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  1. Article: Stage-Dependent Impact of RIPK1 Inhibition on Atherogenesis: Dual Effects on Inflammation and Foam Cell Dynamics.

    Zhang, Yuze / Li, Huihui / Huang, Yonghu / Chen, Hong / Rao, Haojie / Yang, Guoli / Wan, Qing / Peng, Zekun / Bertin, John / Geddes, Brad / Reilly, Michael / Tran, Jean-Luc / Wang, Miao

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 715337

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2021-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.715337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.

    Cokorinos, Emily C / Delmore, Jake / Reyes, Allan R / Albuquerque, Bina / Kjøbsted, Rasmus / Jørgensen, Nicolas O / Tran, Jean-Luc / Jatkar, Aditi / Cialdea, Katherine / Esquejo, Ryan M / Meissen, John / Calabrese, Matthew F / Cordes, Jason / Moccia, Robert / Tess, David / Salatto, Christopher T / Coskran, Timothy M / Opsahl, Alan C / Flynn, Declan /
    Blatnik, Matthew / Li, Wenlin / Kindt, Erick / Foretz, Marc / Viollet, Benoit / Ward, Jessica / Kurumbail, Ravi G / Kalgutkar, Amit S / Wojtaszewski, Jørgen F P / Cameron, Kimberly O / Miller, Russell A

    Cell metabolism

    2017  Volume 25, Issue 5, Page(s) 1147–1159.e10

    Abstract: The AMP-activated protein kinase (AMPK) is a potential therapeutic target for metabolic diseases based on its reported actions in the liver and skeletal muscle. We evaluated two distinct direct activators of AMPK: a non-selective activator of all AMPK ... ...

    Abstract The AMP-activated protein kinase (AMPK) is a potential therapeutic target for metabolic diseases based on its reported actions in the liver and skeletal muscle. We evaluated two distinct direct activators of AMPK: a non-selective activator of all AMPK complexes, PF-739, and an activator selective for AMPK β1-containing complexes, PF-249. In cells and animals, both compounds were effective at activating AMPK in hepatocytes, but only PF-739 was capable of activating AMPK in skeletal muscle. In diabetic mice, PF-739, but not PF-249, caused a rapid lowering of plasma glucose levels that was diminished in the absence of skeletal muscle, but not liver, AMPK heterotrimers and was the result of an increase in systemic glucose disposal with no impact on hepatic glucose production. Studies of PF-739 in cynomolgus monkeys confirmed translation of the glucose lowering and established activation of AMPK in skeletal muscle as a potential therapeutic approach to treat diabetic patients.
    Language English
    Publishing date 2017-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2017.04.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Author Correction: Design of amidobenzimidazole STING receptor agonists with systemic activity.

    Ramanjulu, Joshi M / Pesiridis, G Scott / Yang, Jingsong / Concha, Nestor / Singhaus, Robert / Zhang, Shu-Yun / Tran, Jean-Luc / Moore, Patrick / Lehmann, Stephanie / Eberl, H Christian / Muelbaier, Marcel / Schneck, Jessica L / Clemens, Jim / Adam, Michael / Mehlmann, John / Romano, Joseph / Morales, Angel / Kang, James / Leister, Lara /
    Graybill, Todd L / Charnley, Adam K / Ye, Guosen / Nevins, Neysa / Behnia, Kamelia / Wolf, Amaya I / Kasparcova, Viera / Nurse, Kelvin / Wang, Liping / Puhl, Ana C / Li, Yue / Klein, Michael / Hopson, Christopher B / Guss, Jeffrey / Bantscheff, Marcus / Bergamini, Giovanna / Reilly, Michael A / Lian, Yiqian / Duffy, Kevin J / Adams, Jerry / Foley, Kevin P / Gough, Peter J / Marquis, Robert W / Smothers, James / Hoos, Axel / Bertin, John

    Nature

    2019  Volume 570, Issue 7761, Page(s) E53

    Abstract: Change history: In this Letter, author Ana Puhl was inadvertently omitted; this error has been corrected online.An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract Change history: In this Letter, author Ana Puhl was inadvertently omitted; this error has been corrected online.An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Language English
    Publishing date 2019-05-29
    Publishing country England
    Document type Published Erratum
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-019-1265-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Absence of graft-versus-host disease in the isolated vascularized bone marrow transplant.

