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Article ; Online: The genetic landscape of chromosomal aberrations in 3776 Vietnamese fetuses with clinical anomalies during pregnancy.

Tran, Danh-Cuong / Phan, Minh Ngoc / Dao, Hong-Thuy Thi / Nguyen, Hong-Dang Luu / Nguyen, Duy-Anh / Le, Quang Thanh / Hoang, Diem-Tuyet Thi / Tran, Nhat Thang / Thi Ha, Thi Minh / Dinh, Thuy Linh / Nguyen, Canh Chuong / Thi Doan, Kim Phuong / Thi Luong, Lan Anh / Vo, Ta Son / Nhat Trinh, Thu Huong / Nguyen, Van Thong / Vo, Phuong-Anh Ngoc / Nguyen, Yen-Nhi / Dinh, My-An /

Doan, Phuoc-Loc / Do, Thanh-Thuy Thi / Nguyen, Quynh-Tho Thi / Truong, Dinh-Kiet / Nguyen, Hoai-Nghia / Phan, Minh-Duy / Tang, Hung-Sang / Giang, Hoa

Personalized medicine

2024

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2299146-3
ISSN	1744-828X ; 1741-0541
ISSN (online)	1744-828X
ISSN	1741-0541
DOI	10.2217/pme-2023-0113
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Article: Neonatal Citrulline Supplementation and Later Exposure to a High Fructose Diet in Rats Born with a Low Birth Weight: A Preliminary Report

Tran, Nhat-Thang / Alexandre-Gouabau, Marie-Cécile / Pagniez, Anthony / Ouguerram, Khadija / Boquien, Clair-Yves / Winer, Norbert / Darmaun, Dominique

Nutrients. 2017 Apr. 11, v. 9, no. 4

2017

Abstract: A low birth weight (LBW) leads to a higher risk of metabolic syndrome in adulthood. Literature suggests that citrulline supplementation in adulthood prevents the effect of a high fructose diet on energy metabolism. Whether neonatal citrulline ... ...

Abstract	A low birth weight (LBW) leads to a higher risk of metabolic syndrome in adulthood. Literature suggests that citrulline supplementation in adulthood prevents the effect of a high fructose diet on energy metabolism. Whether neonatal citrulline supplementation would alter early growth or energy metabolism in the long-term in rats with LBW is unknown. LBW pups born from dams fed a low (4%) protein diet, were nursed by normally-fed dams and received isonitrogenous supplements of either l-citrulline or l-alanine by gavage from the sixth day of life until weaning, and were subsequently exposed to 10%-fructose in drinking water from weaning to 90 days of age. The oral glucose tolerance was tested (OGTT) at 70 days of age, and rats were sacrificed at 90 days of age. Pre-weaning citrulline supplementation failed to alter the growth trajectory, OGTT, plasma triglycerides, or fat mass accretion in adulthood; yet, it was associated with increased liver triglycerides, decreased liver total cholesterol, and a distinct liver lipidomic profile that may result in a predisposition to liver disease. We conclude that pre-weaning supplementation with citrulline does not impact early growth, but might impact liver fat metabolism in adulthood upon exposure to a high fructose diet.
Keywords	adulthood ; alanine ; animal feeding ; cholesterol ; citrulline ; dams (mothers) ; drinking water ; energy metabolism ; glucose tolerance ; high fructose diet ; lipid metabolism ; liver ; liver diseases ; low birth weight ; metabolic syndrome ; pups ; rats ; triacylglycerols ; weaning
Language	English
Dates of publication	2017-0411
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu9040375
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: L-Citrulline Supplementation Enhances Fetal Growth and Protein Synthesis in Rats with Intrauterine Growth Restriction.

Bourdon, Aurélie / Parnet, Patricia / Nowak, Christel / Tran, Nhat-Thang / Winer, Norbert / Darmaun, Dominique

The Journal of nutrition

2016 Volume 146, Issue 3, Page(s) 532–541

Abstract: Background: Intrauterine growth restriction (IUGR) results from either maternal undernutrition or impaired placental blood flow, exposing offspring to increased perinatal mortality and a higher risk of metabolic syndrome and cardiovascular disease ... ...

