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Article ; Online: Enhanced recovery in acute appendicitis.

Trejo-Ávila, Mario

2019 Volume 87, Issue 3, Page(s) 365–366

Title translation	Recuperación acelerada en apendicitis aguda.
MeSH term(s)	Acute Disease ; Appendectomy ; Appendicitis ; Humans
Language	English
Publishing date	2019-05-27
Publishing country	Mexico
Document type	Letter ; Comment
ZDB-ID	730699-4
ISSN	2444-054X ; 0009-7411
ISSN (online)	2444-054X
ISSN	0009-7411
DOI	10.24875/CIRU.18000898
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Article ; Online: Expedited discharge, outpatient, same-day, fast-track, or ambulatory appendectomy in uncomplicated acute appendicitis: are they all the same?

Trejo-Avila, Mario

American journal of surgery

2019 Volume 219, Issue 4, Page(s) 681–682

MeSH term(s)	Acute Disease ; Appendectomy ; Appendicitis ; Humans ; Length of Stay ; Outpatients ; Patient Discharge
Language	English
Publishing date	2019-05-25
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2019.05.009
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Article: An uncommon case of right hepatic duct entering cystic duct associated to multiple complications of biliary tract disease: acute pancreatitis, hepatolithiasis, acute cholecystitis and hepatic abscess.

Meza-Hernandez, Javier A / Zubillaga-Mares, Asya / Serrano-Sanchez, Minnet / Alvarez-Bautista, Francisco E / Trejo-Avila, Mario / Nuñez-Venzor, Alejandra

Journal of surgical case reports

2024 Volume 2024, Issue 3, Page(s) rjad637

Abstract: Anatomical variations of the biliary tree pose diagnostic and treatment challenges. While most are harmless and often discovered incidentally during procedures, some can lead to clinical issues and biliary complications, making knowledge of these ... ...

Abstract	Anatomical variations of the biliary tree pose diagnostic and treatment challenges. While most are harmless and often discovered incidentally during procedures, some can lead to clinical issues and biliary complications, making knowledge of these variants crucial to prevent surgical mishaps. Here, we present an unusual and clinically significant case. A 61-year-old man is admitted to the hospital with epigastric pain and diagnosis of pancreatitis of biliary origin and intermediate risk of choledocholithiasis. Magnetic resonance cholangiopancreatography (MRCP) reported hepatolithiasis and choledocholithiasis, whereas endoscopic retrograde cholangiopancreatography showed cystic drain of the right hepatic duct. One month later the patient presented again to the emergency room with increasing abdominal pain and a computed tomography that demonstrated the presence of hepatic abscess and acute cholecystitis. The patient underwent percutaneous drain abscess and a subtotal laparoscopic cholecystectomy. Biliary anatomical variants present challenges on the diagnostic investigations, interventional and surgical procedures, understanding the possible complications is essential.
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Case Reports
ZDB-ID	2580919-2
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjad637
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Article ; Online: Postoperative complications and predictors of mortality in patients with COVID-19.

Bozada-Gutiérrez, Katya / Trejo-Ávila, Mario / Moreno-Portillo, Mucio

Cirugia y cirujanos

2022 Volume 91, Issue 3, Page(s) 344–353

Abstract: Background: There are limited data about the perioperative outcomes of coronavirus disease 2019 (COVID-19) patients that needed emergency general surgery. The aim of the present study was to describe the perioperative outcomes and mortality of patients ... ...

