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  1. Article ; Online: Nanoparticles as carriers of photosensitizers to improve photodynamic therapy in cancer.

    Truong, Duy Hieu / Tran, Phuong Thi Thu / Tran, Tuan Hiep

    Pharmaceutical development and technology

    2024  Volume 29, Issue 3, Page(s) 221–235

    Abstract: Photodynamic therapy (PDT) has emerged as a promising non invasive therapeutic approach for cancer treatment, offering unique advantages over conventional treatments. The combination of light activation and photosensitizing agents allows for targeted and ...

    Abstract Photodynamic therapy (PDT) has emerged as a promising non invasive therapeutic approach for cancer treatment, offering unique advantages over conventional treatments. The combination of light activation and photosensitizing agents allows for targeted and localized destruction of cancer cells, reducing damage to surrounding healthy tissues. In recent years, the integration of nanoparticles with PDT has garnered significant attention due to their potential to enhance therapeutic outcomes. This review article aims to provide a comprehensive overview of the current state-of-the-art in utilizing nanoparticles for photodynamic therapy in cancer treatment. We summarized various nanoparticle-based approaches, their properties, and their implications in optimizing PDT efficacy, and discussed challenges and prospects in the field.
    MeSH term(s) Humans ; Photosensitizing Agents ; Photochemotherapy ; Neoplasms/drug therapy ; Drug Delivery Systems ; Nanoparticles
    Chemical Substances Photosensitizing Agents
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1331774-x
    ISSN 1097-9867 ; 1083-7450
    ISSN (online) 1097-9867
    ISSN 1083-7450
    DOI 10.1080/10837450.2024.2322570
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  2. Article: Lactoferrin and Nanotechnology: The Potential for Cancer Treatment.

    Tran, Tuan Hiep / Tran, Phuong Thi Thu / Truong, Duy Hieu

    Pharmaceutics

    2023  Volume 15, Issue 5

    Abstract: Lactoferrin (Lf)-a glycoprotein of the transferrin family-has been investigated as a promising molecule with diverse applications, including infection inhibition, anti-inflammation, antioxidant properties and immune modulation. Along with that, Lf was ... ...

    Abstract Lactoferrin (Lf)-a glycoprotein of the transferrin family-has been investigated as a promising molecule with diverse applications, including infection inhibition, anti-inflammation, antioxidant properties and immune modulation. Along with that, Lf was found to inhibit the growth of cancerous tumors. Owing to unique properties such as iron-binding and positive charge, Lf could interrupt the cancer cell membrane or influence the apoptosis pathway. In addition, being a common mammalian excretion, Lf offers is promising in terms of targeting delivery or the diagnosis of cancer. Recently, nanotechnology significantly enhanced the therapeutic index of natural glycoproteins such as Lf. Therefore, in the context of this review, the understanding of Lf is summarized and followed by different strategies of nano-preparation, including inorganic nanoparticles, lipid-based nanoparticles and polymer-based nanoparticles in cancer management. At the end of the study, the potential future applications are discussed to pave the way for translating Lf into actual usage.
    Language English
    Publishing date 2023-04-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15051362
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  3. Article: Targeting the PD-1/PD-L1 axis for cancer treatment: a review on nanotechnology.

    Tran, Tuan Hiep / Phuong Tran, Thi Thu

    Royal Society open science

    2022  Volume 9, Issue 4, Page(s) 211991

    Abstract: Although nanomedicines have been in the oncology field for almost three decades with the introduction of doxil, only a few nanomedicine products have reached approval. Can nanotechnology be a realistic tool to reduce the number of hospital beds? At ... ...

    Abstract Although nanomedicines have been in the oncology field for almost three decades with the introduction of doxil, only a few nanomedicine products have reached approval. Can nanotechnology be a realistic tool to reduce the number of hospital beds? At present, several clinically approved anti-PD-1/PD-L1 antibodies or CAR T cell-based therapies are available; however, the immunotherapy field is far from mature. Will immunotherapy be the fourth pillar of cancer treatment? In this review, we summarized the current status of immunotherapy using PD-1/PD-L1-targeting nanocarriers. The knowledge on material science, therapeutic agents and formulation designs could pave the way for high-efficacy treatment outcomes.
    Language English
    Publishing date 2022-04-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.211991
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  4. Article ; Online: IgG-Complexed Adenoviruses Induce Human Plasmacytoid Dendritic Cell Activation and Apoptosis.

