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  1. Article ; Online: Viral, Host Factors or Both as Coronavirus Disease 2019 (COVID-19) Biomarkers.

    Trøseid, Marius

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  

    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad779
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  2. Article ; Online: When COVID-19 meets the African health service.

    Trøseid, Marius

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

    2020  Volume 140, Issue 7

    Title translation Når covid-19 møter afrikansk helsevesen.
    MeSH term(s) Africa ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Delivery of Health Care ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language Norwegian
    Publishing date 2020-04-06
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 603504-8
    ISSN 0807-7096 ; 0029-2001
    ISSN (online) 0807-7096
    ISSN 0029-2001
    DOI 10.4045/tidsskr.20.0283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 422: Show issues Location:
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    Zs.MO 546: Show issues

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  3. Article ; Online: Which trial do we need? Management of elderly, fragile, fully vaccinated patients hospitalized for SARS-CoV-2 infection.

    Trøseid, Marius / Arribas, Jose R

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Volume 29, Issue 4, Page(s) 419–421

    MeSH term(s) Aged ; Humans ; COVID-19/prevention & control ; SARS-CoV-2
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4541: Show issues Location:
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    Zs.MO 284: Show issues

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  4. Article ; Online: Bone marrow transplantation – a cure for HIV?

    Trøseid, Marius

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

    2019  Volume 139, Issue 7

    Title translation Benmargstransplantasjon – en kur mot hiv?
    MeSH term(s) Bone Marrow Transplantation ; HIV Infections/therapy ; Humans ; Stem Cell Transplantation ; Transplantation, Homologous
    Language Norwegian
    Publishing date 2019-03-22
    Publishing country Norway
    Document type Editorial
    ZDB-ID 603504-8
    ISSN 0807-7096 ; 0029-2001
    ISSN (online) 0807-7096
    ISSN 0029-2001
    DOI 10.4045/tidsskr.19.0199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 422: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 546: Show issues

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  6. Article ; Online: Gut microbiota and acute coronary syndromes: ready for use in the emergency room?

    Trøseid, Marius

    European heart journal

    2017  Volume 38, Issue 11, Page(s) 825–827

    MeSH term(s) Acute Coronary Syndrome ; Emergency Service, Hospital ; Gastrointestinal Microbiome ; Humans ; Methylamines ; Prognosis ; Risk Factors
    Chemical Substances Methylamines ; trimethyloxamine (FLD0K1SJ1A)
    Language English
    Publishing date 2017-02-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehx005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1563: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 640: Show issues

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  7. Article ; Online: Phenylacetylglutamine From the Gut Microbiota: A Future Therapeutic Target in Heart Failure?

    Awoyemi, Ayodeji / Hov, Johannes R / Trøseid, Marius

    Circulation. Heart failure

    2022  Volume 16, Issue 1, Page(s) e010222

    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Heart Failure/drug therapy ; Glutamine ; Dysbiosis
    Chemical Substances phenylacetylglutamine (92358I79RG) ; Glutamine (0RH81L854J)
    Language English
    Publishing date 2022-12-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2429459-7
    ISSN 1941-3297 ; 1941-3289
    ISSN (online) 1941-3297
    ISSN 1941-3289
    DOI 10.1161/CIRCHEARTFAILURE.122.010222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6745: Show issues Location:
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  8. Article ; Online: Bremsemedisiner mot hivinfeksjon.

    Troseid, Marius

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

    2015  Volume 135, Issue 11, Page(s) 1054

    Title translation Antiretroviral drugs against HIV infections.
    MeSH term(s) Antiretroviral Therapy, Highly Active/classification ; Humans ; Norway ; Terminology as Topic
    Language Norwegian
    Publishing date 2015-06-16
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 603504-8
    ISSN 0807-7096 ; 0029-2001
    ISSN (online) 0807-7096
    ISSN 0029-2001
    DOI 10.4045/tidsskr.15.0156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 422: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 546: Show issues

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  9. Article ; Online: Experiences and challenges with the new European Clinical Trials Regulation.

    Patrick-Brown, Thale D J H / Bourner, Josephine / Kali, Sabrina / Trøseid, Marius / Yazdanpanah, Yazdan / Olliaro, Piero / Olsen, Inge Christoffer

    Trials

    2024  Volume 25, Issue 1, Page(s) 3

    Abstract: Background: The new European Medicines Agency (EMA) Clinical Trials Information System (CTIS), based on the Clinical Trials Regulation (CTR EU 536/2014), came into full effect on 31 January 2022 and was intended to provide an easier, more streamlined ... ...

