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  1. Book ; Online: Potential Neuromodulatory Profile of Phytocompounds in Brain Disorders

    Trabace, Luigia

    2017  

    Abstract: Natural and chemical compounds, often used as both dietary supplements and alternative medicines, are characterized by specific chemical properties, allowing their passage across the blood brain barrier with consequent specific effects on ... ...

    Abstract Natural and chemical compounds, often used as both dietary supplements and alternative medicines, are characterized by specific chemical properties, allowing their passage across the blood brain barrier with consequent specific effects on neurotransmission. In particular, several natural compounds have shown beneficial properties in the treatment of neuropsychiatric disorders, especially cognitive impairment and mood disorders, contributing to the maintenance of the physiological brain functioning by interacting with different receptors, transcription factors and signal transduction pathways. Neuroinflammation and oxidative stress have also been proposed as crucial contributors to brain dysfunction development, thus recent investigations have focused on novel therapeutic approaches based on the use of phytoderivates with neuroprotective properties. Thus, this Special Issue includes a collection of 11 papers, describing key findings for the identification of molecular mechanisms required for the development of potential and promising natural therapeutics for the treatment of psychiatric and neurodegenerative disorders
    Keywords Chemistry ; Therapeutics. Pharmacology
    Size 1 electronic resource (VIII, 212 p.)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020092581
    ISBN 9783038423171 ; 9783038423164 ; 3038423173 ; 3038423165
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Editorial: The role of alcohol in modifying behavior.

    Peters, Jamie / Trabace, Luigia / Di Giovanni, Giuseppe

    Frontiers in behavioral neuroscience

    2023  Volume 17, Page(s) 1175405

    Language English
    Publishing date 2023-03-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2023.1175405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Sex Differences in Inflammatory Diseases.

    Trabace, Luigia / Roviezzo, Fiorentina / Rossi, Antonietta

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 962869

    Language English
    Publishing date 2022-07-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.962869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of early life stress on psychiatric disorders: searching new biomarkers and innovative pharmacological targets.

    Trabace, Luigia

    Current pharmaceutical design

    2014  Volume 21, Issue 11, Page(s) 1357

    MeSH term(s) Biomarkers/metabolism ; Humans ; Mental Disorders/etiology ; Mental Disorders/psychology ; Risk Factors ; Stress, Psychological/complications ; Stress, Psychological/psychology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2014-11-20
    Publishing country United Arab Emirates
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/1381612821666150105150114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4714: Show issues Location:
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  5. Article: Monoaminergic System Modulation in Depression and Alzheimer's Disease: A New Standpoint?

    Morgese, Maria Grazia / Trabace, Luigia

    Frontiers in pharmacology

    2019  Volume 10, Page(s) 483

    Abstract: The prevalence of depression has dramatically increased, and it has been estimated that over 300 million people suffer from depression all over the world. Depression is highly comorbid with many central and peripheral disorders. In this regard, ... ...

    Abstract The prevalence of depression has dramatically increased, and it has been estimated that over 300 million people suffer from depression all over the world. Depression is highly comorbid with many central and peripheral disorders. In this regard, depressive states have been associated with the development of neurological disorders such as Alzheimer's disease (AD). Accordingly, depression is a risk factor for AD and depressive symptomatology is common in pre-clinical AD, representing an early manifestation of this disease. Neuropsychiatric symptoms may represent prodromal symptoms of dementia deriving from neurobiological changes in specific cerebral regions; thus, the search for common biological substrates is becoming an imperative and intriguing field of research. Soluble forms of beta amyloid peptide (Aβ) have been implicated both in the development of early memory deficits and neuropsychiatric symptoms. Indeed, soluble Aβ species have been shown to induce a depressive-like phenotype in AD animal models. Alterations in monoamine content are a common feature of these neuropathologies. Interestingly, serotonergic system modulation has been implicated in alteration of Aβ production. In addition, noradrenaline is considered crucially involved in compensatory mechanisms, leading to increased Aβ degradation
    Language English
    Publishing date 2019-05-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2019.00483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Soluble beta amyloid in a continuum from physiology to pathology: searching the determinants of its effects and designing new pharmacological treatments.

    Trabace, Luigia

    Current pharmaceutical design

    2013  Volume 20, Issue 15, Page(s) 2457

    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/etiology ; Amyloid beta-Peptides/physiology ; Animals ; Humans
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2013-07-09
    Publishing country United Arab Emirates
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/13816128113199990511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4714: Show issues Location:
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  7. Article ; Online: Increased stress vulnerability in the offspring of socially isolated rats: Behavioural, neurochemical and redox dysfunctions.

    Bove, Maria / Morgese, Maria Grazia / Dimonte, Stefania / Sikora, Vladyslav / Agosti, Lisa Pia / Palmieri, Maria Adelaide / Tucci, Paolo / Schiavone, Stefania / Trabace, Luigia

    Progress in neuro-psychopharmacology & biological psychiatry

    2024  Volume 131, Page(s) 110945

    Abstract: Stressful events during pregnancy impact on the progeny neurodevelopment. However, little is known about preconceptional stress effects. The rat social isolation represents an animal model of chronic stress inducing a variety of dysfunctions. Moreover, ... ...

