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Article ; Online: Fifty years of research at CERN and elsewhere

Treille D.

EPJ Web of Conferences, Vol 95, p

2015 Volume 06002

Abstract: A brief overview of fifty years of particle physics at CERN and elsewhere is given. ...

Abstract	A brief overview of fifty years of particle physics at CERN and elsewhere is given.
Keywords	Science ; Q ; Physics ; QC1-999
Publishing date	2015-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Supersymmetry facing experiment: much ado (already) about nothing (yet).

Pape, Luc / Treille, Daniel

Reports on progress in physics. Physical Society (Great Britain)

2018 Volume 69, Issue 11

Abstract: This report emphasizes the comparison between supersymmetric models and experiments. A minimal theoretical introduction is included as a guide to the interpretation of results. The existing constraints from low energy measurements, accelerator searches ( ... ...

Abstract	This report emphasizes the comparison between supersymmetric models and experiments. A minimal theoretical introduction is included as a guide to the interpretation of results. The existing constraints from low energy measurements, accelerator searches (LEP, Tevatron and HERA) and non-accelerator searches for neutralinos are presented. Prospects for upgrades of these facilities and for the LHC and linear collider are summarized. Most discussions are made in the framework of the minimal supersymmetric standard model inspired by supergravity (MSUGRA). But alternatives such as gauge mediated supersymmetry breaking (GMSB), anomaly mediated supersymmetry breaking (AMSB), models with R-parity violation and even alternatives to supersymmetry are also briefly considered.
Language	English
Publishing date	2018-12-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	205657-4
ISSN	1361-6633 ; 0034-4885
ISSN (online)	1361-6633
ISSN	0034-4885
DOI	10.1088/0034-4885/69/11/R01
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Article: Correlation of MDR1/P-170 expression with daunorubicin uptake and sensitivity of leukemic progenitors in acute myeloid leukemia.

Campos, L / Guyotat, D / Jaffar, C / Solary, E / Archimbaud, E / Treille, D

European journal of haematology

1992 Volume 48, Issue 5, Page(s) 254–258

Abstract: Prior studies have shown that multidrug resistance gene products may be detected in acute myeloid leukemia (AML) cells, and are associated with poor response to therapy. We studied whether P-170 expression was associated with in vitro daunorubicin (DNR) ... ...

Abstract	Prior studies have shown that multidrug resistance gene products may be detected in acute myeloid leukemia (AML) cells, and are associated with poor response to therapy. We studied whether P-170 expression was associated with in vitro daunorubicin (DNR) accumulation and sensitivity of leukemic clonogenic cells (CFU-L) to DNR in 16 newly diagnosed AML samples. P-170 expression was assessed by indirect immunofluorescence using the monoclonal antibody MRK16. DNR cellular content was measured by flow cytometry after short incubation with increasing concentrations of DNR, and was not correlated with P-170 expression, although there was a trend for higher values in P-170-negative samples. The sensitivity of CFU-L was studied in a semisolid culture assay by calculating the dose of DNR inhibiting the growth of 90% of CFU-L (D90). The D90 was significantly higher in P-170-positive than in P-170-negative samples (mean = 1.68 +/- 0.42 microgram/ml versus 0.97 +/- 0.35 micrograms/ml respectively, p less than 0.005). Eight of 9 cases achieving complete remission (CR) after intensive chemotherapy were P-170-negative, whereas 7 of 7 nonresponders were P-170-positive (p less than 10(-5)). D90 was significantly lower for patients achieving CR than for those who did not achieve CR (1.12 +/- 0.55 micrograms/ml versus 1.59 +/- 0.37 micrograms/ml, p = 0.04). It is concluded that P-170 expression is correlated with in vitro resistance of clonogenic cells to DNR and may be one mechanism of resistance to chemotherapy.
MeSH term(s)	ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Adult ; Aged ; Biological Transport ; Daunorubicin/metabolism ; Drug Resistance ; Humans ; In Vitro Techniques ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; Membrane Glycoproteins/metabolism ; Middle Aged ; Neoplastic Stem Cells/drug effects ; Prognosis ; Tumor Cells, Cultured/drug effects
Chemical Substances	ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Membrane Glycoproteins ; Daunorubicin (ZS7284E0ZP)
Language	English
Publishing date	1992-05
Publishing country	England
Document type	Journal Article
ZDB-ID	392482-8
ISSN	1600-0609 ; 0902-4441
ISSN (online)	1600-0609
ISSN	0902-4441
DOI	10.1111/j.1600-0609.1992.tb01803.x
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Article: Acute leukaemia following high-dose chemoradiotherapy with bone marrow rescue for ovarian teratoma.

