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  1. Article: Phenobarbital-induced autoimmune haemolytic anaemia, thrombocytopenia and peripheral lymphadenomegaly due to reactive lymphoid hyperplasia in a cat

    Walton-Clark, Michelle / Travail, Victoria / Best, Matthew

    Journal of feline medicine and surgery open reports. 2022 Mar., v. 8, no. 1

    2022  

    Abstract: A female neutered domestic longhair cat, aged 1 year and 5 months, presented with lymphadenomegaly and anaemia following therapy with phenobarbital for idiopathic epilepsy. Physical examination revealed pale pink mucous membranes and peripheral ... ...

    Abstract A female neutered domestic longhair cat, aged 1 year and 5 months, presented with lymphadenomegaly and anaemia following therapy with phenobarbital for idiopathic epilepsy. Physical examination revealed pale pink mucous membranes and peripheral lymphadenomegaly. Haematology showed a regenerative anaemia (haematocrit 19.3%, reticulocyte count 118.08 ×10⁹/l), and saline agglutination was positive. Infectious disease screening was negative and lymph node cytology was consistent with reactive lymphoid hyperplasia. A diagnosis of phenobarbital-induced reactive lymphoid hyperplasia and immune-mediated anaemia was suspected. Complete resolution of the lymphadenomegaly and anaemia was documented within 4 weeks of phenobarbital discontinuation. There are limited case reports of phenobarbital-induced haematological changes and lymphadenomegaly; however, the combination has not previously been reported in cats and is similar to the rare but significant syndrome in humans known as ‘anticonvulsant hypersensitivity syndrome’. Anticonvulsant hypersensitivities should be considered as a potentially serious, yet reversible, sequela to phenobarbital treatment that may be mistaken for more severe illness such as neoplasia.
    Keywords agglutination ; cats ; clinical examination ; disease severity ; epilepsy ; females ; hematocrit ; hematology ; hemolytic anemia ; hyperplasia ; hypersensitivity ; infectious diseases ; lymph nodes ; medicine ; neoplasms ; phenobarbital ; reticulocyte count ; surgery ; thrombocytopenia
    Language English
    Dates of publication 2022-03
    Publishing place SAGE Publications
    Document type Article
    ZDB-ID 2822177-1
    ISSN 2055-1169
    ISSN 2055-1169
    DOI 10.1177/20551169221079238
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Phenobarbital-induced autoimmune haemolytic anaemia, thrombocytopenia and peripheral lymphadenomegaly due to reactive lymphoid hyperplasia in a cat.

    Walton-Clark, Michelle / Travail, Victoria / Best, Matthew

    JFMS open reports

    2022  Volume 8, Issue 1, Page(s) 20551169221079238

    Abstract: Case summary: A female neutered domestic longhair cat, aged 1 year and 5 months, presented with lymphadenomegaly and anaemia following therapy with phenobarbital for idiopathic epilepsy. Physical examination revealed pale pink mucous membranes and ... ...

    Abstract Case summary: A female neutered domestic longhair cat, aged 1 year and 5 months, presented with lymphadenomegaly and anaemia following therapy with phenobarbital for idiopathic epilepsy. Physical examination revealed pale pink mucous membranes and peripheral lymphadenomegaly. Haematology showed a regenerative anaemia (haematocrit 19.3%, reticulocyte count 118.08 ×10
    Relevance and novel information: There are limited case reports of phenobarbital-induced haematological changes and lymphadenomegaly; however, the combination has not previously been reported in cats and is similar to the rare but significant syndrome in humans known as 'anticonvulsant hypersensitivity syndrome'. Anticonvulsant hypersensitivities should be considered as a potentially serious, yet reversible, sequela to phenobarbital treatment that may be mistaken for more severe illness such as neoplasia.
    Language English
    Publishing date 2022-03-07
    Publishing country England
    Document type Case Reports
    ZDB-ID 2822177-1
    ISSN 2055-1169 ; 2055-1169
    ISSN (online) 2055-1169
    ISSN 2055-1169
    DOI 10.1177/20551169221079238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mycophenolate mofetil and telmisartan for the treatment of proteinuria secondary to minimal change disease podocytopathy in a dog.

