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  1. Book ; Online: ExoMDN

    Baumeister, Philipp / Tosi, Nicola

    Rapid characterization of exoplanet interior structures with Mixture Density Networks

    2023  

    Abstract: Characterizing the interior structure of exoplanets is essential for understanding their diversity, formation, and evolution. As the interior of exoplanets is inaccessible to observations, an inverse problem must be solved, where numerical structure ... ...

    Abstract Characterizing the interior structure of exoplanets is essential for understanding their diversity, formation, and evolution. As the interior of exoplanets is inaccessible to observations, an inverse problem must be solved, where numerical structure models need to conform to observable parameters such as mass and radius. This is a highly degenerate problem whose solution often relies on computationally-expensive and time-consuming inference methods such as Markov Chain Monte Carlo. We present ExoMDN, a machine-learning model for the interior characterization of exoplanets based on Mixture Density Networks (MDN). The model is trained on a large dataset of more than 5.6 million synthetic planets below 25 Earth masses consisting of an iron core, a silicate mantle, a water and high-pressure ice layer, and a H/He atmosphere. We employ log-ratio transformations to convert the interior structure data into a form that the MDN can easily handle. Given mass, radius, and equilibrium temperature, we show that ExoMDN can deliver a full posterior distribution of mass fractions and thicknesses of each planetary layer in under a second on a standard Intel i5 CPU. Observational uncertainties can be easily accounted for through repeated predictions from within the uncertainties. We use ExoMDN to characterize the interior of 22 confirmed exoplanets with mass and radius uncertainties below 10% and 5% respectively, including the well studied GJ 1214 b, GJ 486 b, and the TRAPPIST-1 planets. We discuss the inclusion of the fluid Love number $k_2$ as an additional (potential) observable, showing how it can significantly reduce the degeneracy of interior structures. Utilizing the fast predictions of ExoMDN, we show that measuring $k_2$ with an accuracy of 10% can constrain the thickness of core and mantle of an Earth analog to $\approx13\%$ of the true values.

    Comment: 15 pages, 15 figures, accepted for publication in Astronomy & Astrophysics. The ExoMDN model is freely accessible at https://github.com/philippbaumeister/ExoMDN
    Keywords Astrophysics - Earth and Planetary Astrophysics ; Computer Science - Machine Learning
    Subject code 520
    Publishing date 2023-06-15
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A long-lived magma ocean on a young Moon.

    Maurice, M / Tosi, N / Schwinger, S / Breuer, D / Kleine, T

    Science advances

    2020  Volume 6, Issue 28, Page(s) eaba8949

    Abstract: A giant impact onto Earth led to the formation of the Moon, resulted in a lunar magma ocean (LMO), and initiated the last event of core segregation on Earth. However, the timing and temporal link of these events remain uncertain. Here, we demonstrate ... ...

    Abstract A giant impact onto Earth led to the formation of the Moon, resulted in a lunar magma ocean (LMO), and initiated the last event of core segregation on Earth. However, the timing and temporal link of these events remain uncertain. Here, we demonstrate that the low thermal conductivity of the lunar crust combined with heat extraction by partial melting of deep cumulates undergoing convection results in an LMO solidification time scale of 150 to 200 million years. Combining this result with a crystallization model of the LMO and with the ages and isotopic compositions of lunar samples indicates that the Moon formed 4.425 ± 0.025 billion years ago. This age is in remarkable agreement with the U-Pb age of Earth, demonstrating that the U-Pb age dates the final segregation of Earth's core.
    Language English
    Publishing date 2020-07-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.aba8949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Thesis ; Online: Numerical modeling of present-day mantle convection

    Tosi, N.

    2008  

    Keywords 550 - Earth sciences
    Publishing country de
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Long-lived lunar volcanism sustained by precession-driven core-mantle friction.

    Yu, Shuoran / Xiao, Xiao / Gong, Shengxia / Tosi, Nicola / Huang, Jun / Breuer, Doris / Xiao, Long / Ni, Dongdong

    National science review

    2023  Volume 11, Issue 2, Page(s) nwad276

    Abstract: Core-mantle friction induced by the precession of the Moon's spin axis is a strong heat source in the deep lunar mantle during the early phase of a satellite's evolution, but its influence on the long-term thermal evolution still remains poorly explored. ...

