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  1. Article ; Online: CD137 Signaling Is Critical in Fungal Clearance during Systemic

    Tran, Vuvi G / Nguyen, Na N Z / Kwon, Byungsuk

    Journal of fungi (Basel, Switzerland)

    2021  Volume 7, Issue 5

    Abstract: Invasive fungal infections ... ...

    Abstract Invasive fungal infections by
    Language English
    Publishing date 2021-05-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof7050382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: IL-33 Coordinates Innate Defense to Systemic

    Nguyen, Nu Z N / Tran, Vuvi G / Baek, Jiyeon / Kim, Younghee / Youn, Eun H / Na, Seung W / Park, Sang J / Seo, Su-Kil / Kwon, Byungsuk

    Journal of immunology (Baltimore, Md. : 1950)

    2022  Volume 208, Issue 3, Page(s) 660–671

    Abstract: Invasive candidiasis has high mortality rates in immunocompromised patients, causing serious health problems. In mouse models, innate immunity protects the host by rapidly mobilizing a variety of resistance and tolerance mechanisms to ... ...

    Abstract Invasive candidiasis has high mortality rates in immunocompromised patients, causing serious health problems. In mouse models, innate immunity protects the host by rapidly mobilizing a variety of resistance and tolerance mechanisms to systemic
    MeSH term(s) Animals ; Candida albicans/immunology ; Candidiasis/immunology ; Candidiasis/microbiology ; Dendritic Cells/immunology ; Disease Models, Animal ; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Histocompatibility Antigens Class II/immunology ; Immunity, Innate/immunology ; Immunocompromised Host/immunology ; Interleukin-10/genetics ; Interleukin-10/metabolism ; Interleukin-23 Subunit p19/metabolism ; Interleukin-33/genetics ; Interleukin-33/immunology ; Killer Cells, Natural/immunology ; Macrophages/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neutrophils/immunology ; Phagocytosis/immunology ; Signal Transduction/immunology
    Chemical Substances Histocompatibility Antigens Class II ; IL10 protein, mouse ; Il23a protein, mouse ; Il33 protein, mouse ; Interleukin-23 Subunit p19 ; Interleukin-33 ; Interleukin-10 (130068-27-8) ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1)
    Language English
    Publishing date 2022-01-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2100495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: IL-33 Priming Enhances Peritoneal Macrophage Activity in Response to Candida albicans.

    Tran, Vuvi G / Cho, Hong R / Kwon, Byungsuk

    Immune network

    2014  Volume 14, Issue 4, Page(s) 201–206

    Abstract: IL-33 is a member of the IL-1 cytokine family and plays a role in the host defense against bacteria, viruses, and fungi. In this study, we investigated the function of IL-33 and its receptor in in vitro macrophage responses to Candida albicans. Our ... ...

    Abstract IL-33 is a member of the IL-1 cytokine family and plays a role in the host defense against bacteria, viruses, and fungi. In this study, we investigated the function of IL-33 and its receptor in in vitro macrophage responses to Candida albicans. Our results demonstrate that pre-sensitization of isolated peritoneal macrophages with IL-33 enhanced their pro-inflammatory cytokine production and phagocytic activity in response to C. albicans. These macrophage activities were entirely dependent on the ST2-MyD88 signaling pathway. In addition, pre-sensitization with IL-33 also increased ROS production and the subsequent killing ability of macrophages following C. albicans challenge. These results indicate that IL-33 may increase anti-fungal activity against Candida through macrophage-mediated resistance mechanisms.
    Language English
    Publishing date 2014-08-22
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2536191-0
    ISSN 2092-6685 ; 1598-2629
    ISSN (online) 2092-6685
    ISSN 1598-2629
    DOI 10.4110/in.2014.14.4.201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Development and validation of a rabbit model of

    Gras, Emmanuelle / Vu, Trang T T / Nguyen, Nhu T Q / Tran, Vuvi G / Mao, Yanjie / Tran, Nguyen D / Mai, Nam H / Dong, Oliver X / Jung, David H / Iorio, Natalia L P P / Povoa, Helvecio C C / Pinheiro, Marcos Gabriel / Aguiar-Alves, Fabio / Weiss, William J / Zheng, Bo / Cheng, Lily I / Stover, Charles K / Sellman, Bret R / DiGiandomenico, Antonio /
    Gibault, Laure / Valour, Florent / Diep, Binh An

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1297281

    Abstract: Background: New drugs targeting antimicrobial resistant pathogens, including : Methods: We report here an FDA-funded study to develop a rabbit model of non-ventilated pneumonia with : Results: In a rabbit model of non-ventilated pneumonia, ... ...

