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  1. Article ; Online: The Effect of Composition on the Properties and Application of CuO-NiO Nanocomposites Synthesized Using a Saponin-Green/Microwave-Assisted Hydrothermal Method.

    Al-Yunus, Amnah / Al-Arjan, Wafa / Traboulsi, Hassan / Hessien, Manal

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: In this study, we explored the formation of CuO nanoparticles, NiO nanoflakes, and CuO-NiO nanocomposites using saponin extract and a microwave-assisted hydrothermal method. Five green synthetic samples were prepared using aqueous saponin extract and a ... ...

    Abstract In this study, we explored the formation of CuO nanoparticles, NiO nanoflakes, and CuO-NiO nanocomposites using saponin extract and a microwave-assisted hydrothermal method. Five green synthetic samples were prepared using aqueous saponin extract and a microwave-assisted hydrothermal procedure at 200 °C for 30 min. The samples were pristine copper oxide (100C), 75% copper oxide-25% nickel oxide (75C25N), 50% copper oxide-50% nickel oxide (50C50N), 25% copper oxide-75% nickel oxide (25C75N), and pristine nickel oxide (100N). The samples were characterized using FT-IR, XRD, XPS, SEM, and TEM. The XRD results showed that copper oxide and nickel oxide formed monoclinic and cubic phases, respectively. The morphology of the samples was useful and consisted of copper oxide nanoparticles and nickel oxide nanoflakes. XPS confirmed the +2 oxidation state of both the copper and nickel ions. Moreover, the optical bandgaps of copper oxide and nickel oxide were determined to be in the range of 1.29-1.6 eV and 3.36-3.63 eV, respectively, and the magnetic property studies showed that the synthesized samples exhibited ferromagnetic and superparamagnetic properties. In addition, the catalytic activity was tested against para-nitrophenol, demonstrating that the catalyst efficiency gradually improved in the presence of CuO. The highest rate constants were obtained for the 100C and 75C25N samples, with catalytic efficiencies of 98.7% and 78.2%, respectively, after 45 min.
    MeSH term(s) Copper ; Microwaves ; Spectroscopy, Fourier Transform Infrared ; Nanocomposites ; Saponins ; Oxides ; Nickel
    Chemical Substances nickel monoxide (C3574QBZ3Y) ; cuprous oxide (T8BEA5064F) ; Copper (789U1901C5) ; Saponins ; Oxides ; Nickel (7OV03QG267)
    Language English
    Publishing date 2024-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25074119
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  2. Article: Effect of pH and Nanoparticle Capping Agents on Cr (III) Monitoring in Water: A Kinetic Way to Control the Parameters of Ultrasensitive Environmental Detectors.

    Awada, Chawki / Traboulsi, Hassan

    Micromachines

    2020  Volume 11, Issue 12

    Abstract: In this work, we apply surface-enhanced Raman spectroscopy (SERS) to study the kinetics of chromium Cr (III) detection in solution using EDTA and silver nanoparticles (AgNPs). We examine for the first time the effect of pH and nanoparticles' capping ... ...

    Abstract In this work, we apply surface-enhanced Raman spectroscopy (SERS) to study the kinetics of chromium Cr (III) detection in solution using EDTA and silver nanoparticles (AgNPs). We examine for the first time the effect of pH and nanoparticles' capping agent on the kinetic mechanism of Cr (III) detection using SERS temporal variations. The full width at half maximum (FWHM) and Raman shift variations show that the mechanism of detection is composed of two steps: a first one consisting of chemical coordination between Cr (III) and AgNPs that leads to exalted chemical and electromagnetic enhancement and the second one is an aggregation process with an important optical enhancement. The obtained results showed that the first step in the detection at lower pH was five times faster than in a basic medium using citrate capped silver nanoparticles (Cit-AgNPs). On the other hand, using a capping agent with dicarboxylate groups such as oxalate (Oxa-AgNPs) led to an important enhancement in SERS detection signal (more than 30 times) compared with Cit-AgNPs, although the detection kinetic's mechanism was slower.
    Language English
    Publishing date 2020-11-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi11121045
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  3. Article ; Online: Toward the Development of Ultrasensitive Detectors for Environmental Applications: A Kinetic Study of Cr(III) Monitoring in Water Using EDTA and SERS Techniques.

    Traboulsi, Hassan / Awada, Chawki

    ACS omega

    2020  Volume 5, Issue 48, Page(s) 31352–31361

    Abstract: We report for the first time kinetic studies on chromium(III) detection in aqueous solution using citrate-capped silver nanoparticles (AgNPs) and the surface-enhanced Raman spectroscopy (SERS) technique. Moreover, we have shown an important effect of ... ...