    Abstract Core-mantle friction induced by the precession of the Moon's spin axis is a strong heat source in the deep lunar mantle during the early phase of a satellite's evolution, but its influence on the long-term thermal evolution still remains poorly explored. Using a one-dimensional thermal evolution model, we show that core-mantle friction can sustain global-scale partial melting in the upper lunar mantle until ∼3.1 Ga, thus accounting for the intense volcanic activity on the Moon before ∼3.0 Ga. Besides, core-mantle friction tends to suppress the secular cooling of the lunar core and is unlikely to be an energy source for the long-lived lunar core dynamo. Our model also favours the transition of the Cassini state before the end of the lunar magma ocean phase (∼4.2 Ga), which implies a decreasing lunar obliquity over time after the solidification of the lunar magma ocean. Such a trend of lunar obliquity evolution may allow volcanically released water to be buried in the lunar regolith of the polar regions. As a consequence, local water ice could be more abundant than previously thought when considering only its accumulation caused by solar wind and comet spreading.
    Language English
    Publishing date 2023-10-31
    Publishing country China
    Document type Journal Article
    ZDB-ID 2745465-4
    ISSN 2053-714X ; 2053-714X
    ISSN (online) 2053-714X
    ISSN 2053-714X
    DOI 10.1093/nsr/nwad276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Unravelling phenolic metabotypes in the frame of the COMBAT study, a randomized, controlled trial with cranberry supplementation.

    Tosi, Nicole / Favari, Claudia / Bresciani, Letizia / Flanagan, Emma / Hornberger, Michael / Narbad, Arjan / Del Rio, Daniele / Vauzour, David / Mena, Pedro

    Food research international (Ottawa, Ont.)

    2023  Volume 172, Page(s) 113187

    Abstract: Cranberry (poly)phenols may have potential health benefits. Circulating (poly)phenol metabolites can act as mediators of these effects, but they are subjected to an extensive inter-individual variability. This study aimed to quantify both plasma and ... ...

    Abstract Cranberry (poly)phenols may have potential health benefits. Circulating (poly)phenol metabolites can act as mediators of these effects, but they are subjected to an extensive inter-individual variability. This study aimed to quantify both plasma and urine (poly)phenol metabolites following a 12-week intake of a cranberry powder in healthy older adults, and to investigate inter-individual differences by considering the existence of urinary metabotypes related to dietary (poly)phenols. Up to 13 and 67 metabolites were quantified in plasma and urine respectively. Cranberry consumption led to changes in plasma metabolites, mainly hydroxycinnamates and hippuric acid. Individual variability in urinary metabolites was assessed using different data sets and a combination of statistical models. Three phenolic metabotypes were identified, colonic metabolism being the main driver for subject clustering. Metabotypes were characterized by quali-quantitative differences in the excretion of some metabolites such as phenyl-γ-valerolactones, hydroxycinnamic acids, and phenylpropanoic acids. Metabotypes were further confirmed when applying a model only focused on flavan-3-ol colonic metabolites. 5-(3',4'-dihydroxyphenyl)-γ-valerolactone derivatives were the most relevant metabolites for metabotyping. Metabotype allocation was well preserved after 12-week intervention. This metabotyping approach for cranberry metabolites represents an innovative step to handle the complexity of (poly)phenol metabolism in free-living conditions, deciphering the existence of metabotypes derived from the simultaneous consumption of different classes of (poly)phenols. These results will help contribute to studying the health effects of cranberries and other (poly)phenol-rich foods, mainly considering gut microbiota-driven individual differences.
    MeSH term(s) Phenol ; Vaccinium macrocarpon ; Phenols ; Cluster Analysis ; Dietary Supplements
    Chemical Substances Phenol (339NCG44TV) ; Phenols
    Language English
    Publishing date 2023-06-28
    Publishing country Canada
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2023.113187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: A systematic review of human studies.