Guyotat, D / Coiffier, B / Campos, L / Archimbaud, E / Treille, D / Ehrsam, A / Fiere, D

Acta haematologica

1988 Volume 80, Issue 1, Page(s) 52–53

Abstract: A case of acute leukaemia following intensive chemo- and radiotherapy for solid tumour is reported. A 15-year-old girl received four courses of chemotherapy with adriamycin, cyclophosphamide and cisplatinum after the surgical diagnosis of ovarian ... ...

Abstract	A case of acute leukaemia following intensive chemo- and radiotherapy for solid tumour is reported. A 15-year-old girl received four courses of chemotherapy with adriamycin, cyclophosphamide and cisplatinum after the surgical diagnosis of ovarian immature teratoma. An intensification treatment was performed with cyclophosphamide and total body irradiation, followed by marrow rescue. The diagnosis of myelomonocytic acute leukaemia was performed 8 months later. The patient died after a transient improvement following a treatment by hydroxyurea. The roles of the primary tumour, of the chemotherapy and of the marrow transplantation in the occurrence of leukaemia are discussed.
MeSH term(s)	Acute Disease ; Adolescent ; Bone Marrow Transplantation ; Dose-Response Relationship, Radiation ; Drug Administration Schedule ; Female ; Humans ; Leukemia/chemically induced ; Leukemia, Radiation-Induced/etiology ; Ovarian Neoplasms/complications ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/radiotherapy ; Teratoma/complications ; Teratoma/drug therapy ; Teratoma/radiotherapy ; Transplantation, Autologous
Language	English
Publishing date	1988
Publishing country	Switzerland
Document type	Case Reports ; Journal Article
ZDB-ID	80008-9
ISSN	1421-9662 ; 0001-5792
ISSN (online)	1421-9662
ISSN	0001-5792
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Article: Surface markers in acute non-lymphoid leukemia: analysis with a panel of 36 monoclonal antibodies.

Campos, L / Guyotat, D / Gentilhomme, O / Treille, D / Archimbaud, E / Fiere, D / Germain, D

Blut

1987 Volume 54, Issue 2, Page(s) 65–71

Abstract: The reactivity of a panel of monoclonal antibodies was studied in fifty-four cases of acute myeloid (AML) or undifferentiated (AUL) leukemias. Thirty-six antibodies from the Myeloid section of the Second Workshop on Human Leukocyte Differentiation ... ...

Abstract	The reactivity of a panel of monoclonal antibodies was studied in fifty-four cases of acute myeloid (AML) or undifferentiated (AUL) leukemias. Thirty-six antibodies from the Myeloid section of the Second Workshop on Human Leukocyte Differentiation Antigens were used in an indirect immunofluorescence assay. The antibodies could be classified into three groups recognizing respectively granulocytic, monocytic or granulomonocytic leukemias. Most antibodies stained erythroblastic and megakaryoblastic leukemias. In each group, it was possible to define antibodies staining either the less differentiated forms (FAB M 1 and M 5 a) or the more differentiated forms (M 2, M 3, M 4 and M 5 b). Six out of eight AUL were stained by some of the antibodies (mainly from the monocytic group). However, a heterogeneity of stainings in a same blast population was observed.
MeSH term(s)	Acute Disease ; Antibodies, Monoclonal/classification ; Antigens, Surface/analysis ; Bone Marrow/immunology ; Bone Marrow/pathology ; Humans ; Leukemia/immunology ; Leukemia/pathology
Chemical Substances	Antibodies, Monoclonal ; Antigens, Surface
Language	English
Publishing date	1987-02
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	213648-x
ISSN	0006-5242
ISSN	0006-5242
DOI	10.1007/bf00321031
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Article: Expression of a B-lymphoid differentiation antigen (CD 19) on acute non-lymphoblastic leukaemia cells.

