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  1. Article ; Online: Post-COVID condition: a survey of patients recovered from COVID-19 in Central Vietnam.

    Tran, Toan Khanh / Nguyen Truong, Son / Tran Thanh, Loan / Le Hoang Gia, Ngoc / Pham Trung, Hieu / Tran Dinh, Binh

    Journal of infection in developing countries

    2023  Volume 17, Issue 9, Page(s) 1213–1220

    Abstract: Introduction: Evidence on post-COVID-19 conditions is emerging. This study aims to assess post-COVID conditions and related factors in COVID-19 patients in Central Vietnam.: Methodology: A descriptive cross-sectional study was performed on people who ...

    Abstract Introduction: Evidence on post-COVID-19 conditions is emerging. This study aims to assess post-COVID conditions and related factors in COVID-19 patients in Central Vietnam.
    Methodology: A descriptive cross-sectional study was performed on people who have recovered from COVID-19 at least 2 weeks prior to the online survey. Participants were interviewed face-to-face after 6 and 9 months from the first survey.
    Results: 53 patients (21.2%) were confirmed to have persistent symptoms, of which, 100% and 94.3% reported prolonged fatigue and full-body weakness respectively. Loss of appetite was reported by 90.6%, while persistent cough, insomnia, and trouble sleeping were reported by 86.3% of patients. Headaches and dyspnea were reported by 69.5% and 56.8% respectively, while other symptoms had lower rates. The prevalence of post-COVID condition showed a statistically significant relationship with the time of infection, duration of illness, treatment place, use of herbal medicine, adherence to the 5K message from Vietnam's Ministry of Health, and daily saltwater mouthwash (p < 0.05). However, the use of medicine and supplements was not related to the post-COVID condition (p > 0.05). After 6 months, 125 participants were interviewed face-to-face, and only 15 people (12.0%) reported having post-COVID symptoms, mainly prolonged fatigue (33.3%) and persistent cough (26.7%). After 9 months, these 15 patients no longer had symptoms related to the post- COVID-19 condition.
    Conclusions: The post-COVID condition can persist for several weeks or months, but will mostly be in remission after 6 months, and completely resolve after 9 months from the onset of the infection.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Cough/epidemiology ; Cross-Sectional Studies ; Vietnam/epidemiology ; Post-Acute COVID-19 Syndrome ; Fatigue/epidemiology
    Language English
    Publishing date 2023-09-30
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2394024-4
    ISSN 1972-2680 ; 2036-6590
    ISSN (online) 1972-2680
    ISSN 2036-6590
    DOI 10.3855/jidc.18029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Identification of hsa_circ_0001445 of a novel circRNA-miRNA-mRNA regulatory network as potential biomarker for coronary heart disease.

    Dinh, PhongSon / Peng, JunHua / Tran, ThanhLoan / Wu, DongFeng / Tran, ChauMyThanh / Dinh, ThiPhuongHoai / Pan, ShangLing

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1104223

    Abstract: Objects: To evaluate the hsa_circ_0001445 level in peripheral blood leukocytes of patients with coronary heart disease (CHD) and its related clinical factors, and predict its circRNA-miRNA-mRNA regulatory network in CHD pathogenesis : Methods: ... ...

    Abstract Objects: To evaluate the hsa_circ_0001445 level in peripheral blood leukocytes of patients with coronary heart disease (CHD) and its related clinical factors, and predict its circRNA-miRNA-mRNA regulatory network in CHD pathogenesis
    Methods: Peripheral blood leukocytes were isolated from the whole blood samples of 94 CHD patients (aged 65.96 ± 9.78 years old) and 126 healthy controls (aged 60.75 ± 8.81 years old). qRT-PCR was used to quantify the expression level of circRNA and subsequently analyze its association with CHD clinical parameters. Via bioinformatics algorithm and GEO datasets, differential miRNA expression was evaluated using the Limma package. A miRNA-mRNA regulatory network was predicted by cyTargetLinker. ClusterProfiler was employed to perform functional enrichment analysis of the circRNA network to investigate its role in CHD pathogenesis.
    Results: The expression of hsa_circ_0001445 in peripheral blood leukocytes of CHD patients was downregulated compared with that of healthy controls. Positive correlations were evident between hsa_circ_0001445 expression level and the levels of hemoglobin, triglycerides, high- and low-density lipoprotein cholesterol. A significant negative correlation was also found between hsa_circ_0001445 expression level and age and the neutrophil level. Low expression of hsa_circ_0001445 exhibited a discriminatory ability between CHD patients and healthy controls with a sensitivity of 67.5% and a specificity of 76.6% (
    Conclusion: The hsa_circ_0001445 level in peripheral blood leukocytes may serve as a biomarker for CHD diagnosis. Our work on circRNA-miRNA-mRNA networks suggests a potential role for hsa_circ_0001445 in CHD development.
    Language English
    Publishing date 2023-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1104223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: First Molecular Detection of Zoonotic Chlamydia Species in Vietnamese Goats

