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  1. Article ; Online: Z-drugs and falls in nursing home patients: data from the INCUR study.

    Damanti, Sarah / Tresoldi, Moreno / de Souto Barreto, Philipe / Rolland, Yves / Cesari, Matteo

    Aging clinical and experimental research

    2022  Volume 34, Issue 12, Page(s) 3145–3149

    Abstract: Background: Z-drugs are the most prescribed treatment for insomnia, but their negative effect on the body sway can increase the risk of falls.: Aims: Evaluating the association between Z-drugs and falls in a resident cohort.: Methods: Prospective ... ...

    Abstract Background: Z-drugs are the most prescribed treatment for insomnia, but their negative effect on the body sway can increase the risk of falls.
    Aims: Evaluating the association between Z-drugs and falls in a resident cohort.
    Methods: Prospective observational study using the data collected in the Incidence of pNeumonia and related ConseqUences in nursing home Residents (INCUR) study.
    Results: During the one-year follow-up, among the 800 participants (median age 87), 93 individuals fell (64 fracturing and 29 without fracturing). Lower calf circumference (adjusted OR 0.92, 95% CI 0.86-0.97, p = 0.006) and the use of selective serotonin reuptake inhibitors (adjusted OR 1.86, 95% CI 1.1-3.05, p = 0.01) predicted falls, whereas the use of Z-drugs (adjusted OR 2.37, 95% CI 1.13-4.94, p = 0.02) and lower body mass index (adjusted OR 0.9, 95% CI 0.84-0.97, p = 0.005) were associated with falls without fractures.
    Conclusions: Z-drugs predicted falls without fractures in residents. Alternative strategies to promote sleep in residents should be pursued.
    MeSH term(s) Humans ; Aged, 80 and over ; Accidental Falls ; Nursing Homes ; Fractures, Bone/epidemiology ; Incidence ; Sleep Initiation and Maintenance Disorders ; Risk Factors
    Language English
    Publishing date 2022-09-20
    Publishing country Germany
    Document type Observational Study ; Journal Article
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-022-02237-2
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    Zs.A 3343: Show issues Location:
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  2. Article ; Online: Edoxaban and/or colchicine in outpatients with COVID-19: rationale and design of the CONVINCE trial.

    Landi, Antonio / Morici, Nuccia / Vranckx, Pascal / Frigoli, Enrico / Bonacchini, Luca / Omazzi, Barbara / Tresoldi, Moreno / Camponovo, Claudio / Moccetti, Tiziano / Valgimigli, Marco

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2023  Volume 24, Issue 12, Page(s) 920–930

    Abstract: Background: An excessive inflammatory response and a hypercoagulable state are not infrequent in patients with coronavirus disease-2019 (COVID-19) and are associated with adverse clinical outcomes. However, the optimal treatment strategy for COVID-19 ... ...

    Abstract Background: An excessive inflammatory response and a hypercoagulable state are not infrequent in patients with coronavirus disease-2019 (COVID-19) and are associated with adverse clinical outcomes. However, the optimal treatment strategy for COVID-19 patients managed in the out-of-hospital setting is still uncertain.
    Design: The CONVINCE (NCT04516941) is an investigator-initiated, open-label, blinded-endpoint, 2 × 2 factorial design randomized trial aimed at assessing two independently tested hypotheses (anticoagulation and anti-inflammatory ones) in COVID-19 patients. Adult symptomatic patients (≥18 years of age) within 7 days from reverse transcription-PCR (RT-PCR) diagnosis of SARS-CoV-2 infection managed at home or in nursery settings were considered for eligibility. Eligible patients fulfilling all inclusion and no exclusion criteria were randomized to edoxaban versus no treatment (anticoagulation hypothesis) and colchicine versus no treatment (anti-inflammatory hypothesis) in a 1 : 1:1 : 1 ratio. The study had two co-primary endpoints (one for each randomization), including the composite of major vascular thrombotic events at 25 ± 3 days for the anticoagulation hypothesis and the composite of SARS-CoV-2 detection rates at 14 ± 3 days by RT-PCR or freedom from death or hospitalizations (anti-inflammatory hypothesis). Study endpoints will be adjudicated by a blinded Clinical Events Committee. With a final sample size of 420 patients, this study projects an 80% power for each of the two primary endpoints appraised separately.
    Conclusion: The CONVINCE trial aims at determining whether targeting anticoagulation and/or anti-inflammatory pathways may confer benefit in COVID-19 patients managed in the out-of-hospital setting.
    Trial registration: ClinicalTrials.gov number, NCT04516941.
    MeSH term(s) Adult ; Humans ; Infant, Newborn ; COVID-19 ; SARS-CoV-2 ; Outpatients ; Colchicine/adverse effects ; Anticoagulants/adverse effects ; Anti-Inflammatory Agents/adverse effects ; Treatment Outcome
    Chemical Substances edoxaban (NDU3J18APO) ; Colchicine (SML2Y3J35T) ; Anticoagulants ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0000000000001556
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  3. Article ; Online: Platelet prothrombotic activity in COVID-19 survivors with persisting respiratory symptoms after 2 years from hospital discharge.

