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  1. Article ; Online: Low surveillance receipt in cirrhotic patients with cured HCV: Where are the barriers?

    Toyoda, Hidenori

    Liver international : official journal of the International Association for the Study of the Liver

    2023  Volume 43, Issue 5, Page(s) 962–963

    MeSH term(s) Humans ; Antiviral Agents/therapeutic use ; Liver Neoplasms ; Liver Cirrhosis/complications ; Hepatitis C/complications ; Hepatitis C/drug therapy ; Hepacivirus
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1632: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The Essence of Clinical Practice Guidelines for Lumbar Disc Herniation, 2021: 5. Prognosis.

    Toyoda, Hiromitsu

    Spine surgery and related research

    2022  Volume 6, Issue 4, Page(s) 333–336

    Language English
    Publishing date 2022-07-27
    Publishing country Japan
    Document type Journal Article
    ISSN 2432-261X
    ISSN (online) 2432-261X
    DOI 10.22603/ssrr.2022-0046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Sofosbuvir/velpatasvir and glecaprevir/pibrentasvir: how should we choose among these two latest and probably the last regimens?

    Toyoda, Hidenori

    Hepatology research : the official journal of the Japan Society of Hepatology

    2022  Volume 52, Issue 10, Page(s) 815–816

    Language English
    Publishing date 2022-09-29
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 1387041-5
    ISSN 1386-6346 ; 0928-4346
    ISSN 1386-6346 ; 0928-4346
    DOI 10.1111/hepr.13828
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3826: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: CB1 cannabinoid receptor-mediated plasticity of GABAergic synapses in the mouse insular cortex.

    Toyoda, Hiroki

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 7187

    Abstract: The insular cortex plays pivotal roles in taste learning. As cellular mechanisms of taste learning, long-term potentiation (LTP) at glutamatergic synapses is well studied. However, little is known about long-term changes of synaptic efficacy at GABAergic ...

    Abstract The insular cortex plays pivotal roles in taste learning. As cellular mechanisms of taste learning, long-term potentiation (LTP) at glutamatergic synapses is well studied. However, little is known about long-term changes of synaptic efficacy at GABAergic synapses in the insular cortex. Here, we examined the synaptic mechanisms of long-term plasticity at GABAergic synapses in layer V pyramidal neurons of the mouse insular cortex. In response to a prolonged high-frequency stimulation (HFS), GABAergic synapses displayed endocannabinod (eCB)-mediated long-term depression (LTD
    MeSH term(s) Animals ; Cerebral Cortex/metabolism ; GABAergic Neurons/metabolism ; Long-Term Potentiation ; Male ; Mice ; Nitric Oxide/metabolism ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Receptor, Cannabinoid, CB1/metabolism ; Signal Transduction ; Synapses/metabolism
    Chemical Substances CNR1 protein, mouse ; Receptor, Cannabinoid, CB1 ; Nitric Oxide (31C4KY9ESH)
    Keywords covid19
    Language English
    Publishing date 2020-04-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-64236-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Insect Physical Control: Electric Field-Based Pest Management Approach.

    Toyoda, Hideyoshi

    Insects

    2020  Volume 11, Issue 8

    Abstract: The Special Issue 'Insect physical control: electric field-based pest management approach' was launched to showcase valuable new research on pest control using applied electrostatic engineering. Some phenomena generated in static and dynamic electric ... ...

    Abstract The Special Issue 'Insect physical control: electric field-based pest management approach' was launched to showcase valuable new research on pest control using applied electrostatic engineering. Some phenomena generated in static and dynamic electric fields can be used to build new devices to capture or kill target insects using an attractive force or a force striking insects entering an electric field. This research field is new, and there are few researchers currently working within it. Consequently, this editorial introduces the history and general principles of electric field generation. I then discuss future directions for this field.
    Language English
    Publishing date 2020-07-29
    Publishing country Switzerland
    Document type Editorial
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects11080480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Management of dialysis patients with hepatitis C virus in the era of direct-acting antiviral therapy.

