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Book ; Online: Reaction-diffusion systems derived from kinetic models for Multiple Sclerosis

Travaglini, Romina / Oliveira, João Miguel

2023

Abstract: We present a mathematical study for the development of Multiple Sclerosis in which a spatio-temporal kinetic model describes, at mesoscopic level, the dynamics of a high number of interacting agents. We consider both interactions among different ... ...

Abstract	We present a mathematical study for the development of Multiple Sclerosis in which a spatio-temporal kinetic model describes, at mesoscopic level, the dynamics of a high number of interacting agents. We consider both interactions among different populations of human cells and motion of immune cells, stimulated by cytokines. Moreover, we reproduce the consumption of myelin sheath due to anomalously activated lymphocytes and its restoration by oligodendrocytes. Successively, we fix a small time parameter and assume that the considered processes occur at different scales. This allows to perform a formal limit, obtaining macroscopic reaction-diffusion equations for the number densities with a chemotaxis term. A natural step is then to study the system, inquiring about the formation of spatial patterns through a Turing instability analysis of the problem and basing the discussion on microscopic parameters of the model. In particular, we get spatial patterns oscillating in time that may reproduce brain lesions characteristic of different phases of the pathology.
Keywords	Mathematics - Analysis of PDEs ; Electrical Engineering and Systems Science - Systems and Control ; 35B36 ; 37N25 ; 92C17 ; 92C45 ; 92C50
Subject code	612
Publishing date	2023-09-10
Publishing country	us
Document type	Book ; Online
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Article ; Online: Huge malignant phyllodes breast tumor: a real entity in a new era of early breast cancer.

Testori, Alberto / Meroni, Stefano / Errico, Valentina / Travaglini, Roberto / Voulaz, Emanuele / Alloisio, Marco

World journal of surgical oncology

2015 Volume 13, Page(s) 81

Abstract: Phyllodes tumor is an extremely rare tumor of the breast. It occurs in females in the third and fourth decades. The difficulty in distinguishing between phyllodes tumors and benign fibroadenoma may lead to misdiagnosis. Lymph node involvement is rarely ... ...

Abstract	Phyllodes tumor is an extremely rare tumor of the breast. It occurs in females in the third and fourth decades. The difficulty in distinguishing between phyllodes tumors and benign fibroadenoma may lead to misdiagnosis. Lymph node involvement is rarely described in phyllodes tumors; for this reason, sentinel node biopsy may be warranted. We present a case of a 33-year-old woman affected by huge tumor of the right breast with ulceration in the skin with a rapid tumor growth and with omolateral axillary metastasis.
MeSH term(s)	Adult ; Axilla ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Female ; Fibroadenoma/pathology ; Fibroadenoma/surgery ; Humans ; Phyllodes Tumor/secondary ; Phyllodes Tumor/surgery ; Prognosis ; Sentinel Lymph Node Biopsy
Language	English
Publishing date	2015-02-27
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2118383-1
ISSN	1477-7819 ; 1477-7819
ISSN (online)	1477-7819
ISSN	1477-7819
DOI	10.1186/s12957-015-0508-7
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Article: Gynecomastia possibly induced by rosuvastatin.

Oteri, Alessandro / Catania, Maria Antonietta / Travaglini, Rita / Russo, Alessandra / Giustini, Saffi E / Caputi, Achille P / Polimeni, Giovanni

Pharmacotherapy

2008 Volume 28, Issue 4, Page(s) 549–551

Abstract: Gynecomastia is characterized by benign progressive enlargement of the male breast. A pharmacologic origin is identified in 10-20% of cases. Several case reports have associated this condition to the use of statins. However, to our knowledge, no case of ... ...

