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  1. AU="Tran, Nham"
  2. AU="Zdrodowska, Kinga"
  3. AU="Kulkarni, Yogesh A"
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  1. Article: Editorial: Non-coding RNA elements as regulators of host-pathogen interactions.

    Gama-Carvalho, Margarida / Tran, Nham

    Frontiers in genetics

    2024  Volume 15, Page(s) 1374636

    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2024.1374636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: miRNA:miRNA Interactions: A Novel Mode of miRNA Regulation and Its Effect On Disease.

    Hill, Meredith / Tran, Nham

    Advances in experimental medicine and biology

    2022  Volume 1385, Page(s) 241–257

    Abstract: MicroRNAs (miRNAs) are known for their role in the post-transcriptional regulation of messenger RNA (mRNA). However, recent evidence has shown that miRNAs are capable of regulating non-coding RNAs, including miRNAs, in what is known as miRNA:miRNA ... ...

    Abstract MicroRNAs (miRNAs) are known for their role in the post-transcriptional regulation of messenger RNA (mRNA). However, recent evidence has shown that miRNAs are capable of regulating non-coding RNAs, including miRNAs, in what is known as miRNA:miRNA interactions. There are three main models for the interplay between miRNAs. These involve direct interaction between two miRNAs, either in their mature or primary form, the subsequent changes in miRNA expression due to miRNA-directed transcriptional changes, and the cell-wide impact on miRNA and mRNA levels as a result of miRNA manipulation. Networks of mRNA and miRNA regulatory connections are invaluable to the discovery of miRNA:miRNA pathways, but this cannot be applied without consideration of the specific cell type or condition.In this chapter, we discuss what is understood about miRNA:miRNA interactions, their mechanisms and consequences in disease biology, and suggest further avenues of investigation based on current gaps in the literature and in our understanding of miRNA biology. We also address the pitfalls in contemporary methods relating to the identification of miRNA:miRNA interactions. Future work in this area may ultimately change the definitional role of miRNAs, and have far-reaching impacts on therapeutic and diagnostic developments.
    MeSH term(s) MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Gene Expression Regulation ; Gene Regulatory Networks
    Chemical Substances MicroRNAs ; RNA, Messenger
    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-031-08356-3_9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Emerging botulism in Vietnam: Identifiable risk factors, future perspective, and recommendations.

    Tran, Ngoc Ha / Tran, Van Phu / Nguyen, Dang / Tran, Nham

    Journal of global health

    2024  Volume 14, Page(s) 3004

    MeSH term(s) Humans ; Botulism/epidemiology ; Botulism/etiology ; Vietnam/epidemiology ; Risk Factors
    Language English
    Publishing date 2024-01-12
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2741629-X
    ISSN 2047-2986 ; 2047-2986
    ISSN (online) 2047-2986
    ISSN 2047-2986
    DOI 10.7189/jogh.14.03004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The knowns and unknowns of helminth-host miRNA cross-kingdom communication.

    Chowdhury, Sumaiya / Sais, Dayna / Donnelly, Sheila / Tran, Nham

    Trends in parasitology

    2023  Volume 40, Issue 2, Page(s) 176–191

    Abstract: MicroRNAs (miRNAs) are small noncoding RNAs that oversee gene modulation. They are integral to cellular functions and can migrate between species, leading to cross-kingdom gene suppression. Recent breakthroughs in helminth genome studies have sparked ... ...

    Abstract MicroRNAs (miRNAs) are small noncoding RNAs that oversee gene modulation. They are integral to cellular functions and can migrate between species, leading to cross-kingdom gene suppression. Recent breakthroughs in helminth genome studies have sparked curiosity about helminth RNA regulators and their ability to regulate genes across species. Growing data indicate that helminth miRNAs have a significant impact on the host's immune system. Specific miRNAs from helminth parasites can merge with the host's miRNA system, implying that parasites could exploit their host's regulatory machinery and function. This review highlights the role of cross-kingdom helminth-derived miRNAs in the interplay between host and parasite, exploring potential routes for their uptake, processing, and consequences in host interaction.
    MeSH term(s) Animals ; MicroRNAs/genetics ; Helminths/genetics ; Parasites/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-12-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2023.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: miRNA interplay: mechanisms and consequences in cancer.

    Hill, Meredith / Tran, Nham

    Disease models & mechanisms

    2021  Volume 14, Issue 4

    Abstract: Canonically, microRNAs (miRNAs) control mRNA expression. However, studies have shown that miRNAs are also capable of targeting non-coding RNAs, including long non-coding RNAs and miRNAs. The latter, termed a miRNA:miRNA interaction, is a form of self- ... ...

    Abstract Canonically, microRNAs (miRNAs) control mRNA expression. However, studies have shown that miRNAs are also capable of targeting non-coding RNAs, including long non-coding RNAs and miRNAs. The latter, termed a miRNA:miRNA interaction, is a form of self-regulation. In this Review, we discuss the three main modes of miRNA:miRNA regulation: direct, indirect and global interactions, and their implications in cancer biology. We also discuss the cell-type-specific nature of miRNA:miRNA interactions, current experimental approaches and bioinformatic techniques, and how these strategies are not sufficient for the identification of novel miRNA:miRNA interactions. The self-regulation of miRNAs and their impact on gene regulation has yet to be fully understood. Investigating this hidden world of miRNA self-regulation will assist in discovering novel regulatory mechanisms associated with disease pathways.
    MeSH term(s) Animals ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Models, Biological ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/pathology ; Transcription Factors/metabolism
    Chemical Substances MicroRNAs ; Transcription Factors
    Language English
    Publishing date 2021-04-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.047662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Commandeering the mammalian Ago2 miRNA network: a newly discovered mechanism of helminth immunomodulation.

