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  1. Article ; Online: Commentary: Feasibility and Morbidity of Magnetic Resonance Imaging-Guided Stereotactic Laser Ablation of Deep Cerebral Cavernous Malformations: A Report of 4 Cases.

    Traylor, Jeffrey I / Lega, Bradley

    Neurosurgery

    2021  Volume 89, Issue 4, Page(s) E211–E212

    MeSH term(s) Feasibility Studies ; Hemangioma, Cavernous, Central Nervous System/diagnostic imaging ; Hemangioma, Cavernous, Central Nervous System/surgery ; Humans ; Laser Therapy ; Magnetic Resonance Imaging ; Morbidity
    Language English
    Publishing date 2021-07-27
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyab287
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    Zs.A 1424: Show issues Location:
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  2. Article ; Online: Clip Ligation of a Recurrent Middle Cerebral Artery Aneurysm After Treatment With Woven EndoBridge: 2-Dimensional Operative Video.

    Traylor, Jeffrey I / Venkatesh, Pooja / Fabiano, Alexander S / Beach, Corbyn / de Oliveira Sillero, Rafael

    Operative neurosurgery (Hagerstown, Md.)

    2023  Volume 26, Issue 2, Page(s) 229

    MeSH term(s) Humans ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/surgery ; Ligation ; Treatment Outcome
    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Video-Audio Media ; Journal Article
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1227/ons.0000000000000909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: "Liquid Biopsy" of Circulating Tumor DNA Characterizes Treatment Response in Pediatric Patients Diffuse Midline Glioma.

    Traylor, Jeffrey I / Kuo, John S

    Neurosurgery

    2019  Volume 85, Issue 2, Page(s) E167–E168

    Language English
    Publishing date 2019-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyz029
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  4. Article ; Online: Delta-24-RGD Adenoviral Therapy Directs Oncolytic and Immune-Mediated Anti-Tumor Effects in Recurrent Malignant Glioma Patients.

    Traylor, Jeffrey I / Kuo, John S

    Neurosurgery

    2018  Volume 84, Issue 1, Page(s) E11–E12

    Language English
    Publishing date 2018-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyy504
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  5. Article ; Online: Combined Nivolumab and Ipilimumab Is an Effective Treatment for Melanoma Brain Metastases.

    Traylor, Jeffrey I / Kuo, John S

    Neurosurgery

    2018  Volume 84, Issue 3, Page(s) E134–E135

    Language English
    Publishing date 2018-12-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyy619
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  6. Article ; Online: Distance traveled to glioblastoma treatment: A measure of the impact of socioeconomic status on survival.

    Bird, Cylaina E / Traylor, Jeffrey I / Youssef, Michael / Abdullah, Kalil G

    Clinical neurology and neurosurgery

    2021  Volume 209, Page(s) 106909

    Abstract: Background: Previous studies have shown improved post-surgical outcomes in patients who travel farther for glioblastoma treatment. This study investigates socioeconomic and facility factors that may influence this relationship.: Methods: Overall ... ...

    Abstract Background: Previous studies have shown improved post-surgical outcomes in patients who travel farther for glioblastoma treatment. This study investigates socioeconomic and facility factors that may influence this relationship.
    Methods: Overall survival was calculated and compared by distance to treatment facility using univariate and multivariate survival models. The analysis was stratified by facility type, income quartile and insurance status and the association re-evaluated. Kaplan-Meier survival curves were created to analyze the relationship between overall survival and distance group.
    Results: Individuals who traveled less than 5 miles to treatment had the shortest overall survival (11.8 months), while those who traveled greater than 50 miles had the longest survival (12.9 months). Stratification by income quartile failed to demonstrate an association between distance traveled and survival for those making less than $63,000 (adjusted hazard ratio range: 0.94-1.01). There was no association between survival and distance traveled for patients treated at a community cancer center, comprehensive community cancer center or an integrated network cancer program (adjusted hazard ratio range: 0.86-1.04).
    Conclusion: Financial strain, rather than distance traveled to treatment, may be associated with glioblastoma survival.
    MeSH term(s) Aged ; Brain Neoplasms/therapy ; Female ; Glioblastoma/therapy ; Health Services Accessibility ; Humans ; Income ; Male ; Middle Aged ; Retrospective Studies ; Social Class ; Socioeconomic Factors ; Time Factors ; Travel
    Language English
    Publishing date 2021-08-28
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2021.106909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Repeat laser interstitial thermal therapy for recurrent primary and metastatic intracranial tumors.