Abstract	Gynecomastia is characterized by benign progressive enlargement of the male breast. A pharmacologic origin is identified in 10-20% of cases. Several case reports have associated this condition to the use of statins. However, to our knowledge, no case of rosuvastatin-induced gynecomastia has been reported in the literature. We describe a 57-year-old man who developed bilateral gynecomastia after 2 months of rosuvastatin therapy. After switching to a different statin, atorvastatin, his symptoms resolved within 1 month. Use of the Naranjo adverse drug reaction probability scale indicated a possible relationship between the patient's development of gynecomastia and rosuvastatin therapy. The relatively strong effect of rosuvastatin on inhibiting steroidogenesis might have explained why our patient's gynecomastia occurred only with this agent. Clinicians should be aware of the possibility of adverse endocrine reactions when statins are prescribed, including newer agents such as rosuvastatin.
MeSH term(s)	Atorvastatin Calcium ; Fluorobenzenes/adverse effects ; Gynecomastia/chemically induced ; Heptanoic Acids/therapeutic use ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Male ; Middle Aged ; Probability ; Pyrimidines/adverse effects ; Pyrroles/therapeutic use ; Rosuvastatin Calcium ; Steroids/biosynthesis ; Sulfonamides/adverse effects
Chemical Substances	Fluorobenzenes ; Heptanoic Acids ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Pyrimidines ; Pyrroles ; Steroids ; Sulfonamides ; Atorvastatin Calcium (48A5M73Z4Q) ; Rosuvastatin Calcium (83MVU38M7Q)
Language	English
Publishing date	2008-04
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	603158-4
ISSN	1875-9114 ; 0277-0008
ISSN (online)	1875-9114
ISSN	0277-0008
DOI	10.1592/phco.28.4.549
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Zs.A 1738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 585: Show issues

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Article: Quality of life and overweight: the obesity related well-being (Orwell 97) questionnaire.

Mannucci, E / Ricca, V / Barciulli, E / Di Bernardo, M / Travaglini, R / Cabras, P L / Rotella, C M

Addictive behaviors

1999 Volume 24, Issue 3, Page(s) 345–357

Abstract: The development and validation of a self-reported measure of obesity-related quality of life, the Obesity Related Well-Being (ORWELL 97), were undertaken to examine the intensity and the subjective relevance of physical and psychosocial distress. The ... ...

Abstract	The development and validation of a self-reported measure of obesity-related quality of life, the Obesity Related Well-Being (ORWELL 97), were undertaken to examine the intensity and the subjective relevance of physical and psychosocial distress. The questionnaire was validated in a sample of 147 obese patients (99 females, 48 males). The Eating Disorder Examination 12.0D interview, a structured diagnostic interview for DSM-III-R (DSM-IV criteria for binge eating disorder), Beck Depression Inventory, Binge Eating Scale, and the State-Trait Anxiety Inventory 1 and 2 scales were also applied. Internal consistency and test-retest reliability were satisfactory. Factor analysis allowed the identification of two subscales: ORWELL 97-1 related to psychological status and social adjustment, and ORWELL 97-2 related to physical symptoms impairment. Obese female patients showed a lower quality of life, and the severity of obesity appeared to interfere with physical functioning rather than psychological status and social adjustment. The ORWELL 97 questionnaire appears to be a simple and reliable measure of obesity-related quality of life, which can be used in current clinical practice.
MeSH term(s)	Adolescent ; Adult ; Aged ; Depressive Disorder/diagnosis ; Depressive Disorder/psychology ; Feeding and Eating Disorders/diagnosis ; Feeding and Eating Disorders/psychology ; Female ; Health Status ; Humans ; Male ; Middle Aged ; Obesity/diagnosis ; Obesity/psychology ; Psychological Tests ; Quality of Life ; Reproducibility of Results ; Self Concept ; Severity of Illness Index ; Surveys and Questionnaires
Language	English
Publishing date	1999-05
Publishing country	England
Document type	Journal Article
ZDB-ID	197618-7
ISSN	1873-6327 ; 0306-4603
ISSN (online)	1873-6327
ISSN	0306-4603
DOI	10.1016/s0306-4603(98)00055-0
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Zs.A 1214: Show issues

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Article ; Online: Surgical sentinel lymph node biopsy in early breast cancer. Could it be avoided by performing a preoperative staging procedure? A pilot study.

Testori, Alberto / Meroni, Stefano / Moscovici, Oana Codrina / Magnoni, Paola / Malerba, Paolo / Chiti, Arturo / Rahal, Daoud / Travaglini, Roberto / Cariboni, Umberto / Alloisio, Marco / Orefice, Sergio

Medical science monitor : international medical journal of experimental and clinical research

2012 Volume 18, Issue 9, Page(s) CR543–9

Abstract: Background: The aim of this pilot trial was to study the feasibility of sentinel node percutaneous preoperative gamma probe-guided biopsy as a valid preoperative method of assessment of nodal status compared to surgical sentinel lymph node biopsy.: ... ...

