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  1. Article ; Online: Rural housing as field of modernist experiences

    Cardoso Alexandra / Trevisan Alexandra / Figueiredo Rute / Maia Maria Helena

    SHS Web of Conferences, Vol 63, p

    2019  Volume 01001

    Abstract: The Portuguese proposal to CIAM X (Dubrovnik 1956) wasfocused on the issue of rural planning. A new village was established among a set of existing ones, working as a structural core. The vernacular influence was clearly present through the images of ... ...

    Abstract The Portuguese proposal to CIAM X (Dubrovnik 1956) wasfocused on the issue of rural planning. A new village was established among a set of existing ones, working as a structural core. The vernacular influence was clearly present through the images of Trás-os-Montes (Survey on Portuguese Regional Architecture) used as a reference source for the new house typology. In addition to the vernacular, one can also identify modern references, in both Portugaland Spain, within the scope of internal colonization in the 20th century,regarding the settlement of the Portuguese agricultural colonies (1920smid1950s) and the pueblos in Spain (1940s-1971), which had significance for the contemporary countryside image. Considering “theevolutive house” of the Portuguese proposal in CIAM X, or the modularsolutions of the colonization settlements, one can find examples lyingbetween the trendy and those in rooted architectural culture. In this paper, we analysed the rural 20th century housing idea present in theinternal Iberian colonization settlements and in the ideological and political context under the dictatorial regimes. Using a comparative method, two case studies were examined in order to identify andabstract through cross-referencing main rural directions in the differentIberian contexts, and to frame common factors or different experiences,in the application of the planning schemes in both settlement and housing attributes.
    Keywords Rural house ; Iberian internal colonization ; Modernist landscape ; Social Sciences ; H
    Subject code 720
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Synaptic plasticity in human thalamocortical assembloids.

    Patton, Mary H / Thomas, Kristen T / Bayazitov, Ildar T / Newman, Kyle D / Kurtz, Nathaniel B / Robinson, Camenzind G / Ramirez, Cody A / Trevisan, Alexandra J / Bikoff, Jay B / Peters, Samuel T / Pruett-Miller, Shondra M / Jiang, Yanbo / Schild, Andrew B / Nityanandam, Anjana / Zakharenko, Stanislav S

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Synaptic plasticities, such as long-term potentiation (LTP) and depression (LTD), tune synaptic efficacy and are essential for learning and memory. Current studies of synaptic plasticity in humans are limited by a lack of adequate human models. Here, we ... ...

    Abstract Synaptic plasticities, such as long-term potentiation (LTP) and depression (LTD), tune synaptic efficacy and are essential for learning and memory. Current studies of synaptic plasticity in humans are limited by a lack of adequate human models. Here, we modeled the thalamocortical system by fusing human induced pluripotent stem cell-derived thalamic and cortical organoids. Single-nucleus RNA-sequencing revealed that most cells in mature thalamic organoids were glutamatergic neurons. When fused to form thalamocortical assembloids, thalamic and cortical organoids formed reciprocal long-range axonal projections and reciprocal synapses detectable by light and electron microscopy, respectively. Using whole-cell patch-clamp electrophysiology and two-photon imaging, we characterized glutamatergic synaptic transmission. Thalamocortical and corticothalamic synapses displayed short-term plasticity analogous to that in animal models. LTP and LTD were reliably induced at both synapses; however, their mechanisms differed from those previously described in rodents. Thus, thalamocortical assembloids provide a model system for exploring synaptic plasticity in human circuits.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.01.578421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Jedi-1 deficiency increases sensory neuron excitability through a non-cell autonomous mechanism.

    Trevisan, Alexandra J / Bauer, Mary Beth / Brindley, Rebecca L / Currie, Kevin P M / Carter, Bruce D

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 1300

    Abstract: The dorsal root ganglia (DRG) house the primary afferent neurons responsible for somatosensation, including pain. We previously identified Jedi-1 (PEAR1/MEGF12) as a phagocytic receptor expressed by satellite glia in the DRG involved in clearing ... ...