    Travail, Victoria / Cianciolo, Rachel E / Peak, Kerry / Di Bella, Andrea

    Journal of veterinary internal medicine

    2022  Volume 36, Issue 6, Page(s) 2187–2190

    Abstract: A 3-year-old entire female Springer Spaniel, with a previous diagnosis of meningoencephalitis of unknown origin diagnosed 2 years before presentation and treated with long term administration of prednisolone, developed proteinuria. Laboratory findings ... ...

    Abstract A 3-year-old entire female Springer Spaniel, with a previous diagnosis of meningoencephalitis of unknown origin diagnosed 2 years before presentation and treated with long term administration of prednisolone, developed proteinuria. Laboratory findings revealed hypoalbuminemia, hypercholesterolemia, and proteinuria. Further investigations excluded underlying causes. Renal biopsies were performed. The glomeruli and the tubulointerstitial compartment did not show any anomalies on light microscopy and immunofluorescence staining did not reveal abnormalities. Transmission electron microscopy revealed moderate podocyte injury consisting of foot process effacement and microvillus transformation of the cytoplasm. The dog was diagnosed with primary minimal change disease of the podocytes and treated with telmisartan and mycophenolate mofetil. Abnormalities of serum albumin, cholesterol, and proteinuria resolved within 4 weeks. Minimal change disease has been reported in dogs, but this is a case report of proteinuria secondary to minimal change disease successfully treated with mycophenolate mofetil and telmisartan.
    MeSH term(s) Dogs ; Female ; Animals ; Nephrosis, Lipoid/drug therapy ; Nephrosis, Lipoid/veterinary ; Nephrosis, Lipoid/complications ; Mycophenolic Acid/therapeutic use ; Telmisartan/therapeutic use ; Proteinuria/drug therapy ; Proteinuria/veterinary ; Kidney Glomerulus/pathology ; Dog Diseases/drug therapy ; Dog Diseases/pathology
    Chemical Substances Mycophenolic Acid (HU9DX48N0T) ; Telmisartan (U5SYW473RQ)
    Language English
    Publishing date 2022-09-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 92798-3
    ISSN 1939-1676 ; 0891-6640
    ISSN (online) 1939-1676
    ISSN 0891-6640
    DOI 10.1111/jvim.16534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4095: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  4. Article ; Online: Mycophenolate mofetil and telmisartan for the treatment of proteinuria secondary to minimal change disease podocytopathy in a dog

    Travail, Victoria / Cianciolo, Rachel E. / Peak, Kerry / Di Bella, Andrea

    Journal of Veterinary Internal Medicine. 2022 Nov., v. 36, no. 6 p.2187-2190

    2022  

    Abstract: A 3‐year‐old entire female Springer Spaniel, with a previous diagnosis of meningoencephalitis of unknown origin diagnosed 2 years before presentation and treated with long term administration of prednisolone, developed proteinuria. Laboratory findings ... ...

    Abstract A 3‐year‐old entire female Springer Spaniel, with a previous diagnosis of meningoencephalitis of unknown origin diagnosed 2 years before presentation and treated with long term administration of prednisolone, developed proteinuria. Laboratory findings revealed hypoalbuminemia, hypercholesterolemia, and proteinuria. Further investigations excluded underlying causes. Renal biopsies were performed. The glomeruli and the tubulointerstitial compartment did not show any anomalies on light microscopy and immunofluorescence staining did not reveal abnormalities. Transmission electron microscopy revealed moderate podocyte injury consisting of foot process effacement and microvillus transformation of the cytoplasm. The dog was diagnosed with primary minimal change disease of the podocytes and treated with telmisartan and mycophenolate mofetil. Abnormalities of serum albumin, cholesterol, and proteinuria resolved within 4 weeks. Minimal change disease has been reported in dogs, but this is a case report of proteinuria secondary to minimal change disease successfully treated with mycophenolate mofetil and telmisartan.
    Keywords case studies ; cholesterol ; cytoplasm ; dogs ; females ; fluorescent antibody technique ; hypercholesterolemia ; hypoalbuminemia ; light microscopy ; meningoencephalitis ; microvilli ; prednisolone ; proteinuria ; serum albumin ; telmisartan ; transmission electron microscopy ; veterinary medicine
    Language English
    Dates of publication 2022-11
    Size p. 2187-2190.
    Publishing place John Wiley & Sons, Inc.
    Document type Article ; Online
    Note Case Reports
    ZDB-ID 92798-3
    ISSN 1939-1676 ; 0891-6640
    ISSN (online) 1939-1676
    ISSN 0891-6640
    DOI 10.1111/jvim.16534
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4095: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Assessment of the likelihood of hypothyroidism in dogs diagnosed with and treated for hypothyroidism at primary care practices: 102 cases (2016-2021).

