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Article ; Online: Cardiopulmonary exercise test in dilated cardiomyopathy: If once is good, twice is better in terms of cardiovascular prognosis.

Triantafyllidi, Helen / Benas, Dimitris / Iliodromitis, Efstathios

2023 Volume 394, Page(s) 131356

MeSH term(s)	Humans ; Exercise Test ; Cardiomyopathy, Dilated/diagnosis ; Prognosis ; Heart ; Cardiovascular System
Language	English
Publishing date	2023-09-12
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2023.131356
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Article ; Online: Endothelium: The Trivial Fence Became a Powerful Gatekeeper of Vascular Health.

Triantafyllidi, Helen / Benas, Dimitris

Angiology

2021 Volume 72, Issue 7, Page(s) 601–603

MeSH term(s)	Endothelium ; Humans
Language	English
Publishing date	2021-02-04
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	80040-5
ISSN	1940-1574 ; 0003-3197
ISSN (online)	1940-1574
ISSN	0003-3197
DOI	10.1177/0003319721992238
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Article ; Online: Cardiopulmonary exercise testing: Is it time to be included in a routine checkup for a relatively healthy population?

Triantafyllidi, Helen / Benas, Dimitrios / Iliodromitis, Efstathios

International journal of cardiology

2022 Volume 373, Page(s) 81–82

MeSH term(s)	Humans ; Exercise Test ; Heart ; Exercise ; Oxygen Consumption
Language	English
Publishing date	2022-11-21
Publishing country	Netherlands
Document type	Editorial ; Comment
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2022.11.028
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Article ; Online: Evaluation of cardiovascular risk factors in children aged 6-16 years and their evolution in early adulthood in a 10-year follow-up study.

Ntretsiou, Eleni / Benas, Dimitris / Trivilou, Paraskevi / Pavlidis, George / Ikonomidis, Ignatios / Attilakos, Achilleas / Iliodromitis, Efstathios / Triantafyllidi, Helen

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

2024

Abstract: Objective: Obesity and arterial hypertension (AH) in children represent well-recognized risk factors for cardiovascular (CV) events during adult life. We investigated any changes regarding several CV risk (CVR) factors in children after a 10-year follow- ...

Abstract	Objective: Obesity and arterial hypertension (AH) in children represent well-recognized risk factors for cardiovascular (CV) events during adult life. We investigated any changes regarding several CV risk (CVR) factors in children after a 10-year follow-up period. Methods: A cohort of 143 healthy children, elementary/high school students, 6-16 years old, was initially evaluated in 2010-2011 regarding CVR factors [obesity, blood pressure (BP), aortic stiffness (PWV), lipid profile] plus food habits/sports activity. At 10-years follow-up (2020-2021), 63/143 (44%) young adults were re-evaluated. Results: Children with obesity (45%) had increased BP (p < 0.001) and a less favorable LDL-C/triglycerides profile (p = 0.001) compared to overweight/normoweight ones. In a 10-year follow-up, obesity and exercise improved (p < 0.001 and p = 0.005), systolic BP (SBP) (102 ± 13 vs. 118 ± 11 mmHg, p < 0.001) and PWV increased (6.1 ± 1 vs. 7.7 ± 1.1 m/sec, p < 0.001), LDL-C (96 ± 21 vs. 86 ± 24 mg/dl, p = 0.004) and HDL-C + (64 ± 18 vs. 55 ± 10 mg/dl, p < 0.001) decreased, triglycerides increased (62 ± 21 vs. 73 ± 34 mg/dl, p = 0.04), and food approached the western model of nutrition (less fish/fruits). In children/young adults, BMI was associated with age (Beta = 0.47, p < 0.001 and Beta = 0.36, p = 0.004), SBP (Beta = 0.46 and Beta = 0.52, p < 0.001), and LDL-C (Beta = 0.27 and Beta = 0.44, p < 0.001). Conclusions: In children with obesity, increased BMI and waist circumference were related to SBP and a less favorable lipid profile. At the 10-year re-evaluation, obesity was partially improved, physical activity was increased, and SBP had reached the high-normal levels in a substantial number of young adults, while lipid profile was less favorable (for HDL-C/triglycerides) compared to baseline evaluation. Our results highlight the evolution of CVR factors from childhood to early adulthood.
Language	English
Publishing date	2024-02-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2215027-4
ISSN	2241-5955 ; 1109-9666
ISSN (online)	2241-5955
ISSN	1109-9666
DOI	10.1016/j.hjc.2024.02.006
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Article ; Online: Chronic thromboembolic pulmonary hypertension due to an implantable cardioverter-defibrillator's lead thrombosis.