    Abstract The dorsal root ganglia (DRG) house the primary afferent neurons responsible for somatosensation, including pain. We previously identified Jedi-1 (PEAR1/MEGF12) as a phagocytic receptor expressed by satellite glia in the DRG involved in clearing apoptotic neurons during development. Here, we further investigated the function of this receptor in vivo using Jedi-1 null mice. In addition to satellite glia, we found Jedi-1 expression in perineurial glia and endothelial cells, but not in sensory neurons. We did not detect any morphological or functional changes in the glial cells or vasculature of Jedi-1 knockout mice. Surprisingly, we did observe changes in DRG neuron activity. In neurons from Jedi-1 knockout (KO) mice, there was an increase in the fraction of capsaicin-sensitive cells relative to wild type (WT) controls. Patch-clamp electrophysiology revealed an increase in excitability, with a shift from phasic to tonic action potential firing patterns in KO neurons. We also found alterations in the properties of voltage-gated sodium channel currents in Jedi-1 null neurons. These results provide new insight into the expression pattern of Jedi-1 in the peripheral nervous system and indicate that loss of Jedi-1 alters DRG neuron activity indirectly through an intercellular interaction between non-neuronal cells and sensory neurons.
    MeSH term(s) Action Potentials ; Animals ; Biomarkers ; Cell Line ; Ganglia, Spinal/cytology ; Ganglia, Spinal/metabolism ; Humans ; Immunohistochemistry ; Mice ; Mice, Knockout ; Mice, Transgenic ; Neuroglia/metabolism ; Neuroglia/ultrastructure ; Patch-Clamp Techniques ; Receptors, Cell Surface/deficiency ; Sensory Receptor Cells/metabolism ; Sensory Receptor Cells/ultrastructure
    Chemical Substances Biomarkers ; PEAR1 protein, mouse ; Receptors, Cell Surface
    Language English
    Publishing date 2020-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-57971-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Jedi-1/MEGF12-mediated phagocytosis controls the pro-neurogenic properties of microglia in the ventricular-subventricular zone.

    Morrison, Vivianne / Houpert, Matthew / Trapani, Jonathan / Brockman, Asa / Kingsley, Philip / Katdare, Ketaki / Layden, Hillary / Nguena-Jones, Gabriela / Trevisan, Alexandra / Maguire-Zeiss, Kathleen / Marnett, Lawrence / Bix, Gregory / Ihrie, Rebecca / Carter, Bruce

    Cell reports

    2023  Volume 42, Issue 11, Page(s) 113423

    Abstract: Microglia are the primary phagocytes in the central nervous system and clear dead cells generated during development or disease. The phagocytic process shapes the microglia phenotype, which affects the local environment. A unique population of microglia ... ...

    Abstract Microglia are the primary phagocytes in the central nervous system and clear dead cells generated during development or disease. The phagocytic process shapes the microglia phenotype, which affects the local environment. A unique population of microglia resides in the ventricular-subventricular zone (V-SVZ) of neonatal mice, but how they influence the neurogenic niche is not well understood. Here, we demonstrate that phagocytosis contributes to a pro-neurogenic microglial phenotype in the V-SVZ and that these microglia phagocytose apoptotic cells via the engulfment receptor Jedi-1. Deletion of Jedi-1 decreases apoptotic cell clearance, triggering a neuroinflammatory microglia phenotype that resembles dysfunctional microglia in neurodegeneration and aging and that reduces neural precursor proliferation via elevated interleukin-1β signaling; interleukin-1 receptor inhibition rescues precursor proliferation in vivo. Together, these results reveal a critical role for Jedi-1 in connecting microglial phagocytic activity to the maintenance of a pro-neurogenic phenotype in the developing V-SVZ.
    MeSH term(s) Animals ; Mice ; Lateral Ventricles ; Microglia/physiology ; Phagocytes ; Phagocytosis/physiology ; Signal Transduction
    Chemical Substances PEAR1 protein, mouse
    Language English
    Publishing date 2023-11-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.113423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Jedi-1/MEGF12-mediated phagocytosis controls the pro-neurogenic properties of microglia in the ventricular-subventricular zone.

