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Article ; Online: Rethinking the organizational culture of the health system to address burnout.

Sinan, Kouadio Ibrahime / Tremblay, Marie-Philippe / Tounkara, Fatoumata Korika / Fleet, Richard

2022 Volume 76, Issue 8, Page(s) 404–405

MeSH term(s)	Burnout, Professional/prevention & control ; Burnout, Psychological ; Humans ; Job Satisfaction ; Organizational Culture
Language	English
Publishing date	2022-06-04
Publishing country	Australia
Document type	Letter
ZDB-ID	1292906-2
ISSN	1440-1819 ; 1323-1316
ISSN (online)	1440-1819
ISSN	1323-1316
DOI	10.1111/pcn.13371
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Article ; Online: Through the big top: An exploratory study of circus-based artistic knowledge translation in rural healthcare services, Québec, Canada.

Théberge, Julie / Smithman, Mélanie Ann / Turgeon-Pelchat, Catherine / Tounkara, Fatoumata Korika / Richard, Véronique / Aubertin, Patrice / Léonard, Patrick / Alami, Hassane / Singhroy, Diane / Fleet, Richard

PloS one

2024 Volume 19, Issue 4, Page(s) e0302022

Abstract: Background: The conventional methods and strategies used for knowledge translation (KT) in academic research often fall short in effectively reaching stakeholders, such as citizens, practitioners, and decision makers, especially concerning complex ... ...

Abstract	Background: The conventional methods and strategies used for knowledge translation (KT) in academic research often fall short in effectively reaching stakeholders, such as citizens, practitioners, and decision makers, especially concerning complex healthcare issues. In response, a growing number of scholars have been embracing arts-based knowledge translation (ABKT) to target a more diverse audience with varying backgrounds and expectations. Despite the increased interest, utilization, and literature on arts-based knowledge translation over the past three decades, no studies have directly compared traditional knowledge translation with arts-based knowledge translation methods. Thus, our study aimed to evaluate and compare the impact of an arts-based knowledge translation intervention-a circus show-with two traditional knowledge translation interventions (webinar and research report) in terms of awareness, accessibility, engagement, advocacy/policy influence, and enjoyment. Methods: To conduct this exploratory convergent mixed method study, we randomly assigned 162 participants to one of the three interventions. All three knowledge translation methods were used to translate the same research project: "Rural Emergency 360: Mobilization of decision-makers, healthcare professionals, patients, and citizens to improve healthcare and services in Quebec's rural emergency departments (UR360)." Results: The findings revealed that the circus show outperformed the webinar and research report in terms of accessibility and enjoyment, while being equally effective in raising awareness, increasing engagement, and influencing advocacy/policy. Each intervention strategy demonstrates its unique array of strengths and weaknesses, with the circus show catering to a diverse audience, while the webinar and research report target more informed participants. These outcomes underscore the innovative and inclusive attributes of Arts-Based Knowledge translation, showcasing its capacity to facilitate researchers' engagement with a wider array of stakeholders across diverse contexts. Conclusion: As a relevant first step and a complementary asset, arts-based knowledge translation holds immense potential in increasing awareness and mobilization around crucial health issues.
MeSH term(s)	Humans ; Quebec ; Translational Science, Biomedical ; Delivery of Health Care ; Canada ; Emergency Service, Hospital
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0302022
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Article ; Online: Prevalence and Factors Associated With HIV and Sexually Transmitted Infections Among Female Sex Workers in Bamako, Mali.

Tounkara, Fatoumata Korika / Téguété, Ibrahima / Guédou, Fernand A / Keita, Bintou / Alary, Michel

Sexually transmitted diseases

2020 Volume 47, Issue 10, Page(s) 679–685

Abstract: Background: We aimed to (1) estimate the prevalence of HIV and other sexually transmitted infections (STIs) among female sex workers (FSWs) in Bamako, Mali, and (2) identify factors associated with STIs including HIV infection in this population.: ... ...