    Abstract Background: New drugs targeting antimicrobial resistant pathogens, including
    Methods: We report here an FDA-funded study to develop a rabbit model of non-ventilated pneumonia with
    Results: In a rabbit model of non-ventilated pneumonia, endobronchial challenge with live
    Conclusion: The rabbit model may be used to help predict clinical efficacy of new antibacterial drugs for the treatment of non-ventilated
    MeSH term(s) Humans ; Animals ; Rabbits ; Meropenem/therapeutic use ; Pseudomonas aeruginosa ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/microbiology ; Tobramycin/pharmacology ; Tobramycin/therapeutic use ; Pneumonia/drug therapy ; Drug Development
    Chemical Substances Meropenem (FV9J3JU8B1) ; Anti-Bacterial Agents ; Tobramycin (VZ8RRZ51VK)
    Language English
    Publishing date 2023-12-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1297281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: CCR5-mediated Recruitment of NK Cells to the Kidney Is a Critical Step for Host Defense to Systemic

    Nguyen, Nu Z N / Tran, Vuvi G / Lee, Saerom / Kim, Minji / Kang, Sang W / Kim, Juyang / Kim, Hye J / Lee, Jong S / Cho, Hong R / Kwon, Byungsuk

    Immune network

    2020  Volume 20, Issue 6, Page(s) e49

    Abstract: C-C chemokine receptor type 5 (CCR5) regulates the trafficking of various immune cells to sites of infection. In this study, we showed that expression of CCR5 and its ligands was rapidly increased in the kidney after ... ...

    Abstract C-C chemokine receptor type 5 (CCR5) regulates the trafficking of various immune cells to sites of infection. In this study, we showed that expression of CCR5 and its ligands was rapidly increased in the kidney after systemic
    Language English
    Publishing date 2020-12-14
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2536191-0
    ISSN 2092-6685 ; 1598-2629
    ISSN (online) 2092-6685
    ISSN 1598-2629
    DOI 10.4110/in.2020.20.e49
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Protective Efficacy of Monoclonal Antibodies Neutralizing Alpha-Hemolysin and Bicomponent Leukocidins in a Rabbit Model of Staphylococcus aureus Necrotizing Pneumonia.

    Vu, Trang T T / Nguyen, Nhu T Q / Tran, Vuvi G / Gras, Emmanuelle / Mao, Yanjie / Jung, David H / Tkaczyk, Christine / Sellman, Bret R / Diep, Binh An

    Antimicrobial agents and chemotherapy

    2020  Volume 64, Issue 3

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus aureus
    MeSH term(s) Acute Lung Injury/drug therapy ; Acute Lung Injury/immunology ; Acute Lung Injury/microbiology ; Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/therapeutic use ; Disease Models, Animal ; Hemolysin Proteins/immunology ; Inflammation/drug therapy ; Inflammation/immunology ; Inflammation/microbiology ; Leukocidins/therapeutic use ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Methicillin-Resistant Staphylococcus aureus/pathogenicity ; Pneumonia, Necrotizing/drug therapy ; Pneumonia, Necrotizing/immunology ; Rabbits ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/pathogenicity
    Chemical Substances Antibodies, Monoclonal ; Hemolysin Proteins ; Leukocidins
    Language English
    Publishing date 2020-02-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.02220-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Antivirulence Bispecific Monoclonal Antibody-Mediated Protection against Pseudomonas aeruginosa Ventilator-Associated Pneumonia in a Rabbit Model.

