Article ; Online: CD49b identifies functionally and epigenetically distinct subsets of lineage-biased hematopoietic stem cells.
2022 Volume 17, Issue 7, Page(s) 1546–1560
Abstract: Hematopoiesis is maintained by functionally diverse lineage-biased hematopoietic stem cells (HSCs). The functional significance of HSC heterogeneity and the regulatory mechanisms underlying lineage bias are not well understood. However, absolute ... ...
Abstract | Hematopoiesis is maintained by functionally diverse lineage-biased hematopoietic stem cells (HSCs). The functional significance of HSC heterogeneity and the regulatory mechanisms underlying lineage bias are not well understood. However, absolute purification of HSC subtypes with a pre-determined behavior remains challenging, highlighting the importance of continued efforts toward prospective isolation of homogeneous HSC subsets. In this study, we demonstrate that CD49b subdivides the most primitive HSC compartment into functionally distinct subtypes: CD49b |
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MeSH term(s) | Cell Differentiation/genetics ; Cell Lineage/genetics ; Hematopoiesis/genetics ; Hematopoietic Stem Cells ; Integrin alpha2 ; Multipotent Stem Cells |
Chemical Substances | Integrin alpha2 |
Language | English |
Publishing date | 2022-06-16 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2720528-9 |
ISSN | 2213-6711 ; 2213-6711 |
ISSN (online) | 2213-6711 |
ISSN | 2213-6711 |
DOI | 10.1016/j.stemcr.2022.05.014 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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