Abstract	Background: We aimed to (1) estimate the prevalence of HIV and other sexually transmitted infections (STIs) among female sex workers (FSWs) in Bamako, Mali, and (2) identify factors associated with STIs including HIV infection in this population. Methods: We analyzed baseline data from a prospective observational cohort study on cervical cancer screening, human papillomavirus, and HIV infections among FSWs 18 years or older recruited in Bamako. Multivariable log-binomial regression was used to estimate the adjusted prevalence ratios (APRs) with 95% confidence interval (95% CI) for HIV infection and STIs versus associated factors. Results: Among 353 women participating in the study, mean age was 26.8 (±7.6) years. HIV prevalence was 20.4%, whereas 35.1% of the FSWs had at least one STI. Factors significantly associated with HIV were older age (P < 0.0001, test for trend), duration of sex work ≥6 years (APR, 1.92; 95% CI, 1.22-3.02), uneducated status (APR, 2.24; 95% CI, 1.16-4.34), less than 10 clients in the last 7 days (APR, 1.55; 95% CI, 1.02-2.34), and gonococcal (APR, 1.85; 95% CI, 1.21-2.82) and chlamydial (APR, 2.58; 95% CI, 1.44-4.62) infections. Younger age (P = 0.018, test for trend), having ≥10 clients in the last week (APR, 1.47; 95% CI, 1.11-1.94), and HIV infection (APR, 2.00; 95% CI, 1.49-2.69) were significantly associated with STIs. Conclusions: HIV and curable STI prevalence are high among FSWs in Bamako. There is thus a need to enhance the efficiency of interventions toward FSWs in Mali to reduce the burden of HIV and STIs among them and prevent HIV spread to the general population.
MeSH term(s)	Adult ; Cross-Sectional Studies ; Early Detection of Cancer ; Female ; HIV Infections/epidemiology ; Humans ; Mali/epidemiology ; Prevalence ; Prospective Studies ; Risk Factors ; Sex Workers ; Sexually Transmitted Diseases/epidemiology ; Uterine Cervical Neoplasms ; Young Adult
Language	English
Publishing date	2020-09-12
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	435191-5
ISSN	1537-4521 ; 0148-5717
ISSN (online)	1537-4521
ISSN	0148-5717
DOI	10.1097/OLQ.0000000000001231
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Article ; Online: Longitudinal study of pregnancy intention and its association with pregnancy occurrence among female sex workers in Benin and Mali.

Perrault Sullivan, Gentiane / Guédou, Fernand Aimé / Tounkara, Fatoumata Korika / Béhanzin, Luc / Camara, Nana / Aza-Gnandji, Marlène / Keita, Bintou Dembele / Azonnadou, Odette / Thera, Ismaila / Avery, Lisa / Alary, Michel

Reproductive health

2023 Volume 20, Issue 1, Page(s) 25

Abstract: Background: The intention of becoming pregnant has an evident impact on the prenatal and postnatal period. For female sex workers (FSWs) in West Africa, among whom pregnancies are frequent as are HIV and sexually transmitted infections, a better ... ...

Abstract	Background: The intention of becoming pregnant has an evident impact on the prenatal and postnatal period. For female sex workers (FSWs) in West Africa, among whom pregnancies are frequent as are HIV and sexually transmitted infections, a better understanding of their pregnancy intention and its influence on pregnancy occurrence could help prevent unwanted pregnancies and adverse effects on wanted pregnancies. Methods: We recruited 330 FSWs in Benin and 322 in Mali and followed them for 12 months. We evaluated their pregnancy intention at recruitment and 6-month follow-up, using a multidimensional prospective measure that we developed. We assessed pregnancy occurrence with a pregnancy test and a retrospective questionnaire at 6 and 12 months. A Cox proportional hazard model was used to estimate the association between intention and pregnancy. We carried out an analysis to take losses to follow-up into account using the inverse of probability of censoring weights and a cluster analysis to corroborate that the multidimensional measure of pregnancy intention fitted the data. Results: 407 FSWs were included in the first 6-month analysis and 284 at 12 months. Mean age was 30.9 years. The pregnancy intention distribution was similar between the two periods: 15.2% in the first period and 16.3% in the second had a positive intention. One out of four were ambivalent and almost 60% (57.7% and 56.3%) had a negative intention. For 38.2% of the FSWs, the intention changed between the two periods. The global incidence rate (to first event) was 19.1 pregnancies per 100 person-years. There was a borderline significant trend (p = 0.0529) of decreased pregnancy incidence with decreasing intention. Compared to positive intention, the adjusted hazard ratio (aHR) for ambivalent and negative intentions were 0.71 [95% confidence interval (95% CI) 0.32-1.60] and 0.46 (95% CI 0.21-1.01), respectively. Conclusion: The level of pregnancy intention influences its occurrence among FSWs and nearly one out of six wants a baby despite working in the sex trade. Programmatically, early identification of these women could facilitate provision of quality antenatal and postnatal care. Given other health risks associated with sex work this care may decrease potential risks of adverse maternal, fetal and neonatal outcomes.
MeSH term(s)	Infant, Newborn ; Female ; Pregnancy ; Humans ; Adult ; Sex Workers ; HIV Infections/epidemiology ; Longitudinal Studies ; Intention ; Benin/epidemiology ; Prospective Studies ; Mali/epidemiology ; Retrospective Studies ; Pregnancy, Unwanted
Language	English
Publishing date	2023-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2149029-6
ISSN	1742-4755 ; 1742-4755
ISSN (online)	1742-4755
ISSN	1742-4755
DOI	10.1186/s12978-023-01565-4
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Article ; Online: Type-specific incidence, persistence and factors associated with human papillomavirus infection among female sex workers in Benin and Mali, West Africa.