Abstract	Background: Intrauterine growth restriction (IUGR) results from either maternal undernutrition or impaired placental blood flow, exposing offspring to increased perinatal mortality and a higher risk of metabolic syndrome and cardiovascular disease during adulthood. l-Citrulline is a precursor of l-arginine and nitric oxide (NO), which regulates placental blood flow. Moreover, l-citrulline stimulates protein synthesis in other models of undernutrition. Objective: The aim of the study was to determine whether l-citrulline supplementation would enhance fetal growth in a model of IUGR induced by maternal dietary protein restriction. Methods: Pregnant rats were fed either a control (20% protein) or a low-protein (LP; 4% protein) diet. LP dams were randomly allocated to drink tap water either as such or supplemented with l-citrulline (2 g · kg(-1) · d(-1)), an isonitrogenous amount of l-arginine, or nonessential l-amino acids (NEAAs). On day 21 of gestation, dams received a 2-h infusion of l-[1-(13)C]-valine until fetuses were extracted by cesarean delivery. Isotope enrichments were measured in free amino acids and fetal muscle, liver, and placenta protein by GC-mass spectrometry. Results: Fetal weight was ∼29% lower in the LP group (3.82 ± 0.06 g) than in the control group (5.41 ± 0.10 g) (P < 0.001). Regardless of supplementation, fetal weight remained below that of control fetuses. Yet, compared with the LP group, l-citrulline and l-arginine equally increased fetal weight to 4.15 ± 0.08 g (P < 0.05) and 4.13 ± 0.1 g (P < 0.05 compared with LP), respectively, whereas NEAA did not (4.05 ± 0.05 g; P = 0.07). Fetal muscle protein fractional synthesis rate was 35% lower in the LP fetuses (41% ± 11%/d) than in the control (61% ± 13%/d) fetuses (P < 0.001) and was normalized by l-citrulline (56% ± 4%/d; P < 0.05 compared with LP, NS compared with control) and not by other supplements. Urinary nitrite and nitrate excretion was lower in the LP group (6.4 ± 0.8 μmol/d) than in the control group (17.9 ± 1.1 μmol/d; P < 0.001) and increased in response to l-citrulline or l-arginine (12.1 ± 2.2 and 10.6 ± 0.9 μmol/d; P < 0.05), whereas they did not in the LP + NEAA group. Conclusion: l-Citrulline increases fetal growth in a model of IUGR, and the effect may be mediated by enhanced fetal muscle protein synthesis and/or increased NO production.
MeSH term(s)	Animals ; Arginine/metabolism ; Citrulline/administration & dosage ; Diet, Protein-Restricted/adverse effects ; Dietary Supplements ; Female ; Fetal Development/drug effects ; Fetal Growth Retardation/drug therapy ; Fetal Weight/drug effects ; Fetus/drug effects ; Fetus/metabolism ; Maternal Nutritional Physiological Phenomena ; Nitric Oxide/metabolism ; Nutritional Status ; Placenta/drug effects ; Placenta/metabolism ; Pregnancy ; Protein Biosynthesis/drug effects ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Citrulline (29VT07BGDA) ; Nitric Oxide (31C4KY9ESH) ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2016-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.3945/jn.115.221267
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Article ; Online: Neonatal Citrulline Supplementation and Later Exposure to a High Fructose Diet in Rats Born with a Low Birth Weight: A Preliminary Report.

Tran, Nhat-Thang / Alexandre-Gouabau, Marie-Cécile / Pagniez, Anthony / Ouguerram, Khadija / Boquien, Clair-Yves / Winer, Norbert / Darmaun, Dominique

Nutrients

2017 Volume 9, Issue 4

Abstract	A low birth weight (LBW) leads to a higher risk of metabolic syndrome in adulthood. Literature suggests that citrulline supplementation in adulthood prevents the effect of a high fructose diet on energy metabolism. Whether neonatal citrulline supplementation would alter early growth or energy metabolism in the long-term in rats with LBW is unknown. LBW pups born from dams fed a low (4%) protein diet, were nursed by normally-fed dams and received isonitrogenous supplements of either l-citrulline or l-alanine by gavage from the sixth day of life until weaning, and were subsequently exposed to 10%-fructose in drinking water from weaning to 90 days of age. The oral glucose tolerance was tested (OGTT) at 70 days of age, and rats were sacrificed at 90 days of age. Pre-weaning citrulline supplementation failed to alter the growth trajectory, OGTT, plasma triglycerides, or fat mass accretion in adulthood; yet, it was associated with increased liver triglycerides, decreased liver total cholesterol, and a distinct liver lipidomic profile that may result in a predisposition to liver disease. We conclude that pre-weaning supplementation with citrulline does not impact early growth, but might impact liver fat metabolism in adulthood upon exposure to a high fructose diet.
MeSH term(s)	Animals ; Animals, Newborn ; Birth Weight ; Citrulline/adverse effects ; Citrulline/therapeutic use ; Diet, Carbohydrate Loading/adverse effects ; Diet, Protein-Restricted/adverse effects ; Dietary Supplements/adverse effects ; Female ; Fetal Growth Retardation/etiology ; Fetal Growth Retardation/metabolism ; Fetal Growth Retardation/physiopathology ; Fructose/adverse effects ; Hepatic Insufficiency/etiology ; Hepatic Insufficiency/metabolism ; Hepatic Insufficiency/physiopathology ; Lactation ; Lipid Metabolism ; Liver/metabolism ; Liver/physiopathology ; Male ; Maternal Nutritional Physiological Phenomena ; Metabolic Syndrome/etiology ; Metabolic Syndrome/prevention & control ; Pilot Projects ; Pregnancy ; Random Allocation ; Rats, Sprague-Dawley ; Weaning
Chemical Substances	Citrulline (29VT07BGDA) ; Fructose (30237-26-4)
Language	English
Publishing date	2017-04-11
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu9040375
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Article ; Online: Maternal citrulline supplementation enhances placental function and fetal growth in a rat model of IUGR: involvement of insulin-like growth factor 2 and angiogenic factors.