Abstract	Background: The aim of this pilot trial was to study the feasibility of sentinel node percutaneous preoperative gamma probe-guided biopsy as a valid preoperative method of assessment of nodal status compared to surgical sentinel lymph node biopsy. Material/methods: This prospective study enrolled 10 consecutive patients without evidence of axillary lymph node metastases at preoperative imaging. All patients underwent sentinel node occult lesion localization (SNOLL) using radiotracer intradermic injection that detected a "hot spot" corresponding to the sentinel node in all cases. Gamma probe over the skin detection with subsequent ultrasonographically guided needle biopsy of the sentinel node were performed. The percutaneous needle core histopathological diagnosis was compared to the results of the surgical biopsy. Results: Preoperative sentinel node identification was successful in all patients. Conclusions: The combination of preoperative gamma probe sentinel node detection and ultrasound-guided biopsy could represent a valid alternative to intraoperative sentinel node biopsy in clinically and ultrasonographically negative axillary nodes, resulting in shorter duration of surgery and lower intraoperative risks.
MeSH term(s)	Biopsy, Needle/methods ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Female ; Humans ; Image-Guided Biopsy/methods ; Neoplasm Staging/methods ; Pilot Projects ; Prospective Studies ; Radioactive Tracers ; Sentinel Lymph Node Biopsy/methods ; Ultrasonography/methods
Chemical Substances	Radioactive Tracers
Language	English
Publishing date	2012-08-30
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/msm.883349
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Zs.A 4924: Show issues

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Article: Rationale for a study adding tamoxifen to HRT.

Rotmensz, N / Decensi, A / Maisonneuve, P / Costa, A / Sacchini, V / Travaglini, R / D'Aiuto, G / Lovison, F / Gucciardo, G / Muraca, M G / Pizzichetta, M A / Conforti, S / Robertson, C / Boyle, P / Veronesi, U

European journal of cancer (Oxford, England : 1990)

2002 Volume 38 Suppl 6, Page(s) S22–3

MeSH term(s)	Adult ; Aged ; Antineoplastic Agents, Hormonal/administration & dosage ; Breast Neoplasms/prevention & control ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Hormone Replacement Therapy/methods ; Humans ; Middle Aged ; Randomized Controlled Trials as Topic ; Selective Estrogen Receptor Modulators/administration & dosage ; Tamoxifen/administration & dosage
Chemical Substances	Antineoplastic Agents, Hormonal ; Selective Estrogen Receptor Modulators ; Tamoxifen (094ZI81Y45)
Language	English
Publishing date	2002-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	82061-1
ISSN	1879-0852 ; 0959-8049 ; 0277-5379 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0959-8049 ; 0277-5379 ; 0964-1947
DOI	10.1016/s0959-8049(02)00272-1
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Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 583: Show issues

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Article: Eating behavior in obese patients with and without type 2 diabetes mellitus.

Mannucci, E / Tesi, F / Ricca, V / Pierazzuoli, E / Barciulli, E / Moretti, S / Di Bernardo, M / Travaglini, R / Carrara, S / Zucchi, T / Placidi, G F / Rotella, C M

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity

2002 Volume 26, Issue 6, Page(s) 848–853

Abstract: Objective: Aim of this study was the assessment of the prevalence of eating disorders, and of eating disorder symptoms, in obese patients with type 2 diabetes, compared to non-diabetic subjects.: Design: Three samples of individuals were studied: a ... ...

