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  1. Article ; Online: Systematic Surveillance of Rickettsial Diseases in 27 Hospitals from 26 Provinces throughout Vietnam

    Nguyen Vu Trung / Le Thi Hoi / Tran Mai Hoa / Dang Thi Huong / Ma Thi Huyen / Vuong Quang Tien / Dao Thi Tuyet Mai / Nguyen Thi Thu Ha / Nguyen Van Kinh / Christina M. Farris / Allen L. Richards

    Tropical Medicine and Infectious Disease, Vol 7, Iss 88, p

    2022  Volume 88

    Abstract: In Vietnam, the public health burden of rickettsial infections continues to be underestimated due to knowledge gaps in the epidemiology of these diseases. We conducted a systematic study among 27 hospitals from 26 provinces in eight ecological regions ... ...

    Abstract In Vietnam, the public health burden of rickettsial infections continues to be underestimated due to knowledge gaps in the epidemiology of these diseases. We conducted a systematic study among 27 hospitals from 26 provinces in eight ecological regions throughout Vietnam to investigate the prevalence, distribution, and clinical characteristics of rickettsial diseases. We recruited 1834 patients in the study from April 2018 to October 2019. The findings showed that rickettsial diseases were common among undifferentiated febrile patients, with 564 (30.8%) patients positive by qPCR for scrub typhus, murine typhus or spotted fever. Scrub typhus (484, 85.8%) was the most common rickettsial disease, followed by murine typhus (67, 11.9%) and spotted fever (10, 1.8%). Rickettsial diseases were widely distributed in all regions of Vietnam and presented with nonspecific clinical manifestations.
    Keywords rickettsial diseases ; scrub typhus ; murine typhus ; spotted fever rickettsioses ; hospital surveillance ; epidemiology ; Medicine ; R
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015–2017

    Nguyen Vu Trung / Le Thi Hoi / Vu Minh Dien / Dang Thi Huong / Tran Mai Hoa / Vu Ngoc Lien / Phan Van Luan / Sonia Odette Lewycka / Marc Choisy / Juliet E. Bryant / Behzad Nadjm / H. Rogier van Doorn / Allen L. Richards / Nguyen Van Kinh

    Emerging Infectious Diseases, Vol 25, Iss 4, Pp 633-

    2019  Volume 641

    Abstract: Rickettsioses are endemic to Vietnam; however, only a limited number of clinical studies have been performed on these vectorborne bacteria. We conducted a prospective hospital-based study at 2 national referral hospitals in Hanoi to describe the clinical ...

    Abstract Rickettsioses are endemic to Vietnam; however, only a limited number of clinical studies have been performed on these vectorborne bacteria. We conducted a prospective hospital-based study at 2 national referral hospitals in Hanoi to describe the clinical characteristics of scrub typhus and murine typhus in northern Vietnam and to assess the diagnostic applicability of quantitative real-time PCR assays to diagnose rickettsial diseases. We enrolled 302 patients with acute undifferentiated fever and clinically suspected rickettsiosis during March 2015–March 2017. We used a standardized case report form to collect clinical information and laboratory results at the time of admission and during treatment. We confirmed scrub typhus in 103 (34.1%) patients and murine typhus in 12 (3.3%) patients. These results highlight the need for increased emphasis on training for healthcare providers for earlier recognition, prevention, and treatment of rickettsial diseases in Vietnam.
    Keywords Scrub typhus ; murine typhus ; rickettsial diseases ; qPCR ; Vietnam ; bacteria ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Subject code 610
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Analysis of the 56-kDa type specific antigen gene of Orientia tsutsugamushi from northern Vietnam.

    Nguyen Vu Trung / Le Thi Hoi / Do Duy Cuong / Doan The Ha / Tran Mai Hoa / Vu Ngoc Lien / Nguyen Thi Hoa / Le Nguyen Minh Hoa / Dang Thi Huong / Vu Thi Ngoc Bich / H Rogier van Doorn / Behzad Nadjm / Allen L Richards

    PLoS ONE, Vol 14, Iss 8, p e

    2019  Volume 0221588

    Abstract: Scrub typhus has been documented since 1932 in Vietnam, however, the disease burden of scrub typhus remains poorly understood in the country. We conducted this study to describe the phylogenetic analysis of the 56-kDa type-specific antigen (TSA) gene of ... ...

    Abstract Scrub typhus has been documented since 1932 in Vietnam, however, the disease burden of scrub typhus remains poorly understood in the country. We conducted this study to describe the phylogenetic analysis of the 56-kDa type-specific antigen (TSA) gene of Orientia tsutsugamushi associated with PCR positive cases of scrub typhus. Of 116 positive samples, 65 type-specific antigen gene sequences were obtained and classified into 3 genogroups: Karp, Kato and Gilliam. The Karp genogroup was the most frequently detected phylogenetic cluster in the study with 30 samples (46%), followed by Kato and Gilliam with 20 (31%) and 15 (23%), respectively. All sequences showed 94-100% nucleotide similarity to reference sequences collected in the central part of Vietnam in 2017. Patients infected with Karp genogroup were more likely to have significant thrombocytopenia than the other genogroups. These results suggest that any scrub typhus vaccine considered for use in Vietnam should provide protection against each of these 3 genogroups.
    Keywords Medicine ; R ; Science ; Q
    Subject code 572
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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