Triantafyllidi, Helen / Mpahara, Aikaterini / Mademli, Maria / Mayer, Eckhard

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

2021 Volume 62, Issue 6, Page(s) 488–489

MeSH term(s)	Chronic Disease ; Defibrillators, Implantable/adverse effects ; Humans ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/therapy ; Pulmonary Embolism/etiology ; Pulmonary Embolism/therapy ; Thrombosis/etiology
Language	English
Publishing date	2021-01-30
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2215027-4
ISSN	2241-5955 ; 1109-9666
ISSN (online)	2241-5955
ISSN	1109-9666
DOI	10.1016/j.hjc.2021.01.008
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Article ; Online: Hypertension-Mediated Organ Damage In Young Patients With First-Diagnosed And Never Treated Systolic Hypertension.

Benas, Dimitris / Triantafyllidi, Helen / Birmpa, Dionyssia / Fambri, Anastasia / Schoinas, Antonios / Thymis, Ioannis / Kostelli, Gavriela / Ikonomidis, Ignatios

Current vascular pharmacology

2023 Volume 21, Issue 3, Page(s) 197–204

Abstract: Objective: Early onset of untreated arterial hypertension is associated with an increased risk for cardiovascular (CV) diseases. The evaluation of hypertension-mediated organ damage (HMOD) helps estimating CV risk. We investigated the incidence of HMOD ... ...

Abstract	Objective: Early onset of untreated arterial hypertension is associated with an increased risk for cardiovascular (CV) diseases. The evaluation of hypertension-mediated organ damage (HMOD) helps estimating CV risk. We investigated the incidence of HMOD in young first, diagnosed and nevertreated patients with systolic arterial hypertension (SH) to identify high CV-risk patients based on the presence of HMOD. Methods: CV risk factors [smoking, obesity (body mass index, BMI)], hyperlipidemia and 5 HMODs [arterial stiffness (pulse wave velocity, PWV), left ventricular diastolic dysfunction [(DD (E/Ea)], cardiac hypertrophy (left ventricular mass index, LVMI), coronary artery microcirculation (CFR), and carotid intima-media thickness (cIMT)] were evaluated before treatment initiation in 220 patients, aged ≤50 years [median (interquartile range, IQR) age=43(38-47)], with SH diagnosed by ambulatory blood pressure monitoring (24-h ABPM). Results: Smoking (40%) and obesity [median (IQR) BMI=30(26-32) kg/m Conclusion: The presence of ≥2 of the studied HMOD (PWV, LVMI, cIMT, E/Ea, CFR) in young hypertensives characterizes a "high-risk population". Arterial stiffness represents the predominant HMOD and in the whole population and "high-risk population".
MeSH term(s)	Humans ; Blood Pressure Monitoring, Ambulatory ; Pulse Wave Analysis/adverse effects ; Carotid Intima-Media Thickness ; Isolated Systolic Hypertension ; Hypertension/diagnosis ; Hypertension/epidemiology ; Hypertension/complications ; Blood Pressure ; Cardiovascular Diseases/etiology ; Obesity/complications ; Vascular Stiffness/physiology
Language	English
Publishing date	2023-08-02
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2192362-0
ISSN	1875-6212 ; 1570-1611
ISSN (online)	1875-6212
ISSN	1570-1611
DOI	10.2174/1570161121666230531153431
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Article ; Online: Cardiopulmonary Exercise Testing: The ABC for the Clinical Cardiologist.