    Tran, Thi Thu Phuong / Tran, Tuan Hiep / Kremer, Eric J

    Viruses

    2021  Volume 13, Issue 9

    Abstract: Following repeat exposure to many human adenoviruses (HAdVs), most adults harbour long-lived B- and T-cell responses. Combined, this response typically protects us for years from re-infection by the same HAdV type. In spite of these immune responses, ... ...

    Abstract Following repeat exposure to many human adenoviruses (HAdVs), most adults harbour long-lived B- and T-cell responses. Combined, this response typically protects us for years from re-infection by the same HAdV type. In spite of these immune responses, some HAdV types are associated with persistent infections that constitute a life-threatening risk when an individual's T-cell response is compromised. By contrast, patients with B-cell deficiencies do not appear to be at a greater risk of HAdV disease. This dichotomy begs the question of the secondary role of anti-HAdV antibodies during host defence. In this study, we explored IgG-complexed (IC)-HAdV5 and primary human plasmacytoid dendritic cell (pDC) interactions. We found that IC-HAdV5 are efficiently internalized in pDCs, stimulate their activation through TLR9 signalling, and cause apoptosis. These data may help reconcile the enigma of robust immune response to HAdVs, while concurrently allowing persistence.
    MeSH term(s) Adenoviruses, Human/immunology ; Antigen Presentation ; Apoptosis/immunology ; Cells, Cultured ; Dendritic Cells/immunology ; Dendritic Cells/pathology ; Dendritic Cells/virology ; Humans ; Immunity, Innate ; Immunoglobulin G/immunology ; Signal Transduction
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2021-08-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13091699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Anti-inflammatory effect of

    Phan, Uyen Thi Tu / Nguyen, Hai Dang / Nguyen, Thi Kieu Oanh / Tran, Tuan Hiep / Le, Thanh Huong / Tran, Thi Thu Phuong

    Heliyon

    2024  Volume 10, Issue 4, Page(s) e26174

    Abstract: Context: The : Objectives: Our study want to examine the anti-inflammatory effects of : Method: This study examined the chemical profiling of PLE by LC-HRMS analysis and measured the presence of nitric oxide (NO), interleukin-6 (IL-6) and tumor ... ...

    Abstract Context: The
    Objectives: Our study want to examine the anti-inflammatory effects of
    Method: This study examined the chemical profiling of PLE by LC-HRMS analysis and measured the presence of nitric oxide (NO), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) in the supernatant using the Griess reagent assay and enzyme-linked immunosorbent assay (ELISA), respectively. The mRNA expression of IL-6, TNF-α, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) were evaluated by using real-time quantitative polymerase chain reaction (RT-qPCR). Furthermore, the protein expression of COX-2, iNOS and the phosphorylation of MAPK family, c-Jun N-terminal kinase (JNK), p38 in protein level were observed by western blotting.
    Result: PLE have detected 66 compounds which belong to different classes such as alkaloids, flavonoids, terpenoids, phenolics, lactones, and organic acids inhibited nitric oxide products with the IC
    Conclusion: These results shown chemical profiling of PLE and demonstrated that PLE exhibits anti-inflammatory effects by regulating the MAPK family and could be a potential candidate for the treatment of inflammatory diseases.
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e26174
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  6. Article ; Online: Antimicrobial peptides - Advances in development of therapeutic applications.

    Luong, Huy Xuan / Thanh, Tung Truong / Tran, Tuan Hiep

    Life sciences

    2020  Volume 260, Page(s) 118407

    Abstract: The severe infection is becoming a significant health problem which threaten the lives of patients and the safety and economy of society. In the way of finding new strategy, antimicrobial peptides (AMPs) - an important part of host defense family, ... ...

    Abstract The severe infection is becoming a significant health problem which threaten the lives of patients and the safety and economy of society. In the way of finding new strategy, antimicrobial peptides (AMPs) - an important part of host defense family, emerged with tremendous potential. Up to date, huge numbers of AMPs has been investigated from both natural and synthetic sources showing not only the ability to kill microbial pathogens but also propose other benefits such as wound healing, anti-tumor, immune modulation. In this review, we describe the involvements of AMPs in biological systems and discuss the opportunity in developing AMPs for clinical applications. In the detail, their properties in antibacterial activity is followed by their application in some infection diseases and cancer. The key discussions are the approaches to improve biological activities of AMPs either by modifying chemical structure or incorporating into delivery systems. The new applications and perspectives for the future of AMPs would open the new era of their development.
    MeSH term(s) Animals ; Anti-Bacterial Agents/therapeutic use ; Antimicrobial Cationic Peptides/therapeutic use ; Bacteria/drug effects ; Bacterial Infections/drug therapy ; Bacterial Infections/microbiology ; Humans
    Chemical Substances Anti-Bacterial Agents ; Antimicrobial Cationic Peptides
    Keywords covid19
    Language English
    Publishing date 2020-09-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2020.118407
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  7. Article ; Online: Coronaviruses pandemics: Can neutralizing antibodies help?