    Abstract Stressful events during pregnancy impact on the progeny neurodevelopment. However, little is known about preconceptional stress effects. The rat social isolation represents an animal model of chronic stress inducing a variety of dysfunctions. Moreover, social deprivation during adolescence interferes with key neurodevelopmental processes. Here, we investigated the development of behavioural, neurochemical and redox alterations in the male offspring of socially isolated female rats before pregnancy, reared in group (GRP) or in social isolation (ISO) from weaning until young-adulthood. To this aim, females were reared in GRP or in ISO conditions, from PND21 to PND70, when they were mated. Their male offspring was housed in GRP or ISO conditions through adolescence and until PND70, when passive avoidance-PA, novel object recognition-NOR and open field-OF tests were performed. Levels of noradrenaline (NA), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), glutamate (GLU) and GABA were assessed in the prefrontal cortex (PFC). Moreover, cortical ROS levels were quantified, as well as NF-kB and the NADPH oxidase NOX2 expression, redox status (expressed as GSH:GSSG ratio) and SOD1 amount. A significant decrease of the latency time in the PA was observed in the offspring of ISO females. In the NOR test, while a significant increase in the exploratory activity towards the novel object was observed in the offspring of GRP females, no significant differences were found in the offspring of ISO females. No significant differences were found in the OF test among experimental groups. Theoffspring of ISO females showed increased NA and 5-HIAA levels, whereas in the offspring persistently housed in isolation condition from weaninguntil adulthood, we detected reduced 5-HT levels and ehnanced 5-HIAA amount. No significant changes in GLU concentrations were detected, while decreased GABA content was observed in the offspring of ISO females exposed to social isolation. Increased ROS levels as well as reduced NF-κB, NOX2 expression were detected in the offspring of ISO females. This was accompanied by reduced redox status and enhanced SOD1 levels. In conclusion, our results suggest that female exposure to chronic social stress before pregnancy might have a profound influence on the offspring neurodevelopment in terms of cognitive, neurochemical and redox-related alterations, identifying this specific time window for possible preventive and therapeutic strategies.
    MeSH term(s) Female ; Male ; Pregnancy ; Animals ; Rats ; Hydroxyindoleacetic Acid ; Reactive Oxygen Species ; Serotonin ; Superoxide Dismutase-1 ; Glutamic Acid ; NF-kappa B ; Norepinephrine ; Oxidation-Reduction ; gamma-Aminobutyric Acid
    Chemical Substances Hydroxyindoleacetic Acid (54-16-0) ; Reactive Oxygen Species ; Serotonin (333DO1RDJY) ; Superoxide Dismutase-1 (EC 1.15.1.1) ; Glutamic Acid (3KX376GY7L) ; NF-kappa B ; Norepinephrine (X4W3ENH1CV) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 781181-0
    ISSN 1878-4216 ; 0278-5846
    ISSN (online) 1878-4216
    ISSN 0278-5846
    DOI 10.1016/j.pnpbp.2024.110945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1342: Show issues Location:
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  8. Article ; Online: Sex-oriented perspectives in immunopharmacology.

    Cignarella, Andrea / Vegeto, Elisabetta / Bolego, Chiara / Trabace, Luigia / Conti, Lucia / Ortona, Elena

    Pharmacological research

    2023  Volume 197, Page(s) 106956

    Abstract: Several immunopharmacological agents are effective in the treatment of cancer and immune-mediated conditions, with a favorable impact on life expectancy and clinical outcomes for a large number of patients. Nevertheless, response variation and ... ...

    Abstract Several immunopharmacological agents are effective in the treatment of cancer and immune-mediated conditions, with a favorable impact on life expectancy and clinical outcomes for a large number of patients. Nevertheless, response variation and undesirable effects of these drugs represent major issues, and overall efficacy remains unpredictable. Males and females show a distinct difference in immune system responses, with females generally mounting stronger responses to a variety of stimuli. Therefore, exploring sex differences in the efficacy and safety of immunopharmacological agents would strengthen the practice of precision medicine. As a pharmacological target highlight, programmed cell death 1 ligand 1 (PD-L1) is the first functionally characterized ligand of the coinhibitory programmed death receptor 1 (PD-1). The PD-L1/PD-1 crosstalk plays an important role in the immune response and is relevant in cancer, infectious and autoimmune disease. Sex differences in the response to immune checkpoint inhibitors are well documented, with male patients responding better than female patients. Similarly, higher efficacy of and adherence to tumor necrosis factor inhibitors in chronic inflammatory conditions including rheumatoid arthritis and Crohn's disease have been reported in male patients. The pharmacological basis of sex-specific responses to immune system modulating drugs is actively investigated in other settings such as stroke and type 1 diabetes. Advances in therapeutics targeting the endothelium could soon be wielded against autoimmunity and metabolic disorders. Based on the established sexual dimorphism in immune-related pathophysiology and disease presentation, sex-specific immunopharmacological protocols should be integrated into clinical guidelines.
    MeSH term(s) Humans ; Male ; Female ; B7-H1 Antigen ; Programmed Cell Death 1 Receptor ; Neoplasms/drug therapy ; Immune Checkpoint Inhibitors/therapeutic use ; Autoimmunity
    Chemical Substances B7-H1 Antigen ; Programmed Cell Death 1 Receptor ; Immune Checkpoint Inhibitors
    Language English
    Publishing date 2023-10-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2023.106956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 721: Show issues Location:
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  9. Article ; Online: Small Molecules: Therapeutic Application in Neuropsychiatric and Neurodegenerative Disorders.