Campos, L / Guyotat, D / Gentilhomme, O / Treille, D / Fiere, D / Germain, D

European journal of haematology

1987 Volume 38, Issue 3, Page(s) 220–224

Abstract: The expression of CD 19 (B4) surface antigen was investigated in 41 cases of acute myeloid leukaemia (AML), and 8 cases of acute undifferentiated leukaemia (AUL). Diagnosis was carried out by usual cytological and cytochemical means, and leukaemias were ... ...

Abstract	The expression of CD 19 (B4) surface antigen was investigated in 41 cases of acute myeloid leukaemia (AML), and 8 cases of acute undifferentiated leukaemia (AUL). Diagnosis was carried out by usual cytological and cytochemical means, and leukaemias were classified according to the FAB classification. CD 19 antigen is thought to be expressed on B lymphoid cells only. However, 2 cases out of 9 FAB M1, M2 and M3 subtypes were weakly stained (20 to 25%) by B4 antibody; 7 out of 11, and 17 out of 18 cases of M4 and M5 subtypes were markedly stained (25 to 70% of cells). 3 cases of AUL were also stained. Moreover, B4 expression was often correlated with expression of monocyte-associated antigens, as recognized by CRIS6, My9, KiM1 and UCHM1 antibodies. It is concluded that B4 antigen is probably expressed before B differentiation and is retained in early stages of monocytic differentiation.
MeSH term(s)	Antigens, Neoplasm/immunology ; Growth Substances/immunology ; Histocytochemistry ; Humans ; Immunologic Techniques ; Interleukin-4 ; Leukemia/immunology ; Leukemia/pathology ; Lymphokines/immunology
Chemical Substances	Antigens, Neoplasm ; Growth Substances ; Lymphokines ; Interleukin-4 (207137-56-2)
Language	English
Publishing date	1987-03
Publishing country	England
Document type	Journal Article
ZDB-ID	392482-8
ISSN	1600-0609 ; 0902-4441
ISSN (online)	1600-0609
ISSN	0902-4441
DOI	10.1111/j.1600-0609.1987.tb01167.x
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Article: CD1-reactive leukemic cells in bone marrow: presence of Langerhans cell marker on leukemic monocytic cells.

Misery, L / Campos, L / Dezutter-Dambuyant, C / Guyotat, D / Treille, D / Schmitt, D / Thivolet, J

European journal of haematology

1992 Volume 48, Issue 1, Page(s) 27–32

Abstract: Langerhans cells originate in bone marrow and probably belong to the monocyte-macrophage lineage. CD1 is a specific marker of Langerhans cells. By immunofluorescence and immunoelectron microscopy, CD1a antigen and myeloid markers (CD11, CD13, CD14, CD15, ...

Abstract	Langerhans cells originate in bone marrow and probably belong to the monocyte-macrophage lineage. CD1 is a specific marker of Langerhans cells. By immunofluorescence and immunoelectron microscopy, CD1a antigen and myeloid markers (CD11, CD13, CD14, CD15, CD33, HLA-DR) were studied in 53 cases of acute myeloid leukemias (AML) and 3 acute lymphoblastic leukemias (ALL). The 11 ANLL without monocytic component were CD1a negative. 2/5 of acute myelomonocytic leukemias (AML4) and 9/37 of acute monocytic leukemias (AML5) were positive. All 3 ALL were negative. No correlation was found between CD1a and myeloid markers. CD1a+ AML did not differ from CD1a- AML with regard to cytogenetics or response to therapy. The CD1a positive cells may originate from an abnormal proliferation of CD1a positive cells which are present in bone marrow and which may differentiate into Langerhans cell precursors.
MeSH term(s)	Antigens, CD/analysis ; Antigens, CD1 ; Antigens, Surface/analysis ; Biomarkers ; Bone Marrow/immunology ; Bone Marrow/pathology ; Fluorescent Antibody Technique ; HLA-DR Antigens/analysis ; Humans ; Karyotyping ; Langerhans Cells/immunology ; Langerhans Cells/pathology ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/immunology ; Leukemia, Myeloid, Acute/pathology ; Leukemia, Myeloid, Acute/therapy ; Microscopy, Electron ; Middle Aged ; Monocytes/immunology ; Monocytes/pathology ; Monocytes/ultrastructure ; Prognosis
Chemical Substances	Antigens, CD ; Antigens, CD1 ; Antigens, Surface ; Biomarkers ; HLA-DR Antigens
Language	English
Publishing date	1992-01
Publishing country	England
Document type	Journal Article
ZDB-ID	392482-8
ISSN	1600-0609 ; 0902-4441
ISSN (online)	1600-0609
ISSN	0902-4441
DOI	10.1111/j.1600-0609.1992.tb01789.x
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Article: Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis.