    Favari, Claudia / Rinaldi de Alvarenga, José Fernando / Sánchez-Martínez, Lorena / Tosi, Nicole / Mignogna, Cristiana / Cremonini, Eleonora / Manach, Claudine / Bresciani, Letizia / Del Rio, Daniele / Mena, Pedro

    Redox biology

    2024  Volume 71, Page(s) 103095

    Abstract: This systematic review provides an overview of the available evidence on the inter-individual variability (IIV) in the absorption, distribution, metabolism, and excretion (ADME) of phenolic metabolites and its determinants. Human studies were included ... ...

    Abstract This systematic review provides an overview of the available evidence on the inter-individual variability (IIV) in the absorption, distribution, metabolism, and excretion (ADME) of phenolic metabolites and its determinants. Human studies were included investigating the metabolism and bioavailability of (poly)phenols and reporting IIV. One hundred fifty-three studies met the inclusion criteria. Inter-individual differences were mainly related to gut microbiota composition and activity but also to genetic polymorphisms, age, sex, ethnicity, BMI, (patho)physiological status, and physical activity, depending on the (poly)phenol sub-class considered. Most of the IIV has been poorly characterised. Two major types of IIV were observed. One resulted in metabolite gradients that can be further classified into high and low excretors, as seen for all flavonoids, phenolic acids, prenylflavonoids, alkylresorcinols, and hydroxytyrosol. The other type of IIV is based on clusters of individuals defined by qualitative differences (producers vs. non-producers), as for ellagitannins (urolithins), isoflavones (equol and O-DMA), resveratrol (lunularin), and preliminarily for avenanthramides (dihydro-avenanthramides), or by quali-quantitative metabotypes characterized by different proportions of specific metabolites, as for flavan-3-ols, flavanones, and even isoflavones. Future works are needed to shed light on current open issues limiting our understanding of this phenomenon that likely conditions the health effects of dietary (poly)phenols.
    MeSH term(s) Humans ; Biological Availability ; Phenols ; Flavonoids ; Isoflavones/metabolism ; Diet
    Chemical Substances Phenols ; Flavonoids ; Isoflavones
    Language English
    Publishing date 2024-02-20
    Publishing country Netherlands
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2024.103095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: (Poly)phenolic compounds and gut microbiome: new opportunities for personalized nutrition.

    Narduzzi, Luca / Agulló, Vicente / Favari, Claudia / Tosi, Nicole / Mignogna, Cristiana / Crozier, Alan / Rio, Daniele Del / Mena, Pedro

    Microbiome research reports

    2022  Volume 1, Issue 3, Page(s) 16

    Abstract: For decades, (poly)phenols have been linked to cardiometabolic health, but population heterogeneity limits their apparent efficacy and the development of tailored, practical protocols in dietary interventions. This heterogeneity is likely determined by ... ...

    Abstract For decades, (poly)phenols have been linked to cardiometabolic health, but population heterogeneity limits their apparent efficacy and the development of tailored, practical protocols in dietary interventions. This heterogeneity is likely determined by the existence of different metabotypes, sub-populations of individuals metabolizing some classes of (poly)phenols differently. The gut microbiota plays a major role in this process. The impact of microbiota-related phenolic metabotypes on cardiometabolic health is becoming evident, although the picture is still incomplete, and data are absent for some classes of (poly)phenols. The lack of a complete understanding of the main microbial actors involved in the process complicates the picture. Elucidation of the mechanisms behind phenolic metabotypes requires novel experimental designs that can dissect the inter-individual variability. This paper, in addition to providing an overview on the current state-of-the-art, proposes wider metabotyping approaches as a means of paving the way towards effective personalized nutrition with dietary (poly)phenols.
    Language English
    Publishing date 2022-04-27
    Publishing country United States
    Document type Journal Article
    ISSN 2771-5965
    ISSN (online) 2771-5965
    DOI 10.20517/mrr.2022.06
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Comparison of point shear wave elastography and transient elastography in the evaluation of patients with NAFLD.

