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Article ; Online: Bowel seromuscular flaps used to repair pelvic defects in patients undergoing reoperative surgery.

Bauzon, J S / Tran, N V / Hebert, B R / Mathis, K L

2022 Volume 27, Issue 5, Page(s) 373–378

Abstract: Background: Pedicled seromuscular bowel flaps may serve as an alternative for pelvic floor reconstruction when conventional omental and muscular flaps are not an option in patients undergoing reoperative abdominopelvic surgery. The aim of this study was ...

Abstract	Background: Pedicled seromuscular bowel flaps may serve as an alternative for pelvic floor reconstruction when conventional omental and muscular flaps are not an option in patients undergoing reoperative abdominopelvic surgery. The aim of this study was to evaluate a unique series of bowel seromuscular flaps used to obliterate intrapelvic defects. Methods: We conducted a retrospective study on all patients in a single tertiary care institutional database who had undergone pelvic reconstruction with a seromuscular bowel flap from January 2006 to December 2018. The primary outcomes measured were the 30-day morbidity and mortality rates. Results: Twelve patients (6 men 6 women, median age 56.5 years [range 33-77 years]) underwent reoperative abdominopelvic surgery requiring the use of a native small or large seromuscular bowel flap to obliterate pelvic defects. The indications for surgery included chronic infections, fistulizing Crohn's disease, and cancer. In all cases, no residual omentum was available and rectus abdominis muscle flaps were not feasible due to prior operative scars. Thirty-day morbidity occurred in 5 patients (42%), and included urine leak from ureteral injury, anastomotic leak, acute kidney injury, and superficial surgical site infection. No flaps became ischemic or required removal in the postoperative setting. No mortality was recorded. Conclusions: Bowel seromuscular flaps are a feasible and safe alternative for covering pelvic defects in patients who are undergoing reoperative surgery without the option to use traditional omental and muscular flaps.
MeSH term(s)	Male ; Humans ; Female ; Adult ; Middle Aged ; Aged ; Retrospective Studies ; Postoperative Complications/etiology ; Surgical Flaps ; Plastic Surgery Procedures ; Pelvis/surgery
Language	English
Publishing date	2022-09-06
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2083309-X
ISSN	1128-045X ; 1123-6337
ISSN (online)	1128-045X
ISSN	1123-6337
DOI	10.1007/s10151-022-02697-8
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Article: Ion-molecule reactions of oxygenated chemical ionization reagents with vincamine.

Bauerle, G F / Hall, B J / Tran, N V / Brodbelt, J S

Journal of the American Society for Mass Spectrometry

2013 Volume 7, Issue 3, Page(s) 250–260

Abstract: The ion-molecule reactions of ions from acetone, dimethyl ether, 2-methoxyethanol, and vinyl methyl ether with vincamine were investigated. Reactions with dimethyl ether result in [M+13](+) and [M+45](+) products, reactions with 2-methoxyethanol produce [ ...

Abstract	The ion-molecule reactions of ions from acetone, dimethyl ether, 2-methoxyethanol, and vinyl methyl ether with vincamine were investigated. Reactions with dimethyl ether result in [M+13](+) and [M+45](+) products, reactions with 2-methoxyethanol produce [M+13](+) and [M+89](+) ions, and reactions with acetone or vinyl methyl ether ions generate predominantly [M+43](+) ions. Collision-activated dissociation and deuterium labeling experiments allowed speculation about the product structures and mechanisms of dissociation. The methylene substitution process was shown to occur at the hydroxyl oxygen and the phenyl ring of vincamine for dimethyl ether reactions, but the methylene substitution process was not favored at the hydroxyl oxygen for the 2-methoxyethanol reactions, instead favored at the 12 phenyl position. The reaction site is likely different for the 2-methoxyethanol ion due to its capability for secondary hydrogen-bonding interactions. For the [M+45](+) and [M+89](+) ions, evidence suggests that charge-remote fragmentation processes occur from these products. In general, the use of dimethyl ether ions or 2-methoxyethanol ions for ionmolecule reactions prove highly diagnostic for the characterization of vincamine; both molecular weight and structural information are obtained. Limits of detection for vincamine with dimethyl ether chemical ionization via this technique on a benchtop ion trap gas chromatography-tandem mass spectrometer are in the upper parts per trillion range.
Language	English
Publishing date	2013-11-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1073671-2
ISSN	1044-0305
ISSN	1044-0305
DOI	10.1016/1044-0305(95)00650-8
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Book ; Online: Accelerator Real-time Edge AI for Distributed Systems (READS) Proposal

Seiya, K. / Hazelwood, K. J. / Ibrahim, M. A. / Nagaslaev, V. P. / Nicklaus, D. J. / Schupbach, B. A. / Thurman-Keup, R. M. / Tran, N. V. / Liu, H. / Memik, S.