    Aguiar-Alves, Fábio / Le, Hoan N / Tran, Vuvi G / Gras, Emmanuelle / Vu, Trang T T / Dong, Oliver X / Quetz, Josiane Silva / Cheng, Lily I / Yu, Li / Sellman, Bret R / Stover, Charles K / DiGiandomenico, Antonio / Diep, Binh An

    Antimicrobial agents and chemotherapy

    2021  Volume 66, Issue 2, Page(s) e0202221

    Abstract: Ventilator-associated pneumonia is an important clinical manifestation of the nosocomial pathogen Pseudomonas aeruginosa. We characterized the correlates of protection with MEDI3902, a bispecific human IgG1 monoclonal antibody that targets the P. ... ...

    Abstract Ventilator-associated pneumonia is an important clinical manifestation of the nosocomial pathogen Pseudomonas aeruginosa. We characterized the correlates of protection with MEDI3902, a bispecific human IgG1 monoclonal antibody that targets the P. aeruginosa type 3 secretion system PcrV protein and the Psl exopolysaccharide, in a rabbit model of ventilator-associated pneumonia using lung-protective, low-tidal-volume mechanical ventilation. Rabbits infused with MEDI3902 prophylactically were protected, whereas those pretreated with irrelevant isotype-matched control IgG (c-IgG) succumbed between 12 and 44 h postinfection (100% survival [8/8 rabbits] versus 0% survival [8/8 rabbits];
    MeSH term(s) Animals ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Bacteremia/drug therapy ; Pneumonia, Ventilator-Associated/drug therapy ; Pneumonia, Ventilator-Associated/prevention & control ; Pseudomonas Infections ; Pseudomonas aeruginosa ; Rabbits
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2021-12-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.02022-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Efficacy of Active Immunization With Attenuated α-Hemolysin and Panton-Valentine Leukocidin in a Rabbit Model of Staphylococcus aureus Necrotizing Pneumonia.

    Tran, Vuvi G / Venkatasubramaniam, Arundhathi / Adhikari, Rajan P / Krishnan, Subramaniam / Wang, Xing / Le, Vien T M / Le, Hoan N / Vu, Trang T T / Schneider-Smith, Erika / Aman, M Javad / Diep, Binh An

    The Journal of infectious diseases

    2019  Volume 221, Issue 2, Page(s) 267–275

    Abstract: Staphylococcus aureus is a common pathogen causing infections in humans with various degrees of severity, with pneumonia being one of the most severe infections. In as much as staphylococcal pneumonia is a disease driven in large part by α-hemolysin (Hla) ...

    Abstract Staphylococcus aureus is a common pathogen causing infections in humans with various degrees of severity, with pneumonia being one of the most severe infections. In as much as staphylococcal pneumonia is a disease driven in large part by α-hemolysin (Hla) and Panton-Valentine leukocidin (PVL), we evaluated whether active immunization with attenuated forms of Hla (HlaH35L/H48L) alone, PVL components (LukS-PVT28F/K97A/S209A and LukF-PVK102A) alone, or combination of all 3 toxoids could prevent lethal challenge in a rabbit model of necrotizing pneumonia caused by the USA300 community-associated methicillin-resistant S. aureus (MRSA). Rabbits vaccinated with Hla toxoid alone or PVL components alone were only partially protected against lethal pneumonia, whereas those vaccinated with all 3 toxoids had 100% protection against lethality. Vaccine-mediated protection correlated with induction of polyclonal antibody response that neutralized not only α-hemolysin and PVL, but also other related toxins, produced by USA300 and other epidemic MRSA clones.
    MeSH term(s) Animals ; Bacterial Toxins/administration & dosage ; Bacterial Toxins/immunology ; Disease Models, Animal ; Exotoxins/administration & dosage ; Exotoxins/immunology ; Hemolysin Proteins/administration & dosage ; Hemolysin Proteins/immunology ; Humans ; Leukocidins/administration & dosage ; Leukocidins/immunology ; Methicillin-Resistant Staphylococcus aureus ; Pneumonia, Necrotizing/immunology ; Pneumonia, Necrotizing/prevention & control ; Pneumonia, Staphylococcal/immunology ; Pneumonia, Staphylococcal/prevention & control ; Rabbits ; Vaccination
    Chemical Substances Bacterial Toxins ; Exotoxins ; Hemolysin Proteins ; Leukocidins ; Panton-Valentine leukocidin
    Language English
    Publishing date 2019-09-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiz437
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  9. Article ; Online: MEDI3902 Correlates of Protection against Severe Pseudomonas aeruginosa Pneumonia in a Rabbit Acute Pneumonia Model.