    Morrison, Vivianne E / Houpert, Matthew G / Trapani, Jonathan B / Brockman, Asa A / Kingsley, Philip J / Katdare, Ketaki A / Layden, Hillary M / Nguena-Jones, Gabriela / Trevisan, Alexandra J / Maguire-Zeiss, Kathleen A / Marnett, Lawrence J / Bix, Gregory J / Ihrie, Rebecca A / Carter, Bruce D

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Microglia are the primary phagocytes in the central nervous system and are responsible for clearing dead cells generated during development or disease. The phagocytic process shapes the phenotype of the microglia, which affects the local environment. A ... ...

    Abstract Microglia are the primary phagocytes in the central nervous system and are responsible for clearing dead cells generated during development or disease. The phagocytic process shapes the phenotype of the microglia, which affects the local environment. A unique population of microglia reside in the ventricular-subventricular zone (V-SVZ) of neonatal mice, but how they influence this neurogenic niche is not well-understood. Here, we demonstrate that phagocytosis creates a pro-neurogenic microglial phenotype in the V-SVZ and that these microglia phagocytose apoptotic cells via the engulfment receptor Jedi-1. Deletion of
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.03.531012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Peripheral myelin protein 22 modulates store-operated calcium channel activity, providing insights into Charcot-Marie-Tooth disease etiology.

    Vanoye, Carlos G / Sakakura, Masayoshi / Follis, Rose M / Trevisan, Alexandra J / Narayan, Malathi / Li, Jun / Sanders, Charles R / Carter, Bruce D

    The Journal of biological chemistry

    2019  Volume 294, Issue 32, Page(s) 12054–12065

    Abstract: Charcot-Marie-Tooth (CMT) disease is a peripheral neuropathy associated with gene duplication and point mutations in the peripheral myelin protein 22 ( ...

    Abstract Charcot-Marie-Tooth (CMT) disease is a peripheral neuropathy associated with gene duplication and point mutations in the peripheral myelin protein 22 (
    MeSH term(s) Animals ; Calcium/metabolism ; Calcium Channels/chemistry ; Calcium Channels/metabolism ; Charcot-Marie-Tooth Disease/metabolism ; Charcot-Marie-Tooth Disease/pathology ; Endoplasmic Reticulum/metabolism ; Evoked Potentials/drug effects ; Gadolinium/pharmacology ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mutagenesis, Site-Directed ; Myelin Proteins/deficiency ; Myelin Proteins/genetics ; Myelin Proteins/metabolism ; Schwann Cells/cytology ; Schwann Cells/metabolism ; Stromal Interaction Molecule 1/metabolism ; TRPC Cation Channels/metabolism
    Chemical Substances Calcium Channels ; Myelin Proteins ; Stromal Interaction Molecule 1 ; TRPC Cation Channels ; transient receptor potential cation channel, subfamily C, member 1 ; Gadolinium (AU0V1LM3JT) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2019-06-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.RA118.006248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.108: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Book: Dicionário de personalidades portuenses do século 20

    Silva, Germano / Trevisan, Alexandra

    2001  

    Author's details concepção e coord. geral Germano Silva ... Pesquisa e red. Alexandra Trevisan
    Language Portuguese
    Size [ca. 300] Bl, zahlr. Ill
    Edition 1. ed
    Publisher Porto Ed
    Publishing place Porto
    Document type Book
    ISBN 9720062819 ; 9789720062819
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article: Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate second messengers.