2021

Abstract: Our objective will be to integrate ML into Fermilab accelerator operations and furthermore provide an accessible framework which can also be used by a broad range of other accelerator systems with dynamic tuning needs. We will develop of real-time ... ...

Abstract	Our objective will be to integrate ML into Fermilab accelerator operations and furthermore provide an accessible framework which can also be used by a broad range of other accelerator systems with dynamic tuning needs. We will develop of real-time accelerator control using embedded ML on-chip hardware and fast communication between distributed systems in this proposal. We will demonstrate this technology for the Mu2e experiment by increasing the overall duty factor and uptime of the experiment through two synergistic projects. First, we will use deep reinforcement learning techniques to improve the performance of the regulation loop through guided optimization to provide stable proton beams extracted from the Delivery Ring to the Mu2e experiment. This requires the development of a digital twin of the system to model the accelerator and develop real-time ML algorithms. Second, we will use de-blending techniques to disentangle and classify overlapping beam losses in the Main Injector and Recycler Ring to reduce overall beam downtime in each machine. This ML model will be deployed within a semi-autonomous operational mode. Both applications require processing at the millisecond scale and will share similar ML-in-hardware techniques and beam instrumentation readout technology. A collaboration between Fermilab and Northwestern University will pull together the talents and resources of accelerator physicists, beam instrumentation engineers, embedded system architects, FPGA board design experts, and ML experts to solve complex real-time accelerator controls challenges which will enhance the physics program. More broadly, the framework developed for Accelerator Real-time Edge AI Distributed Systems (READS) can be applied to future projects as the accelerator complex is upgraded for the PIP-II and DUNE era.
Keywords	Physics - Accelerator Physics
Subject code	629
Publishing date	2021-03-05
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: ML-based Real-Time Control at the Edge

Shi, R. / Ogrenci, S. / Arnold, J. M. / Berlioz, J. R. / Hanlet, P. / Hazelwood, K. J. / Ibrahim, M. A. / Liu, H. / Nagaslaev, V. P. / 1, A. Narayanan / Nicklaus, D. J. / Mitrevski, J. / Pradhan, G. / Saewert, A. L. / Schupbach, B. A. / Seiya, K. / Thieme, M. / Thurman-Keup, R. M. / Tran, N. V.

An Approach Using hls4ml

2023

Abstract: This study focuses on implementing a real-time control system for a particle accelerator facility that performs high energy physics experiments. A critical operating parameter in this facility is beam loss, which is the fraction of particles deviating ... ...

Abstract	This study focuses on implementing a real-time control system for a particle accelerator facility that performs high energy physics experiments. A critical operating parameter in this facility is beam loss, which is the fraction of particles deviating from the accelerated proton beam into a cascade of secondary particles. Accelerators employ a large number of sensors to monitor beam loss. The data from these sensors is monitored by human operators who predict the relative contribution of different sub-systems to the beam loss. Using this information, they engage control interventions. In this paper, we present a controller to track this phenomenon in real-time using edge-Machine Learning (ML) and support control with low latency and high accuracy. We implemented this system on an Intel Arria 10 SoC. Optimizations at the algorithm, high-level synthesis, and interface levels to improve latency and resource usage are presented. Our design implements a neural network, which can predict the main source of beam loss (between two possible causes) at speeds up to 575 frames per second (fps) (average latency of 1.74 ms). The practical deployed system is required to operate at 320 fps, with a 3ms latency requirement, which has been met by our design successfully.
Keywords	Computer Science - Hardware Architecture
Subject code	006
Publishing date	2023-11-09
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Free-tissue transfer experience at a county hospital.

Maffi, T R / Tran, N V

Journal of reconstructive microsurgery

2001 Volume 17, Issue 6, Page(s) 431–433

Abstract: As reimbursement for free-tissue transfer decreases, the authors find an increase in the number of free flaps performed at their county facility. Over 60 percent of the free flaps performed during the past 10 years were completed within the last 4 years. ...

