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Article ; Online: The ever increasing role of percutaneous interventions in coronary revascularisation.

Spanos, Vassilis N / Toutouzas, Pavlos K

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

2010 Volume 51, Issue 6, Page(s) 512–517

MeSH term(s)	Angioplasty, Balloon, Coronary ; Cardiology/trends ; Coronary Angiography ; Coronary Artery Bypass ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/surgery ; Coronary Artery Disease/therapy ; Drug-Eluting Stents ; Humans ; Myocardial Revascularization/trends ; Stents
Language	English
Publishing date	2010-12-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2215027-4
ISSN	2241-5955 ; 1109-9666
ISSN (online)	2241-5955
ISSN	1109-9666
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Zs.A 6187: Show issues

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Article: Cardiovascular risk factor profile in Greece: results from the CARDIO2000 and ATTICA epidemiological studies.

Pitsavos, Christos E / Toutouzas, Pavlos K

Current medical research and opinion

2002 Volume 18, Issue 5, Page(s) 277–283

Abstract: During the past decades several epidemiological studies have provided a 'portrait' of the potential candidate for cardiovascular disease, introducing many emerging life-style risk factors such as obesity, unhealthy diet, exposure to passive smoking, lack ...

Abstract	During the past decades several epidemiological studies have provided a 'portrait' of the potential candidate for cardiovascular disease, introducing many emerging life-style risk factors such as obesity, unhealthy diet, exposure to passive smoking, lack of exercise, psychosocial stress, and depression, as well as elevated levels of triglycerides and clotting factors in the blood. Additionally, many differences have arisen in the estimated risk models, between populations as well as among individuals within populations, that make it difficult to generalise the results. This variation could be attributed to several geographical, cultural, social and behavioural differences between the investigated populations. Thus, the development of local epidemiological studies is considered essential. We present the results from two major epidemiological projects conducted in Greece during 2000-2002, the CARDI02000 and the ATTICA studies. Among several investigated parameters that were assessed for their influence on the risk of developing non-fatal acute coronary syndromes (CARDIO2000) we selected to present in this report the adverse effect of passive smoking, short-term depressive episodes and the protective effect of moderate alcohol consumption on coronary risk. Moreover, from the ongoing population-based survey (ATTICA) we selected to present our findings regarding the protective effect of the Mediterranean diet as well as the J-shape association between alcohol intake and several clinical and biochemical markers related to cardiovascular disease. Finally, we present the results from the Corfu cohort of the Seven Countries Study that completed four decades of prospective evaluation in the summer of 2001.
MeSH term(s)	Adult ; Aged ; Alcohol Drinking/epidemiology ; Cardiovascular Diseases/epidemiology ; Depression/epidemiology ; Diet, Mediterranean ; Female ; Greece/epidemiology ; Humans ; Life Style ; Lipids/blood ; Male ; Middle Aged ; Prognosis ; Risk Factors ; Smoking/epidemiology
Chemical Substances	Lipids
Language	English
Publishing date	2002
Publishing country	England
Document type	Journal Article
ZDB-ID	80296-7
ISSN	1473-4877 ; 0300-7995
ISSN (online)	1473-4877
ISSN	0300-7995
DOI	10.1185/030079902125000525
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Zs.A 955: Show issues

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Article: Efficacy of antithrombotic therapy in chronic heart failure: the HELAS study.

Cokkinos, Dennis V / Haralabopoulos, George C / Kostis, John B / Toutouzas, Pavlos K

European journal of heart failure

2006 Volume 8, Issue 4, Page(s) 428–432

Abstract: Background: It is not clear if long-term antithrombotic treatment has a beneficial effect on the incidence of thromboembolism in chronic heart failure (CHF). The HELAS study (Heart failure Long-term Antithrombotic Study) is a multicentre, randomised, ... ...