    Argalia, Giulio / Ventura, Claudio / Tosi, Niccolò / Campioni, Daniele / Tagliati, Corrado / Tufillaro, Marianna / Cucco, Monica / Svegliati Baroni, Gianluca / Giovagnoni, Andrea

    La Radiologia medica

    2022  Volume 127, Issue 5, Page(s) 571–576

    Abstract: Purpose: To compare point shear wave elastography (pSWE, ElastPQ®) and transient elastography (TE) with Liver Biopsy in order to evaluate fibrosis stage in non-alcoholic fatty liver disease (NAFLD).: Methods: Our prospective study from September 2017 ...

    Abstract Purpose: To compare point shear wave elastography (pSWE, ElastPQ®) and transient elastography (TE) with Liver Biopsy in order to evaluate fibrosis stage in non-alcoholic fatty liver disease (NAFLD).
    Methods: Our prospective study from September 2017 to October 2020 included 50 consecutively enrolled patients with NAFLD (52.2 ± 13.0 years, 32 male). All patients underwent clinical evaluation, B-mode ultrasound, pSWE, TE and liver biopsy in a single evaluation. The clinical, laboratory and liver biopsy data were compared with liver stiffness (LS) measurement obtained with pSWE and TE. TE and pSWE diagnostic accuracy for the diagnosis of the different fibrosis stages were evaluated using the area under receiver operating characteristic curve (AUROC).
    Results: Only fibrosis stage was independently associated with TE and pSWE. The median liver stiffness measurement for fibrosis stages F0, F1, F2, F3, and F4 using TE was 4.8 (4.7-6.1) kPa, 5.5 (4.4-7.3) kPa, 7.7 (6.1-9.1) kPa, 9.9 (8.8-13.8) kPa, and 20.2 kPa, respectively. The corresponding median liver stiffness measurement using pSWE was 4.2 (4.0-4.8) kPa, 4.7 (4.2-5.8) kPa, 5.1 (4.1-6.9) kPa, 8.5 (5.2-13.3), and 15.1 kPa, respectively. The AUROC of TE for diagnosis of fibrosis stage F1, ≥ F2, ≥ F3, and F4 were 0.795, 0.867, 0.927, and 0.990, respectively. The corresponding AUROC of pSWE was 0.717, 0.733, 0.908, and 1.000, respectively. No association was observed with other histological parameters.
    Conclusion: TE was significantly better than pSWE for the diagnosis of fibrosis stage ≥ F2. No statistically significant differences were found between TE and pSWE AUROC of fibrosis stage ≥ F1, ≥ F3, and F4.
    MeSH term(s) Biopsy ; Elasticity Imaging Techniques ; Fibrosis ; Humans ; Liver/diagnostic imaging ; Liver/pathology ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/pathology ; Male ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Non-alcoholic Fatty Liver Disease/pathology ; Prospective Studies ; ROC Curve
    Language English
    Publishing date 2022-03-15
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 205751-7
    ISSN 1826-6983 ; 0033-8362
    ISSN (online) 1826-6983
    ISSN 0033-8362
    DOI 10.1007/s11547-022-01475-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Unraveling the parahormetic mechanism underlying the health-protecting effects of grapeseed procyanidins.

    Baron, G / Altomare, A / Della Vedova, L / Gado, F / Quagliano, O / Casati, S / Tosi, N / Bresciani, L / Del Rio, D / Roda, G / D'Amato, A / Lammi, C / Macorano, A / Vittorio, S / Vistoli, G / Fumagalli, L / Carini, M / Leone, A / Marino, M /
    Del Bo', C / Miotto, G / Ursini, F / Morazzoni, P / Aldini, G

    Redox biology

    2023  Volume 69, Page(s) 102981

    Abstract: Proanthocyanidins (PACs), the predominant constituents within Grape Seed Extract (GSE), are intricate compounds composed of interconnected flavan-3-ol units. Renowned for their health-affirming properties, PACs offer a shield against a spectrum of ... ...