    Le, Hoan N / Quetz, Josiane Silva / Tran, Vuvi G / Le, Vien T M / Aguiar-Alves, Fábio / Pinheiro, Marcos G / Cheng, Lily / Yu, Li / Sellman, Bret R / Stover, Charles K / DiGiandomenico, Antonio / Diep, Binh An

    Antimicrobial agents and chemotherapy

    2018  Volume 62, Issue 5

    Abstract: Pseudomonas ... ...

    Abstract Pseudomonas aeruginosa
    MeSH term(s) Acute Lung Injury/drug therapy ; Acute Lung Injury/immunology ; Acute Lung Injury/microbiology ; Animals ; Antibodies, Monoclonal/metabolism ; Antibodies, Monoclonal/therapeutic use ; Disease Models, Animal ; Male ; Pneumonia/drug therapy ; Pneumonia/immunology ; Pneumonia/microbiology ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/immunology ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/immunology ; Pseudomonas aeruginosa/pathogenicity ; Rabbits
    Chemical Substances Antibodies, Monoclonal ; MEDI3902
    Language English
    Publishing date 2018-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.02565-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: IL-33 Enhances Host Tolerance to Candida albicans Kidney Infections through Induction of IL-13 Production by CD4+ T Cells.

    Tran, Vuvi G / Kim, Hye J / Kim, Juyang / Kang, Sang W / Moon, U J / Cho, Hong R / Kwon, Byungsuk

    Journal of immunology (Baltimore, Md. : 1950)

    2015  Volume 194, Issue 10, Page(s) 4871–4879

    Abstract: Susceptibility to systemic Candida albicans infection is determined by immune resistance, as well as by the ability to control Candida-induced immunopathologies. We showed previously that exogenous IL-33 can increase resistance to peritoneal C. albicans ... ...

    Abstract Susceptibility to systemic Candida albicans infection is determined by immune resistance, as well as by the ability to control Candida-induced immunopathologies. We showed previously that exogenous IL-33 can increase resistance to peritoneal C. albicans infection by regulating multiple steps of the neutrophil anti-Candida response. In this study, using a mouse model of systemic candidiasis, we observed that IL-33 administration limited fungal burden and inflammation and increased survival. In kidneys, IL-33 seemed to directly act on neutrophils and CD4(+) T cells: IL-33 administration enhanced fungal clearance by increasing neutrophil phagocytic activity without which Candida proliferation was uncontrollable. In contrast, IL-33 stimulated CD4(+) T cells to produce IL-13, which, in turn, drove the polarization of macrophages toward the M2 type. Furthermore, the absence of IL-13 abolished IL-33-mediated polarization of M2 macrophages and renal functional recovery. In addition, IL-33 and IL-13 acted synergistically to increase M2 macrophage polarization and its phagocytic activity. Overall, this study identifies IL-33 as a cytokine that is able to induce resistance and tolerance and suggests that targeting resistance and tolerance simultaneously with therapeutic IL-33 may benefit patients with systemic candidiasis.
    MeSH term(s) Animals ; CD4-Positive T-Lymphocytes/immunology ; Candida albicans/immunology ; Candidiasis/immunology ; Disease Models, Animal ; Flow Cytometry ; Immune Tolerance/immunology ; Interleukin-13/biosynthesis ; Interleukin-13/immunology ; Interleukin-33 ; Interleukins/immunology ; Kidney Diseases/immunology ; Kidney Diseases/microbiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Real-Time Polymerase Chain Reaction
    Chemical Substances Il33 protein, mouse ; Interleukin-13 ; Interleukin-33 ; Interleukins
    Language English
    Publishing date 2015-05-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1402986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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