    Muir, Matthew / Traylor, Jeffrey I / Gadot, Ron / Patel, Rajan / Prabhu, Sujit S

    Surgical neurology international

    2022  Volume 13, Page(s) 311

    Abstract: Background: Repeat craniotomy in patients with primary and metastatic brain tumors carries significant morbidity and can delay adjuvant treatments. Repeat laser interstitial thermal therapy (LITT) for recurrent disease has been described and could ... ...

    Abstract Background: Repeat craniotomy in patients with primary and metastatic brain tumors carries significant morbidity and can delay adjuvant treatments. Repeat laser interstitial thermal therapy (LITT) for recurrent disease has been described and could benefit patients with limited cytoreductive options. We aim to describe the indications, safety, and efficacy of repeat LITT for recurrent primary and metastatic intracranial tumors.
    Methods: Patients undergoing repeat ablations for the same lesion were included in the study. We retrospectively analyzed 13 patients treated with 29 total LITT ablations.
    Results: Eleven patients were treated for glioblastoma (GBM), while two had brain metastases. Eleven patients had LITT performed only 2 times, while three patients underwent three total iterations of LITT for disease recurrence. Median length of stay after the 1
    Conclusion: Recurrent tumors, especially GBM, can be safely treated using repeat LITT when surgery cannot be effectively performed. Our results indicate that patients tolerate the procedure well and have a meaningful survival given the salvage nature of the procedure.
    Language English
    Publishing date 2022-07-22
    Publishing country United States
    Document type Journal Article
    ISSN 2229-5097
    ISSN 2229-5097
    DOI 10.25259/SNI_418_2022
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  8. Article ; Conference proceedings: Impact of Patient Age on Length of Surgery and Blood Loss During Microsurgery for Vestibular Schwannoma

    Fabiano, Alexander S. / Traylor, Jeffrey I. / Venkatesh, Pooja / Zhu, Michelle / Schmitt, Kelsey / Pulipaka, Srinivas / Plitt, Aaron R. / Patel, Ankur / Barnett, Samuel L.

    Journal of Neurological Surgery Part B: Skull Base

    2024  Volume 85, Issue S 01

    Event/congress 33rd Annual Meeting North American Skull Base Society, Atlanta Marriott Marquis Atlanta, Georgia, United States, 2024-02-16
    Language English
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0044-1779953
    Database Thieme publisher's database

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    Zs.A 3425: Show issues Location:
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  9. Article ; Online: Neoantigen-Targeting Vaccine Promotes T-Cell Response in Glioblastoma.

    Traylor, Jeffrey I / Satarasinghe, Praveen / Kuo, John S

    Neurosurgery

    2019  Volume 85, Issue 2, Page(s) E207–E209

    Language English
    Publishing date 2019-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyz164
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  10. Article: Matched three-dimensional organoids and two-dimensional cell lines of melanoma brain metastases mirror response to targeted molecular therapy.

    Hicks, William H / Gattie, Lauren C / Traylor, Jeffrey I / Davar, Diwakar / Najjar, Yana G / Richardson DO, Timothy E / McBrayer, Samuel K / Abdullah, Kalil G

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Purpose: Despite significant advances in the treatment paradigm for patients with metastatic melanoma, melanoma brain metastasis (MBM) continues to represent a significant treatment challenge. The study of MBM is limited, in part, by shortcomings in ... ...

    Abstract Purpose: Despite significant advances in the treatment paradigm for patients with metastatic melanoma, melanoma brain metastasis (MBM) continues to represent a significant treatment challenge. The study of MBM is limited, in part, by shortcomings in existing preclinical models. Surgically eXplanted Organoids (SXOs) are ex vivo, three-dimensional cultures prepared from primary tissue samples with minimal processing that recapitulate genotypic and phenotypic features of parent tumors and are grown without artificial extracellular scaffolding. We aimed to develop the first matched patient-derived SXO and cell line models of MBM to investigate responses to targeted therapy.
    Methods: MBM SXOs were created by a novel protocol incorporating techniques for establishing glioma and cutaneous melanoma organoids. A BRAF
    Results: Organoid growth was observed within 3-4 weeks, and MBM SXOs retained histological features of the parent tissue, including pleomorphic epithelioid cells with abundant cytoplasm, large nuclei, focal melanin accumulation, and strong SOX10 positivity. After sufficient growth, organoids could be manually parcellated to increase the number of replicates. Matched SXOs and cell lines demonstrated sensitivity to BRAF and MEK inhibitors.
    Conclusion: Here, we describe the creation of a scaffold-free organoid model of MBM. Further study using SXOs may improve the translational relevance of preclinical studies and enable the study of the metastatic melanoma tumor microenvironment.
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.18.576318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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