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  1. Article ; Online: Single-Ion Behavior in New 2-D and 3-D Gadolinium 4f

    Oyeka, Ebube E / Tran, Thao T

    ACS organic & inorganic Au

    2022  Volume 2, Issue 6, Page(s) 502–510

    Abstract: The recent creation of ... ...

    Abstract The recent creation of 4f
    Language English
    Publishing date 2022-09-04
    Publishing country United States
    Document type Journal Article
    ISSN 2694-247X
    ISSN (online) 2694-247X
    DOI 10.1021/acsorginorgau.2c00031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial: Recent Development of Drug Delivery Systems for Improving Bioavailability and Pharmacokinetics.

    Tran, Thao T D

    Current drug metabolism

    2018  Volume 18, Issue 11, Page(s) 972

    MeSH term(s) Biological Availability ; Drug Delivery Systems ; Pharmaceutical Preparations/administration & dosage ; Pharmaceutical Preparations/chemistry ; Pharmaceutical Preparations/metabolism ; Pharmacokinetics
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2018-01-25
    Publishing country Netherlands
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2064815-7
    ISSN 1875-5453 ; 1389-2002
    ISSN (online) 1875-5453
    ISSN 1389-2002
    DOI 10.2174/138920021811180117141059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5584: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Blueberry Supplementation in Neuronal Health and Protective Technologies for Efficient Delivery of Blueberry Anthocyanins.

    Tran, Phuong H L / Tran, Thao T D

    Biomolecules

    2021  Volume 11, Issue 1

    Abstract: Blueberries are consumed as healthy fruits that provide a variety of benefits to the nervous system. Scientists have found that blueberries can be used as a daily edible source for supplementation to prevent and minimize complexities of age-related ... ...

    Abstract Blueberries are consumed as healthy fruits that provide a variety of benefits to the nervous system. Scientists have found that blueberries can be used as a daily edible source for supplementation to prevent and minimize complexities of age-related diseases as well as to improve learning and memory in children. Anthocyanins are the most mentioned compounds among the components in blueberries, as they play a major role in providing the health benefits of this fruit. However, while they are highly active in impeding biological impairment in neuronal functions, they have poor bioavailability. This review focuses on neurological investigations of blueberries from in vitro cell studies to in vivo studies, including animal and human studies, with respect to their positive outcomes of neuroprotection and intervention in neurodegenerative conditions. Readers will also find information on the bioavailability of anthocyanins and the considerable factors affecting them so that they can make informed decisions regarding the daily consumption of blueberries. In this context, the ways in which blueberries or blueberry supplementation forms are consumed and which of these forms is best for maximizing the health benefits of blueberries should be considered important decision-making factors in the consumption of blueberries; all of these aspects are covered in this review. Finally, we discuss recent technologies that have been employed to improve the bioavailability of blueberry anthocyanins in the development of effective delivery vehicles supporting brain health.
    MeSH term(s) Animals ; Anthocyanins/pharmacology ; Biological Availability ; Blueberry Plants/chemistry ; Clinical Trials as Topic ; Dietary Supplements ; Humans ; Neurons/drug effects ; Neurons/physiology ; Neuroprotection/drug effects
    Chemical Substances Anthocyanins
    Language English
    Publishing date 2021-01-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom11010102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Encapsulation of Lipid-based Formulations in Porous Carriers for Controlled Drug Delivery.

    Tran, Phuong H L / Tran, Thao T D

    Current medicinal chemistry

    2021  Volume 28, Issue 42, Page(s) 8711–8721

    Abstract: Lipid-based formulations have recently been investigated as a promising approach to enhance the bioavailability of drugs, especially poorly water-soluble drugs. The encapsulation of lipid-based formulations in porous materials can result in a ... ...

