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Article ; Online: Pituitary Infiltration by Lymphoma.

Tovar-Méndez, Víctor Hugo / Cuenca, Dalia / Gómez-Pérez, Francisco J / Cuevas-Ramos, Daniel

Journal of the Endocrine Society

2022 Volume 6, Issue 12, Page(s) bvac161

Abstract: Lymphoma infiltration to the pituitary is rare. It represents less than 0.5% of all reported pituitary metastases (PMs). Here we present a case series of 3 patients with PMs from a systemic lymphoma. Also, we performed a literature review of the cases ... ...

Abstract	Lymphoma infiltration to the pituitary is rare. It represents less than 0.5% of all reported pituitary metastases (PMs). Here we present a case series of 3 patients with PMs from a systemic lymphoma. Also, we performed a literature review of the cases reported. We identified additional 31 cases in which non-Hodgkin lymphoma (NHL) was the most common (n = 28, 90%), with large B-cell NHL the most frequent histological subtype (n = 14, 45%). Central hypothyroidism (n = 21, 67%) was the most frequent pituitary deficiency followed by adrenal insufficiency (n = 19, 61%) and diabetes insipidus (DI; n = 18, 58%). Full endocrine recovery was found in only 12% (n = 4) of patients after treatment, and magnetic resonance imaging showed tumor regression in 22% of them. In our series, 2 patients were diagnosed with diffuse large B-cell lymphoma, and 1 had mixed cellularity of classic Hodgkin lymphoma. The mean age was 54 ± 6.92 years. Hypopituitarism and DI were present in all of them, with 100% of mortality because of advanced systemic disease.
Language	English
Publishing date	2022-10-27
Publishing country	United States
Document type	Case Reports
ISSN	2472-1972
ISSN (online)	2472-1972
DOI	10.1210/jendso/bvac161
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Article: Heterogeneity of Genetic Admixture Determines SLE Susceptibility in Mexican.

Hernández-Doño, Susana / Jakez-Ocampo, Juan / Márquez-García, José Eduardo / Ruiz, Daniela / Acuña-Alonzo, Víctor / Lima, Guadalupe / Llorente, Luis / Tovar-Méndez, Víctor Hugo / García-Silva, Rafael / Granados, Julio / Zúñiga, Joaquín / Vargas-Alarcón, Gilberto

Frontiers in genetics

2021 Volume 12, Page(s) 701373

Abstract: Systemic Lupus Erythematosus (SLE) is an autoimmune inflammatory disorder for which Major Histocompatibility Complex (MHC) genes are well identified as risk factors. SLE patients present different clinical phenotypes, which are partly explained by ... ...

Abstract	Systemic Lupus Erythematosus (SLE) is an autoimmune inflammatory disorder for which Major Histocompatibility Complex (MHC) genes are well identified as risk factors. SLE patients present different clinical phenotypes, which are partly explained by admixture patterns variation among Mexicans. Population genetic has insight into the high genetic variability of Mexicans, mainly described through HLA gene studies with anthropological and biomedical importance. A prospective, case-control study was performed. In this study, we recruited 146 SLE patients, and 234 healthy individuals were included as a control group; both groups were admixed Mexicans from Mexico City. The HLA typing methods were based on Next Generation Sequencing and Sequence-Based Typing (SBT). The data analysis was performed with population genetic programs and statistical packages. The admixture estimations based on HLA-B and -DRB1 revealed that SLE patients have a higher Southwestern European ancestry proportion (48 ± 8%) than healthy individuals (30 ± 7%). In contrast, Mexican Native American components are diminished in SLE patients (44 ± 1%) and augmented in Healthy individuals (63 ± 4%). HLA alleles and haplotypes' frequency analysis found variants previously described in SLE patients from Mexico City. Moreover, a conserved extended haplotype that confers risk to develop SLE was found, the HLA-A
Language	English
Publishing date	2021-08-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2021.701373
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Article ; Online: Correction: In-hospital mortality from severe COVID-19 in a tertiary care center in Mexico City; causes of death, risk factors and the impact of hospital saturation.

Olivas-Martínez, Antonio / Cárdenas-Fragoso, José Luis / Jiménez, José Víctor / Lozano-Cruz, Oscar Arturo / Ortiz-Brizuela, Edgar / Tovar-Méndez, Víctor Hugo / Medrano-Borromeo, Carla / Martínez-Valenzuela, Alejandra / Román-Montes, Carla Marina / Martínez-Guerra, Bernardo / González-Lara, María Fernanda / Hernandez-Gilsoul, Thierry / Herrero, Alfonso Gulias / Tamez-Torres, Karla María / Ochoa-Hein, Eric / Ponce-de-León, Alfredo / Galindo-Fraga, Arturo / Kershenobich-Stalnikowitz, David / Sifuentes-Osornio, José

PloS one

2022 Volume 17, Issue 5, Page(s) e0269053

Abstract: This corrects the article DOI: 10.1371/journal.pone.0245772.]. ...