Abstract	Background: It is not clear if long-term antithrombotic treatment has a beneficial effect on the incidence of thromboembolism in chronic heart failure (CHF). The HELAS study (Heart failure Long-term Antithrombotic Study) is a multicentre, randomised, double-blind, placebo-controlled trial to evaluate antithrombotic treatment in patients with CHF. Methods: 197HF patients (EF <35%) were enrolled. Patients with Ischaemic Heart Disease were randomised to receive either aspirin 325mg or warfarin. Patients with Dilated Cardiomyopathy (DCM) were randomised to receive either warfarin or placebo. Results: Analysis of the data from 312 patient years showed an incidence of 2.2 embolic events per 100 patient years, with no significant difference between groups. The incidence of myocardial infarction, hospitalisation, exacerbation of heart failure, death and haemorrhage were not different between the groups. No peripheral or pulmonary emboli were reported. Echocardiographic follow-up for 2years showed an overall increase in left ventricular ejection fraction from 28.2+/-6 to 30.3+/-7 p<0.05, which was most obvious in patients with DCM taking warfarin (EF 26.8+/-5.3 at baseline, 30.7+/-10 at 2 years, p<0.05). Conclusions: (1) Overall embolic events are rare in heart failure regardless of treatment. (2) Treatment does not seem to affect outcome.
MeSH term(s)	Aged ; Anticoagulants/adverse effects ; Anticoagulants/therapeutic use ; Antithrombins/adverse effects ; Antithrombins/therapeutic use ; Aspirin/adverse effects ; Aspirin/therapeutic use ; Cardiac Output, Low/complications ; Cardiomyopathy, Dilated/complications ; Cardiomyopathy, Dilated/drug therapy ; Cardiomyopathy, Dilated/physiopathology ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Myocardial Ischemia/complications ; Myocardial Ischemia/drug therapy ; Myocardial Ischemia/physiopathology ; Placebos ; Thromboembolism/complications ; Thromboembolism/prevention & control ; Warfarin/adverse effects ; Warfarin/therapeutic use
Chemical Substances	Anticoagulants ; Antithrombins ; Placebos ; Warfarin (5Q7ZVV76EI) ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2006-06
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	1483672-5
ISSN	1879-0844 ; 1388-9842
ISSN (online)	1879-0844
ISSN	1388-9842
DOI	10.1016/j.ejheart.2006.02.012
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Zs.A 5299: Show issues

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Article ; Online: Paradoxical clinical value of another smoker's paradox.

Andrikopoulos, George K / Chimonas, Elias T / Toutouzas, Pavlos K

Circulation

2002 Volume 105, Issue 8, Page(s) e55

MeSH term(s)	Angioplasty, Balloon, Coronary ; Causality ; Confounding Factors (Epidemiology) ; Coronary Artery Disease/therapy ; Coronary Restenosis/etiology ; Humans ; Multicenter Studies as Topic ; Myocardial Revascularization/mortality ; Patient Acceptance of Health Care ; Smoking/adverse effects ; Survival Rate
Language	English
Publishing date	2002-02-26
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
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Article ; Online: Eleven-year prevalence trends of obesity in Greek children: first evidence that prevalence of obesity is leveling off.

Tambalis, Konstantinos D / Panagiotakos, Demosthenes B / Kavouras, Stavros A / Kallistratos, Achilles A / Moraiti, Ioanna P / Douvis, Stavros J / Toutouzas, Pavlos K / Sidossis, Labros S

Obesity (Silver Spring, Md.)

2010 Volume 18, Issue 1, Page(s) 161–166

Abstract: We examined 11-year (1997-2007) trends in underweight, overweight, and obesity in Greek children. Population data derived from a yearly, school-based health survey carried out between 1997 and 2007 in >80% of all Greek schools. Height and weight ... ...