    Abstract Background: The new European Medicines Agency (EMA) Clinical Trials Information System (CTIS), based on the Clinical Trials Regulation (CTR EU 536/2014), came into full effect on 31 January 2022 and was intended to provide an easier, more streamlined approach to the registration of clinical trials taking place in Europe. Using the experience gained on the new regulatory framework from three multi-national European clinical research studies of outbreak-prone infectious diseases, this article describes the advantages and shortcomings of the new clinical trial submission procedure.
    Methods: We report the time to approval, size of the application dossier, and number of requests for information (RFIs) for each study. We also explore the experience of each study within the regulatory framework and its use of CTIS to document the real-world, practical consequences of the system on individual studies. The study assesses the experience of three multi-country studies conducted in Europe working within the EU and non-EU regulatory environments.
    Results: While the time to regulatory and ethical approval has improved since the implementation of the new regulation, the timelines for approvals are still unacceptably slow, particularly for studies being conducted in the context of an evolving outbreak. Within the new regulatory approval procedure, there is evidence of conflicting application requirements, increased document burden, barriers to submitting important modifications, and debilitating technical hurdles.
    Conclusions: CTIS promised to lower the administrative bar, but unfortunately this has not been achieved. There are challenges that need to be urgently confronted and addressed for international research collaborators to effectively manage health crises in the future. While the value of multi-national outbreak research is clear, the limitations and delays imposed by the system, which raise challenging ethical questions about the regulation, are prejudicial to all clinical research, especially publicly funded academic studies. This report is relevant to both regulators and clinical researchers. It is hoped that these findings can help improve pan-European clinical trials, especially for the purpose of epidemic preparedness and response.
    Trial registration: This paper references experiences gained during management of three pan-European trials: EU-SolidAct's Bari-SolidAct (CT No. 2022-500385-99-00 - 15 March 2022) and AXL-SolidAct (CT No. 2022-500363-12-00 - 19 April 2022), and MOSAIC (CT No. 2022-501132-42-00 - 22 June 2022).
    MeSH term(s) Humans ; Europe ; Forecasting ; Clinical Trials as Topic
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-023-07869-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Fatty Acids Composition and HIV Infection: Altered Levels of n-6 Polyunsaturated Fatty Acids Are Associated with Disease Progression.

    Ueland, Thor / Waagsbø, Bjørn / Berge, Rolf K / Trøseid, Marius / Aukrust, Pål / Damås, Jan K

    Viruses

    2023  Volume 15, Issue 7

    Abstract: Fatty acids (FAs) are important regulators of immune responses and innate defense mechanisms. We hypothesized that disturbed FA metabolism could contribute to the progression of HIV infection. Plasma levels of 45 FAs were analyzed with gas chromatography ...

    Abstract Fatty acids (FAs) are important regulators of immune responses and innate defense mechanisms. We hypothesized that disturbed FA metabolism could contribute to the progression of HIV infection. Plasma levels of 45 FAs were analyzed with gas chromatography in healthy controls and HIV-infected patients with regard to Mycobacterium avium complex (MAC) infection. In vitro, we assessed MAC-PPD-induced release of inflammatory cytokines in peripheral and bone marrow mononuclear cells (PBMC and BMMC) according to levels of n-6 polyunsaturated fatty acids (PUFAs). While plasma saturated FAs were higher in HIV infection, PUFAs, and in particular the n-6 PUFA arachidonic acid (AA), were lower in patients with advanced disease. The ratio between AA and precursor dihomo-γ-linolenic acid, reflecting Δ5-desaturase activity, was markedly lower and inversely correlated with plasma HIV RNA levels in these patients. Depletion of AA was observed prior to MAC infection, and MAC-PPD-induced release of TNF and IL-6 in PBMC and BMMC was lower in patients with low plasma AA. Our findings suggest that dysregulated metabolism of n-6 PUFAs may play a role in the progression of HIV infection. While high AA may contribute to chronic inflammation in asymptomatic HIV-infected patients, low AA seems to increase the susceptibility to MAC infection in patients with advanced disease.
    MeSH term(s) Humans ; Fatty Acids, Omega-6 ; Fatty Acids ; HIV Infections ; Leukocytes, Mononuclear ; Fatty Acids, Unsaturated/analysis ; Arachidonic Acid ; Disease Progression
    Chemical Substances Fatty Acids, Omega-6 ; Fatty Acids ; Fatty Acids, Unsaturated ; Arachidonic Acid (27YG812J1I)
    Language English
    Publishing date 2023-07-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15071613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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