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  1. Article: A Rare Case Report of Granular Cell Tumour of the Abdominal Wall and a Review of the Literature.

    Mangan, Simone H / Ng, Jessica Y / Townend, Philip

    Cureus

    2024  Volume 16, Issue 2, Page(s) e54399

    Abstract: Granular cell tumours (GCTs) are rare soft tissue tumours of neural origin. They have been reported in multiple anatomical sites. However, only 14 cases worldwide have been reported arising from the abdominal wall. While they can clinically manifest in a ...

    Abstract Granular cell tumours (GCTs) are rare soft tissue tumours of neural origin. They have been reported in multiple anatomical sites. However, only 14 cases worldwide have been reported arising from the abdominal wall. While they can clinically manifest in a variety of ways, often they present as a small, slow-growing nodule with benign features. They can, however, be malignant, and in rare cases, they have been reported to metastasise. Here, we present a case of a rare abdominal wall GCT, which was managed with local excision. The purpose of this paper is to report the patient's clinical history, presentation, and surgical management, as well as to review the current literature to highlight the existence of this rare entity and the possibility that this may occur and should be considered a differential diagnosis in clinical practice.
    Language English
    Publishing date 2024-02-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.54399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Open sandwich mesh repair of a large recurrent incisional flank hernia.

    Tran, Elisa / Summers, Zara / Parker, David / Townend, Philip

    BMJ case reports

    2024  Volume 17, Issue 4

    MeSH term(s) Humans ; Surgical Mesh ; Incisional Hernia/surgery ; Herniorrhaphy/methods ; Recurrence ; Male ; Female ; Hernia, Ventral/surgery ; Aged
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-259361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Current management of gastro-oesophageal reflux disease-treatment costs, safety profile, and effectiveness: a narrative review.

    Lata, Tahmina / Trautman, Jodie / Townend, Philip / Wilson, Robert B

    Gastroenterology report

    2023  Volume 11, Page(s) goad008

    Abstract: Background: The purpose of this study was to review the current management of gastro-oesophageal reflux disease (GORD), including treatment costs, safety profile and effectiveness.: Methods: A literature review was performed of randomized-controlled ... ...

    Abstract Background: The purpose of this study was to review the current management of gastro-oesophageal reflux disease (GORD), including treatment costs, safety profile and effectiveness.
    Methods: A literature review was performed of randomized-controlled trials, systematic reviews, Cochrane reports and National/Societal guidelines of the medical, endoscopic and surgical management of GORD. Proton pump inhibitor (PPI) prescribing patterns and expenditure were reviewed in different countries, including Australia, Canada, New Zealand, UK and USA.
    Results: Proton pump inhibitors (PPIs) are primarily indicated for control of GORD, Helicobacter pylori eradication (combined with antibiotics), preventing NSAID-induced gastrointestinal bleeding and treating peptic ulcer disease. There is widespread overprescribing of PPIs in Western and Eastern nations in terms of indication and duration, with substantial expense for national health providers. Despite a favourable short-term safety profile, there are observational associations of adverse effects with long-term PPIs. These include nutrient malabsorption, enteric infections and cardiovascular events. The prevalence of PPI use makes their long-term safety profile clinically relevant. Cost-benefit, symptom control and quality-of-life outcomes favour laparoscopic fundoplication rather than chronic PPI treatment. Laparoscopic fundoplication in long-term management of PPI-responsive GORD is supported by SAGES, NICE and ACG, and PPI-refractory GORD by AGA and SAGES guidelines. The importance of establishing a definitive diagnosis prior to invasive management is emphasized, especially in PPI-refractory heartburn.
    Conclusions: We examined evidence-based guidelines for PPI prescribing and deprescribing in primary care and hospital settings and the need for PPI stewardship and education of health professionals. This narrative review presents the advantages and disadvantages of surgical, endoscopic and medical management of GORD, which may assist in shared decision making and treatment choice in individual patients.This paper was presented (GS020) at the 88th RACS Annual Scientific Conference, 6-10 May, 2019.
    Language English
    Publishing date 2023-04-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2710871-5
    ISSN 2052-0034
    ISSN 2052-0034
    DOI 10.1093/gastro/goad008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A case series of bread clip ingestions.

    Chuang, Fred J / Townend, Philip J / Cooper, Michelle L

    Journal of surgical case reports

    2022  Volume 2022, Issue 6, Page(s) rjac163

    Abstract: The bread clip is one of the most insidious foreign body ingested. The bread clip poses a serious medical danger to patients yet may often fail to manifest itself clinically on initial ingestion. We present a case series of three patients with bread ... ...