    Tong, Phuoc-Bao-Viet / Lin, Li-Yun / Tran, Tuan Hiep

    Life sciences

    2020  Volume 255, Page(s) 117836

    Abstract: For the first time in Homo sapiens history, possibly, most of human activities is stopped by coronavirus disease 2019 (COVID-19). Nearly eight billion people of this world are facing a great challenge, maybe not "to be or not to be" yet, but ... ...

    Abstract For the first time in Homo sapiens history, possibly, most of human activities is stopped by coronavirus disease 2019 (COVID-19). Nearly eight billion people of this world are facing a great challenge, maybe not "to be or not to be" yet, but unpredictable. What happens to other major pandemics in the past, and how human beings went through these hurdles? The human body is equipped with the immune system that can recognize, respond and fight against pathogens such as viruses. Following the innate response, immune system processes the adaptive response by which each pathogen is encoded and recorded in memory system. The humoral reaction containing cytokines and antibodies is expected to activate when the pathogens come back. Exploiting this nature of body protection, neutralizing antibodies have been investigated. Learning from past, in parallel to SARS-CoV-2, other coronaviruses SARS-CoV and MERS-CoV who caused previous pandemics, are recalled in this review. We here propose insights of origin and characteristics and perspective for the future of antibodies development.
    MeSH term(s) Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/therapeutic use ; Betacoronavirus/immunology ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2
    Chemical Substances Antibodies, Neutralizing
    Keywords covid19
    Language English
    Publishing date 2020-05-22
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2020.117836
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  8. Article: Engineered nanoparticles to enhance natural killer cell activity towards onco-immunotherapy: a review.

    Phung, Cao Dai / Tran, Tuan Hiep / Kim, Jong Oh

    Archives of pharmacal research

    2020  Volume 43, Issue 1, Page(s) 32–45

    Abstract: Natural killer (NK) cells have emerged as a potent alternative immunotherapeutic approach to T cell therapy for cancer. Despite promising results from preclinical and clinical studies, numerous challenges have limited the application of NK cell-based ... ...

    Abstract Natural killer (NK) cells have emerged as a potent alternative immunotherapeutic approach to T cell therapy for cancer. Despite promising results from preclinical and clinical studies, numerous challenges have limited the application of NK cell-based therapy, including poor expansion of NK cells in vitro, their short in vivo life span, time-intensiveness, treatment complexities, and the cost burden of the treatment. Recent advancements in the development of immune cell-delivering nanosystems have led to promising strategies to overcome these limitations and enhance NK cell toxicity towards cancer cells. This review first summarizes the biological roles of NK cells and their tumoricidal mechanisms. NK cells, in the context of the immune system and the tumor microenvironment, have reportedly provided novel insights into specific therapeutic targets. Eventually, various strategies targeting NK cells using nanoplatforms to modulate the NK cell responses for effective cancer immunotherapy are described herein. Altogether, this review discusses the potential of nanotechnology in advancements in NK cell-based onco-immunotherapy.
    MeSH term(s) Animals ; Humans ; Immunotherapy ; Killer Cells, Natural/immunology ; Nanoparticles/chemistry ; Neoplasms/immunology ; Neoplasms/therapy
    Language English
    Publishing date 2020-01-28
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 447623-2
    ISSN 1976-3786 ; 0253-6269
    ISSN (online) 1976-3786
    ISSN 0253-6269
    DOI 10.1007/s12272-020-01218-1
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  9. Article ; Online: Application of Computational Screening Tools and Nanotechnology for Enhanced Drug Synergism in Cancer Therapy.

    Ninh, Thu Thi Kim / Tran, Tuan Hiep / F Huang, Chi-Ying / Nguyen, Chien Ngoc

    Current drug delivery

    2022  Volume 20, Issue 7, Page(s) 1015–1029

    Abstract: Background: Chemoresistance continues to limit the recovery of patients with cancer. New strategies, such as combination therapy or nanotechnology, can be further improved.: Objective: In this study, we applied the computational strategy by ... ...