Tounkara, Fatoumata Korika / Téguété, Ibrahima / Guédou, Fernand A / Talbot, Denis / Traoré, Cheick B / Béhanzin, Luc / Traoré, Sidy / Goma-Matsétsé, Ella / Aza-Gnandji, Marlène / Keita, Bintou / Guenoun, Julie / Coutlée, François / Alary, Michel

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2021 Volume 106, Page(s) 348–357

Abstract: Objectives: This study in female sex workers (FSWs) aimed to: (1) estimate type-specific incidence and persistence of human papillomavirus (HPV) infection in Cotonou (Benin) and Bamako (Mali); and (2) identify the factors associated with type-specific ... ...

Abstract	Objectives: This study in female sex workers (FSWs) aimed to: (1) estimate type-specific incidence and persistence of human papillomavirus (HPV) infection in Cotonou (Benin) and Bamako (Mali); and (2) identify the factors associated with type-specific incidence and persistence of high-risk HPV (HR-HPV) infection. Methods: A 1-year prospective cohort study on cervical cancer screening, and HPV and human immunodeficiency virus (HIV) infections was conducted among FSWs in Cotonou and Bamako from 2017 to 2019. Poisson regression models assessed factors associated with the incidence of HR-HPV infection, while log-binomial regression was performed to identify factors associated with the persistence of HR-HPV infection. Adjusted relative risks (ARR) and 95% confidence intervals (95% CI) were estimated. Results: The incidence of HR-HPV infection was 46.98 per 1000 women-months (predominant types HPV16, HPV35 and HPV59). Factors associated with the incidence of HR-HPV infection were age <20 years (ARR 15.10; 95% CI 3.29-69.19), age at sexual debut <18 years (ARR 6.92; 95% CI 1.97-24.27) and sex work duration ≤1 year (ARR 7.40; 95% CI 1.84-29.69). The persistence of HR-HPV infection at 12 months was 38.7% (most persistent types HPV59, HPV52 and HPV51). Persistence of HR-HPV infection was higher in women with chlamydia (P = 0.031), HIV infection (P < 0.001) and multiple-type HPV infections (P < 0.001). Conclusion: FSWs in West Africa are at high risk of incident and persistent HR-HPV infection, suggesting an urgent need for cervical cancer screening in this population.
Language	English
Publishing date	2021-04-10
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2021.04.008
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Article ; Online: Lack of CT scanner in a rural emergency department increases inter-facility transfers: a pilot study.

Bergeron, Catherine / Fleet, Richard / Tounkara, Fatoumata Korika / Lavallée-Bourget, Isabelle / Turgeon-Pelchat, Catherine

BMC research notes

2017 Volume 10, Issue 1, Page(s) 772

Abstract: Objective: Rural emergency departments (EDs) are an important gateway to care for the 20% of Canadians who reside in rural areas. Less than 15% of Canadian rural EDs have access to a computed tomography (CT) scanner. We hypothesized that a significant ... ...