Abstract	[This corrects the article DOI: 10.1371/journal.pone.0245772.].
Language	English
Publishing date	2022-05-23
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0269053
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Article ; Online: In-hospital mortality from severe COVID-19 in a tertiary care center in Mexico City; causes of death, risk factors and the impact of hospital saturation.

Olivas-Martínez, Antonio / Cárdenas-Fragoso, José Luis / Jiménez, José Víctor / Lozano-Cruz, Oscar Arturo / Ortiz-Brizuela, Edgar / Tovar-Méndez, Víctor Hugo / Medrano-Borromeo, Carla / Martínez-Valenzuela, Alejandra / Román-Montes, Carla Marina / Martínez-Guerra, Bernardo / González-Lara, María Fernanda / Hernandez-Gilsoul, Thierry / Herrero, Alfonso Gulias / Tamez-Flores, Karla María / Ochoa-Hein, Eric / Ponce-de-León, Alfredo / Galindo-Fraga, Arturo / Kershenobich-Stalnikowitz, David / Sifuentes-Osornio, José

PloS one

2021 Volume 16, Issue 2, Page(s) e0245772

Abstract: Background: As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has remained in Latin America, Mexico has become the third country with the highest death rate worldwide. Data regarding in-hospital mortality and its risk factors, ...

Abstract	Background: As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has remained in Latin America, Mexico has become the third country with the highest death rate worldwide. Data regarding in-hospital mortality and its risk factors, as well as the impact of hospital overcrowding in Latin America has not been thoroughly explored. Methods and findings: In this prospective cohort study, we enrolled consecutive adult patients hospitalized with severe confirmed COVID-19 pneumonia at a SARS-CoV-2 referral center in Mexico City from February 26th, 2020, to June 5th, 2020. A total of 800 patients were admitted with confirmed diagnosis, mean age was 51.9 ± 13.9 years, 61% were males, 85% were either obese or overweight, 30% had hypertension and 26% type 2 diabetes. From those 800, 559 recovered (69.9%) and 241 died (30.1%). Among survivors, 101 (18%) received invasive mechanical ventilation (IMV) and 458 (82%) were managed outside the intensive care unit (ICU); mortality in the ICU was 49%. From the non-survivors, 45.6% (n = 110) did not receive full support due to lack of ICU bed availability. Within this subgroup the main cause of death was acute respiratory distress syndrome (ARDS) in 95% of the cases, whereas among the non-survivors who received full (n = 105) support the main cause of death was septic shock (45%) followed by ARDS (29%). The main risk factors associated with in-hospital death were male sex (RR 2.05, 95% CI 1.34-3.12), obesity (RR 1.62, 95% CI 1.14-2.32)-in particular morbid obesity (RR 3.38, 95%CI 1.63-7.00)-and oxygen saturation < 80% on admission (RR 4.8, 95%CI 3.26-7.31). Conclusions: In this study we found similar in-hospital and ICU mortality, as well as risk factors for mortality, compared to previous reports. However, 45% of the patients who did not survive justified admission to ICU but did not receive IMV / ICU care due to the unavailability of ICU beds. Furthermore, mortality rate over time was mainly due to the availability of ICU beds, indirectly suggesting that overcrowding was one of the main factors that contributed to hospital mortality.
MeSH term(s)	Aged ; Bed Occupancy/statistics & numerical data ; COVID-19/complications ; COVID-19/mortality ; COVID-19/pathology ; COVID-19/virology ; Cause of Death ; Female ; Hospital Mortality ; Humans ; Intensive Care Units ; Male ; Mexico ; Middle Aged ; Obesity/complications ; Obesity/pathology ; Prospective Studies ; Respiration, Artificial ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/mortality ; Risk Factors ; SARS-CoV-2/isolation & purification ; Severity of Illness Index ; Shock, Septic/diagnosis ; Shock, Septic/etiology ; Shock, Septic/mortality ; Tertiary Care Centers
Language	English
Publishing date	2021-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0245772
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Article ; Online: Low Thoracic Skeletal Muscle Area Is Not Associated With Negative Outcomes in Patients With COVID-19.