Title translation	Complicaciones posoperatorias y predictores de mortalidad en pacientes con COVID-19.
Abstract	Background: There are limited data about the perioperative outcomes of coronavirus disease 2019 (COVID-19) patients that needed emergency general surgery. The aim of the present study was to describe the perioperative outcomes and mortality of patients with COVID-19 who underwent emergency surgery. Materials and methods: Retrospective study of COVID-19 patients symptomatic versus asymptomatic from March 2020 to February 2022 that needed an emergency surgery in a national referral hospital. Results: Forty-four patients were included in this study. Patients with symptomatic COVID-19 have higher ICU admissions and prolonged length of stay (LOS) as compared with asymptomatic COVID-19 patients. The 90-day survival probability of the entire cohort was 70.1% (60.3-79.9) and was significantly lower in patients with COVID-19 symptomatic 63.4% (50.5-76.2). The cut-off preoperative values for the prediction of mortality: Ferritin ≥ 438.5 ng/mL (Area under the curve [AUC] = 0.908), C-reactive protein (CRP) ≥ 12.5 mg/dL (AUC = 0.715), leukocyte ≥ 13.8 × 10 Conclusion: Patients with symptomatic COVID-19 who needed emergency surgery have higher ICU admissions, prolonged LOS, and decreased 90-day survival as compared with asymptomatic COVID-19 patients. Preoperative ferritin, CRP, leukocytes, and albumin could be used as predictors of mortality.
MeSH term(s)	Humans ; COVID-19/complications ; Retrospective Studies ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; C-Reactive Protein/analysis
Chemical Substances	C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2022-04-27
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	730699-4
ISSN	2444-054X ; 0009-7411
ISSN (online)	2444-054X
ISSN	0009-7411
DOI	10.24875/CIRU.22000512
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Article ; Online: Open versus laparoscopic surgery for the treatment of diverticular colovesical fistulas: A systematic review and meta-analysis.

Trejo-Avila, Mario / Vergara-Fernández, Omar

ANZ journal of surgery

2021 Volume 91, Issue 9, Page(s) E570–E577

Abstract: Background: The aim of this study was to analyze the evidence regarding open versus laparoscopic surgery for the treatment of diverticular colovesical fistula (CVF) in terms of perioperative outcomes.: Methods: A systematic review was performed using ...

Abstract	Background: The aim of this study was to analyze the evidence regarding open versus laparoscopic surgery for the treatment of diverticular colovesical fistula (CVF) in terms of perioperative outcomes. Methods: A systematic review was performed using PubMed, Cochrane, Google Scholar, and Web of Science databases for studies comparing laparoscopic versus open surgery for CVF. We pooled odds ratios (OR) and mean differences (MD) using random or fixed effects models. Results: Five non-randomized studies with 227 patients met the inclusion criteria. All were retrospective studies, published between 2014 and 2020. For laparoscopic surgery, the pooled rate for conversion to laparotomy was 36%. Laparoscopic and open procedures required similar operative time (MD: -11.62; 95% confidence interval [CI]: -51.41 to 28.16). No difference was found in terms of stoma rates between laparoscopic and open surgery (OR: 1.12; 95% CI 0.44-2.86). Overall, the rate of total postoperative complications was lower in the laparoscopic group (OR: 0.55; 95% CI: 0.30-0.99). The pooled analysis showed equivalent rates of anastomotic leaks (OR: 0.61; 95% CI 0.15-2.45), surgical site infections (OR: 0.44; 95% CI 0.19-1.01), and mortality (OR: 0.18; 95% CI 0.03-1.15). The length of stay was significantly reduced with laparoscopic surgery (MD: -2.89; 95% CI -4.20 to -1.58). Conclusion: Among patients with CVF, the laparoscopic approach appears to have shorter hospital length of stay, with no differences in anastomotic leaks, surgical site infections, stoma rates, and mortality, when compared with open surgery.
MeSH term(s)	Colectomy ; Humans ; Intestinal Fistula/etiology ; Intestinal Fistula/surgery ; Laparoscopy ; Length of Stay ; Operative Time ; Postoperative Complications/epidemiology ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-05-31
Publishing country	Australia
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	2050749-5
ISSN	1445-2197 ; 1445-1433 ; 0004-8682
ISSN (online)	1445-2197
ISSN	1445-1433 ; 0004-8682
DOI	10.1111/ans.16985
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Article ; Online: Assessing demographic and socioeconomic factors in patients with advanced colorectal cancer.