Tran, Nhat-Thang / Amarger, Valerie / Bourdon, Aurelie / Misbert, Emilie / Grit, Isabelle / Winer, Norbert / Darmaun, Dominique

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2017 Volume 30, Issue 16, Page(s) 1906–1911

Abstract: Objective: To determine the effects of maternal citrulline supplementation on fetal growth and placental efficiency in a rat model of intrauterine growth restriction (IUGR) induced by maternal protein restriction.: Methods: Pregnant Sprague-Dawley ... ...

Abstract	Objective: To determine the effects of maternal citrulline supplementation on fetal growth and placental efficiency in a rat model of intrauterine growth restriction (IUGR) induced by maternal protein restriction. Methods: Pregnant Sprague-Dawley rats were randomly assigned to three groups: NP (receiving a control 20% protein diet), LP (a 4% protein diet), or LP-CIT (an LP diet along with L-citrulline, 2 g/kg/d in drinking water). On the 15th and 21st day of gestation (GD15 and GD21, respectively), dams underwent a C-section, by which fetuses and placentas were extracted. The expression of genes involved in placental growth and angiogenesis was studied by quantitative RT-PCR. Results: Maternal citrulline supplementation increased fetal weight at GD21, and fetal weight/placental weight ratio, an index of placental efficiency, from mid gestation (p < 0.001). The expression of Igf2-P0, a placenta-specific variant of insulin-like growth factor 2 (Igf2) gene, and Vegf and Flt-1, involved in angiogenic pathways, was enhanced in the LP-CIT group (versus NP, p < 0.001, p < 0.01, and p < 0.05 for Igf2-P0, Vegf, and Flt-1, respectively). Conclusions: In a model of IUGR induced by protein deprivation, citrulline enhances fetal growth, placental efficiency, and the expression of genes involved in angiogenesis. The relevance of such effect in human pregnancies complicated by IUGR warrants further study.
Language	English
Publishing date	2017-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2016.1229768
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Article ; Online: De novo

Tran, Nhat-Thang / Vo, Son Ta / Nguyen, Duy-Anh / Nguyen, Canh-Chuong / Dinh, Linh Thuy / Tran, Minh-Thu Thi / Tran, Danh-Cuong / Luong, Lan-Anh Thi / Doan, Kim-Phuong / Huy Nguyen, Vu Quoc / Thi Ha, Thi Minh / Truong, Linh-Giang Thi / Cao, Phuong Thi-Mai / Tran, Vy Thi-Nhat / Nhut Trinh, Thu Huong / Le, Quang Thanh / Nguyen, Van Thong / Hoang, Diem-Tuyet Thi / Nguyen, My-Nhi Ba /

Bui, Chi-Thuong / Tran, Son-Tra Thi / Lam, Duc-Tam / Le, Hong-Thinh / Nguyen, My-Ngoc Ba / Ho, Viet-Thang / Nguyen, Minh-Trung / Dao, Trang Thi / Nguyen, Phuong Minh / Nguyen, Thu-Hang Le / Ha, Nhung Phuong / Lu, Y-Thanh / Do, Thanh-Thuy Thi / Truong, Dinh-Kiet / Phan, Minh-Duy / Nguyen, Hoai-Nghia / Giang, Hoa / Tang, Hung-Sang

