetics ; Primate T-lymphotropic virus 2/isolation & purification ; Primate T-lymphotropic virus 3/classification ; Primate T-lymphotropic virus 3/genetics ; Primate T-lymphotropic virus 3/isolation & purification ; Retroviridae Infections/epidemiology ; Retroviridae Infections/transmission ; Retroviridae Infections/virology ; Simian foamy virus/classification ; Simian foamy virus/genetics ; Simian foamy virus/isolation & purification ; Young Adult
Language	English
Publishing date	2011-02-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	200425-2
ISSN	1096-0341 ; 0042-6822
ISSN (online)	1096-0341
ISSN	0042-6822
DOI	10.1016/j.virol.2010.10.025
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Article ; Online: Molecular epidemiology of merkel cell polyomavirus: evidence for geographically related variant genotypes.

Martel-Jantin, Claire / Filippone, Claudia / Tortevoye, Patricia / Afonso, Philippe V / Betsem, Edouard / Descorps-Declere, Stéphane / Nicol, Jérôme T J / Touzé, Antoine / Coursaget, Pierre / Crouzat, Maryse / Berthet, Nicolas / Cassar, Olivier / Gessain, Antoine

Journal of clinical microbiology

2014 Volume 52, Issue 5, Page(s) 1687–1690

Abstract: Merkel cell polyomavirus (MCPyV) is linked to a cutaneous cancer mainly occurring in Caucasians. DNA from skin swabs of 255 adults, originating from the 5 continents, were subjected to MCPyV PCRs. Phylogenetic analyses demonstrate the existence of 5 ... ...

Abstract	Merkel cell polyomavirus (MCPyV) is linked to a cutaneous cancer mainly occurring in Caucasians. DNA from skin swabs of 255 adults, originating from the 5 continents, were subjected to MCPyV PCRs. Phylogenetic analyses demonstrate the existence of 5 major geographically related MCPyV genotypes (Europe/North America, Africa [sub-Saharan], Oceania, South America, and Asia/Japan).
MeSH term(s)	Adult ; Aged, 80 and over ; Carcinoma, Merkel Cell/epidemiology ; Carcinoma, Merkel Cell/virology ; DNA, Viral/genetics ; Female ; Genotype ; Humans ; Male ; Merkel cell polyomavirus/genetics ; Middle Aged ; Molecular Epidemiology ; Molecular Sequence Data ; Phylogeny ; Polymerase Chain Reaction/methods ; Polyomavirus Infections/epidemiology ; Polyomavirus Infections/virology ; Tumor Virus Infections/epidemiology ; Tumor Virus Infections/virology ; Young Adult
Chemical Substances	DNA, Viral
Language	English
Publishing date	2014-02-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/JCM.02348-13
Database	MEDical Literature Analysis and Retrieval System OnLINE

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