    Toyoda, Hidenori / Kikuchi, Kan

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

    2023  Volume 27, Issue 5, Page(s) 831–838

    Abstract: The clinical use of direct-acting antivirals (DAAs) for hepatitis C virus (HCV) infection has dramatically changed management of patients with HCV liver disease since 2014; this is also true for patients undergoing dialysis. Due to the high tolerability ... ...

    Abstract The clinical use of direct-acting antivirals (DAAs) for hepatitis C virus (HCV) infection has dramatically changed management of patients with HCV liver disease since 2014; this is also true for patients undergoing dialysis. Due to the high tolerability and antiviral efficacy of anti-HCV therapy, most dialysis patients with HCV infection should currently be candidates for this treatment. Many patients with HCV antibodies no longer have HCV infection, and it is difficult to identify patients with actual HCV infection based only on HCV antibody assays. Despite the high rate of successful HCV eradication, the risk of liver-related events such as hepatocellular carcinoma (HCC), the major complication of HCV infection, persists even after HCV cure, and patients at risk of HCC should undergo continuous HCC surveillance. Finally, the rarity of HCV reinfection and the survival benefit of HCV eradication in dialysis patients should be explored in further studies.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular ; Antiviral Agents/therapeutic use ; Hepacivirus ; Liver Neoplasms/complications ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Renal Dialysis/adverse effects ; Hepatitis C/drug therapy ; Hepatitis C/complications
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-05-22
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2119809-3
    ISSN 1744-9987 ; 1091-6660 ; 1744-9979
    ISSN (online) 1744-9987
    ISSN 1091-6660 ; 1744-9979
    DOI 10.1111/1744-9987.14003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Authors response to Management of dialysis patients with hepatitis C virus in the era of direct-acting antiviral therapy.

    Toyoda, Hidenori / Kikuchi, Kan

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

    2023  Volume 28, Issue 1, Page(s) 160–161

    MeSH term(s) Humans ; Antiviral Agents/therapeutic use ; Hepacivirus ; Hepatitis C, Chronic/drug therapy ; Renal Dialysis ; Hepatitis C/drug therapy
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-09-28
    Publishing country Australia
    Document type Letter
    ZDB-ID 2119809-3
    ISSN 1744-9987 ; 1091-6660 ; 1744-9979
    ISSN (online) 1744-9987
    ISSN 1091-6660 ; 1744-9979
    DOI 10.1111/1744-9987.14070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Direct-acting antiviral therapy for chronic hepatitis C virus genotype 4 infection: Exploring new regimens.

    Toyoda, Hidenori

    Health science reports

    2019  Volume 2, Issue 3, Page(s) e106

    Abstract: The optimal antiviral regimen for hepatitis C virus (HCV) genotype 4 is still a subject of investigation. The report in this issue ... ...

    Abstract The optimal antiviral regimen for hepatitis C virus (HCV) genotype 4 is still a subject of investigation. The report in this issue of
    Language English
    Publishing date 2019-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 2398-8835
    ISSN (online) 2398-8835
    DOI 10.1002/hsr2.106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Interaction of nicotinic acetylcholine receptors with dopamine receptors in synaptic plasticity of the mouse insular cortex.

    Toyoda, Hiroki

    Synapse (New York, N.Y.)

    2019  Volume 73, Issue 7, Page(s) e22094

    Abstract: The insular cortex plays essential roles in nicotine addiction. However, much is still unknown about its cellular and synaptic mechanisms responsible for nicotine addiction. We have previously shown that in layer 5 pyramidal neurons of the mouse insular ... ...