Moctezuma-Velázquez, Paulina / Miranda-Zazueta, Godolfino / Ortiz-Brizuela, Edgar / González-Lara, María Fernanda / Tamez-Torres, Karla Maria / Román-Montes, Carla Marina / Díaz-Mejía, Bruno Alejandro / Pérez-García, Esteban / Villanueva-Reza, Marco / Tovar-Méndez, Víctor Hugo / Medrano-Borromeo, Carla / Martínez-Valenzuela, Alejandra / Jandete-Medina, Míguel Ángel / Martínez-Guerra, Bernardo Alonso / Uscanga-Domínguez, Luis / Sifuentes-Osornio, José / Ponce-de-León, Alfredo / Olivas-Martinez, Antonio / Moctezuma-Velázquez, Carlos

American journal of physical medicine & rehabilitation

2021 Volume 100, Issue 5, Page(s) 413–418

Abstract: Objective: Sarcopenia has been related to negative outcomes in different clinical scenarios from critical illness to chronic conditions. The aim of this study was to verify whether there was an association between low skeletal muscle index and in- ... ...

Abstract	Objective: Sarcopenia has been related to negative outcomes in different clinical scenarios from critical illness to chronic conditions. The aim of this study was to verify whether there was an association between low skeletal muscle index and in-hospital mortality, intensive care unit admission, and invasive mechanical ventilation need in hospitalized patients with COVID-19. Design: This was a retrospective cohort study of a referral center for COVID-19. We included all consecutive patients admitted to the hospital between February 26 and May 15, 2020, with a confirmed diagnosis of COVID-19. Skeletal muscle index was assessed from a transverse computed tomography image at the level of twelfth thoracic vertebra with National Institutes of Health ImageJ software, and statistical analysis was performed to find an association between skeletal muscle index and in-hospital mortality, need of invasive mechanical ventilation, and intensive care unit admission. Results: We included 519 patients, the median age was 51 (42-61) yrs, and 115 patients (22%) had low skeletal muscle index. On multivariable analysis, skeletal muscle index was not associated with mortality, intensive care unit admission, or invasive mechanical ventilation need nor in a subanalysis of patients 65 yrs or older. Conclusions: Skeletal muscle index determined by computed tomography at the level of twelfth thoracic vertebra was not associated with negative outcomes in hospitalized patients with COVID-19.
MeSH term(s)	Adult ; Aged ; COVID-19/complications ; COVID-19/mortality ; COVID-19/therapy ; Critical Care ; Female ; Hospital Mortality ; Hospitalization ; Humans ; Male ; Middle Aged ; Muscle, Skeletal ; Outcome Assessment, Health Care ; Respiration, Artificial ; Retrospective Studies ; Risk Factors ; Sarcopenia/complications ; Sarcopenia/diagnosis ; Sarcopenia/mortality ; Tomography, X-Ray Computed
Language	English
Publishing date	2021-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	219390-5
ISSN	1537-7385 ; 0002-9491 ; 0894-9115
ISSN (online)	1537-7385
ISSN	0002-9491 ; 0894-9115
DOI	10.1097/PHM.0000000000001716
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Article ; Online: Diversity of HLA Class I and Class II blocks and conserved extended haplotypes in Lacandon Mayans.

Barquera, Rodrigo / Zuniga, Joaquin / Flores-Rivera, José / Corona, Teresa / Penman, Bridget S / Hernández-Zaragoza, Diana Iraíz / Soler, Manuel / Jonapá-Gómez, Letisia / Mallempati, Kalyan C / Yescas, Petra / Ochoa-Morales, Adriana / Barsakis, Konstantinos / Aguilar-Vázquez, José Artemio / García-Lechuga, Maricela / Mindrinos, Michael / Yunis, María / Jiménez-Alvarez, Luis / Mena-Hernández, Lourdes / Ortega, Esteban /

Cruz-Lagunas, Alfredo / Tovar-Méndez, Víctor Hugo / Granados, Julio / Fernández-Viña, Marcelo / Yunis, Edmond

Scientific reports

2020 Volume 10, Issue 1, Page(s) 3248

Abstract: Here we studied HLA blocks and haplotypes in a group of 218 Lacandon Maya Native American using a high-resolution next generation sequencing (NGS) method. We assessed the genetic diversity of HLA class I and class II in this population, and determined ... ...