    Wu, Mingxuan / Dul, Barbara E / Trevisan, Alexandra J / Fiedler, Dorothea

    Chemical science

    2013  Volume 4, Issue 1, Page(s) 405–410

    Abstract: The diphosphoinositol polyphosphates (PP-IPs) are a central group of eukaryotic second messengers. They regulate numerous processes, including cellular energy homeostasis and adaptation to environmental stresses. To date, most of the molecular details in ...

    Abstract The diphosphoinositol polyphosphates (PP-IPs) are a central group of eukaryotic second messengers. They regulate numerous processes, including cellular energy homeostasis and adaptation to environmental stresses. To date, most of the molecular details in PP-IP signalling have remained elusive, due to a lack of appropriate methods and reagents. Here we describe the expedient synthesis of methylene-bisphosphonate PP-IP analogues. Their characterization revealed that the analogues exhibit significant stability and mimic their natural counterparts very well. This was further confirmed in two independent biochemical assays, in which our analogues potently inhibited phosphorylation of the protein kinase Akt and hydrolytic activity of the Ddp1 phosphohydrolase. The non-hydrolysable PP-IPs thus emerge as important tools and hold great promise for a variety of applications.
    Language English
    Publishing date 2013-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/C2SC21553E
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comportamento de formas imaturas de Aedes aegypti, no litoral do Estado de São Paulo.

    Glasser, Carmen Moreno / Arduino, Marylene de Brito / Barbosa, Gerson Laurindo / Ciaravolo, Ricardo Mario de Carvalho / Domingos, Maria de Fátima / Oliveira, Cleide Dantas / Pereira, Marisa / Silva, Marcos / Trevisan, Alexandra Myuki Yoshioka

    Revista da Sociedade Brasileira de Medicina Tropical

    2011  Volume 44, Issue 3, Page(s) 349–355

    Abstract: Introduction: In a region of high dengue incidence, on the coast of the State of São Paulo, 9 areas were selected to evaluate the behavior of immature Aedes aegypti.: Methods: The 9 areas were grouped into 4 strata according to soil use and ... ...

    Title translation Behavior of immatures Aedes aegypti in the coast State of São Paulo, Brazil.
    Abstract Introduction: In a region of high dengue incidence, on the coast of the State of São Paulo, 9 areas were selected to evaluate the behavior of immature Aedes aegypti.
    Methods: The 9 areas were grouped into 4 strata according to soil use and occupation. Larvae and pupas were collected in a sample of approximately 500 buildings in each area.
    Results: Although tires and canvas presented the highest positive rates for Aedes aegypti, drains and other containers fixed to the buildings were highly predominant among positive containers; 32 to 76% of the positive containers in the 4 study strata. Public areas of apartment buildings and large non-residential premises presented the highest positive rates for Aedes Aegypti, while apartments presented the lowest. Infestation levels were greater in residential areas with predominance of apartment buildings, where 76% of the breeding sites detected were containers fixed to the buildings.
    Conclusions: This knowledge is an important tool in the control strategy, since it reinforces the need for special attention regarding certain types of buildings and the adjustment of technical norms for pluvial water drains and improvement of building maintenance. Moreover, systematic observations are required to follow-up the occupancy dynamic of different buildings and containers by Aedes aegypti and the incorporation of this knowledge in the control of vectors in the region.
    MeSH term(s) Aedes/growth & development ; Animals ; Brazil ; Disease Reservoirs/classification ; Disease Reservoirs/statistics & numerical data ; Housing/classification ; Housing/statistics & numerical data ; Insect Vectors/growth & development ; Larva/growth & development ; Pupa/growth & development
    Language Portuguese
    Publishing date 2011-07-01
    Publishing country Brazil
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1038126-0
    ISSN 1678-9849 ; 0037-8682
    ISSN (online) 1678-9849
    ISSN 0037-8682
    DOI 10.1590/s0037-86822011005000042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2726: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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