Triantafyllidi, Helen / Birmpa, Dionyssia / Benas, Dimitrios / Trivilou, Paraskevi / Fambri, Anastasia / Iliodromitis, Efstathios K

Cardiology

2021 Volume 147, Issue 1, Page(s) 62–71

Abstract: Background: Cardiopulmonary exercise testing (CPET) is the most comprehensive technique which allows a holistic approach to cardiopulmonary diseases.: Summary: This article provides basic information addressed to the Clinical Cardiologist regarding ... ...

Abstract	Background: Cardiopulmonary exercise testing (CPET) is the most comprehensive technique which allows a holistic approach to cardiopulmonary diseases. Summary: This article provides basic information addressed to the Clinical Cardiologist regarding the utility and the indications of the CPET technique in the everyday clinical practice. Clinical application of CPET continues to evolve and protocols should be adapted to each specific patient to obtain the most reliable and useful information. Key Messages: Clinical Cardiologists with an interest over CPET may become familiar with this exercise method and its main measured variables, refresh their knowledge regarding the underlying pathophysiological mechanisms of oxygen transport chain, learn how to interpret the CPET results and promote appropriate patient referrals to experts.
MeSH term(s)	Cardiologists ; Exercise ; Exercise Test/methods ; Exercise Tolerance ; Heart ; Heart Failure ; Humans
Language	English
Publishing date	2021-10-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	80092-2
ISSN	1421-9751 ; 0008-6312
ISSN (online)	1421-9751
ISSN	0008-6312
DOI	10.1159/000520024
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Article ; Online: Peak exercise myocardial deformation indices during cardiopulmonary exercise testing are associated with exercise capacity and ventilatory efficiency in patients with dilated cardiomyopathy.

Triantafyllidi, Helen / Birmpa, Dionyssia / Ikonomidis, Ignatios / Benas, Dimitrios / Makavos, George / Cokkinos, Dennis V / Triposkiadis, Filippos / Iliodromitis, Efstathios K

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

2022 Volume 70, Page(s) 28–35

Abstract: Objective: Little is known about the exercise-induced changes in the multidimensional mechanical properties of the heart. We aimed to evaluate the myocardial deformation indices (MDI) at rest and their response at peak exercise during the same ... ...

Abstract	Objective: Little is known about the exercise-induced changes in the multidimensional mechanical properties of the heart. We aimed to evaluate the myocardial deformation indices (MDI) at rest and their response at peak exercise during the same cardiopulmonary exercise testing (CPET) session, investigating their relationship to exercise capacity and ventilatory sufficiency in dilated cardiomyopathy (DCM) patients. Methods: We evaluated left ventricular (LV) function using speckle tracking imaging (STI) at rest and peak exercise during the same CPET session in 57 idiopathic DCM patients in New York Heart Association (NYHA) I-II class [54 ± 12 years, 42 males, ejection fraction (EF) 33 ± 9%]. We measured global longitudinal strain (GLS), longitudinal strain rate at systole (LSRS) and diastole (LSRD), and circumferential strain rate (CircS). Results: Resting GLS, LSRS, and LSRD were impaired compared with the predicted values but were improved at peak exercise (p < 0.001). All MDI at rest and/or at peak exercise were related to several CPET-derived parameters, including peak VO Conclusions: Peak exercise LSRS and GLS in NYHA I-II DCM patients subjected to CPET were associated with aerobic exercise capacity and ventilatory efficiency. Consequently, LSRS and GLS at peak exercise, through their association with CPET-derived CV risk indices, may underline the severity of heart failure and predict future CV events in this DCM population.
MeSH term(s)	Male ; Humans ; Exercise Test/methods ; Cardiomyopathy, Dilated ; Exercise Tolerance/physiology ; Ventricular Function, Left/physiology ; Heart Failure ; Exercise/physiology ; Oxygen Consumption/physiology ; Stroke Volume/physiology
Language	English
Publishing date	2022-12-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2215027-4
ISSN	2241-5955 ; 1109-9666
ISSN (online)	2241-5955
ISSN	1109-9666
DOI	10.1016/j.hjc.2022.12.009
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Article ; Online: Reference values for aerobic capacity estimated by cardiopulmonary exercise test on a cycle ergometer in a healthy Greek population.