Abstract	We examined 11-year (1997-2007) trends in underweight, overweight, and obesity in Greek children. Population data derived from a yearly, school-based health survey carried out between 1997 and 2007 in >80% of all Greek schools. Height and weight measurements from 651,582 children, aged 8-9 years (boys: 51.2%) were analyzed. The gender- and age-specific BMI cutoff points by the International Obesity Task Force (IOTF) were used in order to define underweight, normal weight, overweight, and obesity. Trend analysis showed an increase in the prevalence of obesity from 7.2 +/- 0.2% in 1997 to 11.3 +/- 0.2% in 2004 for girls (P < 0.001) and from 8.1 +/- 0.2% in 1997 to 12.3 +/- 0.2% in 2004 for boys (P < 0.001). An apparent leveling off in obesity rates was observed during 2004-2007 for both boys and girls. The prevalence of overweight rose between 1997 and 2007 from 20.2 +/- 0.2% to 26.7 +/- 0.2% for girls (P < 0.001) and from 19.6 +/- 0.2% to 26.5 +/- 0.2% for boys (P < 0.001). The overall prevalence of thinness in the same period remained constant in both sexes. The presented population-based data revealed that the prevalence of overweight and obesity among 8- to 9-year-old Greek children is alarmingly elevated, with the overweight rates rising continuously. However, an apparent leveling off in obesity rates for the past 4 consecutive years was documented for the first time in both genders.
MeSH term(s)	Anthropometry ; Body Mass Index ; Chi-Square Distribution ; Child ; Female ; Greece/epidemiology ; Health Status ; Health Surveys ; Humans ; Male ; Obesity/epidemiology ; Overweight/epidemiology ; Prevalence ; Regression Analysis
Language	English
Publishing date	2010-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2230457-5
ISSN	1930-739X ; 1071-7323 ; 1930-7381
ISSN (online)	1930-739X
ISSN	1071-7323 ; 1930-7381
DOI	10.1038/oby.2009.188
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Zs.A 4061: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Assessment of arterial ventricular coupling changes in patients under therapy with various antihypertensive agents by a non-invasive echocardiographic method.

Iakovou, Ioannis / Karpanou, Evaggelia A / Vyssoulis, Gregory P / Toutouzas, Pavlos K / Cokkinos, Dennis V

International journal of cardiology

2004 Volume 96, Issue 3, Page(s) 355–360

Abstract: Background: The integration between arterial and ventricular function has been studied by mostly invasive techniques. We considered assessing the influence of various antihypertensive medications on arterial-ventricular coupling (AVC) with the use of a ... ...

Abstract	Background: The integration between arterial and ventricular function has been studied by mostly invasive techniques. We considered assessing the influence of various antihypertensive medications on arterial-ventricular coupling (AVC) with the use of a non-invasive echocardiographic method. Methods: A total of 9037 patients, who had been under treatment for essential arterial hypertension were studied echocardiographically at baseline prior to therapy and after 6 months of antihypertensive monotherapy (diuretics, beta-blockers without intrinsic sympathomimetic activity (ISA), beta-blockers with ISA, a-blockers, angiotensin converting enzyme inhibitors (ACEI), angiotensin II receptor blockers (AIIRA), non-dihydropyridine calcium antagonists, and dihydropyridine calcium antagonists). The AVC was calculated by echocardiographic measurements based on the equation: AVC=ESV/SV (ESV, end systolic volume; SV, stroke volume). Results: ACEI, AIIRA, and dihydropyridine calcium antagonists decreased (P<0.0001 for all) while diuretics, alpha-blockers, both beta-blocker groups, and non-dihydropyridines increased significantly the AVC values compared to baseline measurements (P<0.0001 for all, except P=0.02 for alpha-blockers). Changes in AVC were the most highly correlated with changes in EF (r=-0.979, P<0.0001). Conclusion: Various antihypertensive drugs have a differential effect on AVC with ACEI, AIIRA, and dihydropyridine calcium antagonists having the most favorable effect on this index. AVC provides a meaningful index of cardiovascular performance in hypertension and offers the possibility of wide employment and serial follow-up in large numbers of patients because of its completely non-invasive nature.
MeSH term(s)	Adult ; Aged ; Antihypertensive Agents/pharmacology ; Blood Pressure/drug effects ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/drug effects ; Coronary Vessels/physiopathology ; Elasticity/drug effects ; Follow-Up Studies ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/drug effects ; Heart Ventricles/physiopathology ; Humans ; Hypertension/diagnostic imaging ; Hypertension/physiopathology ; Middle Aged ; Stroke Volume/drug effects ; Ultrasonography
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2004-09
Publishing country	Netherlands
Document type	Clinical Trial ; Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2003.07.022
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Article: Exercise-induced left bundle branch block accompanied by chest pain. Correlation with coronary artery disease.

Michaelides, Andreas P / Kartalis, Athanasios N / Aigyptiadou, Maria-Niki K / Toutouzas, Pavlos K

Journal of electrocardiology

2004 Volume 37, Issue 4, Page(s) 325–328

Abstract: A case of a 25-year-old woman with familiar hypercholesterolemia, who was admitted complaining for chest pain on exertion, is presented. She underwent a treadmill stress test and during the exercise left bundle branch block with concomitant chest pain in ...