Abstract	Here we studied HLA blocks and haplotypes in a group of 218 Lacandon Maya Native American using a high-resolution next generation sequencing (NGS) method. We assessed the genetic diversity of HLA class I and class II in this population, and determined the most probable ancestry of Lacandon Maya HLA class I and class II haplotypes. Importantly, this Native American group showed a high degree of both HLA homozygosity and linkage disequilibrium across the HLA region and also lower class II HLA allelic diversity than most previously reported populations (including other Native American groups). Distinctive alleles present in the Lacandon population include HLA-A24:14 and HLA-B40:08. Furthermore, in Lacandons we observed a high frequency of haplotypes containing the allele HLA-DRB1*04:11, a relatively frequent allele in comparison with other neighboring indigenous groups. The specific demographic history of the Lacandon population including inbreeding, as well as pathogen selection, may have elevated the frequencies of a small number of HLA class II alleles and DNA blocks. To assess the possible role of different selective pressures in determining Native American HLA diversity, we evaluated the relationship between genetic diversity at HLA-A, HLA-B and HLA-DRB1 and pathogen richness for a global dataset and for Native American populations alone. In keeping with previous studies of such relationships we included distance from Africa as a covariate. After correction for multiple comparisons we did not find any significant relationship between pathogen diversity and HLA genetic diversity (as measured by polymorphism information content) in either our global dataset or the Native American subset of the dataset. We found the expected negative relationship between genetic diversity and distance from Africa in the global dataset, but no relationship between HLA genetic diversity and distance from Africa when Native American populations were considered alone.
MeSH term(s)	Adolescent ; Adult ; Africa ; Alleles ; Female ; Gene Frequency ; Genetic Variation ; Genetics, Population ; Genotype ; Geography ; HLA-A Antigens/genetics ; HLA-B Antigens/genetics ; HLA-DRB1 Chains/genetics ; Haplotypes ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class II/genetics ; Homozygote ; Humans ; Linkage Disequilibrium ; Male ; Mexico/ethnology ; Middle Aged ; Principal Component Analysis ; Young Adult ; American Indian or Alaska Native
Chemical Substances	HLA-A Antigens ; HLA-B Antigens ; HLA-DRB1 Chains ; Histocompatibility Antigens Class I ; Histocompatibility Antigens Class II
Language	English
Publishing date	2020-02-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-58897-5
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Article ; Online: Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population.

Romero-Hidalgo, Sandra / Flores-Rivera, José / Rivas-Alonso, Verónica / Barquera, Rodrigo / Villarreal-Molina, María Teresa / Antuna-Puente, Bárbara / Macias-Kauffer, Luis Rodrigo / Villalobos-Comparán, Marisela / Ortiz-Maldonado, Jair / Yu, Neng / Lebedeva, Tatiana V / Alosco, Sharon M / García-Rodríguez, Juan Daniel / González-Torres, Carolina / Rosas-Madrigal, Sandra / Ordoñez, Graciela / Guerrero-Camacho, Jorge Luis / Treviño-Frenk, Irene / Escamilla-Tilch, Monica /

García-Lechuga, Maricela / Tovar-Méndez, Víctor Hugo / Pacheco-Ubaldo, Hanna / Acuña-Alonzo, Victor / Bortolini, Maria-Cátira / Gallo, Carla / Bedoya, Gabriel / Rothhammer, Francisco / González-Jose, Rolando / Ruiz-Linares, Andrés / Canizales-Quinteros, Samuel / Yunis, Edmond / Granados, Julio / Corona, Teresa

Scientific reports

2020 Volume 10, Issue 1, Page(s) 13706

Abstract: Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, ... ...

Abstract	Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10
MeSH term(s)	American Natives/genetics ; Aquaporin 4/genetics ; Case-Control Studies ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; HLA Antigens/genetics ; Humans ; Male ; Mexico/epidemiology ; Neuromyelitis Optica/epidemiology ; Neuromyelitis Optica/genetics
Chemical Substances	AQP4 protein, human ; Aquaporin 4 ; HLA Antigens
Language	English
Publishing date	2020-08-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-69224-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pituitary Infiltration by Lymphoma.

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Article: Heterogeneity of Genetic Admixture Determines SLE Susceptibility in Mexican.

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Article ; Online: Correction: In-hospital mortality from severe COVID-19 in a tertiary care center in Mexico City; causes of death, risk factors and the impact of hospital saturation.

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Article ; Online: In-hospital mortality from severe COVID-19 in a tertiary care center in Mexico City; causes of death, risk factors and the impact of hospital saturation.

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Article ; Online: Low Thoracic Skeletal Muscle Area Is Not Associated With Negative Outcomes in Patients With COVID-19.

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Article ; Online: Diversity of HLA Class I and Class II blocks and conserved extended haplotypes in Lacandon Mayans.

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Article ; Online: Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population.

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