    Abstract Proanthocyanidins (PACs), the predominant constituents within Grape Seed Extract (GSE), are intricate compounds composed of interconnected flavan-3-ol units. Renowned for their health-affirming properties, PACs offer a shield against a spectrum of inflammation associated diseases, such as diabetes, obesity, degenerations and possibly cancer. While monomeric and dimeric PACs undergo some absorption within the gastrointestinal tract, their larger oligomeric and polymeric counterparts are not bioavailable. However, higher molecular weight PACs engage with the colonic microbiota, fostering the production of bioavailable metabolites that undergo metabolic processes, culminating in the emergence of bioactive agents capable of modulating physiological processes. Within this investigation, a GSE enriched with polymeric PACs was employed to explore in detail their impact. Through comprehensive analysis, the present study unequivocally verified the gastrointestinal-mediated transformation of medium to high molecular weight polymeric PACs, thereby establishing the bioaccessibility of a principal catabolite termed 5-(3',4'-dihydroxyphenyl)-γ-valerolactone (VL). Notably, our findings, encompassing cell biology, chemistry and proteomics, converge to the proposal of the notion of the capacity of VL to activate, upon oxidation to the corresponding quinone, the nuclear factor E2-related factor 2 (Nrf2) pathway-an intricate process that incites cellular defenses and mitigates stress-induced responses, such as a challenge brought by TNFα. This mechanistic paradigm seamlessly aligns with the concept of para-hormesis, ultimately orchestrating the resilience to stress and the preservation of cellular redox equilibrium and homeostasis as benchmarks of health.
    MeSH term(s) Humans ; Proanthocyanidins/pharmacology ; Gastrointestinal Tract/metabolism ; Colon/metabolism ; Inflammation/metabolism
    Chemical Substances Proanthocyanidins
    Language English
    Publishing date 2023-12-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2023.102981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online: Deep learning for surrogate modelling of 2D mantle convection

    Agarwal, Siddhant / Tosi, Nicola / Kessel, Pan / Breuer, Doris / Montavon, Grégoire

    2021  

    Abstract: Traditionally, 1D models based on scaling laws have been used to parameterized convective heat transfer rocks in the interior of terrestrial planets like Earth, Mars, Mercury and Venus to tackle the computational bottleneck of high-fidelity forward runs ... ...

    Abstract Traditionally, 1D models based on scaling laws have been used to parameterized convective heat transfer rocks in the interior of terrestrial planets like Earth, Mars, Mercury and Venus to tackle the computational bottleneck of high-fidelity forward runs in 2D or 3D. However, these are limited in the amount of physics they can model (e.g. depth dependent material properties) and predict only mean quantities such as the mean mantle temperature. We recently showed that feedforward neural networks (FNN) trained using a large number of 2D simulations can overcome this limitation and reliably predict the evolution of entire 1D laterally-averaged temperature profile in time for complex models [Agarwal et al. 2020]. We now extend that approach to predict the full 2D temperature field, which contains more information in the form of convection structures such as hot plumes and cold downwellings. Using a dataset of 10,525 two-dimensional simulations of the thermal evolution of the mantle of a Mars-like planet, we show that deep learning techniques can produce reliable parameterized surrogates (i.e. surrogates that predict state variables such as temperature based only on parameters) of the underlying partial differential equations. We first use convolutional autoencoders to compress the temperature fields by a factor of 142 and then use FNN and long-short term memory networks (LSTM) to predict the compressed fields. On average, the FNN predictions are 99.30% and the LSTM predictions are 99.22% accurate with respect to unseen simulations. Proper orthogonal decomposition (POD) of the LSTM and FNN predictions shows that despite a lower mean absolute relative accuracy, LSTMs capture the flow dynamics better than FNNs. When summed, the POD coefficients from FNN predictions and from LSTM predictions amount to 96.51% and 97.66% relative to the coefficients of the original simulations, respectively.
    Keywords Astrophysics - Earth and Planetary Astrophysics ; Computer Science - Machine Learning ; Physics - Fluid Dynamics ; Physics - Geophysics
    Publishing date 2021-08-23
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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