    Consolo, Filippo / Marmiere, Marilena / Ramirez, Giuseppe A / Marinosci, Alessandro / Tresoldi, Moreno / Landoni, Giovanni / Zangrillo, Alberto

    Minerva medica

    2023  

    Language English
    Publishing date 2023-05-19
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123586-2
    ISSN 1827-1669 ; 0026-4806
    ISSN (online) 1827-1669
    ISSN 0026-4806
    DOI 10.23736/S0026-4806.23.08661-5
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  4. Article ; Online: Muscle quality assessment in COVID-19 survivors: agreement between echointensity and stiffness.

    Damanti, Sarah / Cilla, Marta / Tuscano, Bruno / Pomaranzi, Chiara / Tiraferri, Valeria / Papaioannu, Rebecka / Ponta, Giacomo / DE Lorenzo, Rebecca / Chiabrando, Filippo / Vitali, Giordano / Tresoldi, Moreno / Rovere Querini, Patrizia

    Panminerva medica

    2024  

    Language English
    Publishing date 2024-04-05
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123572-2
    ISSN 1827-1898 ; 0031-0808
    ISSN (online) 1827-1898
    ISSN 0031-0808
    DOI 10.23736/S0031-0808.24.05122-X
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  5. Article ; Online: Colchicine treatment in community healthcare setting to prevent severe COVID-19.

    Della-Torre, Emanuel / Ramirez, Giuseppe A / Dagna, Lorenzo / Tresoldi, Moreno

    Annals of the rheumatic diseases

    2020  Volume 81, Issue 10, Page(s) e198

    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal ; COVID-19 ; Colchicine/therapeutic use ; Community Health Services ; Humans
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Colchicine (SML2Y3J35T)
    Keywords covid19
    Language English
    Publishing date 2020-08-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2020-218759
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  6. Article ; Online: Serum IgG4 level predicts COVID-19 related mortality.

    Della-Torre, Emanuel / Lanzillotta, Marco / Strollo, Marta / Ramirez, Giuseppe Alvise / Dagna, Lorenzo / Tresoldi, Moreno

    European journal of internal medicine

    2021  Volume 93, Page(s) 107–109

    MeSH term(s) COVID-19 ; Humans ; Immunoglobulin G ; SARS-CoV-2
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2021-09-24
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2021.09.012
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  7. Article ; Online: Serum IgG4 elevation in hyper-inflamed COVID-19 patients. Author's reply.

    Della-Torre, Emanuel / Lanzillotta, Marco / Ramirez, Giuseppe Alvise / Dagna, Lorenzo / Tresoldi, Moreno

    European journal of internal medicine

    2021  Volume 95, Page(s) 98–99

    MeSH term(s) COVID-19 ; Humans ; Immunoglobulin G ; SARS-CoV-2
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2021-10-22
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2021.10.025
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  8. Article ; Online: Hypereosinophilia management in patients with type 2 chronic rhinosinusitis treated with dupilumab: preliminary results.

    Vinciguerra, Alessandro / Rampi, Andrea / Yacoub, Mona-Rita / Tresoldi, Moreno / Tanzini, Umberto / Bussi, Mario / Trimarchi, Matteo

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2022  Volume 279, Issue 11, Page(s) 5231–5238

    Abstract: Purpose: Biological therapies are gaining relevance in the management of CRSwNP with few adverse events reported. Among these, dupilumab, an anti-IL4-Ra monoclonal antibody, is frequently associated with hypereosinophilia (HE) which usually remains ... ...