    Travail, Victoria / Fernandez Sanchez, Carolina / Costo, Jose M / Valentine, Nicola / Conroy, Megan / Lee, Venessa / Bouziopoulos, Dimitrios / Bateman, Kathryn / Gatehouse, Emma / Cruzado-Perez, Judith / Pollard, Danica / Lamb, Valerie / Juvet, Florence / Kelly, Darren

    Journal of veterinary internal medicine

    2024  Volume 38, Issue 2, Page(s) 931–941

    Abstract: Background: There is a possibility that an incorrect diagnosis of hypothyroidism could be made in euthyroid dogs, and the prevalence of hypothyroidism in the dog population remains unknown.: Objectives: To retrospectively assess the percentage of ... ...

    Abstract Background: There is a possibility that an incorrect diagnosis of hypothyroidism could be made in euthyroid dogs, and the prevalence of hypothyroidism in the dog population remains unknown.
    Objectives: To retrospectively assess the percentage of dogs diagnosed with, and treated for, hypothyroidism at first opinion practice which are likely to be hypothyroid and require levothyroxine supplementation.
    Animals: One hundred two client-owned dogs were included in this study.
    Materials and methods: The computerized databases of 7 first opinion practices were searched to identify dogs treated with levothyroxine supplementation. Three European College of Veterinary Internal Medicine-Companian Animals (ECVIM-CA) diplomates independently assigned 1 of 4 clinical assessments to each case as follows: confirmed or likely hypothyroid, hypothyroidism suspected but not confirmed, hypothyroidism considered unlikely, and no reason to suspect hypothyroidism. They commented as to whether or not they thought levothyroxine supplementation was appropriate.
    Results: The clinical assessments of "confirmed or likely hypothyroid"; "Hypothyroidism suspected but not confirmed"; "Hypothyroidism considered unlikely"; and "No reason to suspect hypothyroidism" was assigned respectively by Clinician 1 to 38.2%, 5.9%, 3.9%, and 52% of cases, by Clinician 2 to 48%, 22.6%, 22.6%, 6.9% of cases, and by Clinician 3 to 55.9%, 11.8%, 13.7% and 18.6%. Clinician 1, Clinician 2, and Clinician 3 considered levothyroxine supplementation not indicated in 58.8%, 52.9%, and 45.1% of cases, respectively.
    Conclusion: These results support the concern that hypothyroidism might be overly and incorrectly diagnosed in first opinion practice, and that thyroid function testing should be performed only in those dogs with a high pretest probability of the disease.
    MeSH term(s) Humans ; Dogs ; Animals ; Thyroxine/therapeutic use ; Retrospective Studies ; Dog Diseases/diagnosis ; Dog Diseases/drug therapy ; Hypothyroidism/diagnosis ; Hypothyroidism/drug therapy ; Hypothyroidism/veterinary ; Probability ; Primary Health Care
    Chemical Substances Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 92798-3
    ISSN 1939-1676 ; 0891-6640
    ISSN (online) 1939-1676
    ISSN 0891-6640
    DOI 10.1111/jvim.16993
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4095: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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