Abstract	Objective: Aim of this study was the assessment of the prevalence of eating disorders, and of eating disorder symptoms, in obese patients with type 2 diabetes, compared to non-diabetic subjects. Design: Three samples of individuals were studied: a series of 156 (76 male, 80 female) overweight and obese type 2 diabetic patients, aged 30-65 y, with a body mass index (BMI)>28 kg/m(2) (DM); a series of 192 (20 male, 172 female) obese (BMI>30 kg/m(2)) non-diabetic patients aged 30-65 y seeking treatment for weight loss (OC); and a non-clinical sample of 48 (22 male, 26 female) obese (BMI>30 kg/m(2)) subjects aged 30-65 y selected from the lists of two general practices (OP). Eating behavior was assessed using the Eating Disorder Examination (EDE 12.0D). Results: The prevalence of Binge Eating Disorder was lower than 5% in all the three samples. Median EDE scores in females were significantly higher in OC (3.0) and OP (3.4) than in DM (1.7), while diabetic patients showed higher scores on Restraint than both non-diabetic samples. Among diabetic patients, a significant correlation of EDE scores with HbA(1)c was observed. Conclusions: Type 2 diabetes is unlikely to induce relevant eating disturbances in obese patients, apart from an increase in restraint. Abnormalities of eating attitudes and behavior are associated with an impairment of metabolic control.
MeSH term(s)	Adult ; Aged ; Body Mass Index ; Bulimia/complications ; Bulimia/epidemiology ; Diabetes Complications ; Diabetes Mellitus, Type 2/complications ; Feeding and Eating Disorders/complications ; Feeding and Eating Disorders/epidemiology ; Female ; Glycated Hemoglobin A/analysis ; Humans ; Linear Models ; Male ; Middle Aged ; Obesity/complications
Chemical Substances	Glycated Hemoglobin A
Language	English
Publishing date	2002-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1103255-8
ISSN	0307-0565
ISSN	0307-0565
DOI	10.1038/sj.ijo.0801976
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Article ; Online: Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: data from the Italian Tamoxifen Trial.

Bonanni, Bernardo / Macis, Debora / Maisonneuve, Patrick / Johansson, Harriet A / Gucciardo, Giacomo / Oliviero, Pasquale / Travaglini, Roberto / Muraca, Maria G / Rotmensz, Nicole / Veronesi, Umberto / Decensi, Andrea U

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2006 Volume 24, Issue 22, Page(s) 3708–9; author reply 3709

MeSH term(s)	Adult ; Aged ; Anticarcinogenic Agents/metabolism ; Antineoplastic Agents, Hormonal/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/prevention & control ; Cytochrome P-450 CYP2D6/genetics ; Estrogen Receptor Modulators/metabolism ; Female ; Gene Frequency ; Genotype ; Hot Flashes/prevention & control ; Humans ; Italy ; Middle Aged ; Polymorphism, Genetic ; Randomized Controlled Trials as Topic ; Tamoxifen/metabolism
Chemical Substances	Anticarcinogenic Agents ; Antineoplastic Agents, Hormonal ; Estrogen Receptor Modulators ; Tamoxifen (094ZI81Y45) ; Cytochrome P-450 CYP2D6 (EC 1.14.14.1)
Language	English
Publishing date	2006-08-01
Publishing country	United States
Document type	Comment ; Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.2006.06.8072
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 650: Show issues

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Article: Impaired growth hormone response to clonidine in obesity.

Altomonte, L / Zoli, A / Mirone, L / Berchicci, M / Travaglini, R / Pellicano, P / Greco, A V

Experimental and clinical endocrinology

1988 Volume 92, Issue 2, Page(s) 231–234

Abstract: Clonidine, an imidazoline derivative, is an antihypertensive agent which reduces sympathetic tone by acting in the central nervous system to stimulate alpha-2 adrenoceptors. There is evidence that dopamine and norepinephrine modulate the secretion of GH. ...

Abstract	Clonidine, an imidazoline derivative, is an antihypertensive agent which reduces sympathetic tone by acting in the central nervous system to stimulate alpha-2 adrenoceptors. There is evidence that dopamine and norepinephrine modulate the secretion of GH. Stimulation of GH release is a well-known effect of clonidine in man. Obesity is characterized by an impairment of GH release in response to various stimuli. The aim of this work is to study GH release in response to alpha-2 adrenoceptors stimulation by clonidine in obesity. 12 volunteer obese subjects were studied. 10 normal weight subjects, sex and age matched, were controls. The GH responsiveness was tested with a single oral dose of clonidine (0.15 mg). Blood was sampled for GH radioimmunoassay at 0', 30', 60', 90', 120', 150', 180'. Serum GH basal levels were not significant different in obese subjects compared to controls. In obese subjects, no significant changes occurred in blood GH concentration after clonidine. In normal weight controls, instead, a significant increase of GH values was reached at 90' (P less than 0.05) and at 120' (P less than 0.05) after clonidine. The impairment of GH release after clonidine in obese subjects might be in a reduced serotonin release or in a failure of the hypothalamic-pituitary system to stimulate plasma GH caused by a diminished GH releasing factor stimulatory effect or by an excessive endorphin or somatostatin secretion in obesity.
MeSH term(s)	Administration, Oral ; Adult ; Clonidine/administration & dosage ; Clonidine/pharmacology ; Female ; Growth Hormone/blood ; Humans ; Male ; Obesity/metabolism
Chemical Substances	Growth Hormone (9002-72-6) ; Clonidine (MN3L5RMN02)
Language	English
Publishing date	1988-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	802516-2
ISSN	0232-7384 ; 0013-7251
ISSN	0232-7384 ; 0013-7251
DOI	10.1055/s-0029-1210806
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Article: Biologic activity of tamoxifen at low doses in healthy women.