    Donnelly, Sheila / Tran, Nham

    Trends in parasitology

    2021  Volume 37, Issue 12, Page(s) 1031–1033

    Abstract: MicroRNAs (miRNAs) are a class of noncoding RNAs that contribute to a broad range of biological processes through post-transcriptional regulation of gene expression. Helminths exploit this system to target mammalian gene expression, to modulate the host ... ...

    Abstract MicroRNAs (miRNAs) are a class of noncoding RNAs that contribute to a broad range of biological processes through post-transcriptional regulation of gene expression. Helminths exploit this system to target mammalian gene expression, to modulate the host immune response. Recent discoveries have shed new light on the mechanisms involved.
    MeSH term(s) Animals ; Fasciola hepatica/genetics ; Helminths/genetics ; Immunity ; Immunomodulation ; Mammals ; MicroRNAs/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2021-09-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2021.09.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Cancer Exosomes as miRNA Factories.

    Tran, Nham

    Trends in cancer

    2016  Volume 2, Issue 7, Page(s) 329–331

    Abstract: miRNAs modulate gene expression while exosomes are extracellular cargo vessels that transport miRNAs and other materials to surrounding cells. When exosomes are taken up by recipient cells, the released miRNAs can modulate immune responses, inhibit ... ...

    Abstract miRNAs modulate gene expression while exosomes are extracellular cargo vessels that transport miRNAs and other materials to surrounding cells. When exosomes are taken up by recipient cells, the released miRNAs can modulate immune responses, inhibit apoptosis, and promote angiogenesis to maintain tumor growth. Central to this regulation is the processing of the primary transcripts into active miRNAs, which occurs exclusively within mammalian cells. Challenging this dogma is the discovery that Dicer and Ago2, key components of miRNA processing, are also present inside exosomes. While the exact nature of this processing requires extensive proof, it is an exciting notion that exogenous miRNA factories could exist outside the canonical boundaries of mammalian cells.
    Language English
    Publishing date 2016-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2016.05.008
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  8. Article: Commandeering the mammalian Ago2 miRNA network: a newly discovered mechanism of helminth immunomodulation

    Donnelly, Sheila / Tran, Nham

    Trends in parasitology. 2021 Dec., v. 37, no. 12

    2021  

    Abstract: MicroRNAs (miRNAs) are a class of noncoding RNAs that contribute to a broad range of biological processes through post-transcriptional regulation of gene expression. Helminths exploit this system to target mammalian gene expression, to modulate the host ... ...

    Abstract MicroRNAs (miRNAs) are a class of noncoding RNAs that contribute to a broad range of biological processes through post-transcriptional regulation of gene expression. Helminths exploit this system to target mammalian gene expression, to modulate the host immune response. Recent discoveries have shed new light on the mechanisms involved.
    Keywords gene expression ; gene expression regulation ; helminths ; immune response ; immunomodulation ; mammals ; microRNA ; parasitology
    Language English
    Dates of publication 2021-12
    Size p. 1031-1033.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2021.09.001
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: qPCR multiplex detection of microRNA and messenger RNA in a single reaction.

    Khoury, Samantha / Tran, Nham

    PeerJ

    2020  Volume 8, Page(s) e9004

    Abstract: Reverse Transcription-Quantitative PCR (RT-qPCR) is one of the standards for analytical measurement of different RNA species in biological models. However, current Reverse Transcription (RT) based priming strategies are unable to synthesize differing ... ...

    Abstract Reverse Transcription-Quantitative PCR (RT-qPCR) is one of the standards for analytical measurement of different RNA species in biological models. However, current Reverse Transcription (RT) based priming strategies are unable to synthesize differing RNAs and ncRNAs especially miRNAs, within a single tube. We present a new methodology, referred to as RNAmp, that measures in parallel miRNA and mRNA expression. We demonstrate this in various cell lines, then evaluate clinical utility by quantifying several miRNAs and mRNA simultaneously in sera. PCR efficiency in RNAmp was estimated between 1.8 and 1.9 which is comparable to standard miRNA and random primer RT approaches. Furthermore, when using RNAmp to detect selected mRNA and miRNAs, the quantification cycle (
    Language English
    Publishing date 2020-06-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.9004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Global miRNA to miRNA Interactions: Impacts for miR-21.

    Hill, Meredith / Tran, Nham

    Trends in cell biology

    2020  Volume 31, Issue 1, Page(s) 3–5

    Abstract: miRNAs inherently alter the cellular environment by regulating target genes. miRNAs may also regulate other miRNAs, with far-reaching influence on miRNA and mRNA expression. We explore this realm of small RNA regulation with a focus on the role of the ... ...

    Abstract miRNAs inherently alter the cellular environment by regulating target genes. miRNAs may also regulate other miRNAs, with far-reaching influence on miRNA and mRNA expression. We explore this realm of small RNA regulation with a focus on the role of the oncogenic miR-21 and its impact on other miRNA species.
    MeSH term(s) Animals ; Gene Expression Regulation ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Models, Biological
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2020-11-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2020.10.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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