    Abstract The insular cortex plays essential roles in nicotine addiction. However, much is still unknown about its cellular and synaptic mechanisms responsible for nicotine addiction. We have previously shown that in layer 5 pyramidal neurons of the mouse insular cortex, activation of the nicotinic acetylcholine receptors (nAChRs) suppresses synaptic potentiation through enhancing GABAergic synaptic transmission, although it enhances both glutamatergic and GABAergic synaptic transmission. In the present study, we examined whether dopamine receptors might contribute to the nicotine-induced inhibition of synaptic potentiation. The nicotine-induced inhibition of synaptic potentiation was decreased in the presence of a D1 dopamine receptor antagonist SCH23390 irrespective of the presence of a D2 dopamine receptor antagonist sulpiride, suggesting that D1 dopamine receptors are involved in nicotine-induced inhibition. We also investigated how dopamine receptors might contribute to the nAChR-induced enhancement of glutamatergic and GABAergic synaptic transmission. The nAChR-induced enhancement of GABAergic synaptic transmission was decreased in the presence of SCH23390 irrespective of the presence of sulpiride, whereas that of glutamatergic synaptic transmission was not altered in the presence of SCH23390 and sulpiride. These results suggest that D1 dopamine receptors are involved in the nAChR-induced enhancement of GABAergic synaptic transmission while dopamine receptors are not involved in that of glutamatergic synaptic transmission. These observations indicate that the interaction between nAChRs and D1 dopamine receptors plays critical roles in synaptic activities in layer 5 pyramidal neurons of the mouse insular cortex. These insular synaptic changes might be associated with nicotine addiction.
    MeSH term(s) Animals ; Cerebral Cortex/drug effects ; Cerebral Cortex/metabolism ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Neuronal Plasticity/drug effects ; Neuronal Plasticity/physiology ; Nicotine/pharmacology ; Receptors, Dopamine/metabolism ; Receptors, Nicotinic/metabolism ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology ; Tobacco Use Disorder/metabolism
    Chemical Substances Receptors, Dopamine ; Receptors, Nicotinic ; Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2019-02-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639061-4
    ISSN 1098-2396 ; 0885-8276 ; 0887-4476
    ISSN (online) 1098-2396
    ISSN 0885-8276 ; 0887-4476
    DOI 10.1002/syn.22094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2222: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Role of nicotinic acetylcholine receptors for modulation of microcircuits in the agranular insular cortex.

    Toyoda, Hiroki

    Journal of oral biosciences

    2018  Volume 61, Issue 1, Page(s) 5–11

    Abstract: Background: Acetylcholine (ACh) plays key roles in regulating neuronal excitability throughout the brain by acting muscarinic ACh receptors (mAChRs) and nicotinic ACh receptors (nAChRs). The insular cortex is an important brain region associated with ... ...

    Abstract Background: Acetylcholine (ACh) plays key roles in regulating neuronal excitability throughout the brain by acting muscarinic ACh receptors (mAChRs) and nicotinic ACh receptors (nAChRs). The insular cortex is an important brain region associated with sensory perception, self-awareness, cognitive function, motor control, and drug addiction. The insular cortex receives cholinergic inputs from the basal forebrain, the activation of which stimulates mAChRs and nAChRs in the insular cortex and modulates its microcircuits to perform various functions. Therefore, it is crucial to understand the cholinergic modulation of microcircuits in the insular cortex. To date, we have been focused on the role of nAChRs in modulating neural circuits in the mouse agranular insular cortex.
    Highlight: In this review, we present data on cholinergic inputs to neocortical regions, including the insular cortex, and characteristics of mAChRs and nAChRs. In addition, we describe which type of neurons express functional nAChRs in layer III, V, and VI of the mouse agranular insular cortex and how activation of nAChRs regulates synaptic transmission and plasticity in the layer III, V, and VI pyramidal cells.
    Conclusion: The activation of nAChRs layer specifically modulates synaptic transmission and plasticity in the mouse agranular insular cortex. These synaptic mechanisms are critical to understand the modulating effects of ACh or nicotine on physiological and pathophysiological functions associated with the insular cortex.
    MeSH term(s) Acetylcholine ; Animals ; Cerebral Cortex ; Mice ; Pyramidal Cells ; Receptors, Nicotinic ; Synaptic Transmission
    Chemical Substances Receptors, Nicotinic ; Acetylcholine (N9YNS0M02X)
    Language English
    Publishing date 2018-12-21
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2218267-6
    ISSN 1880-3865 ; 1349-0079
    ISSN (online) 1880-3865
    ISSN 1349-0079
    DOI 10.1016/j.job.2018.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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