    Abstract Background: Chemoresistance continues to limit the recovery of patients with cancer. New strategies, such as combination therapy or nanotechnology, can be further improved.
    Objective: In this study, we applied the computational strategy by exploiting two databases (CellMiner and Prism) to sort out the cell lines sensitive to both anti-cancer drugs, paclitaxel (PTX) and dihydroartemisinin (DHA); both of which are potentially synergistic in several cell lines.
    Methods: The combination of PTX and DHA was screened at different ratios to select the optimal ratio that could inhibit lung adenocarcinoma NCI-H23 the most. To further enhance therapeutic efficacy, these combinations of drugs were incorporated into a nanosystem.
    Results: At a PTX:DHA ratio of 1:2 (w/w), the combined drugs obtained the best combination index (0.84), indicating a synergistic effect. The drug-loaded nanoparticles sized at 135 nm with the drug loading capacity of 15.5 ± 1.34 and 13.8 ± 0.56 corresponding to DHA and PTX, respectively, were used. The nano-sized particles improved drug internalization into the cells, resulting in the significant inhibition of cell growth at all tested concentrations (p < 0.001). Additionally, α-tubulin aggregation, DNA damage suggested the molecular mechanism behind cell death upon PTX-DHA-loaded nanoparticle treatment. Moreover, the rate of apoptosis increased from approximately 5% to more than 20%, and the expression of apoptotic proteins changed 4 and 3 folds corresponding to p-53 and Bcl-2, respectively.
    Conclusion: This study was designed thoroughly by screening cell lines for the optimization of formulations. This novel approach could pave the way for the selection of combined drugs for precise cancer treatment.
    MeSH term(s) Humans ; Drug Synergism ; Early Detection of Cancer ; Paclitaxel/pharmacology ; Antineoplastic Agents/pharmacology ; Nanoparticles ; Apoptosis ; Nanotechnology ; Cell Line, Tumor ; Neoplasms/drug therapy
    Chemical Substances Paclitaxel (P88XT4IS4D) ; Antineoplastic Agents
    Language English
    Publishing date 2022-04-22
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2185284-4
    ISSN 1875-5704 ; 1567-2018
    ISSN (online) 1875-5704
    ISSN 1567-2018
    DOI 10.2174/1567201819666220426092538
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  10. Article ; Online: Nanosized-Loratadine Embedded Orodispersible Films for Enhanced Bioavailability: Scalable Preparations and Characterizations.

    Van Nguyen, Khanh / Nguyen, Huyen Thi / Nghiem, Lien Ha Thi / Van Can, Mao / Tran, Tuan Hiep

    AAPS PharmSciTech

    2022  Volume 23, Issue 3, Page(s) 78

    Abstract: The patient-centric strategy urges the pharmaceutical companies to develop orodispersible films (ODF) as a new approach for pediatrics. However, the most common ODF-fabricated method, solvent casting, is facing the safety challenges of safety during ... ...

    Abstract The patient-centric strategy urges the pharmaceutical companies to develop orodispersible films (ODF) as a new approach for pediatrics. However, the most common ODF-fabricated method, solvent casting, is facing the safety challenges of safety during manufacturing. To obtain favorable formulations with the ease of use and rapid dissolution, nanotechnology has been accounted for the development process. In this work, we investigated the wet-milling technique in preparing nanocarriers for loratadine-a hydrophobic anti-histamine drug. The results showed that the wet-milling technique could produce nanocarriers at the size of 400 nm. The reduction of particle size induced the increase of solubility and the dissolution rate of loratadine. Moreover, the pre-formulation of nanosized materials could adapt to the preparation of orodispersible films that disintegrated (less than 60s) and dissolved quickly. The DSC results showed that after the milling process, the crystallinity of loratadine was unchanged; however, the reduction in size induced an enhancement of drug bioavailability. After orally administrated to rats, the drug was quickly reached to the blood circulation, just after 30 min. C
    MeSH term(s) Administration, Oral ; Animals ; Biological Availability ; Child ; Humans ; Loratadine/chemistry ; Particle Size ; Rats ; Solubility
    Chemical Substances Loratadine (7AJO3BO7QN)
    Language English
    Publishing date 2022-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2052070-0
    ISSN 1530-9932 ; 1530-9932
    ISSN (online) 1530-9932
    ISSN 1530-9932
    DOI 10.1208/s12249-022-02230-y
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