Abstract	As reimbursement for free-tissue transfer decreases, the authors find an increase in the number of free flaps performed at their county facility. Over 60 percent of the free flaps performed during the past 10 years were completed within the last 4 years. This influx of patients prompted a review of their experience with free-tissue transfer. This retrospective study of the free-flap experience at a county hospital reviewed 49 patients with 53 free flaps between 1991 and 1999. Forty-five free flaps (85 percent) were successful, with an overall failure rate of 15 percent. Most free flaps were performed on traumatic wounds. Risk factors, such as smoking, diabetes, and peripheral vascular disease, did not reliably predict free-flap failure. Irradiated, chronic wounds were associated with the highest failure rates. Seventy-five percent of the free-flap failures were due to delayed return to the operating room, once the flap appeared compromised. Delay in reexploration resulted in a zero salvage rate. Prompt recognition of failed flaps and emergent exploration will improve the success rate.
MeSH term(s)	Adolescent ; Adult ; Aged ; California ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Graft Rejection ; Graft Survival ; Hospitals, County/statistics & numerical data ; Humans ; Length of Stay/statistics & numerical data ; Male ; Microsurgery/methods ; Middle Aged ; Retrospective Studies ; Risk Factors ; Sensitivity and Specificity ; Skin Transplantation/adverse effects ; Skin Transplantation/methods ; Skin Transplantation/statistics & numerical data ; Surgical Flaps ; Treatment Outcome ; Wounds and Injuries/surgery
Language	English
Publishing date	2001-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	605983-1
ISSN	0743-684X ; 0743-684X
ISSN (online)	0743-684X
ISSN	0743-684X
DOI	10.1055/s-2001-16357
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Article: Free-Tissue Transfer Experience at a County Hospital

Maffi, Terry R. / Tran, N.V.

Journal of Reconstructive Microsurgery

2001 Volume 17, Issue 06, Page(s) 431–434

Abstract	As reimbursement for free-tissue transfer decreases, the authors find an increase in the number of free flaps performed at their county facility. Over 60 percent of the free flaps performed during the past 10 years were completed within the last 4 years. This influx of patients prompted a review of their experience with free-tissue transfer. This retrospective study of the free-flap experience at a county hospital reviewed 49 patients with 53 free flaps between 1991 and 1999. Forty-five free flaps (85 percent) were successful, with an overall failure rate of 15 percent. Most free flaps were performed on traumatic wounds. Risk factors, such as smoking, diabetes, and peripheral vascular disease, did not reliably predict free-flap failure. Irradiated, chronic wounds were associated with the highest failure rates. Seventy-five percent of the free-flap failures were due to delayed return to the operating room, once the flap appeared compromised. Delay in reexploration resulted in a zero salvage rate. Prompt recognition of failed flaps and emergent exploration will improve the success rate.
Keywords	Free flaps ; salvage rates ; county hospital
Language	English
Publishing date	2001-01-01
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	605983-1
ISSN	1098-8947 ; 0743-684X ; 0743-684X
ISSN (online)	1098-8947 ; 0743-684X
ISSN	0743-684X
DOI	10.1055/s-2001-16357
Database	Thieme publisher's database

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Article: Disorder-induced coherent scattering in slow-light photonic crystal waveguides.

Patterson, M / Hughes, S / Combrié, S / Tran, N-V-Quynh / De Rossi, A / Gabet, R / Jaouën, Y

Physical review letters

2009 Volume 102, Issue 25, Page(s) 253903

Abstract: Light transmission measurements and frequency-delay reflectometry maps for GaAs photonic crystal membranes are presented and analyzed, showing the transition from propagation with a well-defined group velocity to a regime completely dominated by disorder- ...

Abstract	Light transmission measurements and frequency-delay reflectometry maps for GaAs photonic crystal membranes are presented and analyzed, showing the transition from propagation with a well-defined group velocity to a regime completely dominated by disorder-induced coherent scattering. Employing a self-consistent optical scattering theory, with only statistical functions to describe the structural disorder, we obtain excellent agreement with the experiments using no fitting parameters. Our experiments and theory together provide clear physical insight into naturally occurring light localization and multiple coherent-scattering phenomena in slow-light waveguides.
Language	English
Publishing date	2009-06-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.102.253903
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Article: Comparison of immediate and delayed free TRAM flap breast reconstruction in patients receiving postmastectomy radiation therapy.

Tran, N V / Chang, D W / Gupta, A / Kroll, S S / Robb, G L

Plastic and reconstructive surgery

2001 Volume 108, Issue 1, Page(s) 78–82

Abstract: Tumor pathologic features and the extent of nodal involvement dictate whether radiation therapy is given after mastectomy for breast cancer. It is generally well accepted that radiation negatively influences the outcome of implant-based breast ... ...