Personalized medicine

2023 Volume 20, Issue 6, Page(s) 467–475

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Pregnancy ; Female ; Humans ; Vietnam ; Prenatal Diagnosis ; Thanatophoric Dysplasia/diagnosis ; Thanatophoric Dysplasia/genetics ; Receptor, Fibroblast Growth Factor, Type 3
Chemical Substances	Receptor, Fibroblast Growth Factor, Type 3 (EC 2.7.10.1)
Language	English
Publishing date	2023-11-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2299146-3
ISSN	1744-828X ; 1741-0541
ISSN (online)	1744-828X
ISSN	1741-0541
DOI	10.2217/pme-2023-0105
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Article ; Online: Developing and validating noninvasive prenatal testing for

Nguyen, Nhi Yen / Lu, Y-Thanh / Nguyen, Duy-Anh / Nguyen, Canh-Chuong / Dinh, Linh Thuy / Tran, Minh-Thu Thi / Tran, Danh-Cuong / Luong, Lan-Anh Thi / Doan, Kim-Phuong / Huy Nguyen, Vu Quoc / Thi Ha, Thi Minh / Truong, Linh-Giang Thi / Tran, Nhat-Thang / Cao, Phuong Thi-Mai / Tran, Vy Thi-Nhat / Nhut Trinh, Thu Huong / Le, Quang Thanh / Nguyen, Van Thong / Hoang, Diem-Tuyet Thi /

Personalized medicine

2023 Volume 20, Issue 5, Page(s) 425–433

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Pregnancy ; Female ; Infant, Newborn ; Humans ; Noninvasive Prenatal Testing ; Vietnam ; Prenatal Diagnosis
Language	English
Publishing date	2023-08-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2299146-3
ISSN	1744-828X ; 1741-0541
ISSN (online)	1744-828X
ISSN	1741-0541
DOI	10.2217/pme-2023-0076
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Article ; Online: Genetic landscape of recessive diseases in the Vietnamese population from large-scale clinical exome sequencing.

Tran, Ngoc Hieu / Nguyen Thi, Thanh-Huong / Tang, Hung-Sang / Hoang, Le-Phuc / Nguyen, Trung-Hieu Le / Tran, Nhat-Thang / Trinh, Thu-Huong Nhat / Nguyen, Van Thong / Nguyen, Bao-Han Huu / Nguyen, Hieu Trong / Doan, Loc Phuoc / Phan, Ngoc-Minh / Nguyen, Kim-Huong Thi / Nguyen, Hong-Dang Luu / Quach, Minh-Tam Thi / Nguyen, Thanh-Phuong Thi / Tran, Vu Uyen / Tran, Dinh-Vinh / Nguyen, Quynh-Tho Thi /

Do, Thanh-Thuy Thi / Lam, Nien Vinh / Cao Thi Ngoc, Phuong / Truong, Dinh Kiet / Nguyen, Hoai-Nghia / Phan, Minh-Duy / Giang, Hoa

Human mutation

2021 Volume 42, Issue 10, Page(s) 1229–1238

Abstract: Accurate profiling of population-specific recessive diseases is essential for the design of cost-effective carrier screening programs. However, minority populations and ethnic groups, including Vietnamese, are still underrepresented in existing genetic ... ...

Abstract	Accurate profiling of population-specific recessive diseases is essential for the design of cost-effective carrier screening programs. However, minority populations and ethnic groups, including Vietnamese, are still underrepresented in existing genetic studies. Here, we reported the first comprehensive study of recessive diseases in the Vietnamese population. Clinical exome sequencing data of 4503 disease-associated genes obtained from a cohort of 985 Vietnamese individuals was analyzed to identify pathogenic variants, associated diseases and their carrier frequencies in the population. A total of 118 recessive diseases associated with 164 pathogenic or likely pathogenic variants were identified, among which 28 diseases had carrier frequencies of at least 1% (1 in 100 individuals). Three diseases were prevalent in the Vietnamese population with carrier frequencies of 2-12 times higher than in the world populations, including beta-thalassemia (1 in 23), citrin deficiency (1 in 31), and phenylketonuria (1 in 40). Seven novel pathogenic and two likely pathogenic variants associated with nine recessive diseases were discovered. The comprehensive profile of recessive diseases identified in this study enables the design of cost-effective carrier screening programs specific to the Vietnamese population.
MeSH term(s)	Asians ; Cohort Studies ; Ethnicity ; Exome/genetics ; Humans ; Whole Exome Sequencing
Language	English
Publishing date	2021-07-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1126646-6
ISSN	1098-1004 ; 1059-7794
ISSN (online)	1098-1004
ISSN	1059-7794
DOI	10.1002/humu.24253
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Article ; Online: Reducing false positive rate of fetal monosomy X in non-invasive prenatal testing using a combined algorithm to detect maternal mosaic monosomy X.