Abstract	Objective: Rural emergency departments (EDs) are an important gateway to care for the 20% of Canadians who reside in rural areas. Less than 15% of Canadian rural EDs have access to a computed tomography (CT) scanner. We hypothesized that a significant proportion of inter-facility transfers from rural hospitals without CT scanners are for CT imaging. Our objective was to assess inter-facility transfers for CT imaging in a rural ED without a CT scanner. Results: We selected a rural ED that offers 24/7 medical care with admission beds but no CT scanner. Descriptive statistics were collected from 2010 to 2015 on total ED visits and inter-facility transfers. Data was accessible through hospital and government databases. Between 2010 and 2014, there were respectively 13,531, 13,524, 13,827, 12,883, and 12,942 ED visits, with an average of 444 inter-facility transfers. An average of 33% (148/444) of inter-facility transfers were to a rural referral centre with a CT scan, with 84% being for CT scan. Inter-facility transfers incur costs and potential delays in patient diagnosis and management, yet current databases could not capture transfer times. Acquiring a CT scan may represent a reasonable opportunity for the selected rural hospital considering the number of required transfers.
MeSH term(s)	Canada ; Emergency Service, Hospital/economics ; Emergency Service, Hospital/statistics & numerical data ; Health Services Accessibility/statistics & numerical data ; Hospitals, Rural/organization & administration ; Humans ; Patient Transfer/economics ; Patient Transfer/statistics & numerical data ; Pilot Projects ; Referral and Consultation/statistics & numerical data ; Retrospective Studies ; Rural Population ; Tomography Scanners, X-Ray Computed/supply & distribution ; Tomography, X-Ray Computed/statistics & numerical data
Language	English
Publishing date	2017-12-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2413336-X
ISSN	1756-0500 ; 1756-0500
ISSN (online)	1756-0500
ISSN	1756-0500
DOI	10.1186/s13104-017-3071-1
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Article ; Online: Organisation des services dans une urgence rurale éloignée : réflexions autour du cas de Fermont, Québec.

Fleet, Richard / Turgeon-Pelchat, Catherine / Tounkara, Fatoumata Korika / Trottier, Jean-Guy / Ouellet, Jean / Lapointe, Luc / Renaud, Marie-Pierre / Fortin, Jean-Paul

Canadian journal of rural medicine : the official journal of the Society of Rural Physicians of Canada = Journal canadien de la medecine rurale : le journal officiel de la Societe de medecine rurale du Canada

2018 Volume 23, Issue 4, Page(s) 106–112

Abstract: Introduction: The goal of this study was to meet a small, remote emergency department's need to reflect on the minimum threshold of services to offer. The study's main objectives were to 1) provide a statistical profile of the emergency services in ... ...

Abstract	Introduction: The goal of this study was to meet a small, remote emergency department's need to reflect on the minimum threshold of services to offer. The study's main objectives were to 1) provide a statistical profile of the emergency services in Fermont, Quebec, 2) assess the staff's and users' perception of the threshold of services offered and 3) propose solutions for improving care and services. Methods: This case study was conducted with a participatory approach and a mixed methodology. We compared the results from a questionnaire on the emergency services that was validated during a previous study with the results concerning the other rural emergency services in Quebec as well as with national and provincial recommendations. The questionnaire concerned users' sociodemographic characteristics, the hospital's and the emergency services' descriptors, the services available locally, and the physician and nurse staff. Interviews were also carried out with 33 people (health care professionals, policy-makers and citizens). Results: Fermont's emergency department is smaller than the average rural emergency department in Quebec. They have resources that are in some respects comparable to those of other emergency departments and in line with the recommendations; in other respects, their resources are rather limited. Respondents emphasized how important it is to take into account the environment's specific features when establishing the minimum threshold of services. The proposed solutions would promote collaboration, break down silos within professional practice and focus on training. Conclusion: Fermont's case aside, this exploratory case study highlights how important it is to adopt a pluralistic, participatory and local approach in order to support reflection on the minimum threshold of services in remote emergency departments and to improve their overall performance.
MeSH term(s)	Cooperative Behavior ; Emergency Medical Services/organization & administration ; Emergency Medical Services/statistics & numerical data ; Health Services Accessibility/organization & administration ; Health Services Accessibility/statistics & numerical data ; Health Services Needs and Demand/organization & administration ; Health Services Needs and Demand/statistics & numerical data ; Health Services Research ; Hospitals, Rural/organization & administration ; Humans ; Qualitative Research ; Quebec ; Rural Health Services/organization & administration ; Rural Health Services/statistics & numerical data ; Rural Population/statistics & numerical data
Language	English
Publishing date	2018-09-05
Publishing country	India
Document type	Journal Article
ZDB-ID	2029911-4
ISSN	1488-237X ; 1203-7796
ISSN (online)	1488-237X
ISSN	1203-7796
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Article ; Online: Rural versus urban academic hospital mortality following stroke in Canada.