Abstract	Tumor pathologic features and the extent of nodal involvement dictate whether radiation therapy is given after mastectomy for breast cancer. It is generally well accepted that radiation negatively influences the outcome of implant-based breast reconstruction. However, the long-term effect of radiation therapy on the outcome of breast reconstruction with the free transverse rectus abdominis myocutaneous (TRAM) flap is still unclear. For patients who need postmastectomy radiation therapy, the optimal timing of TRAM flap reconstruction is controversial. This study compares the outcome of immediate and delayed free TRAM flap breast reconstruction in patients who received postmastectomy radiation therapy. All patients at The University of Texas M. D. Anderson Cancer Center who received postmastectomy radiation therapy and who also underwent free TRAM flap breast reconstruction between January of 1988 and December of 1998 were included in the study. Patients who received radiation therapy before delayed TRAM flap reconstruction were compared with patients who underwent immediate TRAM flap reconstruction before radiation therapy. Early and late complications were compared between the two groups. Early complications included vessel thrombosis, partial or total flap loss, mastectomy skin flap necrosis, and local wound-healing problems, whereas late complications included fat necrosis, volume loss, and flap contracture of free TRAM breast mounds. Late complications were evaluated at least 1 year after the completion of radiation therapy for patients who had delayed reconstruction and at least 1 year after reconstruction for patients who had immediate reconstruction. During the study period, 32 patients had immediate TRAM flap reconstruction before radiation therapy and 70 patients had radiation therapy before TRAM flap reconstruction. Mean follow-up times for the immediate reconstruction and delayed reconstruction groups were 3 and 5 years, respectively. The mean radiation dose was 50 Gy in the immediate reconstruction group and 51 Gy in the delayed reconstruction group. One complete flap loss occurred in the delayed reconstruction group, and no flap loss occurred in the immediate reconstruction group. The incidence of early complications did not differ significantly between the two groups. However, the incidence of late complications was significantly higher in the immediate reconstruction group than in the delayed reconstruction group (87.5 percent versus 8.6 percent; p = 0.000). Nine patients (28 percent) in the immediate reconstruction group required an additional flap to correct the distorted contour from flap shrinkage and severe flap contraction. These findings indicate that, in patients who are candidates for free TRAM flap breast reconstruction and need postmastectomy radiation therapy, reconstruction should be delayed until radiation therapy is complete.
MeSH term(s)	Breast Neoplasms/radiotherapy ; Breast Neoplasms/surgery ; Combined Modality Therapy ; Female ; Humans ; Mammaplasty/adverse effects ; Mammaplasty/methods ; Mastectomy/rehabilitation ; Middle Aged ; Postoperative Complications ; Surgical Flaps ; Time Factors
Language	English
Publishing date	2001-07
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/00006534-200107000-00013
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Uk I Zs.142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 293: Show issues

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Article: Lateral tracheostomy in patients with cervical spinal cord injury.

Tran, N V / Vernick, J / Cotler, J M / Rabinovici, R

The British journal of surgery

1995 Volume 82, Issue 3, Page(s) 412–413

MeSH term(s)	Cervical Vertebrae/injuries ; Humans ; Respiration Disorders/surgery ; Tracheostomy/methods
Language	English
Publishing date	1995-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2985-3
ISSN	0007-1323 ; 0263-1202 ; 1355-7688
ISSN	0007-1323 ; 0263-1202 ; 1355-7688
DOI	10.1002/bjs.1800820345
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Article: Amphotericin B-induced changes in renal membrane permeation: a model of nephrotoxicity.

Schell, R E / Tran, N V / Bramhall, J S

Biochemical and biophysical research communications

1989 Volume 159, Issue 3, Page(s) 1165–1170

Abstract: As part of an investigation into the nephrotoxic effects of the polyene antibiotic Amphotericin B we have studied its effects on the ion permeability of purified renal brush border membrane vesicles. Membrane potentials were measured using a potential ... ...

Abstract	As part of an investigation into the nephrotoxic effects of the polyene antibiotic Amphotericin B we have studied its effects on the ion permeability of purified renal brush border membrane vesicles. Membrane potentials were measured using a potential sensitive carbocyanine dye, and ion permeabilities were calculated from the constant field equation. Amphotericin B significantly altered the ionic permeability sequence of isolated membranes and caused a selectivity for increasing the permeation of anions. Permeability changes induced by 2.0 micrograms/ml Amphotericin B resulted in an estimated hyperpolarization of the membrane from -50 mV to -72 mV. In addition, the kinetic parameters of Na+ dependent transport of organic metabolites were examined. The maximum change in fluorescence was decreased significantly in the presence of Amphotericin B. These results suggest that the ionic state of the renal cell membrane is significantly altered by the presence of Amphotericin B.
MeSH term(s)	Amphotericin B/pharmacology ; Amphotericin B/toxicity ; Animals ; Cell Membrane Permeability/drug effects ; Kidney/drug effects ; Kidney/metabolism ; Kidney/pathology ; Kinetics ; Microvilli/drug effects ; Microvilli/metabolism ; Models, Biological ; Monosaccharide Transport Proteins/metabolism ; Rabbits
Chemical Substances	Monosaccharide Transport Proteins ; Amphotericin B (7XU7A7DROE)
Language	English
Publishing date	1989-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/0006-291x(89)92232-8
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