    Abstract Purpose: Biological therapies are gaining relevance in the management of CRSwNP with few adverse events reported. Among these, dupilumab, an anti-IL4-Ra monoclonal antibody, is frequently associated with hypereosinophilia (HE) which usually remains silent and progressively resolves, although some cases of systemic involvement occurs. The aim of this paper is to describe our experience and propose a management flowchart for HE during therapy with dupilumab.
    Methods: Patients with CRSwNP who satisfied EPOS2020 criteria for biological therapies were included in this prospective study. Each case was discussed in a multidisciplinary meeting with subsequent prescription of dupilumab; all patients were candidates to follow-up bi-monthly for 6 months, while additional blood tests were scheduled in the event of HE.
    Results: A total of 21 patients with a mean age of 48.4 years were enrolled. Of these, 15 of 21 presented an asthma comorbidity and 9 of 21 ASA sensitivity. Four patients (19%) developed HE with AEC > 1.5 × 10
    Conclusions: During dupilumab therapy, HE may occur and should be considered benign when < 3 × 10
    MeSH term(s) Adrenal Cortex Hormones ; Antibodies, Monoclonal, Humanized/therapeutic use ; Chronic Disease ; Eosinophilia/complications ; Humans ; Middle Aged ; Nasal Polyps/complications ; Prospective Studies ; Rhinitis/complications ; Sinusitis/complications
    Chemical Substances Adrenal Cortex Hormones ; Antibodies, Monoclonal, Humanized ; dupilumab (420K487FSG)
    Language English
    Publishing date 2022-04-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-022-07389-5
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  9. Article: Sustainability in Internal Medicine: A Year-Long Ward-Wide Observational Study.

    Ramirez, Giuseppe A / Damanti, Sarah / Caruso, Pier Francesco / Mette, Francesca / Pagliula, Gaia / Cariddi, Adriana / Sartorelli, Silvia / Falbo, Elisabetta / Scotti, Raffaella / Di Terlizzi, Gaetano / Dagna, Lorenzo / Praderio, Luisa / Sabbadini, Maria Grazia / Bozzolo, Enrica P / Tresoldi, Moreno

    Journal of personalized medicine

    2024  Volume 14, Issue 1

    Abstract: Population aging and multimorbidity challenge health system sustainability, but the role of assistance-related variables rather than individual pathophysiological factors in determining patient outcomes is unclear. To identify assistance-related ... ...

    Abstract Population aging and multimorbidity challenge health system sustainability, but the role of assistance-related variables rather than individual pathophysiological factors in determining patient outcomes is unclear. To identify assistance-related determinants of sustainable hospital healthcare, all patients hospitalised in an Internal Medicine Unit (n = 1073) were enrolled in a prospective year-long observational study and split 2:1 into a training (n = 726) and a validation subset (n = 347). Demographics, comorbidities, provenance setting, estimates of complexity (cumulative illness rating scale, CIRS: total, comorbidity, CIRS-CI, and severity, CIRS-SI subscores) and intensity of care (nine equivalents of manpower score, NEMS) were analysed at individual and Unit levels along with variations in healthcare personnel as determinants of in-hospital mortality, length of stay and nosocomial infections. Advanced age, higher CIRS-SI, end-stage cancer, and the absence of immune-mediated diseases were correlated with higher mortality. Admission from nursing homes or intensive care units, dependency on activity of daily living, community- or hospital-acquired infections, oxygen support and the number of exits from the Unit along with patient/physician ratios were associated with prolonged hospitalisations. Upper gastrointestinal tract disorders, advanced age and higher CIRS-SI were associated with nosocomial infections. In addition to demographic variables and multimorbidity, physician number and assistance context affect hospitalisation outcomes and healthcare sustainability.
    Language English
    Publishing date 2024-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14010115
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  10. Article ; Online: Respiratory Parameters in Patients With COVID-19 After Using Noninvasive Ventilation in the Prone Position Outside the Intensive Care Unit.

    Sartini, Chiara / Tresoldi, Moreno / Scarpellini, Paolo / Tettamanti, Andrea / Carcò, Francesco / Landoni, Giovanni / Zangrillo, Alberto

    JAMA

    2020  Volume 323, Issue 22, Page(s) 2338–2340

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/physiopathology ; Coronavirus Infections/therapy ; Female ; Humans ; Italy ; Male ; Noninvasive Ventilation ; Oxygen/blood ; Pandemics ; Patients' Rooms ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/therapy ; Prone Position ; Respiratory Rate ; SARS-CoV-2
    Chemical Substances Oxygen (S88TT14065)
    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.7861
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