Trejo-Avila, Mario / Solórzano-Vicuña, Danilo / Vergara-Fernández, Omar

Cirugia y cirujanos

2021 Volume 91, Issue 3, Page(s) 312–318

Abstract: Background: The aim of the study was to determine the socioeconomic and demographic factors associated with advanced colorectal cancer (CRC) presentation at our institution.: Methods: From January 2009 to January 2018, patients that underwent CRC ... ...

Title translation	Evaluación de factores demográficos y socioeconómicos en pacientes con cáncer colorrectal avanzado.
Abstract	Background: The aim of the study was to determine the socioeconomic and demographic factors associated with advanced colorectal cancer (CRC) presentation at our institution. Methods: From January 2009 to January 2018, patients that underwent CRC surgery at our institution were included and retrospectively analyzed. Univariate and multivariate logistic regression were used to determine independent risk factors for presenting with advanced CRC. Results: A total of 277 patients were included, 53.5% presented with advanced CRC. The multivariate analysis identified that living in a rural area (odds ratio [OR] = 5.25; 95% confidence interval [95% CI]: 2.27-12-10; p < 0.001), weight loss (OR = 2.33; 95% CI: 1.35-4.09; p = 0.002), needing emergency surgery (OR = 4.68; 95% CI: 1.25-17.49; p = 0.022), location in the rectum in comparison with colon (OR = 2.66; 95% CI: 1.44-4.91; p = 0.002), and location in the mid rectum (OR = 6.10; 95% CI: 2.31-16.12; p < 0.001) were associated with higher odds of advanced CRC stage at presentation. Conclusions: Patients with lower socioeconomic status, with symptoms, and needing emergency surgery were associated with advanced CRC stage at presentation. Special interventions to improve access to care in this population should be planned to enhance CRC outcomes.
MeSH term(s)	Humans ; Retrospective Studies ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/surgery ; Socioeconomic Factors ; Rectum ; Demography
Language	English
Publishing date	2021-04-06
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	730699-4
ISSN	2444-054X ; 0009-7411
ISSN (online)	2444-054X
ISSN	0009-7411
DOI	10.24875/CIRU.22000068
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Article: Sarcopenia in patients with colorectal cancer: A comprehensive review.

Vergara-Fernandez, Omar / Trejo-Avila, Mario / Salgado-Nesme, Noel

World journal of clinical cases

2020 Volume 8, Issue 7, Page(s) 1188–1202

Abstract: Colorectal cancer (CRC) is the third most commonly diagnosed cancer globally and the second cancer in terms of mortality. The prevalence of sarcopenia in patients with CRC ranges between 12%-60%. Sarcopenia comes from the Greek "sarx" for flesh, and " ... ...

Abstract	Colorectal cancer (CRC) is the third most commonly diagnosed cancer globally and the second cancer in terms of mortality. The prevalence of sarcopenia in patients with CRC ranges between 12%-60%. Sarcopenia comes from the Greek "sarx" for flesh, and "penia" for loss. Sarcopenia is considered a phenomenon of the aging process and precedes the onset of frailty (primary sarcopenia), but sarcopenia may also result from pathogenic mechanisms and that disorder is termed secondary sarcopenia. Sarcopenia diagnosis is confirmed by the presence of low muscle quantity or quality. Three parameters need to be measured: muscle strength, muscle quantity and physical performance. The standard method to evaluate muscle mass is by analyzing the tomographic total cross-sectional area of all muscle groups at the level of lumbar 3rd vertebra. Sarcopenia may negatively impact on the postoperative outcomes of patients with colorectal cancer undergoing surgical resection. It has been described an association between sarcopenia and numerous poor short-term CRC outcomes like increased perioperative mortality, postoperative sepsis, prolonged length of stay, increased cost of care and physical disability. Sarcopenia may also negatively impact on overall survival, disease-free survival, recurrence-free survival, and cancer-specific survival in patients with non-metastatic and metastatic colorectal cancer. Furthermore, patients with sarcopenia seem prone to toxic effects during chemotherapy, requiring dose deescalations or treatment delays, which seems to reduce treatment efficacy. A multimodal approach including nutritional support (dietary intake, high energy, high protein, and omega-3 fatty acids), exercise programs and anabolic-orexigenic agents (ghrelin, anamorelin), could contribute to muscle mass preservation. Addition of sarcopenia screening to the established clinical-pathological scores for patients undergoing oncological treatment (chemotherapy, radiotherapy or surgery) seems to be the next step for the best of care of CRC patients.
Language	English
Publishing date	2020-03-30
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v8.i7.1188
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Article ; Online: Prognostic and predictive value of neutrophil-to-lymphocyte ratio after curative rectal cancer resection: A systematic review and meta-analysis.