Campos, L / Guyotat, D / Archimbaud, E / Calmard-Oriol, P / Tsuruo, T / Troncy, J / Treille, D / Fiere, D

Blood

1992 Volume 79, Issue 2, Page(s) 473–476

Abstract: To evaluate the clinical value of the expression of multidrug resistance P-glycoprotein (P-170) on the surface of acute nonlymphoblastic leukemia (ANLL) cells, we analyzed specimens from 150 newly diagnosed patients for staining with MRK16, a monoclonal ... ...

Abstract	To evaluate the clinical value of the expression of multidrug resistance P-glycoprotein (P-170) on the surface of acute nonlymphoblastic leukemia (ANLL) cells, we analyzed specimens from 150 newly diagnosed patients for staining with MRK16, a monoclonal antibody (MoAb) that binds to an external epitope of P-170. Other surface markers (CD13, CD14, CD15, and CD34) were studied by the same technique. A marker was considered positive when 20% or more cells were stained. Of 150 samples, 71 were P-170-positive. These cases did not differ from P-170-negative cases with regard to age, sex, initial white blood cell (WBC) counts, or French-American-British (FAB) type (except for M3 ANLL, which were more frequently negative). However, leukemias arising from previous myelodysplastic syndrome (MDS) and therapy-induced leukemias were more frequently P-170-positive. CD34 and P-170 expression were significantly associated. All patients were treated by intensive chemotherapy. Complete remission (CR) rates were significantly lower in P-170-positive (23/71, 32%) than in P-170-negative cases (64/79, 81%) (P less than 10(-5)). CD34 positivity was also associated with a low remission rate (P less than 10(-5)). Survival was shorter for P-170- and CD34-positive patients (P less than 10(-5)). The prognostic value of both markers was confirmed in multivariate analysis. CR duration was also shorter for P-170-positive cases, but the difference is less significant (P = .05). It is concluded that P-170 analysis may be an important tool for predicting the outcome of intensive chemotherapy in ANLL patients.
MeSH term(s)	ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Antigens, CD/analysis ; Antigens, CD34 ; Drug Resistance ; Fluorescent Antibody Technique ; Humans ; Leukemia, Myeloid, Acute/immunology ; Leukemia, Myeloid, Acute/metabolism ; Membrane Glycoproteins/analysis ; Middle Aged ; Prognosis ; Remission Induction
Chemical Substances	ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Antigens, CD ; Antigens, CD34 ; Membrane Glycoproteins
Language	English
Publishing date	1992-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
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Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Specific detection of monocytic lysozyme within normal and leukemic cells.

Leculier, C / Couprie, N / Francina, A / Archimbaud, E / Adeleine, P / Treille, D / Denoyel, G / Fiere, D

Blood

1992 Volume 79, Issue 3, Page(s) 760–764

Abstract: A murine monoclonal antibody against human lysozyme (AHL MoAb) was produced and tested on normal and leukemic monocytes using flow cytometry. The antibody gave a positive reactivity on normal monocytes permeabilized by saponin (82% to 98% of positive ... ...