    Schiavone, Stefania / Trabace, Luigia

    Molecules (Basel, Switzerland)

    2018  Volume 23, Issue 2

    Abstract: In recent years, an increasing number of studies have been published, focusing on the potential therapeutic use of small catalytic agents with strong biological properties. So far, most of these works have only regarded specific clinical fields, such as ... ...

    Abstract In recent years, an increasing number of studies have been published, focusing on the potential therapeutic use of small catalytic agents with strong biological properties. So far, most of these works have only regarded specific clinical fields, such as oncology, infectivology and general pathology, in particular with respect to the treatment of significant inflammatory processes. However, interesting data on possible therapeutic applications of small molecules for the treatment of neuropsychiatric and neurodegenerative illnesses are emerging, especially with respect to the possibility to modulate the cellular redox state. Indeed, a crucial role of redox dysregulation in the pathogenesis of these disorders has been widely demonstrated by both pre-clinical and clinical studies, being the reduction of the total amount of free radicals a promising novel therapeutic approach for these diseases. In this review, we focused our interest on studies published during the last ten years reporting therapeutic potential of small molecules for the treatment of neuropsychiatric and neurodegenerative disorders, also based on the biological efficiency of these compounds in detecting intracellular disturbances induced by increased production of reactive oxygen species.
    MeSH term(s) Animals ; Antioxidants/chemistry ; Antioxidants/therapeutic use ; Disease Models, Animal ; Humans ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/physiopathology ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/therapeutic use ; Oxidation-Reduction ; Oxidative Stress/drug effects ; Psychotic Disorders/drug therapy ; Psychotic Disorders/metabolism ; Psychotic Disorders/physiopathology ; Psychotropic Drugs/chemistry ; Psychotropic Drugs/therapeutic use ; Reactive Oxygen Species/antagonists & inhibitors ; Reactive Oxygen Species/metabolism ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/therapeutic use ; Structure-Activity Relationship
    Chemical Substances Antioxidants ; Neuroprotective Agents ; Psychotropic Drugs ; Reactive Oxygen Species ; Small Molecule Libraries
    Language English
    Publishing date 2018-02-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules23020411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The use of antioxidant compounds in the treatment of first psychotic episode: Highlights from preclinical studies.

    Schiavone, Stefania / Trabace, Luigia

    CNS neuroscience & therapeutics

    2018  Volume 24, Issue 6, Page(s) 465–472

    Abstract: Recent evidence highlighted a pathogenetic link between redox dysregulation and the early stages of psychosis. Indeed, an increasing number of studies have pointed toward an association between oxidative stress, both at central and peripheral levels, and ...

    Abstract Recent evidence highlighted a pathogenetic link between redox dysregulation and the early stages of psychosis. Indeed, an increasing number of studies have pointed toward an association between oxidative stress, both at central and peripheral levels, and first psychotic episode. Moreover, basal low antioxidant capacity has been shown to directly correlate with cognitive impairment in the early onset of psychosis. In this context, the possibility to use antioxidant compounds in first psychotic episode, especially as supplementation to antipsychotic therapy, has become the focus of numerous investigations on rodents with the aim to translate data on the possible effects of antioxidant therapies to large populations of patients, with a diagnosis of the first psychotic episode. In this review, we will discuss studies, published from January 1st, 2007 to July 31st, 2017, investigating the effects of antioxidant compounds on neuropathological alterations observed in different rodent models characterized by a cluster of psychotic-like symptoms reminiscent of what observed in human first psychotic episode. A final focus on the effective possibility to directly translate data obtained on rodents to humans will be also provided.
    MeSH term(s) Animals ; Antioxidants/therapeutic use ; Antipsychotic Agents/therapeutic use ; Drug Evaluation, Preclinical ; Humans ; Psychotic Disorders/drug therapy
    Chemical Substances Antioxidants ; Antipsychotic Agents
    Language English
    Publishing date 2018-03-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2423461-8
    ISSN 1755-5949 ; 1755-5930
    ISSN (online) 1755-5949
    ISSN 1755-5930
    DOI 10.1111/cns.12847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4537: Show issues Location:
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