    Abstract We report for the first time kinetic studies on chromium(III) detection in aqueous solution using citrate-capped silver nanoparticles (AgNPs) and the surface-enhanced Raman spectroscopy (SERS) technique. Moreover, we have shown an important effect of adding ethylenediaminetetraacetic acid (EDTA) on the enhancement and the stability of the Raman signal. The origin of the SERS signal was attributed to the coordination of Cr(III) by citrate/EDTA molecules and the formation of hot spots on aggregated AgNPs. Depending on the mixing method of Cr(III) and EDTA with AgNPs, the temporal SERS spectral features reveal a Prout-Tompkins or a Langmuir kinetic detection model. The UV-visible data, the temporal response of the Raman signal, and the scanning electron microscopy analysis have allowed us to elucidate the mechanism of Cr(III) detection. We observed that mixing simultaneously Cr(III), AgNPs, and EDTA leads to the most stable and intense time-dependent SERS signal. The obtained results should open the way to perform kinetic studies on different host-guest interactions in solution using the SERS technique.
    Language English
    Publishing date 2020-11-23
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.0c04844
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  4. Article: Effect of Synthesis Conditions on CuO-NiO Nanocomposites Synthesized via Saponin-Green/Microwave Assisted-Hydrothermal Method.

    Al-Yunus, Amnah / Al-Arjan, Wafa / Traboulsi, Hassan / Schuarca, Robson / Chando, Paul / Hosein, Ian D / Hessien, Manal

    Nanomaterials (Basel, Switzerland)

    2024  Volume 14, Issue 3

    Abstract: This work presents the synthesis of CuO-NiO nanocomposites under different synthesis conditions. Nanocomposites were synthesized by merging a green synthesis process with a microwave-assisted hydrothermal method. The synthesis conditions were as follows: ...

    Abstract This work presents the synthesis of CuO-NiO nanocomposites under different synthesis conditions. Nanocomposites were synthesized by merging a green synthesis process with a microwave-assisted hydrothermal method. The synthesis conditions were as follows: concentration of the metal precursors (0.05, 0.1, and 0.2 M), pH (9, 10, and 11), synthesis temperature (150 °C, 200 °C, and 250 °C), microwave treatment time (15, 30, and 45 min), and extract concentration (20 and 40 mL of 1 g saponin/10 mL water, and 30 mL of 2 g saponin/10 mL water). The phases and crystallite sizes of the calcined nanocomposites were characterized using XRD and band gap via UV-Vis spectroscopy, and their morphologies were investigated using SEM and TEM. The XRD results confirmed the formation of a face-centered cubic phase for nickel oxide, while copper oxide has a monoclinic phase. The calculated crystallite size was in the range of 29-39 nm. The direct band gaps of the samples prepared in this work were in the range of 2.39-3.17 eV.
    Language English
    Publishing date 2024-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano14030308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: SARS-CoV-2 Receptor Binding Domain as a Stable-Potential Target for SARS-CoV-2 Detection by Surface-Enhanced Raman Spectroscopy.

    Awada, Chawki / Abdullah, Mohammed Mahfoudh Ba / Traboulsi, Hassan / Dab, Chahinez / Alshoaibi, Adil

    Sensors (Basel, Switzerland)

    2021  Volume 21, Issue 13

    Abstract: In this work, we report a new approach for detecting SARS-CoV-2 RBD protein (RBD) using the surface-enhanced Raman spectroscopy (SERS) technique. The optical enhancement was obtained thanks to the preparation of nanostructured Ag/Au substrates. ... ...

    Abstract In this work, we report a new approach for detecting SARS-CoV-2 RBD protein (RBD) using the surface-enhanced Raman spectroscopy (SERS) technique. The optical enhancement was obtained thanks to the preparation of nanostructured Ag/Au substrates. Fabricated Au/Ag nanostructures were used in the SERS experiment for RBD protein detection. SERS substrates show higher capabilities and sensitivity to detect RBD protein in a short time (3 s) and with very low power. We were able to push the detection limit of proteins to a single protein detection level of 1 pM. The latter is equivalent to 1 fM as a detection limit of viruses. Additionally, we have shown that the SERS technique was useful to figure out the presence of RBD protein on antibody functionalized substrates. In this case, the SERS detection was based on protein-antibody recognition, which led to shifts in the Raman peaks and allowed signal discrimination between RBD and other targets such as Bovine serum albumin (BSA) protein. A perfect agreement between a 3D simulated model based on finite element method and experiment was reported confirming the SERS frequency shift potential for trace proteins detection. Our results could open the way to develop a new prototype based on SERS sensitivity and selectivity for rapid detection at a very low concentration of virus and even at a single protein level.
    MeSH term(s) Animals ; COVID-19 ; Cattle ; Gold ; Humans ; Metal Nanoparticles ; Nanostructures ; SARS-CoV-2 ; Serum Albumin, Bovine ; Spectrum Analysis, Raman
    Chemical Substances Serum Albumin, Bovine (27432CM55Q) ; Gold (7440-57-5)
    Language English
    Publishing date 2021-07-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s21134617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Development of superior antibodies against the S-protein of SARS-Cov-2 using macrocyclic epitopes.