Phan, Minh-Duy / Vo, Binh T / Nguyen, Thong V / Tran, Nhat-Thang / Trinh, Huong N T / Nguyen, Tho T Q / Nguyen, Nguyen H / Tran, Truong T / Tran, Uyen V / Dao, Thuy T H / Pham, Anh H / Tran, Tam H / Truong, Kiet D / Hoang, Tuyet T D / Do, Thanh-Thuy T / Nguyen, Hoai-Nghia / Giang, Hoa

Prenatal diagnosis

2019 Volume 39, Issue 4, Page(s) 324–327

MeSH term(s)	Adult ; Algorithms ; Chromosome Aberrations/statistics & numerical data ; Chromosomes, Human, X/genetics ; False Positive Reactions ; Female ; Fetus/metabolism ; Fetus/pathology ; Humans ; Maternal Serum Screening Tests/methods ; Maternal Serum Screening Tests/statistics & numerical data ; Monosomy/diagnosis ; Monosomy/genetics ; Mosaicism/statistics & numerical data ; Mothers/statistics & numerical data ; Pregnancy ; Prenatal Diagnosis/methods ; Prenatal Diagnosis/statistics & numerical data ; Turner Syndrome/diagnosis ; Turner Syndrome/epidemiology
Language	English
Publishing date	2019-02-20
Publishing country	England
Document type	Evaluation Study ; Journal Article
ZDB-ID	82031-3
ISSN	1097-0223 ; 0197-3851
ISSN (online)	1097-0223
ISSN	0197-3851
DOI	10.1002/pd.5430
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Article ; Online: Detection of maternal carriers of common α-thalassemia deletions from cell-free DNA.

Doan, Phuoc-Loc / Nguyen, Duy-Anh / Le, Quang Thanh / Hoang, Diem-Tuyet Thi / Nguyen, Huu Du / Nguyen, Canh Chuong / Doan, Kim Phuong Thi / Tran, Nhat Thang / Ha, Thi Minh Thi / Trinh, Thu Huong Nhat / Nguyen, Van Thong / Bui, Chi Thuong / Lai, Ngoc-Diep Thi / Duong, Thanh Hien / Mai, Hai-Ly / Huynh, Pham-Uyen Vinh / Huynh, Thu Thanh Thi / Le, Quang Vinh / Vo, Thanh Binh /

Dao, Thi Hong-Thuy / Vo, Phuong Anh / Le, Duy-Khang Nguyen / Tran, Ngoc Nhu Thi / Tran, Quynh Nhu Thi / Van, Yen-Linh Thi / Tran, Huyen-Trang Thi / Nguyen, Hoai Thi / Nguyen, Phuong-Uyen / Do, Thanh-Thuy Thi / Truong, Dinh-Kiet / Tang, Hung Sang / Cao, Ngoc-Phuong Thi / Lam, Tuan-Thanh / Tran, Le Son / Nguyen, Hoai-Nghia / Giang, Hoa / Phan, Minh-Duy

Scientific reports

2022 Volume 12, Issue 1, Page(s) 13581

Abstract: α-Thalassemia is a common inherited blood disorder manifested mainly by the deletions of α-globin genes. In geographical areas with high carrier frequencies, screening of α-thalassemia carrier state is therefore of vital importance. This study presents a ...

Abstract	α-Thalassemia is a common inherited blood disorder manifested mainly by the deletions of α-globin genes. In geographical areas with high carrier frequencies, screening of α-thalassemia carrier state is therefore of vital importance. This study presents a novel method for identifying female carriers of common α-thalassemia deletions using samples routinely taken for non-invasive prenatal tests for screening of fetal chromosomal aneuploidies. A total of 68,885 Vietnamese pregnant women were recruited and α-thalassemia statuses were determined by gap-PCR, revealing 5344 women (7.76%) carried deletions including αα/--
MeSH term(s)	Cell-Free Nucleic Acids ; China ; Female ; Genotype ; Humans ; Mutation ; Polymerase Chain Reaction/methods ; Pregnancy ; alpha-Globins/genetics ; alpha-Thalassemia/diagnosis ; alpha-Thalassemia/genetics ; beta-Thalassemia/genetics
Chemical Substances	Cell-Free Nucleic Acids ; alpha-Globins
Language	English
Publishing date	2022-08-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-17718-7
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