Hamid, Hytham K S / Davis, George N / Trejo-Avila, Mario / Igwe, Patrick O / Garcia-Marín, Andrés

Surgical oncology

2021 Volume 37, Page(s) 101556

Abstract: Background: Neutrophil-to-lymphocyte ratio (NLR) has been shown to be associated with poor prognosis in numerous solid malignancies. Here, we quantify the prognostic value of NLR in rectal cancer patients undergoing curative-intent surgery, and compare ... ...

Abstract	Background: Neutrophil-to-lymphocyte ratio (NLR) has been shown to be associated with poor prognosis in numerous solid malignancies. Here, we quantify the prognostic value of NLR in rectal cancer patients undergoing curative-intent surgery, and compare it with platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR). Methods: A comprehensive search of several electronic databases was performed through January 2021, to identify studies evaluating the prognostic impact of pretreatment NLR in patients undergoing curative rectal cancer resection. The endpoints were overall survival (OS), disease-free survival (DFS), and clinicopathologic parameters. The pooled hazard ratio (HR) or odds ratio with 95% confidence interval (CI) were calculated. Results: Thirty-one studies comprising 7553 patients were assessed. All studies evaluated NLR; thirteen and six evaluated PLR and LMR, respectively. High NLR was associated with worse OS (HR 1.92, 95% CI 1.60-2.30, P < 0.001) and DFS (HR 1.83, 95% CI 1.51-2.22, P < 0.001), and the results were consistent in all subgroup analyses by treatment modality, tumor stage, study location, and NLR cut-off value, except for the subgroups limited to cohorts with cut-off value ≥ 4. The size of effect of NLR on OS and DFS was greater than that of PLR, and similar to that of LMR. Finally, high NLR was associated with lower rate of pathologic complete response. Conclusions: In the setting of curative rectal cancer resection, pretreatment NLR correlates with tumor response to neoadjuvant therapy, and along with LMR, is a robust predictor of poorer prognosis. These biomarkers may thus help risk-stratify patients for individualized treatments and enhanced surveillance.
MeSH term(s)	Humans ; Lymphocyte Count ; Neutrophils ; Platelet Count ; Predictive Value of Tests ; Proctectomy ; Prognosis ; Rectal Neoplasms/blood ; Rectal Neoplasms/mortality ; Rectal Neoplasms/surgery
Language	English
Publishing date	2021-03-31
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	1107810-8
ISSN	1879-3320 ; 0960-7404
ISSN (online)	1879-3320
ISSN	0960-7404
DOI	10.1016/j.suronc.2021.101556
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Article ; Online: Multivariate analysis of risk factors for complications after loop ileostomy closure.

Vergara-Fernández, Omar / Trejo-Avila, Mario / Salgado-Nesme, Noel

Cirugia y cirujanos

2019 Volume 87, Issue 3, Page(s) 337–346

Abstract: Background: Despite the advantages of diverting loop ileostomy construction, it is related to complications.: Objective: The aim of the study was to determine the risk factors for complications after loop ileostomy closure.: Methods: Patients who ... ...