    Traboulsi, Hassan / Khedr, Mohammed A / Elgorashe, Rafea / Al-Faiyz, Yasair / Negm, Amr

    Arabian journal of chemistry

    2021  Volume 15, Issue 3, Page(s) 103631

    Abstract: One of the proven methods to prevent and inhibit viral infections is to use antibodies to block the initial Receptor Binding Domain (RBD) of SARS-CoV-2 S protein and avoid its binding with the host cells. Thus, developing these RBD-targeting antibodies ... ...

    Abstract One of the proven methods to prevent and inhibit viral infections is to use antibodies to block the initial Receptor Binding Domain (RBD) of SARS-CoV-2 S protein and avoid its binding with the host cells. Thus, developing these RBD-targeting antibodies would be a promising approach for treating the SARS-CoV-2 infectious disease and stop virus replication. Macrocyclic epitopes constitute closer mimics of the receptor's actual topology and, as such, are expected to be superior epitopes for antibody generation. This work demonstrated the vital effect of the three-dimensional shape of epitopes on the developed antibodies' activity against RBD protein of SARS-CoV-2. The molecular dynamics studies showed the greater stability of the cyclic epitopes in comparison with the linear counterpart, which was reflected in the activity of their produced antibodies. Indeed, the antibodies we developed using macrocyclic epitopes showed superiority with respect to binding to RBD proteins compared to antibodies formed from a linear peptide. The results of the present work constitute a roadmap for developing superior antibodies that could be used to inhibit the activity of the SARS-CoV-2 and prevent its reproduction.
    Language English
    Publishing date 2021-12-10
    Publishing country Saudi Arabia
    Document type Journal Article
    ISSN 1878-5379
    ISSN (online) 1878-5379
    DOI 10.1016/j.arabjc.2021.103631
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  7. Article ; Online: Structure-Based Epitope Design: Toward a Greater Antibody-SARS-CoV-2 RBD Affinity.

    Traboulsi, Hassan / Khedr, Mohammed A / Al-Faiyz, Yasair S S / Elgorashe, Rafea / Negm, Amr

    ACS omega

    2021  Volume 6, Issue 47, Page(s) 31469–31476

    Abstract: Efficient COVID-19 vaccines are widely acknowledged as the best way to end the global pandemic. SARS-CoV-2 receptor-binding domain (RBD) plays fundamental roles related to cell infection. Antibodies could be developed to target RBD and represent a ... ...

    Abstract Efficient COVID-19 vaccines are widely acknowledged as the best way to end the global pandemic. SARS-CoV-2 receptor-binding domain (RBD) plays fundamental roles related to cell infection. Antibodies could be developed to target RBD and represent a potential approach for the neutralization of the virus. Epitopes used to produce antibodies are generally linear peptides and thus possess multiple confirmations that do not reflect the actual topology of the targeted part in the native protein. On the other hand, macrocyclic epitopes could constitute closer mimics of the native protein topology and, as such, could generate superior antibodies. In this study, we demonstrated the vital effect of the size and the three-dimensional shape of epitopes on the activity of the developed antibodies against the RBD of SARS-CoV-2. The molecular dynamics studies showed the greater stability of the cyclic epitopes compared with the linear counterparts, which was reflected in the affinity of the produced antibodies. The antibodies developed using macrocyclic epitopes showed superiority with respect to binding to RBD compared to antibodies formed from linear peptides. This study constitutes a roadmap for developing superior antibodies that could be used to inhibit the activity of SARS-CoV-2.
    Language English
    Publishing date 2021-11-18
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.1c03348
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  8. Article ; Online: Palladium-Loaded Cucurbit[7]uril-Modified Iron Oxide Nanoparticles for C-C Cross-Coupling Reactions.

    Benyettou, Farah / Motte, Laurence / Traboulsi, Hassan / Mazher, Javed / Pasricha, Renu / Olsen, John-Carl / Trabolsi, Ali / Guenin, Erwan

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2018  Volume 24, Issue 10, Page(s) 2349–2353

    Abstract: Cucurbit[7]uril modified iron oxide nanoparticles (CB[7]NPs) were loaded with palladium to form nano-catalysts (Pd@CB[7]NPs) that, with microwave heating, catalysed Suzuki-Miyaura, Sonogashira, and Mizoroki-Heck cross-coupling reactions. Reactions were ... ...