    Abstract The bread clip is one of the most insidious foreign body ingested. The bread clip poses a serious medical danger to patients yet may often fail to manifest itself clinically on initial ingestion. We present a case series of three patients with bread clips ingestions that were managed in the Gold Coast University Hospital, Queensland, Australia between 2020 and 2021. Bread clips are not always readily identifiable depending on imaging and the management of these patients will often require a multidisciplinary approach between the surgeons, gastroenterologists and radiologists.
    Language English
    Publishing date 2022-06-16
    Publishing country England
    Document type Case Reports
    ZDB-ID 2580919-2
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjac163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Association between neutrophil-lymphocyte ratio and lymph node metastasis in gastric cancer: A meta-analysis.

    Kotecha, Krishna / Singla, Animesh / Townend, Philip / Merrett, Neil

    Medicine

    2022  Volume 101, Issue 25, Page(s) e29300

    Abstract: Introduction and aim: The prognostic role of neutrophil to lymphocyte ratio (NLR) has been explored extensively in the literature. The aim of this meta-analysis was to evaluate the link between NLR and lymph node metastasis in gastric cancer. A method ... ...

    Abstract Introduction and aim: The prognostic role of neutrophil to lymphocyte ratio (NLR) has been explored extensively in the literature. The aim of this meta-analysis was to evaluate the link between NLR and lymph node metastasis in gastric cancer. A method for increasing specificity and sensitivity of pre-treatment staging has implications on treatment algorithms and survival.
    Search strategy: The relevant databases were searched as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses flowchart. After selection, 12 full text articles that met the inclusion criteria were included for quantitative analysis. 2 × 2 squares were generated using lymph node positive/negative, and NLR high/low data. The effect size for each study was calculated using the DerSimonian-Laird random effects model. P values were calculated using the chi-square method. Finally publication bias was evaluated. All statistics were calculated using R Studio.
    Results: Meta-analysis showed a 1.90 times (odds ratio, with 95% CI 1.52-2.38) increase in risk of positive lymph node status with high neutrophil to lymphocyte ratio. This has significant implications for cancer screening and staging, as NLR is a highly reproducible, cost-effective, and widely available prognostic factor for gastric cancer patients. Additionally, high or low NLR values may have implications for management pathways. Patients with lymph node metastasis can be offered neoadjuvant chemotherapy, avoiding salvage therapy in the form of adjuvant chemoradiotherapy, which is poorly tolerated.
    Conclusion: This meta-analysis shows an association between NLR and positive lymph node status in gastric cancer patients with implications for staging, as well as preoperative personalisation of therapy.
    MeSH term(s) Humans ; Lymphatic Metastasis/pathology ; Lymphocytes/pathology ; Neutrophils/pathology ; Prognosis ; Retrospective Studies ; Stomach Neoplasms/pathology ; Stomach Neoplasms/therapy
    Language English
    Publishing date 2022-06-24
    Publishing country United States
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000029300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Early oesophageal reconstruction post caustic injury.

    Yu, Zirong / Luong, David / Ibraheem, Christian / Townend, Philip J / Rutherford, Leigh / Jeyarajan, Eshwarshanker

    ANZ journal of surgery

    2021  Volume 92, Issue 7-8, Page(s) 1902–1904

    MeSH term(s) Burns, Chemical/surgery ; Caustics/toxicity ; Esophageal Diseases ; Esophageal Stenosis/chemically induced ; Esophageal Stenosis/surgery ; Humans
    Chemical Substances Caustics
    Language English
    Publishing date 2021-11-16
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.17370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Modified Longmire procedure: a novel approach to bile duct injury repair.

    Kotecha, Krishna / Kaushal, Devesh / Low, Willy / Townend, Philip / Das, Amitabha / Apostolou, Christos / Merrett, Neil

    ANZ journal of surgery

    2018  Volume 89, Issue 11, Page(s) E554–E555

    MeSH term(s) Anastomotic Leak/etiology ; Anastomotic Leak/surgery ; Cholangiopancreatography, Endoscopic Retrograde/methods ; Cholecystectomy, Laparoscopic/adverse effects ; Common Bile Duct/diagnostic imaging ; Common Bile Duct/injuries ; Common Bile Duct/pathology ; Female ; Humans ; Iatrogenic Disease ; Laparotomy/methods ; Laparotomy/trends ; Middle Aged ; Postoperative Complications/etiology ; Reoperation/trends ; Treatment Outcome
    Language English
    Publishing date 2018-10-22
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.14901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Bilateral extramedullary adrenal plasmacytoma: case report and review of the literature.

    Townend, Philip J / Kraus, Gabriel / Coyle, Luke / Nevell, David / Engelsman, Anton / Sidhu, Stan B

    International journal of endocrine oncology

    2017  Volume 4, Issue 2, Page(s) 67–73

    Abstract: Extramedullary plasmacytoma (EMP) accounts for only 3% of plasma cell malignancies; others include multiple myeloma, plasma cell leukemia and solitary plasmacytoma of bone. The majority of EMPs are found in the upper respiratory tract. Other sites ... ...

