Article ; Online: Etiological Roles of p75
2023 Volume 12, Issue 2
Abstract: Choroidal neovascularization (CNV) is a pathological angiogenesis of the choroidal plexus of the retina and is a key feature in the wet form of age-related macular degeneration. Mononuclear phagocytic cells (MPCs) are known to accumulate in the ... ...
| Abstract | Choroidal neovascularization (CNV) is a pathological angiogenesis of the choroidal plexus of the retina and is a key feature in the wet form of age-related macular degeneration. Mononuclear phagocytic cells (MPCs) are known to accumulate in the subretinal space, generating a chronic inflammatory state that promotes the growth of the choroidal neovasculature. However, how the MPCs are recruited and activated to promote CNV pathology is not fully understood. Using genetic and pharmacological tools in a mouse model of laser-induced CNV, we demonstrate a role for the p75 neurotrophin receptor (p75 |
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| MeSH term(s) | Mice ; Animals ; Wet Macular Degeneration/metabolism ; Retina/metabolism ; Receptor, Nerve Growth Factor/genetics ; Choroidal Neovascularization/metabolism ; Mice, Knockout ; Disease Models, Animal |
| Chemical Substances | Receptor, Nerve Growth Factor |
| Language | English |
| Publishing date | 2023-01-12 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2661518-6 |
| ISSN | 2073-4409 ; 2073-4409 |
| ISSN (online) | 2073-4409 |
| ISSN | 2073-4409 |
| DOI | 10.3390/cells12020297 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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