    Abstract Lipid-based formulations have recently been investigated as a promising approach to enhance the bioavailability of drugs, especially poorly water-soluble drugs. The encapsulation of lipid-based formulations in porous materials can result in a transformation of liquids or semisolid forms to solid dosage forms. Moreover, the specific structure of porous carriers could offer an enhanced ability to load and control active pharmaceutical ingredients. Although there have been prominent reports on lipid-based formulations and porous materials as promising technologies for controlled drug release, the overall methods of encapsulating lipid-based formulations need to be discussed for further formulation investigations. This review aims to present the key strategies used for producing porous carriers containing lipid-based formulations. We also discuss methods that enhance the encapsulation efficiency of loaded drugs within porous structures (instead of lipid-based formulations). Moreover, the critical factors that affect tablet formation are outlined. This overview of lipid-based formulations encapsulated within porous materials provides a summary of the technical methods used in the development of these formulations and their clinical translation.
    MeSH term(s) Drug Carriers ; Drug Delivery Systems ; Drug Liberation ; Humans ; Lipids ; Porosity ; Solubility
    Chemical Substances Drug Carriers ; Lipids
    Language English
    Publishing date 2021-04-21
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867328666210420103841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Study of Integer Spin

    Oyeka, Ebube E / Winiarski, Michał J / Tran, Thao T

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 23

    Abstract: Polar magnetic materials exhibiting appreciable asymmetric exchange interactions can potentially host new topological states of matter such as vortex-like spin textures; however, realizations have been mostly limited to half-integer spins due to rare ... ...

    Abstract Polar magnetic materials exhibiting appreciable asymmetric exchange interactions can potentially host new topological states of matter such as vortex-like spin textures; however, realizations have been mostly limited to half-integer spins due to rare numbers of integer spin systems with broken spatial inversion lattice symmetries. Here, we studied the structure and magnetic properties of the
    Language English
    Publishing date 2021-11-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26237210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  6. Article ; Online: Clay-based Formulations for Bioavailability Enhancement of Poorly Water-soluble Drugs.

    Tran, Phuong H L / Tran, Thao T D

    Current drug metabolism

    2021  Volume 22, Issue 9, Page(s) 726–734

    Abstract: Clays have been used in various health care products, including drug delivery systems. Advanced formulations have been investigated to take full advantage of clays or clay-based materials. The remarkable properties of clays, such as high adsorption, high ...

    Abstract Clays have been used in various health care products, including drug delivery systems. Advanced formulations have been investigated to take full advantage of clays or clay-based materials. The remarkable properties of clays, such as high adsorption, high surface area and high ion exchange capacities, provide an ideal system for the delivery of poorly water-soluble drugs. Currently, there is still limited information on the classification and discussion of clay-based formulations for poorly water-soluble drugs. This review aims to describe efficient delivery systems that use clay as the main excipient in formulations. More details regarding the strategies of using clays in formulations as well as fabrication methods will be discussed. Moreover, combinations with other excipients in hybrid formulations will also be mentioned and the efficacy of these systems will be evaluated. The recent studies on claybased formulations for poorly water-soluble drugs provide fundamental approaches and prospects to be applied in drug development.
    MeSH term(s) Biological Availability ; Clay/chemistry ; Drug Compounding/methods ; Drug Delivery Systems ; Drug Development/methods ; Humans ; Pharmaceutical Preparations/chemistry ; Pharmacokinetics ; Solubility
    Chemical Substances Pharmaceutical Preparations ; Clay (T1FAD4SS2M)
    Language English
    Publishing date 2021-05-19
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2064815-7
    ISSN 1875-5453 ; 1389-2002
    ISSN (online) 1875-5453
    ISSN 1389-2002
    DOI 10.2174/1389200222666210609170423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5584: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs.

    Tran, Thao T D / Tran, Phuong H L

    Pharmaceutics

    2020  Volume 12, Issue 8

    Abstract: Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions. Typically, the detection of molecular interactions will assist in the ... ...

    Abstract Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions. Typically, the detection of molecular interactions will assist in the explanation of different drug performances (e.g., dissolution, solubility, stability) in solid dispersions. Various prominent reviews on solid dispersions have been reported recently. However, there is still no overview of recent techniques for evaluating the molecular interactions that occur within solid dispersions of poorly water-soluble drugs. In this review, we aim to overview common methods that have been used for solid dispersions to identify different bond formations and forces via the determination of interaction energy. In addition, a brief background on the important role of molecular interactions will also be described. The summary and discussion of methods used in the determination of molecular interactions will contribute to further developments in solid dispersions, especially for quick and potent drug delivery applications.
    Language English
    Publishing date 2020-08-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics12080745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Insoluble Polymers in Solid Dispersions for Improving Bioavailability of Poorly Water-Soluble Drugs.