Abstract	A murine monoclonal antibody against human lysozyme (AHL MoAb) was produced and tested on normal and leukemic monocytes using flow cytometry. The antibody gave a positive reactivity on normal monocytes permeabilized by saponin (82% to 98% of positive cells) and a negative reactivity on normal permeabilized neutrophils. This monocyte-specific reactivity had not been observed using a polyclonal antibody. Nevertheless, immunoblotting detected lysozyme in both monocyte and polymorphonuclear leukocyte (PMNL) lysates. The AHL MoAb, in the presence of lysozyme substrate (Micrococcus lysodeikticus cell walls), strongly inhibited the enzymatic activity. Flow cytometric analysis of leukemic cells isolated from patients suffering from different subtypes of acute myeloid leukemia (French-American-British [FAB] classification FAB M1-5) showed a highly significant positivity of FAB M5 for lysozyme compared with the other subtypes. The present results were consistent with the detection of a lysozyme epitope by AHL MoAb located near the catalytic site in monocytes. The same epitope was probably masked in PMNL granules.
MeSH term(s)	Antibodies, Monoclonal/immunology ; Blotting, Western ; Cell Membrane Permeability ; Cytoplasm/enzymology ; Flow Cytometry ; Humans ; Leukemia/enzymology ; Lymphocytes/enzymology ; Monocytes/enzymology ; Muramidase/blood ; Neutrophils/enzymology
Chemical Substances	Antibodies, Monoclonal ; Muramidase (EC 3.2.1.17)
Language	English
Publishing date	1992-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
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Article: Specific binding of anti-N-acetyllactosamine monoclonal antibody 1B2 to acute myeloid leukaemia cells.

Campos, L / Portoukalian, J / Bonnier, S / Shi, Z H / Calmard-Oriol, P / Treille, D / Guyotat, D

European journal of cancer (Oxford, England : 1990)

1992 Volume 28, Issue 1, Page(s) 37–41

Abstract: 1B2 is an IgM monoclonal antibody binding to glycoconjugates bearing the terminal N-acetyllactosamine structure. It agglutinates human erythrocytes. Various cell lines, peripheral blood leucocytes, normal marrow and blast cells from 179 acute myeloid ... ...

Abstract	1B2 is an IgM monoclonal antibody binding to glycoconjugates bearing the terminal N-acetyllactosamine structure. It agglutinates human erythrocytes. Various cell lines, peripheral blood leucocytes, normal marrow and blast cells from 179 acute myeloid leukaemia (AML) and 11 acute lymphoblastic leukaemia (ALL) patients were tested for reactivity with 1B2. Myelomonocytic (CFU-GM), erythroid (BFU-E), mixed (CFU-GEMM) and leukaemic (CFU-L) progenitor cells were tested in clonogenic assays. Granulocytes, monocytes, myeloid cell lines and 152 out of 179 AML were positive. All FAB subtypes were equally recognised. Lymphocytes, T-cell and Burkitt's cell lines, and 10 of 11 ALL samples were negative. 1B2 inhibited partially day 7 CFU-GM, whereas it was not toxic for BFU-E, CFU-GEMM and day 14 CFU-GM. Leukaemic clonogenic cells were killed in 33 out of 36 AML (more than 40% growth inhibition). 1B2 identifies the more mature steps of myeloid differentiation. It may be useful in the diagnosis of AML, and is a candidate for remission marrow purging before autologous transplantation.
MeSH term(s)	Amino Sugars/immunology ; Antibodies, Monoclonal/immunology ; Antibody-Dependent Cell Cytotoxicity ; Antigens, Surface/analysis ; Bone Marrow/immunology ; Cell Line ; Cell Survival ; Colony-Forming Units Assay ; Hematopoietic Stem Cells/immunology ; Humans ; Immunoglobulin M/immunology ; Leukemia, Myeloid/immunology ; Tumor Stem Cell Assay
Chemical Substances	Amino Sugars ; Antibodies, Monoclonal ; Antigens, Surface ; Immunoglobulin M ; N-acetyllactosamine (3Y5B2K5OOK)
Language	English
Publishing date	1992
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	82061-1
ISSN	1879-0852 ; 0959-8049 ; 0277-5379 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0959-8049 ; 0277-5379 ; 0964-1947
DOI	10.1016/0959-8049(92)90380-k
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