Title translation	Análisis multivariable de los factores de riesgo asociados a complicaciones posterior al cierre de ileostomía en asa.
Abstract	Background: Despite the advantages of diverting loop ileostomy construction, it is related to complications. Objective: The aim of the study was to determine the risk factors for complications after loop ileostomy closure. Methods: Patients who underwent loop ileostomy closure from January 2010 to March 2018 were retrospectively analyzed. Multivariate logistic regression was used to determine the effect of the potential risk factors on the rate of each complication. Results: A total of 136 patients underwent reversal. Indications for the initial operation were colorectal cancer (39.7%), diverticulitis (25.7%), idiopathic chronic ulcerative colitis (ICUC) (8.1%), familial adenomatous polyposis (FAP) (7.4%), and others (19.1%). Multivariate analysis identified the following risk factors: type of incision (midline laparotomy) (odds ratio [OR] = 6.5) for wound infection; treatment with immunomodulator (OR = 12.5) for anastomotic leak; history of FAP (OR = 9.8) for intestinal obstruction; previous use of immunomodulator (OR = 10.0) and performing reversal through midline incision (OR = 18.9) for reoperation; and ≥ 65 years old (OR = 3.5) for medical complications. The rate of incisional hernia was 11%, and the risk factors were time to closure < 3 months (OR = 6.4) and parastomal hernia (OR = 13.2). Conclusions: Several patient-related and surgical technique factors should be considered at the time of loop ileostomy closure to reduce post-operative morbidity.
MeSH term(s)	Aged ; Female ; Humans ; Ileostomy/adverse effects ; Male ; Middle Aged ; Multivariate Analysis ; Postoperative Care ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2019-04-25
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	730699-4
ISSN	2444-054X ; 0009-7411
ISSN (online)	2444-054X
ISSN	0009-7411
DOI	10.24875/CIRU.18000611
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Article ; Online: Long-term outcomes of radiofrequency treatment for fecal incontinence: are the results maintainable?

Vergara-Fernandez, Omar / Arciniega-Hernández, Jose Armando / Trejo-Avila, Mario

International journal of colorectal disease

2019 Volume 35, Issue 1, Page(s) 173–176

Abstract: Purpose: Temperature-controlled radiofrequency (RF) energy delivery to the sphincter complex has been proposed as an option for those patients not susceptible to a major surgical procedure for fecal incontinence (FI). The aim of the study was to ... ...

Abstract	Purpose: Temperature-controlled radiofrequency (RF) energy delivery to the sphincter complex has been proposed as an option for those patients not susceptible to a major surgical procedure for fecal incontinence (FI). The aim of the study was to evaluate the long-term (15 years) functional outcomes obtained after RF procedure for FI. Methods: This was a retrospective analysis of our prospectively collected database of patients that underwent RF procedure for FI. Primary outcomes measured were the Cleveland Clinic Florida Fecal Incontinence scale (CCF-FI), Fecal Incontinence-related Quality of Life Score (FIQLS), the 36-Item Short Form survey (SF-36), endoanal ultrasound, and anorectal manometry. Evaluations were compared at baseline and at 15 years of follow-up. Results: Ten patients were followed up 15 years after RF procedure. There was no significant improvement in the CCF-FI score (13.8 vs. 12.4, p = 0.24). No significant changes in the FIQLS were observed including lifestyle (2.39 vs. 2.13, p = 0.23), coping (1.91 vs. 1.92, p = 0.96), and embarrassment (1.66 vs. 1.86; p = 0.43). However, significant worsening was found in the depression category (2.47 vs. 1.60, p = 0.001). The SF-36 showed significant worsening in the mental (36.7 vs. 25.8, p < 0.001), physical (53.1 vs. 41.4, p = 0.01), and social functions (50.9 vs. 31.25, p = 0.001). Anorectal manometry and endoanal ultrasound showed no significant changes. No complications were found in the long-term follow-up. Conclusions: Radiofrequency procedure for fecal incontinence did not maintain its efficacy during long-term follow-up.
MeSH term(s)	Aged ; Fecal Incontinence/physiopathology ; Fecal Incontinence/therapy ; Female ; Humans ; Male ; Manometry ; Middle Aged ; Quality of Life ; Radiofrequency Therapy ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2019-12-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	84975-3
ISSN	1432-1262 ; 0179-1958
ISSN (online)	1432-1262
ISSN	0179-1958
DOI	10.1007/s00384-019-03458-0
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