    Abstract Extramedullary plasmacytoma (EMP) accounts for only 3% of plasma cell malignancies; others include multiple myeloma, plasma cell leukemia and solitary plasmacytoma of bone. The majority of EMPs are found in the upper respiratory tract. Other sites include the GI tract, bladder, CNS, thyroid, breast, testes, parotid gland, lymph nodes and skin. There are eight cases in the literature of adrenal plasmacytoma, however, only two were bilateral. We describe our recent experience of bilateral adrenal plasmacytoma and review of the literature. While EMP may present as aggressive locally destructive lesions, excellent local control can be achieved in a majority of cases. Follow-up should be lifelong due to risk of progression to multiple myeloma.
    Language English
    Publishing date 2017-05-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2764624-5
    ISSN 2045-0877 ; 2045-0869
    ISSN (online) 2045-0877
    ISSN 2045-0869
    DOI 10.2217/ije-2016-0023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Impact of the American Thyroid Association guidelines on the Australian surgical management of papillary thyroid cancer.

    Cole-Clark, Dane / Townend, Philip J / Engelsman, Anton / Wong, Man-Shun / Sywak, Mark / Glover, Anthony / Sidhu, Stan B

    ANZ journal of surgery

    2018  Volume 88, Issue 11, Page(s) 1102–1103

    MeSH term(s) Australia ; Health Care Surveys ; Humans ; Practice Guidelines as Topic ; Practice Patterns, Physicians'/standards ; Practice Patterns, Physicians'/statistics & numerical data ; Societies, Medical ; Thyroid Cancer, Papillary/surgery ; Thyroid Neoplasms/surgery ; Thyroidectomy/methods ; Thyroidectomy/standards ; Thyroidectomy/statistics & numerical data ; United States
    Language English
    Publishing date 2018-11-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.14804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Acinar cell density at the pancreatic resection margin is associated with post-pancreatectomy pancreatitis and the development of postoperative pancreatic fistula.

    Nahm, Christopher B / Brown, Kai M / Townend, Philip J / Colvin, Emily / Howell, Viive M / Gill, Anthony J / Connor, Saxon / Samra, Jaswinder S / Mittal, Anubhav

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2018  Volume 20, Issue 5, Page(s) 432–440

    Abstract: Background: There has been recent evidence supporting post-pancreatectomy pancreatitis as a factor in the development of postoperative pancreatic fistula (POPF). The aims of this study were to evaluate: (i) the correlation of the acinar cell density at ... ...

    Abstract Background: There has been recent evidence supporting post-pancreatectomy pancreatitis as a factor in the development of postoperative pancreatic fistula (POPF). The aims of this study were to evaluate: (i) the correlation of the acinar cell density at the pancreatic resection margin with the intra-operative amylase concentration (IOAC) of peri-pancreatic fluid, postoperative pancreatitis, and POPF; and (ii) the association between postoperative pancreatitis on the first postoperative day and POPF.
    Methods: Consecutive patients who underwent pancreatic resection between June 2016 and July 2017 were included for analysis. Fluid for IOAC was collected, and amylase concentration was determined in drain fluid on postoperative days 1, 3, and 5. Serum amylase and lipase and urinary trypsinogen-2 concentrations were determined on the first postoperative day. Histology slides of the pancreatic resection margin were scored for acinar cell density.
    Results: Sixty-one patients were included in the analysis. Acinar cell density significantly correlated with IOAC (r = 0.566, p < 0.001), and was significantly associated with postoperative pancreatitis (p < 0.001), and POPF (p = 0.003). Postoperative pancreatitis was significantly associated with the development of POPF (OR 17.81, 95%CI 2.17-145.9, p = 0.001).
    Discussion: The development of POPF may involve a complex interaction between acinar cell density, immediate leakage of pancreatic fluid, and postoperative pancreatitis.
    MeSH term(s) Acinar Cells/enzymology ; Acinar Cells/pathology ; Adult ; Aged ; Aged, 80 and over ; Amylases/blood ; Biomarkers/blood ; Biomarkers/urine ; Biopsy ; Female ; Humans ; Lipase/blood ; Male ; Margins of Excision ; Middle Aged ; Pancreatectomy/adverse effects ; Pancreatic Fistula/enzymology ; Pancreatic Fistula/etiology ; Pancreatic Fistula/pathology ; Pancreaticoduodenectomy/adverse effects ; Pancreatitis/enzymology ; Pancreatitis/etiology ; Pancreatitis/pathology ; Risk Factors ; Time Factors ; Treatment Outcome ; Trypsin/urine ; Trypsinogen/urine
    Chemical Substances Biomarkers ; PRSS2 protein, human (103964-84-7) ; Trypsinogen (9002-08-8) ; Lipase (EC 3.1.1.3) ; PNLIP protein, human (EC 3.1.1.3) ; Amylases (EC 3.2.1.-) ; Trypsin (EC 3.4.21.4)
    Language English
    Publishing date 2018-01-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1016/j.hpb.2017.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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