Decensi, A / Bonanni, B / Guerrieri-Gonzaga, A / Gandini, S / Robertson, C / Johansson, H / Travaglini, R / Sandri, M T / Tessadrelli, A / Farante, G / Salinaro, F / Bettega, D / Barreca, A / Boyle, P / Costa, A / Veronesi, U

Journal of the National Cancer Institute

1998 Volume 90, Issue 19, Page(s) 1461–1467

Abstract: Background: Results of a clinical trial recently completed in the United States indicate that administration of tamoxifen (20 mg/day) to women at risk can reduce breast cancer incidence by approximately 50% but is associated with an increased risk of ... ...

Abstract	Background: Results of a clinical trial recently completed in the United States indicate that administration of tamoxifen (20 mg/day) to women at risk can reduce breast cancer incidence by approximately 50% but is associated with an increased risk of developing endometrial cancer and venous thromboembolic events. Since these adverse effects may be dose related, we investigated the effect of tamoxifen on several biomarkers when the drug was given at doses lower than those currently in use. Methods: In two sequential experiments, 127 healthy hysterectomized women aged 35-70 years were randomly assigned to one of the following four treatment arms: placebo (n = 31) or tamoxifen at 20 mg/day (n = 30) (first experiment); or tamoxifen at 10 mg/day (n = 34) or tamoxifen at 10 mg/ alternate days (n = 32) (second experiment). Baseline and 2-month measurements of the following parameters were compared: 1) total cholesterol (primary end point) and other surrogate markers of cardiovascular disease, e.g., low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, and lipoprotein(a); 2) blood cell count; 3) fibrinogen; 4) antithrombin III; 5) osteocalcin; and, 6) in a subgroup of 103 women, insulin-like growth factor-I (IGF-I), a possible surrogate marker for breast cancer. Results: After adjustment for the baseline values, there were reductions in circulating levels of total cholesterol and IGF-I of the same magnitude in all three tamoxifen treatment arms. A similar pattern was observed for most of the other parameters. In the placebo arm, fibrinogen level, which showed a decrease, was the only parameter exhibiting change. Conclusions: Up to a 75% reduction in the conventional dose of tamoxifen (i.e., 20 mg/day) does not affect the activity of the drug on a large number of biomarkers, most of which are surrogate markers of cardiovascular disease. This study was hypothesis generating, and larger studies are warranted to assess the efficacy of tamoxifen at low doses.
MeSH term(s)	Adult ; Aged ; Antineoplastic Agents, Hormonal/administration & dosage ; Antineoplastic Agents, Hormonal/pharmacology ; Biomarkers/blood ; Blood Cell Count/drug effects ; Blood Coagulation Factors/drug effects ; Drug Administration Schedule ; Estrogen Antagonists/administration & dosage ; Estrogen Antagonists/pharmacology ; Female ; Humans ; Hysterectomy ; Insulin-Like Growth Factor I/drug effects ; Lipids/blood ; Middle Aged ; Osteocalcin/blood ; Reference Values ; Tamoxifen/administration & dosage ; Tamoxifen/pharmacology
Chemical Substances	Antineoplastic Agents, Hormonal ; Biomarkers ; Blood Coagulation Factors ; Estrogen Antagonists ; Lipids ; Tamoxifen (094ZI81Y45) ; Osteocalcin (104982-03-8) ; Insulin-Like Growth Factor I (67763-96-6)
Language	English
Publishing date	1998-10-07
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2992-0
ISSN	1460-2105 ; 0027-8874 ; 0198-0157
ISSN (online)	1460-2105
ISSN	0027-8874 ; 0198-0157
DOI	10.1093/jnci/90.19.1461
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