    Tran, Thao T D / Tran, Phuong H L

    Polymers

    2020  Volume 12, Issue 8

    Abstract: In recent decades, solid dispersions have been demonstrated as an effective approach for improving the bioavailability of poorly water-soluble drugs, as have solid dispersion techniques that include the application of nanotechnology. Many studies have ... ...

    Abstract In recent decades, solid dispersions have been demonstrated as an effective approach for improving the bioavailability of poorly water-soluble drugs, as have solid dispersion techniques that include the application of nanotechnology. Many studies have reported on the ability to change drug crystallinity and molecular interactions to enhance the dissolution rate of solid dispersions using hydrophilic carriers. However, numerous studies have indicated that insoluble carriers are also promising excipients in solid dispersions. In this report, an overview of solid dispersion strategies involving insoluble carriers has been provided. In addition to the role of solubility and dissolution enhancement, the perspectives of the use of these polymers in controlled release solid dispersions have been classified and discussed. Moreover, the compatibility between methods and carriers and between drug and carrier is mentioned. In general, this report on solid dispersions using insoluble carriers could provide a specific approach and/or a selection of these polymers for further formulation development and clinical applications.
    Language English
    Publishing date 2020-07-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym12081679
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Mucoadhesive Formulation Designs for Oral Controlled Drug Release at the Colon.

    Tran, Phuong H L / Tran, Thao T D

    Current pharmaceutical design

    2020  Volume 27, Issue 4, Page(s) 540–547

    Abstract: Mucoadhesive formulations have been demonstrated to result in efficient drug delivery systems with advantages over existing systems such as increased local retention and sustained drug release via adhesiveness to mucosal tissues. The controlled release ... ...

    Abstract Mucoadhesive formulations have been demonstrated to result in efficient drug delivery systems with advantages over existing systems such as increased local retention and sustained drug release via adhesiveness to mucosal tissues. The controlled release of colon-targeted, orally administered drugs has recently attracted a number of studies investigating mucoadhesive systems. Consequently, substantial designs, from mucoadhesive cores to shells of particles, have been studied with promising applications. This review will provide an overview of specific strategies for developing mucoadhesive systems for colon-targeted oral delivery with controlled drug release, including mucoadhesive matrices, cross-linked mucoadhesive microparticles, coatings and mucoadhesive nanoparticles. The understanding of the basic principle of these designs and advanced formulations throughout will lead to the development of products with efficient drug delivery at the colon for therapies for different diseases.
    MeSH term(s) Adhesiveness ; Colon ; Drug Delivery Systems ; Drug Liberation ; Excipients ; Humans
    Chemical Substances Excipients
    Language English
    Publishing date 2020-10-01
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/1381612826666200917143816
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Dosage form designs for the controlled drug release of solid dispersions.

    Tran, Phuong H L / Tran, Thao T D

    International journal of pharmaceutics

    2020  Volume 581, Page(s) 119274

    Abstract: Although solid dispersions have been reported as an efficient drug delivery system, the design of specific dosage forms for pharmaceutical therapy is necessary to improve the solubility and bioavailability of poorly water-soluble drugs. Solid dispersions ...

    Abstract Although solid dispersions have been reported as an efficient drug delivery system, the design of specific dosage forms for pharmaceutical therapy is necessary to improve the solubility and bioavailability of poorly water-soluble drugs. Solid dispersions can be incorporated in general solid dosage forms such as powders, granules, capsules and tablets, but only to enhance solubility and the dissolution rate. However, further development of solid dispersions will be required in certain circumstances for further in vivo drug improvement of those solid dosage forms. In the current review, specific designs of solid dosage forms for controlled drug release will be reported. Moreover, methods and strategies for incorporating these solid dispersions into controlled drug release forms will also be discussed. Overall, the outlook of current studies will provide potential approaches for the further improvement of solid dispersions, especially for clinical developments in pharmaceutical therapy.
    MeSH term(s) Biological Availability ; Crystallization ; Delayed-Action Preparations/administration & dosage ; Delayed-Action Preparations/chemistry ; Delayed-Action Preparations/pharmacokinetics ; Drug Carriers/chemistry ; Drug Compounding/methods ; Drug Design ; Drug Liberation ; Excipients/chemistry ; Solubility ; Tablets
    Chemical Substances Delayed-Action Preparations ; Drug Carriers ; Excipients ; Tablets
    Language English
    Publishing date 2020-03-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2020.119274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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