Fleet, Richard / Bussières, Sylvain / Tounkara, Fatoumata Korika / Turcotte, Stéphane / Légaré, France / Plant, Jeff / Poitras, Julien / Archambault, Patrick M / Dupuis, Gilles

PloS one

2018 Volume 13, Issue 1, Page(s) e0191151

Abstract: Introduction: Stroke is one of the leading causes of death in Canada. While stroke care has improved dramatically over the last decade, outcomes following stroke among patients treated in rural hospitals have not yet been reported in Canada.: ... ...

Abstract	Introduction: Stroke is one of the leading causes of death in Canada. While stroke care has improved dramatically over the last decade, outcomes following stroke among patients treated in rural hospitals have not yet been reported in Canada. Objectives: To describe variation in 30-day post-stroke in-hospital mortality rates between rural and urban academic hospitals in Canada. We also examined 24/7 in-hospital access to CT scanners and selected services in rural hospitals. Materials and methods: We included Canadian Institute for Health Information (CIHI) data on adjusted 30-day in-hospital mortality following stroke from 2007 to 2011 for all acute care hospitals in Canada excluding Quebec and the Territories. We categorized rural hospitals as those located in rural small towns providing 24/7 emergency physician coverage with inpatient beds. Urban hospitals were academic centres designated as Level 1 or 2 trauma centres. We computed descriptive data on local access to a CT scanner and other services and compared mean 30-day adjusted post-stroke mortality rates for rural and urban hospitals to the overall Canadian rate. Results: A total of 286 rural hospitals (3.4 million emergency department (ED) visits/year) and 24 urban hospitals (1.5 million ED visits/year) met inclusion criteria. From 2007 to 2011, 30-day in-hospital mortality rates following stroke were significantly higher in rural than in urban hospitals and higher than the Canadian average for every year except 2008 (rural average range = 18.26 to 21.04 and urban average range = 14.11 to 16.78). Only 11% of rural hospitals had a CT-scanner, 1% had MRI, 21% had in-hospital ICU, 94% had laboratory and 92% had basic x-ray facilities. Conclusion: Rural hospitals in Canada had higher 30-day in-hospital mortality rates following stroke than urban academic hospitals and the Canadian average. Rural hospitals also have very limited local access to CT scanners and ICUs. These rural/urban discrepancies are cause for concern in the context of Canada's universal health care system.
MeSH term(s)	Canada/epidemiology ; Hospital Mortality ; Hospitals, Rural/statistics & numerical data ; Hospitals, Urban/statistics & numerical data ; Humans ; Stroke/mortality
Language	English
Publishing date	2018
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0191151
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Article ; Online: Human papillomavirus genotype distribution and factors associated among female sex workers in West Africa.

Tounkara, Fatoumata Korika / Téguété, Ibrahima / Guédou, Fernand A / Goma-Matsétsé, Ella / Koné, Amadou / Béhanzin, Luc / Traoré, Sidy / Aza-Gnandji, Marlène / Keita, Bintou / Guenoun, Julie / Coutlée, François / Alary, Michel

PloS one

2020 Volume 15, Issue 11, Page(s) e0242711

Abstract: Objectives: This study aimed to: (1) Estimate HPV prevalence and genotype distribution among female sex workers (FSWs) in Mali and Benin as well as the prevalence of multiple HPV type infections in this group, and (2) Identify potential risk factors ... ...