    Abstract Cucurbit[7]uril modified iron oxide nanoparticles (CB[7]NPs) were loaded with palladium to form nano-catalysts (Pd@CB[7]NPs) that, with microwave heating, catalysed Suzuki-Miyaura, Sonogashira, and Mizoroki-Heck cross-coupling reactions. Reactions were run in environmentally benign 1:1 ethanol/water solvent under convenient aerobic conditions. In a preliminary screening, conversions and yields were uniformly high with turn over frequencies (TOF) ranging from 64 to 7360 h
    Language English
    Publishing date 2018-02-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-x
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.201705082
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  9. Article ; Online: Aqueous Synthesis of Triphenylphosphine-Modified Gold Nanoparticles for Synergistic In Vitro and In Vivo Photothermal Chemotherapy.

    Benyettou, Farah / Ramdas Nair, Anjana / Dho, Yaereen / Prakasam, Thirumurugan / Pasricha, Renu / Whelan, Jamie / Traboulsi, Hassan / Mazher, Javed / Sadler, Kirsten C / Trabolsi, Ali

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2020  Volume 26, Issue 23, Page(s) 5270–5279

    Abstract: Triphenylphosphine (TPP) surface-functionalized and F-108 Pluronic-stabilized gold nanoparticles (F-108@TPP-AuNPs) have been synthesized through a one-step approach, leading to well-defined (9.6±1.6 nm) and water-soluble nanoparticles by microwave ... ...

    Abstract Triphenylphosphine (TPP) surface-functionalized and F-108 Pluronic-stabilized gold nanoparticles (F-108@TPP-AuNPs) have been synthesized through a one-step approach, leading to well-defined (9.6±1.6 nm) and water-soluble nanoparticles by microwave heating an aqueous solution of TPP-Au
    MeSH term(s) Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Gold/chemistry ; HeLa Cells ; Humans ; Metal Nanoparticles/chemistry ; Organophosphorus Compounds/chemistry ; Phototherapy ; Polymers/chemistry ; Temperature
    Chemical Substances Antineoplastic Agents ; Organophosphorus Compounds ; Polymers ; triphenylphosphine (26D26OA393) ; Gold (7440-57-5)
    Language English
    Publishing date 2020-04-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202000216
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  10. Article: Covalent Organic Framework Embedded with Magnetic Nanoparticles for MRI and Chemo-Thermotherapy

    Benyettou, Farah / Das, Gobinda / Nair, Anjana Ramdas / Prakasam, Thirumurugan / Shinde, Digambar B / Sharma, Sudhir Kumar / Whelan, Jamie / Lalatonne, Yoann / Traboulsi, Hassan / Pasricha, Renu / Abdullah, Osama / Jagannathan, Ramesh / Lai, Zhiping / Motte, Laurence / Gándara, Felipe / Sadler, Kirsten C / Trabolsi, Ali

    Journal of the American Chemical Society. 2020 Oct. 22, v. 142, no. 44

    2020  

    Abstract: Nanoscale imine-linked covalent organic frameworks (nCOFs) were first loaded with the anticancer drug Doxorubicin (Dox), coated with magnetic iron oxide nanoparticles (γ-Fe₂O₃ NPs), and stabilized with a shell of poly(l-lysine) cationic polymer (PLL) for ...

    Abstract Nanoscale imine-linked covalent organic frameworks (nCOFs) were first loaded with the anticancer drug Doxorubicin (Dox), coated with magnetic iron oxide nanoparticles (γ-Fe₂O₃ NPs), and stabilized with a shell of poly(l-lysine) cationic polymer (PLL) for simultaneous synergistic thermo-chemotherapy treatment and MRI imaging. The pH responsivity of the resulting nanoagents (γ-SD/PLL) allowed the release of the drug selectively within the acidic microenvironment of late endosomes and lysosomes of cancer cells (pH 5.4) and not in physiological conditions (pH 7.4). γ-SD/PLL could efficiently generate high heat (48 °C) upon exposure to an alternating magnetic field due to the nCOF porous structure that facilitates the heat conduction, making γ-SD/PLL excellent heat mediators in an aqueous solution. The drug-loaded magnetic nCOF composites were cytotoxic due to the synergistic toxicity of Dox and the effects of hyperthermia in vitro on glioblastoma U251-MG cells and in vivo on zebrafish embryos, but they were not significantly toxic to noncancerous cells (HEK293). To the best of our knowledge, this is the first report of multimodal MRI probe and chemo-thermotherapeutic magnetic nCOF composites.
    Keywords Danio rerio ; aqueous solutions ; cytotoxicity ; doxorubicin ; endosomes ; fever ; glioblastoma ; heat transfer ; lysine ; lysosomes ; magnetic fields ; pH ; polymers
    Language English
    Dates of publication 2020-1022
    Size p. 18782-18794.
    Publishing place American Chemical Society
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.0c05381
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