Abstract	A case of a 25-year-old woman with familiar hypercholesterolemia, who was admitted complaining for chest pain on exertion, is presented. She underwent a treadmill stress test and during the exercise left bundle branch block with concomitant chest pain in low heart rate (105/min) was demonstrated. After these findings TL-201 scintigraphy with dipyridamole infusion was performed: Chest pain and left bundle branch block appeared again during the test, and the stress TL-201 tomographic images showed reversible defect in the anterior wall. Finally, the young woman underwent coronary arteriography, which showed normal coronary vessels. The ergonovine test for coronary spasm was negative.
MeSH term(s)	Adult ; Bundle-Branch Block/diagnosis ; Bundle-Branch Block/etiology ; Chest Pain/etiology ; Coronary Artery Disease/diagnosis ; Electrocardiography ; Exercise ; Exercise Test ; False Positive Reactions ; Female ; Heart Rate ; Humans ; Hyperlipoproteinemia Type II/complications
Language	English
Publishing date	2004-09-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	410286-1
ISSN	1532-8430 ; 0022-0736
ISSN (online)	1532-8430
ISSN	0022-0736
DOI	10.1016/j.jelectrocard.2004.07.007
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Article: Differences in the morphology and duration between premature P waves and the preceding sinus complexes in patients with a history of paroxysmal atrial fibrillation.

Dilaveris, Polychronis E / Pantazis, Antonios / Zervopoulos, George / Kallikazaros, John / Stefanadis, Christodoulos / Toutouzas, Pavlos K

Clinical cardiology

2003 Volume 26, Issue 7, Page(s) 341–347

Abstract: Background: Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice. Experimental and human mapping studies have demonstrated that perpetuation of AF is due to the presence of multiple reentrant wavelets with various ... ...

Abstract	Background: Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice. Experimental and human mapping studies have demonstrated that perpetuation of AF is due to the presence of multiple reentrant wavelets with various sizes in the right and left atria. Hypothesis: Atrial fibrillation may be induced by atrial ectopic beats originating in the pulmonary veins, and premature P-wave (PPW) patterns may help to identify the source of firing. Methods: To evaluate the morphology and duration of PPWs, 12-lead digital electrocardiogram (ECG) strips containing clearly definable PPWs not merging with the preceding T waves were obtained in 25 patients with AF history (9 men, mean age 59.5 +/- 2.2 years) and 25 subjects without any previous AF history (11 men, mean age 53.6 +/- 25 years). The polarity of PPWs was evaluated in all 12 ECG leads. Previously described indices, such as P maximum, P dispersion (= P maximum-P minimum), P mean, and P standard deviation were also calculated. Results: Premature P-wave patterns were characterized by more positive P waves in lead V1. All P-wave analysis indices were significantly higher in patients with AF than in controls when calculated in the sinus beat, whereas they did not differ between the two groups when calculated in the PPW. P-wave indices did not differ between the PPW and the sinus either patients with AF or controls, except for P mean, which was significantly higher in the sinus (110.1 +/- 1.7 ms) than in the PPW (100 +/- 2 ms) only in patients with AF (p = 0.001). Conclusion: The evaluation of PPW patterns is only feasible in a small percentage of short-lasting digital 12-lead ECG recordings containing ectopic atrial beats. Premature P wave patterns characterized by more positive P waves in lead V1, which indicates a left atrial origin in the ectopic foci. The observed differences in P-wave analysis indices between patients with AF and controls and between sinus beats and PPWs may be attributed to the presence of electrophysiologic changes in the atrial substrate.
MeSH term(s)	Atrial Fibrillation/physiopathology ; Electrocardiography ; Female ; Heart Atria/physiopathology ; Heart Conduction System/physiopathology ; Humans ; Male ; Middle Aged
Language	English
Publishing date	2003-07-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	391935-3
ISSN	1932-8737 ; 0160-9289
ISSN (online)	1932-8737
ISSN	0160-9289
DOI	10.1002/clc.4950260709
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Article ; Online: Temperature differences are associated with malignancy on lung lesions

Katsi Vasiliki / Passalidou Elisabeth / Panagiotakos Demosthenes B / Chrysohoou Christina / Stefanadis Christodoulos / Polychronopoulos Vlassios / Toutouzas Pavlos K

BMC Cancer, Vol 3, Iss 1, p

a clinical study

2003 Volume 1

Abstract: Abstract Background Although new endoscopic techniques can enhance the ability to detect a suspicious lung lesion, the primary diagnosis still depends on subjective visual assessment. We evaluated whether thermal heterogeneity of solid tumors, in ... ...