Abstract	Objectives: This study aimed to: (1) Estimate HPV prevalence and genotype distribution among female sex workers (FSWs) in Mali and Benin as well as the prevalence of multiple HPV type infections in this group, and (2) Identify potential risk factors associated with high-risk (HR) HPV infections. Methods: We analyzed baseline data of 665 FSWs aged ≥ 18 years recruited during a prospective cohort of cervical cancer screening in Cotonou (Benin) and Bamako (Mali) from 2017 to 2018. The Linear Array HPV genotyping test was used to identify HPV genotypes. Descriptive statistics and multivariate log-binomial regression were used. Adjusted prevalence ratios (APR) with 95% confidence intervals (95%CI) were estimated to identify risk factors associated with HR-HPV infections. Results: HPV data were available for 659 FSWs (Benin: 309; Mali: 350). The mean age was 35.0 years (± 10.7) in Benin and 26.8 years (± 7.6) in Mali. The overall HPV prevalence rates were 95.5% in Benin and 81.4% in Mali. About 87.7% and 63.4% of FSWs harbored ≥ 2 HPV types in Benin and Mali, respectively. The top three prevalent HR-HPV among FSWs in Benin were: HPV58 (37.5%), HPV16 (36.6%) and HPV52 (28.8%). Corresponding patterns in Mali were HPV16 (15.7%), HPV51 (14.3%) and HPV52 (12.9%). In Benin, the main factors associated with HR-HPV were vaginal douching (APR = 1.17; 95%CI:1.02-1.34) and gonococcal infection (APR = 1.16; 95%CI:1.04-1.28), while in Mali they were sex work duration ≤ 1 year (APR = 1.35; 95%CI:1.10-1.65) and HIV infection (APR = 1.26; 95%CI: 1.06-1.51). Conclusion: Our study found a very high prevalence of HPV infection as well as high frequency of multiple HPV type infections in FSWs in two countries in West Africa. These findings suggest the necessity to emphasize cervical cancer prevention in this high-risk group.
MeSH term(s)	Adolescent ; Adult ; Alphapapillomavirus/genetics ; Benin ; Female ; Genotype ; Humans ; Mali ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/genetics ; Prevalence ; Prospective Studies ; Risk Factors ; Sex Workers ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/virology
Language	English
Publishing date	2020-11-25
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0242711
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Article ; Online: Mild hyperthermia promotes and accelerates development and maturation of erythroid cells.

Tounkara, Fatoumata Korika / Dumont, Nellie / Fournier, Simon / Boyer, Lucie / Nadeau, Philippe / Pineault, Nicolas

Stem cells and development

2012 Volume 21, Issue 17, Page(s) 3197–3208

Abstract: Hyperthermia treatment has at times been associated with increased platelet levels in humans. The heat shock protein HSP70, which can be induced by hyperthermia in megakaryocytes and erythrocytes, was recently shown to protect GATA-1 from degradation and ...

Abstract	Hyperthermia treatment has at times been associated with increased platelet levels in humans. The heat shock protein HSP70, which can be induced by hyperthermia in megakaryocytes and erythrocytes, was recently shown to protect GATA-1 from degradation and to be required for erythroid differentiation. Based on these findings, we hypothesize that mild hyperthermia (MH), such as fever (39°C), could impact the differentiation of hematopoietic progenitors into erythrocytes and their subsequent maturation. Cell growth and erythroid differentiation increased dramatically in cord blood CD34(+) cell cultures incubated under MH. Erythroid maturation was also strongly promoted, which resulted in an increased proportion of hemoglobinized and enucleated erythroids. The rise in erythroid development was traced to a strong synergistic activity between MH and erythropoietin (EPO). The molecular basis for this potent synergy appears to originate from the capacity of MH to increase the basal activation of several signaling molecules downstream of the EPO receptor and the transcriptional activity of GATA-1. Moreover, the potent impact of MH on erythroid development was found be dependent on increased intracellular levels of reactive oxygen species. Thus, fever-like temperatures can promote the differentiation of progenitors along the erythroid lineage and accelerate their maturation through normal regulatory circuitry.
MeSH term(s)	Antigens, CD34/metabolism ; Apoptosis ; Cell Count ; Cell Cycle ; Cell Differentiation ; Cell Nucleus ; Cell Proliferation ; Cells, Cultured ; Erythroid Cells/cytology ; Erythroid Cells/metabolism ; Erythropoiesis ; Erythropoietin/metabolism ; Fetal Blood/cytology ; Fetal Blood/metabolism ; Flow Cytometry ; GATA1 Transcription Factor/genetics ; GATA1 Transcription Factor/metabolism ; Hematopoietic Stem Cells ; Hot Temperature ; Humans ; Reactive Oxygen Species/metabolism ; Receptors, Erythropoietin/metabolism ; Transcriptional Activation
Chemical Substances	Antigens, CD34 ; EPO protein, human ; GATA1 Transcription Factor ; GATA1 protein, human ; Reactive Oxygen Species ; Receptors, Erythropoietin ; Erythropoietin (11096-26-7)
Language	English
Publishing date	2012-11-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2142214-X
ISSN	1557-8534 ; 1547-3287
ISSN (online)	1557-8534
ISSN	1547-3287
DOI	10.1089/scd.2012.0112
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