Triantafyllidi, Helen / Benas, Dimitrios / Birba, Dionyssia / Trivilou, Paraskevi / Iliodromitis, Efstathios

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

2019 Volume 62, Issue 2, Page(s) 121–126

Abstract: Objective: Aerobic capacity (AC) is inversely associated with a high risk of cardiovascular morbidity and mortality as well as all-cause mortality. Cardiopulmonary exercise testing (CPET) represents the gold standard for assessing exercise capacity ... ...

Abstract	Objective: Aerobic capacity (AC) is inversely associated with a high risk of cardiovascular morbidity and mortality as well as all-cause mortality. Cardiopulmonary exercise testing (CPET) represents the gold standard for assessing exercise capacity based on maximum oxygen uptake (VO Methods: A cohort of 194 apparently healthy subjects (118 males and 76 females, age range, 15-69 years) was submitted to CPET using a cycle ergometer. Mean ± SD values for several exercise parameters, VO Results: Male subjects achieved significantly higher levels of relative and absolute VO Conclusion: We provide the first reference data for AC in apparently healthy Greek subjects based on CPET using cycle ergometer. Our findings will allow for more accurate interpretation of CPET in several groups of healthy subjects or patients with CV diseases. The differences found between our reference values and those reported from the USA and northern European countries, underscore the need for individual countries to develop their own AC reference values.
MeSH term(s)	Adolescent ; Adult ; Aged ; Exercise Test ; Exercise Tolerance ; Female ; Greece/epidemiology ; Humans ; Male ; Middle Aged ; Oxygen ; Oxygen Consumption ; Reference Values ; Young Adult
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2019-12-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2215027-4
ISSN	2241-5955 ; 1109-9666
ISSN (online)	2241-5955
ISSN	1109-9666
DOI	10.1016/j.hjc.2019.12.004
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Article ; Online: Cardiovascular disease and risk assessment in people living with HIV: Current practices and novel perspectives.

Fragkou, Paraskevi C / Moschopoulos, Charalampos D / Dimopoulou, Dimitra / Triantafyllidi, Helen / Birmpa, Dionysia / Benas, Dimitrios / Tsiodras, Sotirios / Kavatha, Dimitra / Antoniadou, Anastasia / Papadopoulos, Antonios

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

2023 Volume 71, Page(s) 42–54

Abstract: Human immunodeficiency virus (HIV) infection represents a major cardiovascular risk factor, and the cumulative cardiovascular disease (CVD) burden among aging people living with HIV (PLWH) constitutes a leading cause of morbidity and mortality. To date, ... ...

Abstract	Human immunodeficiency virus (HIV) infection represents a major cardiovascular risk factor, and the cumulative cardiovascular disease (CVD) burden among aging people living with HIV (PLWH) constitutes a leading cause of morbidity and mortality. To date, CVD risk assessment in PLWH remains challenging. Therefore, it is necessary to evaluate and stratify the cardiovascular risk in PLWH with appropriate screening and risk assessment tools and protocols to correctly identify which patients are at a higher risk for CVD and will benefit most from prevention measures and timely management. This review aims to accumulate the current evidence on the association between HIV infection and CVD, as well as the risk factors contributing to CVD in PLWH. Furthermore, considering the need for cardiovascular risk assessment in daily clinical practice, the purpose of this review is also to report the current practices and novel perspectives in cardiovascular risk assessment of PLWH and provide further insights into the development and implementation of appropriate CVD risk stratification and treatment strategies, particularly in countries with high HIV burden and limited resources.
MeSH term(s)	Humans ; HIV Infections/complications ; HIV Infections/epidemiology ; HIV Infections/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/diagnosis ; Risk Factors ; Risk Assessment
Language	English
Publishing date	2023-01-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2215027-4
ISSN	2241-5955 ; 1109-9666
ISSN (online)	2241-5955
ISSN	1109-9666
DOI	10.1016/j.hjc.2022.12.013
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