    Chisu, Valentina / Zobba, Rosanna / Masala, Giovanna / Tran, Thanh Loan / Ngo Viet, Quynh Tram / Tran, Dinh Binh / Nguyen, Hoang Bach / Tran, Khanh Toan / Alberti, Alberto

    Pathogens. 2022 Aug. 10, v. 11, no. 8

    2022  

    Abstract: The genus Chlamydia comprises obligate intracellular bacteria that infect a wide variety of hosts, with infection leading to a range of diseases in humans and animals; they thus constitute a major public health threat. Among the members of the ... ...

    Abstract The genus Chlamydia comprises obligate intracellular bacteria that infect a wide variety of hosts, with infection leading to a range of diseases in humans and animals; they thus constitute a major public health threat. Among the members of the Chlamydiaceae family, Chlamydia suis, C. abortus, C. pecorum, and C. psittaci represent the most important pathogenic species infecting a large range of hosts and are a well-established threat to livestock. Information regarding the circulation of Chlamydia species in ruminants from Vietnam is lacking. In this study, DNA extracted from 60 blood samples collected from goats in Hue province was used for Chlamydia spp. identification by classic PCR and Sanger sequencing. Chlamydia spp. were detected in eleven samples (18.3%) and C. abortus and C. psittaci were molecularly identified by sequencing. Despite the limited sample size in this study, findings point out the relevance of ruminants as hosts of chlamydial species in Central Vietnam and the importance of monitoring chlamydial strains through the activation of surveillance programs in this country. The need for a deeper evaluation of human and animal health risk analysis in terms of chlamydiosis should be also considered.
    Keywords Chlamydia suis ; DNA ; blood ; chlamydiosis ; livestock ; monitoring ; public health ; risk analysis ; sample size ; Vietnam
    Language English
    Dates of publication 2022-0810
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11080903
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: First Molecular Detection of Zoonotic

    Chisu, Valentina / Zobba, Rosanna / Masala, Giovanna / Tran, Thanh Loan / Ngo Viet, Quynh Tram / Tran, Dinh Binh / Nguyen, Hoang Bach / Tran, Khanh Toan / Alberti, Alberto

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 8

    Abstract: ... The ... ...

    Abstract The genus
    Language English
    Publishing date 2022-08-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11080903
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Third-degree burn mouse treatment using recombinant human fibroblast growth factor 2.

    Tran-Nguyen, Thu-Minh / Le, Khanh-Thien / Nguyen, Le-Giang Thi / Tran, Thanh-Loan Thi / Hoang-Thai, Phuong-Cac / Tran, Thuoc Linh / Tan, Sik-Loo / Tran-Van, Hieu

    Growth factors (Chur, Switzerland)

    2021  Volume 38, Issue 5-6, Page(s) 282–290

    Abstract: Fibroblast growth factor 2 (FGF-2) is a multifunctional protein that has major roles in wound healing, tissue repair, and regeneration. This therapeutic protein is widely used for burn treatment because it can stimulate cell proliferation and ... ...

    Abstract Fibroblast growth factor 2 (FGF-2) is a multifunctional protein that has major roles in wound healing, tissue repair, and regeneration. This therapeutic protein is widely used for burn treatment because it can stimulate cell proliferation and differentiation, angiogenesis, and extracellular matrix remodeling. In this study, we developed a simple method using a controlled heated brass rod to create a homogenous third-degree burn murine model and evaluated the treatment using recombinant human FGF-2 (rhFGF-2). The results indicated that the wound area was 0.83 ± 0.05 cm
    MeSH term(s) Animals ; Burns/drug therapy ; Cell Proliferation ; Fibroblast Growth Factor 2 ; Humans ; Mice ; Neovascularization, Pathologic ; Wound Healing
    Chemical Substances Fibroblast Growth Factor 2 (103107-01-3)
    Language English
    Publishing date 2021-08-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1035755-5
    ISSN 1029-2292 ; 0897-7194
    ISSN (online) 1029-2292
    ISSN 0897-7194
    DOI 10.1080/08977194.2021.1967342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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