    Tai, Chau Y / Strande, Louise F / Eydelman, Riva / Sheng, Xiaoli / VanTran, Jean-Luc / Matthews, Martha S / Hewitt, Charles W

    Transplantation

    2004  Volume 77, Issue 2, Page(s) 316–319

    Abstract: An isolated vascularized bone marrow transplant (iVBMT) model was developed to study the contribution of the bone marrow component in a composite tissue allograft. We hypothesized that the iVBMT would be functional and cause graft-versus-host disease ( ... ...

    Abstract An isolated vascularized bone marrow transplant (iVBMT) model was developed to study the contribution of the bone marrow component in a composite tissue allograft. We hypothesized that the iVBMT would be functional and cause graft-versus-host disease (GVHD) in a fraction of the recipients. Lewis iVBMT grafts were transplanted to Lewis-Brown Norway recipients. Animals were sacrificed at various times from 1 to 14 weeks. Polymerase chain reaction for microchimerism was performed on the host's marrow. No animals exhibited signs of GVHD at death. Histologic examination of the grafts showed a normal mix of hematopoietic and fatty elements and appeared to be functional. Tissues usually affected-tongue, ear, liver, and gut-also showed no evidence of disease. Polymerase chain reaction demonstrated microchimerism in both groups. These findings suggest that the vascularized bone marrow within a composite tissue allograft is not the component that causes GVHD; rather, it may serve an immunomodulatory function for tolerance induction.
    MeSH term(s) Animals ; Bone Marrow/blood supply ; Bone Marrow Cells/cytology ; Bone Marrow Transplantation/immunology ; Bone Marrow Transplantation/pathology ; Graft vs Host Disease/prevention & control ; Polymerase Chain Reaction ; Rats ; Rats, Inbred BN ; Rats, Inbred Lew ; Transplantation, Homologous/immunology
    Language English
    Publishing date 2004-01-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/01.TP.0000101511.11171.EF
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 509: Show issues

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  5. Article ; Online: Design of amidobenzimidazole STING receptor agonists with systemic activity.

    Ramanjulu, Joshi M / Pesiridis, G Scott / Yang, Jingsong / Concha, Nestor / Singhaus, Robert / Zhang, Shu-Yun / Tran, Jean-Luc / Moore, Patrick / Lehmann, Stephanie / Eberl, H Christian / Muelbaier, Marcel / Schneck, Jessica L / Clemens, Jim / Adam, Michael / Mehlmann, John / Romano, Joseph / Morales, Angel / Kang, James / Leister, Lara /
    Graybill, Todd L / Charnley, Adam K / Ye, Guosen / Nevins, Neysa / Behnia, Kamelia / Wolf, Amaya I / Kasparcova, Viera / Nurse, Kelvin / Wang, Liping / Puhl, Ana C / Li, Yue / Klein, Michael / Hopson, Christopher B / Guss, Jeffrey / Bantscheff, Marcus / Bergamini, Giovanna / Reilly, Michael A / Lian, Yiqian / Duffy, Kevin J / Adams, Jerry / Foley, Kevin P / Gough, Peter J / Marquis, Robert W / Smothers, James / Hoos, Axel / Bertin, John

    Nature

    2018  Volume 564, Issue 7736, Page(s) 439–443

    Abstract: Stimulator of interferon genes (STING) is a receptor in the endoplasmic reticulum that propagates innate immune sensing of cytosolic pathogen-derived and self ... ...

    Abstract Stimulator of interferon genes (STING) is a receptor in the endoplasmic reticulum that propagates innate immune sensing of cytosolic pathogen-derived and self DNA
    MeSH term(s) Animals ; Benzimidazoles/administration & dosage ; Benzimidazoles/chemistry ; Benzimidazoles/pharmacology ; Benzimidazoles/therapeutic use ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/immunology ; Drug Design ; Humans ; Ligands ; Membrane Proteins/agonists ; Membrane Proteins/immunology ; Mice ; Models, Molecular ; Nucleotides, Cyclic/metabolism
    Chemical Substances Benzimidazoles ; Ligands ; Membrane Proteins ; Nucleotides, Cyclic ; STING1 protein, human ; Sting1 protein, mouse ; cyclic guanosine monophosphate-adenosine monophosphate
    Language English
    Publishing date 2018-11-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-018-0705-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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