Abstract	Abstract Background Although new endoscopic techniques can enhance the ability to detect a suspicious lung lesion, the primary diagnosis still depends on subjective visual assessment. We evaluated whether thermal heterogeneity of solid tumors, in bronchial epithelium, constitutes an additional marker for the diagnosis of benign and malignant lesions. Methods A new method, developed in our institute, is introduced in order to detect temperature in human pulmonary epithelium, in vivo. This method is based on a thermography catheter, which passes the biopsy channel of the fiber optic bronchoscope. We calculated the temperature differences (ΔT) between the lesion and a normal bronchial epithelium area on 22 lesions of 20 subjects, 50 – 65 years old. Results Eleven lesions were benign and 11 were malignant, according to the biopsy histology followed the thermography procedure. We found significant differences of ÄT between patients with benign and malignant tumor (0.71 ± 0.6 vs. 1.23 ± 0.4°C, p < 0.05). Logistic regression analysis showed that 1-Celsius degree differences between normal tissue and suspicious lesion six-fold the probability of malignancy (odds ratio = 6.18, 95% CI 0.89 – 42.7). Also, ΔT values greater than 1.05°C, constitutes a crucial point for the discrimination of malignancy, in bronchial epithelium, with sensitivity (64%) and specificity (91%). Conclusion These findings suggest that the calculated ΔT between normal tissue and a neoplastic area could be a useful criterion for the diagnosis of malignancy in tumors of lung lesions.
Keywords	Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	2003-01-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
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Article: Education and acute coronary syndromes: results from the CARDIO2000 epidemiological study.

Pitsavos, Christos E / Panagiotakos, Demosthenes B / Chrysohoou, Christina A / Skoumas, John / Stefanadis, Christodoulos / Toutouzas, Pavlos K

Bulletin of the World Health Organization

2002 Volume 80, Issue 5, Page(s) 371–377

Abstract: Objective: As a measure of socioeconomic status, low educational level is positively associated with the risk of developing adverse health events. The aim of this study was to investigate the relationship between the level of education and the risk of ... ...

Abstract	Objective: As a measure of socioeconomic status, low educational level is positively associated with the risk of developing adverse health events. The aim of this study was to investigate the relationship between the level of education and the risk of developing non- fatal acute coronary syndromes. Methods: During 2000 and 2001, 1619 randomly selected subjects from several regions of Greece were entered into a case-control study. Of these, 750 were patients with their first acute coronary heart syndrome event, and 869 were hospitalized controls with no cardiovascular disease in their medical history. Trends in cardiovascular risk factors were then examined across patient and control educational level by years of schooling. Findings: In both patients and controls, education status was related to economic and occupation status, smoking habits, physical inactivity, alcohol consumption and non-compliance to treatment. After adjusting for these and other conventional risk factors, as well as for the effects of age and sex, we found that coronary risk increases by 82% (odds ratio (OR) = 1.82, P <0.05) for individuals with a lower level of education, and by 65% (OR = 1.65, P <0.05) for individuals with an average education, compared to those with an academic education. Conclusions: Although the least-educated subjects adopted a more adverse lifestyle than the more-educated subjects, the inverse association between education and coronary risk was independent from such factors. The inverse association may be due to psychosocial differences, and prospective cohort studies are needed to confirm or refute these results.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Demography ; Educational Status ; Female ; Heart Diseases/complications ; Heart Diseases/epidemiology ; Humans ; Life Style ; Male ; Middle Aged ; Random Allocation ; Risk Assessment ; Socioeconomic Factors
Language	English
Publishing date	2002
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80213-x
ISSN	1564-0604 ; 0042-9686 ; 0366-4996 ; 0510-8659
ISSN (online)	1564-0604
ISSN	0042-9686 ; 0366-4996 ; 0510-8659
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